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SK16512000A3 - Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie - Google Patents

Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie Download PDF

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Publication number
SK16512000A3
SK16512000A3 SK1651-2000A SK16512000A SK16512000A3 SK 16512000 A3 SK16512000 A3 SK 16512000A3 SK 16512000 A SK16512000 A SK 16512000A SK 16512000 A3 SK16512000 A3 SK 16512000A3
Authority
SK
Slovakia
Prior art keywords
group
carbon atoms
alkyl
substituent
formula
Prior art date
Application number
SK1651-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Peter William Rodney Caulkett
Roger James
Stuart Eric Pearson
Anthony Michael Slater
Rolf Peter Walker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en
Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK16512000A3 publication Critical patent/SK16512000A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK1651-2000A 1998-05-02 1999-04-27 Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie SK16512000A3 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9809351.1A GB9809351D0 (en) 1998-05-02 1998-05-02 Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en) 1999-02-16 1999-02-16 Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en) 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa

Publications (1)

Publication Number Publication Date
SK16512000A3 true SK16512000A3 (sk) 2001-05-10

Family

ID=26313572

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1651-2000A SK16512000A3 (sk) 1998-05-02 1999-04-27 Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie

Country Status (22)

Country Link
US (2) US6753331B1 (et)
EP (2) EP1528061A1 (et)
JP (1) JP2002513790A (et)
KR (1) KR20010043246A (et)
CN (1) CN1133634C (et)
AT (1) ATE282610T1 (et)
AU (1) AU754453B2 (et)
BR (1) BR9910179A (et)
CA (1) CA2331042A1 (et)
DE (1) DE69921994T2 (et)
EE (1) EE200000527A (et)
ES (1) ES2232131T3 (et)
HU (1) HUP0101712A3 (et)
IL (1) IL139406A (et)
NO (1) NO320893B1 (et)
NZ (1) NZ507835A (et)
PL (1) PL343706A1 (et)
PT (1) PT1082321E (et)
SI (1) SI1082321T1 (et)
SK (1) SK16512000A3 (et)
TR (1) TR200003200T2 (et)
WO (1) WO1999057113A1 (et)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
GB9914342D0 (en) * 1999-06-19 1999-08-18 Zeneca Ltd Compound
GB9917344D0 (en) * 1999-07-24 1999-09-22 Zeneca Ltd Novel salt
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
GB0012448D0 (en) 2000-05-24 2000-07-12 Astrazeneca Ab New process
CA2428784A1 (en) * 2000-11-09 2002-05-16 Astrazeneca Ab Oral pharmaceutical composition containing a block copolymer
GB0104752D0 (en) * 2001-02-27 2001-04-18 Astrazeneca Ab Pharmaceutical compositions
WO2003000657A1 (en) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
AU2004260758B2 (en) * 2003-08-01 2007-06-07 Nippon Soda Co., Ltd. Phenylazole compounds, production process, and antioxidants
SE0400014D0 (sv) * 2004-01-08 2004-01-08 Astrazeneca Ab Heterocyclic derivatives
WO2007008145A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008142A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008143A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008144A1 (en) * 2005-07-08 2007-01-18 Astrazeneca Ab Heterocyclic sulfonamide derivatives as inhibitors of factor xa
CA3093445A1 (en) 2018-03-08 2019-11-28 Incyte Corporation Aminopyrazine diol compounds as pi3k-.gamma. inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
JP7775080B2 (ja) 2019-07-01 2025-11-25 トニックス ファーマ リミテッド 抗cd154抗体およびその使用
MX2023008055A (es) 2021-01-06 2023-08-22 Tonix Pharma Ltd Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
ATE267011T1 (de) * 1995-12-21 2004-06-15 Bristol Myers Squibb Pharma Co Isoxazolin, isothiazolin und pyrazolin als faktor xa inhibitoren
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
CA2287292A1 (en) * 1997-05-30 1998-12-03 Takeda Chemical Industries, Ltd. Sulfonamide derivatives, their production and use
GB9715894D0 (en) * 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate

Also Published As

Publication number Publication date
EP1082321B1 (en) 2004-11-17
SI1082321T1 (en) 2005-06-30
WO1999057113A1 (en) 1999-11-11
EE200000527A (et) 2002-02-15
PL343706A1 (en) 2001-08-27
US20040266759A1 (en) 2004-12-30
ATE282610T1 (de) 2004-12-15
HUP0101712A2 (hu) 2001-11-28
CN1133634C (zh) 2004-01-07
DE69921994D1 (de) 2004-12-23
EP1528061A1 (en) 2005-05-04
IL139406A0 (en) 2001-11-25
BR9910179A (pt) 2001-01-09
NZ507835A (en) 2003-01-31
CA2331042A1 (en) 1999-11-11
TR200003200T2 (tr) 2001-02-21
IL139406A (en) 2004-07-25
CN1308631A (zh) 2001-08-15
DE69921994T2 (de) 2005-12-01
JP2002513790A (ja) 2002-05-14
NO20005497D0 (no) 2000-11-01
EP1082321A1 (en) 2001-03-14
US6753331B1 (en) 2004-06-22
AU754453B2 (en) 2002-11-14
KR20010043246A (ko) 2001-05-25
HUP0101712A3 (en) 2003-01-28
PT1082321E (pt) 2005-03-31
ES2232131T3 (es) 2005-05-16
NO320893B1 (no) 2006-02-06
AU3620699A (en) 1999-11-23
NO20005497L (no) 2000-12-21
HK1034711A1 (en) 2001-11-02

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