SK119498A3 - Porcine reproductive and respiratory syndrome vaccine - Google Patents
Porcine reproductive and respiratory syndrome vaccine Download PDFInfo
- Publication number
- SK119498A3 SK119498A3 SK1194-98A SK119498A SK119498A3 SK 119498 A3 SK119498 A3 SK 119498A3 SK 119498 A SK119498 A SK 119498A SK 119498 A3 SK119498 A3 SK 119498A3
- Authority
- SK
- Slovakia
- Prior art keywords
- virus
- vaccine
- prrs
- neb
- pigs
- Prior art date
Links
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 title claims abstract description 58
- 229960005486 vaccine Drugs 0.000 title claims abstract description 54
- 241000700605 Viruses Species 0.000 claims abstract description 70
- 238000000034 method Methods 0.000 claims abstract description 15
- 230000003612 virological effect Effects 0.000 claims abstract description 12
- 241000282887 Suidae Species 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 21
- 201000010099 disease Diseases 0.000 claims description 18
- 230000009257 reactivity Effects 0.000 claims description 13
- 241000282898 Sus scrofa Species 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 210000001132 alveolar macrophage Anatomy 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 230000000241 respiratory effect Effects 0.000 claims description 7
- 230000001850 reproductive effect Effects 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 238000012512 characterization method Methods 0.000 claims description 4
- 230000002238 attenuated effect Effects 0.000 claims description 3
- 230000009385 viral infection Effects 0.000 claims description 3
- 238000003745 diagnosis Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 19
- 238000002255 vaccination Methods 0.000 description 19
- 208000023504 respiratory system disease Diseases 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 10
- 102100030953 Cleavage and polyadenylation specificity factor subunit 4 Human genes 0.000 description 9
- 101000727105 Homo sapiens Cleavage and polyadenylation specificity factor subunit 4 Proteins 0.000 description 9
- 239000012530 fluid Substances 0.000 description 7
- 208000017443 reproductive system disease Diseases 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 5
- 229930182566 Gentamicin Natural products 0.000 description 5
- 229960002518 gentamicin Drugs 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 235000015277 pork Nutrition 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
- 229930182816 L-glutamine Natural products 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 229920002307 Dextran Polymers 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 206010000210 abortion Diseases 0.000 description 3
- 231100000176 abortion Toxicity 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000120 cytopathologic effect Effects 0.000 description 3
- 238000010908 decantation Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000012137 tryptone Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000001951 Fetal Death Diseases 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 208000005107 Premature Birth Diseases 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000010166 immunofluorescence Methods 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 235000013923 monosodium glutamate Nutrition 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 229940073490 sodium glutamate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000238017 Astacoidea Species 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- -1 EMEM Substances 0.000 description 1
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010055690 Foetal death Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 208000035752 Live birth Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 208000001300 Perinatal Death Diseases 0.000 description 1
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- RAFNCPHFRHZCPS-UHFFFAOYSA-N di(imidazol-1-yl)methanethione Chemical compound C1=CN=CN1C(=S)N1C=CN=C1 RAFNCPHFRHZCPS-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000018773 low birth weight Diseases 0.000 description 1
- 231100000533 low birth weight Toxicity 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 208000030279 prolonged fever Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229960004906 thiomersal Drugs 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60980696A | 1996-03-01 | 1996-03-01 | |
| PCT/US1997/002562 WO1997031651A1 (fr) | 1996-03-01 | 1997-02-26 | Vaccin contre le syndrome dysgenesique respiratoire porcin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK119498A3 true SK119498A3 (en) | 1999-07-12 |
