SK10172001A3 - Ketolidové antibiotiká - Google Patents

Ketolidové antibiotiká Download PDF

Info

Publication number: SK10172001A3
Authority: SK; Slovakia
Prior art keywords: group; alkyl; groups; compound; aryl
Prior art date: 1999-01-27

Application number

SK1017-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Takushi Kaneko

William Thomas Mcmillen

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-27

Filing date

1999-12-28

Publication date

2002-06-04

1999-12-28 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2002-06-04 Publication of SK10172001A3 publication Critical patent/SK10172001A3/sk

Links

239000003242 anti bacterial agent Substances 0.000 title abstract description 6
229940088710 antibiotic agent Drugs 0.000 title description 3
239000003835 ketolide antibiotic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 128
150000003839 salts Chemical class 0.000 claims abstract description 45
208000035143 Bacterial infection Diseases 0.000 claims abstract description 19
208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 19
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 18
230000001580 bacterial effect Effects 0.000 claims abstract description 17
238000000034 method Methods 0.000 claims abstract description 13
239000012453 solvate Substances 0.000 claims abstract description 7
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
-1 azido, hydroxy Chemical group 0.000 claims description 40
125000000623 heterocyclic group Chemical group 0.000 claims description 31
125000000217 alkyl group Chemical group 0.000 claims description 27
125000003118 aryl group Chemical group 0.000 claims description 24
229910052739 hydrogen Inorganic materials 0.000 claims description 22
201000010099 disease Diseases 0.000 claims description 16
229910052736 halogen Inorganic materials 0.000 claims description 15
150000002367 halogens Chemical class 0.000 claims description 15
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
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125000004432 carbon atom Chemical group C* 0.000 claims description 8
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 8
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229910052760 oxygen Inorganic materials 0.000 claims description 6
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
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HCUOEKSZWPGJIM-IYNMRSRQSA-N (e,2z)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical group COCC([N+]([O-])=O)\C(C)=C\C(=N\O)\C(N)=O HCUOEKSZWPGJIM-IYNMRSRQSA-N 0.000 claims description 4
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
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239000007864 aqueous solution Substances 0.000 description 4
125000006615 aromatic heterocyclic group Chemical group 0.000 description 4
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231100000252 nontoxic Toxicity 0.000 description 4
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IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 4
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
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Oncology (AREA)
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Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
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SK1017-2001A 1999-01-27 1999-12-28 Ketolidové antibiotiká SK10172001A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11734299P	1999-01-27	1999-01-27
PCT/IB1999/002051 WO2000044761A2 (en)	1999-01-27	1999-12-28	Ketolide antibiotics

Publications (1)

Publication Number	Publication Date
SK10172001A3 true SK10172001A3 (sk)	2002-06-04

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1017-2001A SK10172001A3 (sk)	1999-01-27	1999-12-28	Ketolidové antibiotiká

Country Status (39)

Country	Link
US (1)	US6833444B2 (is)
EP (1)	EP1147121B1 (is)
JP (1)	JP3947360B2 (is)
KR (1)	KR20020002380A (is)
CN (1)	CN1342163A (is)
AP (1)	AP2001002222A0 (is)
AT (1)	ATE256694T1 (is)
AU (1)	AU1675400A (is)
BG (1)	BG105730A (is)
BR (1)	BR9916969A (is)
CA (1)	CA2359708C (is)
CO (1)	CO5150229A1 (is)
CZ (1)	CZ20012675A3 (is)
DE (1)	DE69913738T2 (is)
DK (1)	DK1147121T3 (is)
DZ (1)	DZ3000A1 (is)
EA (1)	EA200100623A1 (is)
EE (1)	EE200100394A (is)
ES (1)	ES2212655T3 (is)
HK (1)	HK1042707A1 (is)
HN (1)	HN2000000003A (is)
HR (1)	HRP20010559A2 (is)
HU (1)	HUP0105190A3 (is)
ID (1)	ID30233A (is)
IL (1)	IL144178A0 (is)
IS (1)	IS5984A (is)
MA (1)	MA26717A1 (is)
NO (1)	NO20013680L (is)
OA (1)	OA11753A (is)
PA (1)	PA8489501A1 (is)
PE (1)	PE20001422A1 (is)
PT (1)	PT1147121E (is)
SI (1)	SI1147121T1 (is)
SK (1)	SK10172001A3 (is)
TN (1)	TNSN00007A1 (is)
TR (1)	TR200102128T2 (is)
UY (1)	UY25990A1 (is)
WO (1)	WO2000044761A2 (is)
ZA (1)	ZA200105580B (is)

