HUP0101712A3 - Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them - Google Patents

Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them

Info

Publication number: HUP0101712A3
Authority: HU; Hungary
Prior art keywords: pharmaceutical compositions; compositions containing; heterocyclic derivatives; inhibit factor; inhibit
Prior art date: 1998-05-02

Application number

HU0101712A

Other languages

English (en)

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-02

Filing date

1999-04-27

Publication date

2003-01-28

1998-05-02 Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en

1999-02-16 Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en

1999-04-27 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-11-28 Publication of HUP0101712A2 publication Critical patent/HUP0101712A2/hu

2003-01-28 Publication of HUP0101712A3 publication Critical patent/HUP0101712A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

HU0101712A 1998-05-02 1999-04-27 Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them HUP0101712A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9809351.1A GB9809351D0 (en)	1998-05-02	1998-05-02	Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en)	1999-02-16	1999-02-16	Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en)	1998-05-02	1999-04-27	Heterocyclic derivatives which inhibit factor xa

Publications (2)

Publication Number	Publication Date
HUP0101712A2 HUP0101712A2 (hu)	2001-11-28
HUP0101712A3 true HUP0101712A3 (en)	2003-01-28

Family

ID=26313572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0101712A HUP0101712A3 (en)	1998-05-02	1999-04-27	Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them

Country Status (22)

Country	Link
US (2)	US6753331B1 (hu)
EP (2)	EP1528061A1 (hu)
JP (1)	JP2002513790A (hu)
KR (1)	KR20010043246A (hu)
CN (1)	CN1133634C (hu)
AT (1)	ATE282610T1 (hu)
AU (1)	AU754453B2 (hu)
BR (1)	BR9910179A (hu)
CA (1)	CA2331042A1 (hu)
DE (1)	DE69921994T2 (hu)
EE (1)	EE200000527A (hu)
ES (1)	ES2232131T3 (hu)
HU (1)	HUP0101712A3 (hu)
IL (1)	IL139406A (hu)
NO (1)	NO320893B1 (hu)
NZ (1)	NZ507835A (hu)
PL (1)	PL343706A1 (hu)
PT (1)	PT1082321E (hu)
SI (1)	SI1082321T1 (hu)
SK (1)	SK16512000A3 (hu)
TR (1)	TR200003200T2 (hu)
WO (1)	WO1999057113A1 (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9902989D0 (en) *	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
GB9914342D0 (en) *	1999-06-19	1999-08-18	Zeneca Ltd	Compound
GB9917344D0 (en) *	1999-07-24	1999-09-22	Zeneca Ltd	Novel salt
TWI288745B (en)	2000-04-05	2007-10-21	Daiichi Seiyaku Co	Ethylenediamine derivatives
GB0012448D0 (en)	2000-05-24	2000-07-12	Astrazeneca Ab	New process
CN100408099C (zh) *	2000-11-09	2008-08-06	阿斯特拉曾尼卡有限公司	含有嵌段共聚物的口服药物组合物
GB0104752D0 (en) *	2001-02-27	2001-04-18	Astrazeneca Ab	Pharmaceutical compositions
WO2003000657A1 (en)	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Diamine derivatives
DK1569912T3 (en)	2002-12-03	2015-06-29	Pharmacyclics Inc	2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
AU2004260758B2 (en) *	2003-08-01	2007-06-07	Nippon Soda Co., Ltd.	Phenylazole compounds, production process, and antioxidants
SE0400014D0 (sv)	2004-01-08	2004-01-08	Astrazeneca Ab	Heterocyclic derivatives
WO2007008144A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008143A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
US20080221063A1 (en) *	2005-07-08	2008-09-11	Astrazeneca Ab	Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
WO2007008145A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
SMT202200134T1 (it)	2018-03-08	2022-05-12	Incyte Corp	Composti di amminopirazindiolo come inibitori di pi3k-y
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
US20220380478A1 (en)	2019-07-01	2022-12-01	Tonix Pharma Holdings Limited	Anti-cd154 antibodies and uses thereof
EP4274587A1 (en)	2021-01-06	2023-11-15	Tonix Pharma Limited	Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en)	2024-05-31	2025-12-04	Tonix Pharma Limited	Treatment methods comprising administration of modified cd154 antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en) *	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
ATE267011T1 (de) *	1995-12-21	2004-06-15	Bristol Myers Squibb Pharma Co	Isoxazolin, isothiazolin und pyrazolin als faktor xa inhibitoren
GB9602166D0 (en)	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602294D0 (en) *	1996-02-05	1996-04-03	Zeneca Ltd	Heterocyclic compounds
UA56197C2 (uk)	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
US6359134B1 (en) *	1997-05-30	2002-03-19	Takeda Chemical Industries, Ltd.	Sulfonamide derivatives, their production and use
GB9715894D0 (en) *	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic derivatives
DE19743435A1 (de) *	1997-10-01	1999-04-08	Merck Patent Gmbh	Benzamidinderivate

