SK16512000A3 - Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie - Google Patents
Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie Download PDFInfo
- Publication number
- SK16512000A3 SK16512000A3 SK1651-2000A SK16512000A SK16512000A3 SK 16512000 A3 SK16512000 A3 SK 16512000A3 SK 16512000 A SK16512000 A SK 16512000A SK 16512000 A3 SK16512000 A3 SK 16512000A3
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- carbon atoms
- alkyl
- substituent
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9809351.1A GB9809351D0 (en) | 1998-05-02 | 1998-05-02 | Heterocyclic derivatives |
| GBGB9903337.5A GB9903337D0 (en) | 1999-02-16 | 1999-02-16 | Heterocyclic derivatives |
| PCT/GB1999/001308 WO1999057113A1 (en) | 1998-05-02 | 1999-04-27 | Heterocyclic derivatives which inhibit factor xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK16512000A3 true SK16512000A3 (sk) | 2001-05-10 |
Family
ID=26313572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1651-2000A SK16512000A3 (sk) | 1998-05-02 | 1999-04-27 | Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6753331B1 (xx) |
| EP (2) | EP1528061A1 (xx) |
| JP (1) | JP2002513790A (xx) |
| KR (1) | KR20010043246A (xx) |
| CN (1) | CN1133634C (xx) |
| AT (1) | ATE282610T1 (xx) |
| AU (1) | AU754453B2 (xx) |
| BR (1) | BR9910179A (xx) |
| CA (1) | CA2331042A1 (xx) |
| DE (1) | DE69921994T2 (xx) |
| EE (1) | EE200000527A (xx) |
| ES (1) | ES2232131T3 (xx) |
| HU (1) | HUP0101712A3 (xx) |
| IL (1) | IL139406A (xx) |
| NO (1) | NO320893B1 (xx) |
| NZ (1) | NZ507835A (xx) |
| PL (1) | PL343706A1 (xx) |
| PT (1) | PT1082321E (xx) |
| SI (1) | SI1082321T1 (xx) |
| SK (1) | SK16512000A3 (xx) |
| TR (1) | TR200003200T2 (xx) |
| WO (1) | WO1999057113A1 (xx) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| GB9914342D0 (en) * | 1999-06-19 | 1999-08-18 | Zeneca Ltd | Compound |
| GB9917344D0 (en) * | 1999-07-24 | 1999-09-22 | Zeneca Ltd | Novel salt |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| GB0012448D0 (en) | 2000-05-24 | 2000-07-12 | Astrazeneca Ab | New process |
| CA2428784A1 (en) * | 2000-11-09 | 2002-05-16 | Astrazeneca Ab | Oral pharmaceutical composition containing a block copolymer |
| GB0104752D0 (en) * | 2001-02-27 | 2001-04-18 | Astrazeneca Ab | Pharmaceutical compositions |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| AU2004260758B2 (en) * | 2003-08-01 | 2007-06-07 | Nippon Soda Co., Ltd. | Phenylazole compounds, production process, and antioxidants |
| SE0400014D0 (sv) * | 2004-01-08 | 2004-01-08 | Astrazeneca Ab | Heterocyclic derivatives |
| WO2007008145A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| WO2007008142A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| WO2007008143A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| WO2007008144A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| CA3093445A1 (en) | 2018-03-08 | 2019-11-28 | Incyte Corporation | Aminopyrazine diol compounds as pi3k-.gamma. inhibitors |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| JP7775080B2 (ja) | 2019-07-01 | 2025-11-25 | トニックス ファーマ リミテッド | 抗cd154抗体およびその使用 |
| MX2023008055A (es) | 2021-01-06 | 2023-08-22 | Tonix Pharma Ltd | Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados. |
| WO2025248134A1 (en) | 2024-05-31 | 2025-12-04 | Tonix Pharma Limited | Treatment methods comprising administration of modified cd154 antibodies |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| ATE267011T1 (de) * | 1995-12-21 | 2004-06-15 | Bristol Myers Squibb Pharma Co | Isoxazolin, isothiazolin und pyrazolin als faktor xa inhibitoren |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602294D0 (en) | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| CA2287292A1 (en) * | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| GB9715894D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
-
1999
- 1999-04-27 EP EP04022155A patent/EP1528061A1/en not_active Withdrawn
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 EP EP99918178A patent/EP1082321B1/en not_active Expired - Lifetime
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Ceased
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Ceased
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
-
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
-
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1082321B1 (en) | 2004-11-17 |
| SI1082321T1 (en) | 2005-06-30 |
| WO1999057113A1 (en) | 1999-11-11 |
| EE200000527A (et) | 2002-02-15 |
| PL343706A1 (en) | 2001-08-27 |
| US20040266759A1 (en) | 2004-12-30 |
| ATE282610T1 (de) | 2004-12-15 |
| HUP0101712A2 (hu) | 2001-11-28 |
| CN1133634C (zh) | 2004-01-07 |
| DE69921994D1 (de) | 2004-12-23 |
| EP1528061A1 (en) | 2005-05-04 |
| IL139406A0 (en) | 2001-11-25 |
| BR9910179A (pt) | 2001-01-09 |
| NZ507835A (en) | 2003-01-31 |
| CA2331042A1 (en) | 1999-11-11 |
| TR200003200T2 (tr) | 2001-02-21 |
| IL139406A (en) | 2004-07-25 |
| CN1308631A (zh) | 2001-08-15 |
| DE69921994T2 (de) | 2005-12-01 |
| JP2002513790A (ja) | 2002-05-14 |
| NO20005497D0 (no) | 2000-11-01 |
| EP1082321A1 (en) | 2001-03-14 |
| US6753331B1 (en) | 2004-06-22 |
| AU754453B2 (en) | 2002-11-14 |
| KR20010043246A (ko) | 2001-05-25 |
| HUP0101712A3 (en) | 2003-01-28 |
| PT1082321E (pt) | 2005-03-31 |
| ES2232131T3 (es) | 2005-05-16 |
| NO320893B1 (no) | 2006-02-06 |
| AU3620699A (en) | 1999-11-23 |
| NO20005497L (no) | 2000-12-21 |
| HK1034711A1 (en) | 2001-11-02 |
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