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1999
- 1999-12-28 CZ CZ20012675A patent/CZ20012675A3/cs unknown
- 1999-12-28 SK SK1017-2001A patent/SK10172001A3/sk unknown
- 1999-12-28 ID IDW00200101637A patent/ID30233A/id unknown
- 1999-12-28 AT AT99959627T patent/ATE256694T1/de not_active IP Right Cessation
- 1999-12-28 EP EP99959627A patent/EP1147121B1/en not_active Expired - Lifetime
- 1999-12-28 EE EEP200100394A patent/EE200100394A/xx unknown
- 1999-12-28 OA OA1200100191A patent/OA11753A/en unknown
- 1999-12-28 CN CN99815909A patent/CN1342163A/zh active Pending
- 1999-12-28 PT PT99959627T patent/PT1147121E/pt unknown
- 1999-12-28 HU HU0105190A patent/HUP0105190A3/hu unknown
- 1999-12-28 HR HR20010559A patent/HRP20010559A2/hr not_active Application Discontinuation
- 1999-12-28 ES ES99959627T patent/ES2212655T3/es not_active Expired - Lifetime
- 1999-12-28 AU AU16754/00A patent/AU1675400A/en not_active Abandoned
- 1999-12-28 KR KR1020017009382A patent/KR20020002380A/ko not_active Ceased
- 1999-12-28 HK HK02104131.0A patent/HK1042707A1/zh unknown
- 1999-12-28 CA CA002359708A patent/CA2359708C/en not_active Expired - Fee Related
- 1999-12-28 JP JP2000596017A patent/JP3947360B2/ja not_active Expired - Fee Related
- 1999-12-28 TR TR2001/02128T patent/TR200102128T2/xx unknown
- 1999-12-28 DK DK99959627T patent/DK1147121T3/da active
- 1999-12-28 BR BR9916969-0A patent/BR9916969A/pt not_active Application Discontinuation
- 1999-12-28 IL IL14417899A patent/IL144178A0/xx unknown
- 1999-12-28 EA EA200100623A patent/EA200100623A1/ru unknown
- 1999-12-28 AP APAP/P/2001/002222A patent/AP2001002222A0/en unknown
- 1999-12-28 DE DE69913738T patent/DE69913738T2/de not_active Expired - Lifetime
- 1999-12-28 WO PCT/IB1999/002051 patent/WO2000044761A2/en not_active Ceased
- 1999-12-28 SI SI9930486T patent/SI1147121T1/xx unknown
2000
- 2000-01-05 DZ DZ000002A patent/DZ3000A1/xx active
- 2000-01-05 TN TNTNSN00007A patent/TNSN00007A1/fr unknown
- 2000-01-06 PA PA20008489501A patent/PA8489501A1/es unknown
- 2000-01-06 MA MA25883A patent/MA26717A1/fr unknown
- 2000-01-06 PE PE2000000013A patent/PE20001422A1/es not_active Application Discontinuation
- 2000-01-06 HN HN2000000003A patent/HN2000000003A/es unknown
- 2000-01-21 CO CO00003460A patent/CO5150229A1/es unknown
- 2000-01-27 UY UY25990A patent/UY25990A1/es unknown
2001
- 2001-06-28 IS IS5984A patent/IS5984A/is unknown
- 2001-07-06 ZA ZA200105580A patent/ZA200105580B/en unknown