1999
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 EP EP04022155A patent/EP1528061A1/en not_active Withdrawn
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Ceased
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 EP EP99918178A patent/EP1082321B1/en not_active Expired - Lifetime
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Ceased
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU754453B2 (en)	2002-11-14
NO320893B1 (no)	2006-02-06
NZ507835A (en)	2003-01-31
EP1528061A1 (en)	2005-05-04
US20040266759A1 (en)	2004-12-30
EP1082321A1 (en)	2001-03-14
DE69921994T2 (de)	2005-12-01
JP2002513790A (ja)	2002-05-14
CA2331042A1 (en)	1999-11-11
ATE282610T1 (de)	2004-12-15
HUP0101712A2 (hu)	2001-11-28
PL343706A1 (en)	2001-08-27
IL139406A0 (en)	2001-11-25
DE69921994D1 (de)	2004-12-23
KR20010043246A (ko)	2001-05-25
NO20005497L (no)	2000-12-21
SK16512000A3 (sk)	2001-05-10
ES2232131T3 (es)	2005-05-16
BR9910179A (pt)	2001-01-09
SI1082321T1 (en)	2005-06-30
WO1999057113A1 (en)	1999-11-11
TR200003200T2 (tr)	2001-02-21
EE200000527A (et)	2002-02-15
NO20005497D0 (no)	2000-11-01
US6753331B1 (en)	2004-06-22
IL139406A (en)	2004-07-25
AU3620699A (en)	1999-11-23
PT1082321E (pt)	2005-03-31
CN1133634C (zh)	2004-01-07
HK1034711A1 (en)	2001-11-02
CN1308631A (zh)	2001-08-15
EP1082321B1 (en)	2004-11-17

Publication	Publication Date	Title
HUP0101810A3 (en)	2002-05-28	Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them
IL139479A0 (en)	2001-11-25	Heterocyclic compounds and pharmaceutical compositions containing the same
IL148517A0 (en)	2002-09-12	Heterocyclic compounds and pharmaceutical compositions containing the same
IL150077A0 (en)	2002-12-01	Heterocyclic compounds and pharmaceutical compositions containing the same
HUP0101712A3 (en)	2003-01-28	Heterocyclic derivatives which inhibit factor xa and pharmaceutical compositions containing them
IL149883A0 (en)	2002-11-10	Heterocyclic compounds and pharmaceutical compositions containing the same
IL149473A0 (en)	2002-11-10	Heterocyclic dihydropyrimidine derivatives and pharmaceutical compositions containing the same
IL145428A0 (en)	2002-06-30	Alkanoyl-substituted heterocyclic derivatives and pharmaceutical compositions containing the same
HUP0103256A3 (en)	2002-05-28	Thiobenzimidazole derivatives and pharmaceutical compositions containing the compounds
IL144592A0 (en)	2002-05-23	Heterocyclic aromatic compounds and pharmaceutical compositions containing the same
IL138899A0 (en)	2001-11-25	Amidene derivatives and pharmaceutical compositions containing the same
IL142665A0 (en)	2002-03-10	Acyl dipeptidyl derivatives and pharmaceutical compositions containing the same
HUP0203378A3 (en)	2004-07-28	Pharmaceutical compounds and pharmaceutical compositions containing them
HUP0103406A3 (en)	2002-11-28	1h-imidazopyridine derivatives and pharmaceutical compositions thereof
IL138573A0 (en)	2001-10-31	Amide derivatives and pharmaceutical compositions containing the same
IL146540A0 (en)	2002-07-25	Thiazolo derivatives and pharmaceutical compositions containing them
HUP0203939A3 (en)	2004-12-28	Pharmaceutical compounds and compositions containing them and their use
IL143920A0 (en)	2002-04-21	3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same
HUP0102990A3 (en)	2002-09-30	Tetrahydroimidazo-naphtyridine derivatives and pharmaceutical compositions thereof
HUP0003362A3 (en)	2001-04-28	Piperidine derivatives and pharmaceutical compositions containing them
HUP0101381A3 (en)	2002-06-28	Benzofurylpyrone derivatives and pharmaceutical compositions containing them
HUP0002528A3 (en)	2002-09-30	Heterocyclic derivatives which inhibit factor xa
IL143802A0 (en)	2002-04-21	Imidazole derivatives and pharmaceutical compositions containing the same
IL157740A0 (en)	2004-03-28	Heterocyclic derivatives and pharmaceutical compositions containing the same
HUP0201714A3 (en)	2003-05-28	Substituted heterocyclic compounds and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2007-12-28	FD9A	Lapse of provisional protection due to non-payment of fees