BR0111555A - Piridin-2-ilaminoalquilcarbonilglicil-beta-alanina e derivados - Google Patents
Piridin-2-ilaminoalquilcarbonilglicil-beta-alanina e derivadosInfo
- Publication number
- BR0111555A BR0111555A BR0111555-3A BR0111555A BR0111555A BR 0111555 A BR0111555 A BR 0111555A BR 0111555 A BR0111555 A BR 0111555A BR 0111555 A BR0111555 A BR 0111555A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- pyridin
- alanine
- derivatives
- ring structures
- Prior art date
Links
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 title 2
- 229940000635 beta-alanine Drugs 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"PIRIDIN-2-ILAMINOALQUILCARBONILGLICIL-BE-TA-ALANINA E DERIVADOS". A invenção refere-se aos compostos da fórmula I: onde R^ 1^ é H, A, Ar, Hal, -OH, -O-A, CF~ 3~ ou -OCF~ 3~; R^ 2^ e R^ 7^ são H ou A; R^ 3^ é: R^ 4^, R^ 5^ e R^ 6^ são em cada caso, independentemente um do outro, H, A, Hal, -OH, -O-A, -CF~ 3~, -OCF~ 3~, -CN, -NH~ 2~, -A-NH~ 2~; A é C~ 1~-^ (sym)^ .alquila; Ar é um substituinte que é formado por um radical aromático que é opcionalmente substituído uma vez, duas ou três vezes por R^ 5^ e que possui de 1 a 3 estruturas de anel que são opcionalmente fundidas com outras estruturas de anel para formar um sistema de anel fundido; Het é um substituinte que é formado por um heterociclo que possui de 1 a 3 estruturas de anel, com cada estrutura de anel sendo saturada, insaturada ou aromática e sendo opcionalmente fundida com outras estruturas de anel para formar um sistema de anel fundido e o heterociclo possuindo um total de 1 a 4 átomos de N, O e/ou S nas estruturas de anel e sendo opcionalmente substituído por R^ 6^; Hal é F, CI, Br ou I; n é 2, 3, 4, 5 ou 6 e para seu uso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10028402A DE10028402A1 (de) | 2000-06-13 | 2000-06-13 | Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate |
| PCT/EP2001/006661 WO2001096365A1 (de) | 2000-06-13 | 2001-06-12 | PYRIDIN-2-YL-AMINOALKYLCARBONYLGLYCYL-β-ALANIN UND DERIVATE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111555A true BR0111555A (pt) | 2003-07-08 |
Family
ID=7645128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111555-3A BR0111555A (pt) | 2000-06-13 | 2001-06-12 | Piridin-2-ilaminoalquilcarbonilglicil-beta-alanina e derivados |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20030171304A1 (pt) |
| EP (1) | EP1290010A1 (pt) |
| JP (1) | JP2004503562A (pt) |
| KR (1) | KR20030022145A (pt) |
| CN (1) | CN1436196A (pt) |
| AR (1) | AR028714A1 (pt) |
| AU (1) | AU6606301A (pt) |
| BR (1) | BR0111555A (pt) |
| CA (1) | CA2414000A1 (pt) |
| CZ (1) | CZ20023952A3 (pt) |
| DE (1) | DE10028402A1 (pt) |
| HU (1) | HUP0303716A2 (pt) |
| MX (1) | MXPA02012411A (pt) |
| NO (1) | NO20025968L (pt) |
| PL (1) | PL358671A1 (pt) |
| SK (1) | SK17112002A3 (pt) |
| WO (1) | WO2001096365A1 (pt) |
| ZA (1) | ZA200209410B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| HUP0202568A3 (en) | 1999-06-01 | 2009-11-30 | Biogen Idec Inc | A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders |
| UA83791C2 (ru) | 2001-04-13 | 2008-08-26 | Байоджен Айдек Ма Инк. | Антитело против vla-1, фармацевтическая композиция, которая его содержит, и из применение для лечения индивидуума с иммунологическим расстройством, опосредованным vla-1 |