Family
ID=24442410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1194-98A SK119498A3 (en) | 1996-03-01 | 1997-02-26 | Porcine reproductive and respiratory syndrome vaccine |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0894007A1 (fr) |
| JP (1) | JP3135069B2 (fr) |
| KR (1) | KR100297537B1 (fr) |
| CN (1) | CN1165342C (fr) |
| AR (1) | AR006023A1 (fr) |
| AU (1) | AU2277497A (fr) |
| BG (1) | BG64693B1 (fr) |
| BR (1) | BR9708443B1 (fr) |
| CA (1) | CA2248182C (fr) |
| CO (1) | CO4600644A1 (fr) |
| CZ (1) | CZ273798A3 (fr) |
| EE (1) | EE04741B1 (fr) |
| HU (1) | HUP9901958A3 (fr) |
| MY (1) | MY115070A (fr) |
| PL (1) | PL328627A1 (fr) |
| RU (1) | RU2187333C2 (fr) |
| SK (1) | SK119498A3 (fr) |
| WO (1) | WO1997031651A1 (fr) |
| ZA (1) | ZA971663B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0839912A1 (fr) | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Clones infectieux de virus à ARN, vaccins et essais diagnostiques |
| WO2000053787A1 (fr) | 1999-03-08 | 2000-09-14 | Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. | Vaccins contre le virus du syndrome dysgenesique respiratoire porcin (srdp) |
| NZ501264A (en) | 1998-12-22 | 2001-09-28 | Pfizer Prod Inc | Polynucleotide DNA sequence encoding an infectious RNA molecule encoding a North American PRRS |
| EP1183332B1 (fr) | 1999-04-22 | 2010-07-14 | United States Department Of Agriculture | Vaccin contre le syndrome dysgenesique respiratoire porcin base sur l'isolat ja-142 |
| RU2007101725A (ru) | 2004-06-18 | 2008-07-27 | Риджентс Оф Дзе Юниверсити Оф Миннесота (Us) | Идентификация инфицированных вирусом и вакцинированных вирусом организмов |
| US7632636B2 (en) | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
| AU2006262150B2 (en) | 2005-06-24 | 2011-07-21 | Regents Of The University Of Minnesota | PRRS viruses, infectious clones, mutants thereof, and methods of use |
| RU2354333C1 (ru) * | 2007-07-24 | 2009-05-10 | ФГОУ ВПО Омский государственный аграрный университет | Способ ранней диагностики послеродовых заболеваний у свиноматок |
| CN101612395B (zh) * | 2008-06-24 | 2012-02-08 | 扬州优邦生物制药有限公司 | 一种培养敏感细胞生产蓝耳病疫苗的方法 |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
| CN103370077B (zh) | 2011-02-17 | 2016-10-26 | 贝林格尔.英格海姆维特梅迪卡有限公司 | 猪繁殖与呼吸综合征病毒的商业化规模生产方法 |
| MX355058B (es) | 2011-02-17 | 2018-04-04 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del prrsv europea. |
| US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
| WO2013017568A1 (fr) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | Clone d'adnc infectieux du virus srrp européen et ses utilisations |
| KR101300528B1 (ko) * | 2011-10-05 | 2013-09-02 | 캔 테크놀로지스 인코포레이티드 | 액티노바실러스 플루로뉴모니애 감염 방지 및 처치용 조성물 |
| EP2968513A2 (fr) | 2013-03-15 | 2016-01-20 | Boehringer Ingelheim Vetmedica, Inc. | Virus, compositions, vaccin et procédés d'utilisation du syndrome dysgénésique et respiratoire porcin |
| EP4012025A1 (fr) * | 2020-12-10 | 2022-06-15 | Univerzita Palackého v Olomouci | Milieu de transport pour les échantillons contenant des acides nucléiques et/ou des protéines |
| CZ309704B6 (cs) * | 2020-12-10 | 2023-08-09 | Univerzita Palackého v Olomouci | Transportní médium pro transport a skladování virů |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6042830A (en) * | 1992-08-05 | 2000-03-28 | Boehringer Ingelheim Vetmedica, Inc. | Viral agent associated with mystery swine disease |
| DK0610250T4 (da) * | 1991-10-14 | 2009-03-02 | Intervet Int Bv | Vaccine med porcint reproduktivt respiratorisk syndrom (PRRS) og diagnose heraf |
| FR2686097B1 (fr) * | 1992-01-14 | 1994-12-30 | Rhone Merieux | Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie. |
| US5695766A (en) * | 1992-10-30 | 1997-12-09 | Iowa State University Research Foundation | Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome |
| DE69426228T2 (de) * | 1993-02-08 | 2001-03-01 | Bayer Ag | Verfahren zum Vermehren des das Reproduktions- und Atemwegs-Syndrom verursachenden Schweinevirus und dessen Verwendung als Impfstoff. |
| ES2074950B1 (es) * | 1993-09-17 | 1996-03-16 | Iberica Cyanamid | Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda. |
| DE69522984T2 (de) * | 1994-04-11 | 2002-04-25 | Akzo Nobel Nv | Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Schweins |
| US5690940A (en) * | 1995-06-21 | 1997-11-25 | Regents Of The University Of Minnesota | Low pathogencity PRRS live virus vaccines and methods of preparation thereof |
-
1997
- 1997-02-26 JP JP09530994A patent/JP3135069B2/ja not_active Expired - Fee Related
- 1997-02-26 EP EP97906016A patent/EP0894007A1/fr not_active Withdrawn
- 1997-02-26 CO CO97010338A patent/CO4600644A1/es unknown
- 1997-02-26 WO PCT/US1997/002562 patent/WO1997031651A1/fr not_active Ceased
- 1997-02-26 EE EE9800267A patent/EE04741B1/xx unknown
- 1997-02-26 CA CA002248182A patent/CA2248182C/fr not_active Expired - Lifetime
- 1997-02-26 HU HU9901958A patent/HUP9901958A3/hu unknown
- 1997-02-26 BR BRPI9708443-3A patent/BR9708443B1/pt not_active IP Right Cessation
- 1997-02-26 PL PL97328627A patent/PL328627A1/xx unknown
- 1997-02-26 RU RU98118186/13A patent/RU2187333C2/ru active
- 1997-02-26 CN CNB971941092A patent/CN1165342C/zh not_active Expired - Lifetime
- 1997-02-26 AU AU22774/97A patent/AU2277497A/en not_active Abandoned
- 1997-02-26 CZ CZ982737A patent/CZ273798A3/cs unknown
- 1997-02-26 SK SK1194-98A patent/SK119498A3/sk unknown
- 1997-02-26 MY MYPI97000727A patent/MY115070A/en unknown
- 1997-02-26 KR KR1019980706853A patent/KR100297537B1/ko not_active Expired - Lifetime
- 1997-02-26 ZA ZA9701663A patent/ZA971663B/xx unknown
- 1997-02-27 AR ARP970100790A patent/AR006023A1/es not_active Application Discontinuation
-
1998
- 1998-09-29 BG BG102809A patent/BG64693B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY115070A (en) | 2003-03-31 |
| CO4600644A1 (es) | 1998-05-08 |
| BG102809A (en) | 1999-05-31 |
| AU2277497A (en) | 1997-09-16 |
| CA2248182A1 (fr) | 1997-09-04 |
| BR9708443B1 (pt) | 2012-06-12 |
| CN1216922A (zh) | 1999-05-19 |
| EE9800267A (et) | 1999-02-15 |
| EP0894007A1 (fr) | 1999-02-03 |
| HUP9901958A3 (en) | 2000-04-28 |
| AR006023A1 (es) | 1999-07-21 |
| WO1997031651A1 (fr) | 1997-09-04 |
| CZ273798A3 (cs) | 1999-02-17 |
| ZA971663B (en) | 1997-08-26 |
| JP3135069B2 (ja) | 2001-02-13 |
| EE04741B1 (et) | 2006-12-15 |
| MX9807083A (es) | 1998-12-31 |
| JPH11506122A (ja) | 1999-06-02 |
| CN1165342C (zh) | 2004-09-08 |
| HUP9901958A2 (hu) | 1999-10-28 |
| PL328627A1 (en) | 1999-02-15 |
| KR19990087432A (ko) | 1999-12-27 |
| CA2248182C (fr) | 2004-04-20 |
| KR100297537B1 (ko) | 2001-10-26 |
| BG64693B1 (bg) | 2005-12-30 |
| BR9708443A (pt) | 1999-08-03 |
| RU2187333C2 (ru) | 2002-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5866401A (en) | Porcine reproductive and respiratory syndrome vaccine | |
| Wensvoort et al. | Bovine viral diarrhoea virus infections in piglets born to sows vaccinated against swine fever with contaminated vaccine | |
| RU2192887C2 (ru) | Вакцина против репродуктивного и респираторного синдрома свиней (prrs), способ иммунизации свиньи против prrs, способ получения вакцины, выделенный и очищенный штамм вируса репродуктивного и респираторного синдрома свиней | |
| US5698203A (en) | European vaccine strains of the Porcine Reproductive Respiratory Syndrome virus (PRRSV) | |
| Afshar et al. | Viruses associated with bovine semen. | |
| JP2738524B2 (ja) | ウイルスに感染した動物とワクチン接種した動物を区別する方法 | |
| EP0830142B1 (fr) | Vaccin contre le virus prrs (porcine reproductive and respiratory syndrome) | |
| US6001370A (en) | Attenuated strain of the virus causing the porcine reproductive respiratory syndrome (PRRS), and vaccines | |
| SK119498A3 (en) | Porcine reproductive and respiratory syndrome vaccine | |
| KR101152012B1 (ko) | 돼지 생식기 및 호흡기 증후군 바이러스 균주 및 조성물 | |
| Aynaud | Principles of vaccination | |
| US20030017448A1 (en) | Method of prophylaxis and treatment of porcine reproductive and respiratory syndrome | |
| US7824689B2 (en) | Chicken astrovirus type 2 | |
| PL209994B1 (pl) | Wariant wirusa zakaźnego zapalenia torby Fabrycjusza (IBDV), szczepionki, sposób wytwarzania wariantu IBDV, sposób wytwarzania szczepionek, zastosowanie wariantów IBDV | |
| RU2269361C2 (ru) | Вакцина ассоциированная эмульсионная инактивированная против репродуктивно-респираторного синдрома и парвовирусной инфекции свиней | |
| KR20240028924A (ko) | 높은 중화 항체를 유도하는 돼지 유행성 설사병 바이러스 및 불활화 백신 조성물 | |
| MXPA98007083A (en) | Vaccine against the reproductive and respiratory syndrome porc | |
| Tielen | PW de Leeuw¹, JM Wijsmuller2, JW Zantinga³ and | |
| MXPA97010149A (en) | Live pathogenicity live virus vaccines and methods of preparation of mis | |
| MXPA97007302A (en) | New attenuated cepa of the virus causing the respiratory and reproductive swine syndrome (prrs), vaccines and diagnostic media obtained with the same and the procedures for your obtenc |