- 2001-07-25 BG BG105730A patent/BG105730A/xx unknown
- 2001-07-26 NO NO20013680A patent/NO20013680L/no not_active Application Discontinuation
2002
- 2002-04-05 US US10/116,969 patent/US6833444B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
UY25990A1 (es)	2000-09-29
JP3947360B2 (ja)	2007-07-18
BR9916969A (pt)	2001-11-06
US6833444B2 (en)	2004-12-21
TNSN00007A1 (fr)	2005-11-10
HUP0105190A2 (hu)	2002-04-29
PA8489501A1 (es)	2000-09-29
JP2002535414A (ja)	2002-10-22
MA26717A1 (fr)	2004-12-20
AU1675400A (en)	2000-08-18
KR20020002380A (ko)	2002-01-09
ZA200105580B (en)	2003-02-17
CO5150229A1 (es)	2002-04-29
CA2359708A1 (en)	2000-08-03
DZ3000A1 (fr)	2004-03-27
EP1147121A2 (en)	2001-10-24
DK1147121T3 (da)	2004-04-13
TR200102128T2 (tr)	2001-12-21
CN1342163A (zh)	2002-03-27
CZ20012675A3 (cs)	2002-04-17
EA200100623A1 (ru)	2002-02-28
BG105730A (en)	2002-03-29
SI1147121T1 (en)	2004-04-30
CA2359708C (en)	2005-10-25
DE69913738D1 (de)	2004-01-29
NO20013680L (no)	2001-09-19
EP1147121B1 (en)	2003-12-17
IL144178A0 (en)	2002-05-23
ES2212655T3 (es)	2004-07-16
WO2000044761A3 (en)	2001-01-04
HN2000000003A (es)	2001-02-02
PE20001422A1 (es)	2000-12-18
EE200100394A (et)	2002-10-15
HRP20010559A2 (en)	2002-08-31
NO20013680D0 (no)	2001-07-26
AP2001002222A0 (en)	2001-09-30
PT1147121E (pt)	2004-04-30
ATE256694T1 (de)	2004-01-15
DE69913738T2 (de)	2004-06-17
WO2000044761A2 (en)	2000-08-03
HK1042707A1 (zh)	2002-08-23
ID30233A (id)	2001-11-15
OA11753A (en)	2005-07-19
US20020156027A1 (en)	2002-10-24
HUP0105190A3 (en)	2003-03-28
IS5984A (is)	2001-06-28

Publication	Publication Date	Title
SK10172001A3 (sk)	2002-06-04	Ketolidové antibiotiká
EP1132392B1 (en)	2004-03-03	Ketolide antibiotics
BRPI9915480B1 (pt)	2015-12-29	azalídeos de 13 membros, composições farmacêuticas compreendendo os mesmos, método para sua preparação bem como seus usos.
US20020016297A1 (en)	2002-02-07	4-oxo-2- ureido-1,4,5,6,-tetrahydro-pyrimidine derivatives
EP1114826A2 (en)	2001-07-11	Novel antibacterial and prokinetic macrolides
EP1167376B1 (en)	2004-07-14	Macrolide antibiotics
US20030100742A1 (en)	2003-05-29	Erythromycin a derivatives
CA2332686C (en)	2005-06-07	Novel 13 and 14-membered antibacterial and prokinetic macrolides and their intermediates
EP1439186A2 (en)	2004-07-21	Intermediates for novel antibacterial and prokinetic macrolides
MXPA01007584A (en)	2002-05-09	Ketolide antibiotics
MXPA01000114A (en)	2002-06-05	Novel antibacterial and prokinetic macrolides
MXPA01002355A (en)	2002-06-05	Ketolide antibiotics