| US7176322B2 (en) | 2002-05-23 | 2007-02-13 | Amgen Inc. | Calcium receptor modulating agents |
| US6908935B2 (en) | 2002-05-23 | 2005-06-21 | Amgen Inc. | Calcium receptor modulating agents |
| PL1727811T3 (pl) * | 2004-03-24 | 2015-04-30 | Shire Orphan Therapies Gmbh | Nowe związki do hamowania angiogenezy i ich zastosowanie |
| US20090196912A1 (en) * | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
| EP2034830B1 (en) | 2006-05-25 | 2014-09-03 | Biogen Idec MA Inc. | Anti-vla-1 antibody for treating stroke |
| WO2010057922A1 (en) * | 2008-11-24 | 2010-05-27 | Basf Se | Curable composition comprising a thermolatent base |
| NZ629204A (en) | 2012-02-16 | 2016-09-30 | Santarus Inc | Anti-vla1 (cd49a) antibody pharmaceutical compositions |
| EP3703700A4 (en) * | 2017-11-01 | 2021-08-04 | Arrowhead Pharmaceuticals, Inc. | INTEGRIN LIGANDS AND USES OF THESE LATEST |
| JP2024516096A (ja) | 2021-04-08 | 2024-04-12 | アローヘッド ファーマシューティカルズ インコーポレイテッド | 終末糖化産物受容体の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法 |
| WO2025152967A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向αvβ6的化合物及其用途 |
| CN120309684A (zh) * | 2024-01-15 | 2025-07-15 | 武汉人福创新药物研发中心有限公司 | 靶向化合物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ203898A3 (cs) * | 1995-12-29 | 1999-03-17 | Smithkline Beecham Corporation | Antagonista vitronektinového receptoru, farmaceutický přípravek s jeho obsahem, způsob a použití |
-
2000
- 2000-06-13 DE DE10028402A patent/DE10028402A1/de not_active Withdrawn
-
2001
- 2001-06-12 BR BR0111555-3A patent/BR0111555A/pt not_active Application Discontinuation
- 2001-06-12 SK SK1711-2002A patent/SK17112002A3/sk unknown
- 2001-06-12 KR KR1020027016894A patent/KR20030022145A/ko not_active Withdrawn
- 2001-06-12 AU AU66063/01A patent/AU6606301A/en not_active Abandoned
- 2001-06-12 US US10/297,989 patent/US20030171304A1/en not_active Abandoned
- 2001-06-12 MX MXPA02012411A patent/MXPA02012411A/es unknown
- 2001-06-12 EP EP01943499A patent/EP1290010A1/de not_active Withdrawn
- 2001-06-12 WO PCT/EP2001/006661 patent/WO2001096365A1/de not_active Ceased
- 2001-06-12 CN CN01811104A patent/CN1436196A/zh active Pending
- 2001-06-12 PL PL01358671A patent/PL358671A1/xx unknown
- 2001-06-12 CA CA002414000A patent/CA2414000A1/en not_active Abandoned
- 2001-06-12 JP JP2002510506A patent/JP2004503562A/ja active Pending
- 2001-06-12 HU HU0303716A patent/HUP0303716A2/hu unknown
- 2001-06-12 CZ CZ20023952A patent/CZ20023952A3/cs unknown
- 2001-06-13 AR ARP010102804A patent/AR028714A1/es unknown
-
2002
- 2002-11-19 ZA ZA200209410A patent/ZA200209410B/en unknown
- 2002-12-12 NO NO20025968A patent/NO20025968L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20025968D0 (no) | 2002-12-12 |
| MXPA02012411A (es) | 2003-04-25 |
| EP1290010A1 (de) | 2003-03-12 |
| JP2004503562A (ja) | 2004-02-05 |
| CA2414000A1 (en) | 2002-12-03 |
| SK17112002A3 (sk) | 2003-04-01 |
| US20030171304A1 (en) | 2003-09-11 |
| CN1436196A (zh) | 2003-08-13 |
| PL358671A1 (en) | 2004-08-09 |
| KR20030022145A (ko) | 2003-03-15 |
| AU6606301A (en) | 2001-12-24 |
| HUP0303716A2 (hu) | 2004-03-01 |
| NO20025968L (no) | 2002-12-12 |
| CZ20023952A3 (cs) | 2003-03-12 |
| DE10028402A1 (de) | 2001-12-20 |
| WO2001096365A1 (de) | 2001-12-20 |
| ZA200209410B (en) | 2004-02-19 |
| AR028714A1 (es) | 2003-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |