SI9620040B - Postopek in kristalne oblike 2-metil-tieno-benzodiazepina - Google Patents

Postopek in kristalne oblike 2-metil-tieno-benzodiazepina Download PDF

Info

Publication number: SI9620040B
Authority: SI; Slovenia
Prior art keywords: olanzapine; ray powder; polymorph; diffraction pattern; pharmaceutical formulation
Prior art date: 1995-03-24

Application number

SI9620040A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9620040A (sl

Inventor

Charles Arthur Bunnell

Barry Arnold Hendriksen

Samuel Dean Larsen

Original Assignee

Eli Lilly And Company

Lilly Industries Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-24

Filing date

1996-03-22

Publication date

2002-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23621056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9620040(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-03-22 Application filed by Eli Lilly And Company, Lilly Industries Limited filed Critical Eli Lilly And Company

1998-06-30 Publication of SI9620040A publication Critical patent/SI9620040A/sl

2002-02-28 Publication of SI9620040B publication Critical patent/SI9620040B/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicinal Preparation (AREA)

SI9620040A 1995-03-24 1996-03-22 Postopek in kristalne oblike 2-metil-tieno-benzodiazepina SI9620040B (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40956695A	1995-03-24	1995-03-24
PCT/US1996/003917 WO1996030375A1 (en)	1995-03-24	1996-03-22	Process and crystal forms of 2-methyl-thieno-benzodiazepine

Publications (2)

Publication Number	Publication Date
SI9620040A SI9620040A (sl)	1998-06-30
SI9620040B true SI9620040B (sl)	2002-02-28

Family

ID=23621056

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
SI9620040A SI9620040B (sl)	1995-03-24	1996-03-22	Postopek in kristalne oblike 2-metil-tieno-benzodiazepina
SI9630345T SI0733635T1 (en)	1995-03-24	1996-03-22	Crystal forms of a thieno(2,3-B)(1,5) benzodiazepine derivative and process for their preparation
SI9630743T SI1445259T1 (sl)	1995-03-24	1996-03-22	Uporaba kristalnih oblik 2-metil-tienobenzodiazepina
SI9630636T SI1095941T1 (en)	1995-03-24	1996-03-22	Process and crystal forms of 2-methyl-thieno-benzodiazepine

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
SI9630345T SI0733635T1 (en)	1995-03-24	1996-03-22	Crystal forms of a thieno(2,3-B)(1,5) benzodiazepine derivative and process for their preparation
SI9630743T SI1445259T1 (sl)	1995-03-24	1996-03-22	Uporaba kristalnih oblik 2-metil-tienobenzodiazepina
SI9630636T SI1095941T1 (en)	1995-03-24	1996-03-22	Process and crystal forms of 2-methyl-thieno-benzodiazepine

Country Status (48)

Country	Link
US (1)	US5736541A (is)
EP (3)	EP0733635B1 (is)
JP (1)	JPH11502535A (is)
KR (1)	KR100399688B1 (is)
CN (1)	CN1065536C (is)
AP (1)	AP828A (is)
AR (2)	AR002719A1 (is)
AT (4)	ATE331719T1 (is)
AU (1)	AU706471B2 (is)
BG (1)	BG62619B1 (is)
BR (1)	BR9607790A (is)
CA (1)	CA2214005C (is)
CH (1)	CH690579A5 (is)
CO (1)	CO4650278A1 (is)
CZ (1)	CZ292688B6 (is)
DE (4)	DE69614426T2 (is)
DK (4)	DK0733635T3 (is)
EA (1)	EA000149B1 (is)
EE (1)	EE03489B1 (is)
EG (1)	EG23659A (is)
ES (3)	ES2208220T3 (is)
FI (1)	FI973750L (is)
GB (1)	GB2313835B (is)
HU (1)	HU224989B1 (is)
IL (1)	IL117610A (is)
IS (1)	IS1896B (is)
LT (1)	LT4349B (is)
LU (1)	LU90096B1 (is)
LV (1)	LV12018B (is)
MY (1)	MY114701A (is)
NO (1)	NO314663B1 (is)
NZ (1)	NZ306110A (is)
OA (1)	OA10510A (is)
PA (1)	PA8353701A1 (is)
PE (1)	PE44897A1 (is)
PL (1)	PL183723B1 (is)
PT (3)	PT1095941E (is)
RO (1)	RO118872B1 (is)
SE (1)	SE9703205L (is)
SI (4)	SI9620040B (is)
SK (1)	SK284143B6 (is)
SV (1)	SV1996000031A (is)
TR (1)	TR199701017T1 (is)
TW (2)	TW513432B (is)
UA (1)	UA44765C2 (is)
WO (1)	WO1996030375A1 (is)
YU (1)	YU49478B (is)
ZA (2)	ZA962342B (is)

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EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
WO1997011700A1 (en) *	1995-09-29	1997-04-03	Eli Lilly And Company	Method for treating a tic disorder
BR9708181A (pt) *	1996-03-11	1999-07-27	Lilly Co Eli	Método parsa tratamento da insônia
UA57727C2 (uk) *	1996-03-11	2003-07-15	Елі Ліллі Енд Компані	Спосіб лікування надмірної агресивності
PL329221A1 (en) *	1996-03-25	1999-03-15	Lilly Co Eli	Method of relieving hemicrania pains
JP2000507546A (ja) *	1996-03-25	2000-06-20	イーライ・リリー・アンド・カンパニー	麻酔方法
NZ332039A (en) *	1996-03-25	2000-06-23	Lilly Co Eli	Method for treating pain using olanzapine and NSAIDs
CZ298198A3 (cs) *	1996-03-25	1999-06-16	Eli Lilly And Company	Farmaceutický přípravek
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ZA978515B (en) *	1996-09-23	1999-03-23	Lilly Co Eli	Intermediates and process for preparing olanzapine
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US20030022889A1 (en) *	1997-04-15	2003-01-30	Bymaster Franklin P.	Method for providing neuro-protective effects
DK1155696T3 (da) *	1997-04-15	2004-07-12	Lilly Co Eli	Anvendelse af olanzapin til fremstillingen af et medikament til neurobeskyttelse
USRE43932E1 (en)	1997-07-18	2013-01-15	Novartis Ag	Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use
US6617321B2 (en) *	1997-09-30	2003-09-09	Eli Lilly And Company	2-methyl-thieno-benzodiazepine formulation
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FR2802101B1 (fr)	1999-12-10	2003-02-28	Aventis Pharma Sa	Association de cymemazine et d'un neuroleptique atypique
US7022698B2 (en)	1999-12-28	2006-04-04	U & I Pharmaceuticals, Ltd.	Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
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WO2002019998A2 (en) *	2000-09-08	2002-03-14	Eli Lilly And Company	A method of treating weight gain associated with atypical antipsychotic use
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AU2002367119A1 (en) *	2001-12-24	2003-07-15	Sun Pharmaceutical Industries Limited	Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
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CA2477923C (en) *	2002-03-01	2021-02-23	University Of South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
PL196814B1 (pl)	2002-05-17	2008-02-29	Inst Farmaceutyczny	Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty
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SI21270A (sl)	2002-07-15	2004-02-29	Krka, Tovarna Zdravil, D.D., Novo Mesto	Kristalne oblike olanzapina in postopki za njihovo pripravo
PL202856B1 (pl) *	2002-12-20	2009-07-31	Adamed Spo & Lstrok Ka Z Ogran	Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
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CN102093386B (zh) *	2011-01-05	2016-06-01	浙江华海药业股份有限公司	一种制备奥兰扎平晶型ⅱ的方法
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CN104755928B (zh)	2012-08-21	2017-05-10	詹森药业有限公司	奥氮平的抗体及其用途
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GB1548022A (en)	1976-10-06	1979-07-04	Wyeth John & Brother Ltd	Pharmaceutial dosage forms
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1996
- 1996-03-21 EG EG19960250A patent/EG23659A/xx active
- 1996-03-22 PT PT00203573T patent/PT1095941E/pt unknown
- 1996-03-22 DE DE69614426T patent/DE69614426T2/de not_active Expired - Lifetime
- 1996-03-22 ES ES00203573T patent/ES2208220T3/es not_active Expired - Lifetime
- 1996-03-22 DE DE69630324T patent/DE69630324T2/de not_active Expired - Lifetime
- 1996-03-22 AT AT03077455T patent/ATE331719T1/de active
- 1996-03-22 IL IL11761096A patent/IL117610A/xx not_active IP Right Cessation
- 1996-03-22 DE DE19681286T patent/DE19681286T1/de not_active Withdrawn
- 1996-03-22 AU AU54279/96A patent/AU706471B2/en not_active Ceased
- 1996-03-22 CO CO96014567A patent/CO4650278A1/es unknown
- 1996-03-22 AT AT0902196A patent/AT406771B/de not_active IP Right Cessation
- 1996-03-22 PL PL96322501A patent/PL183723B1/pl not_active IP Right Cessation
- 1996-03-22 DE DE69636313T patent/DE69636313T2/de not_active Expired - Lifetime
- 1996-03-22 DK DK96302000T patent/DK0733635T3/da active
- 1996-03-22 JP JP8529532A patent/JPH11502535A/ja not_active Ceased
- 1996-03-22 TW TW085103499A patent/TW513432B/zh not_active IP Right Cessation
- 1996-03-22 BR BR9607790A patent/BR9607790A/pt not_active IP Right Cessation
- 1996-03-22 EA EA199700262A patent/EA000149B1/ru not_active IP Right Cessation
- 1996-03-22 HU HU9802824A patent/HU224989B1/hu not_active IP Right Cessation
- 1996-03-22 UA UA97094737A patent/UA44765C2/uk unknown
- 1996-03-22 RO RO97-01761A patent/RO118872B1/ro unknown
- 1996-03-22 ZA ZA9602342A patent/ZA962342B/xx unknown
- 1996-03-22 YU YU17796A patent/YU49478B/sh unknown
- 1996-03-22 WO PCT/US1996/003917 patent/WO1996030375A1/en not_active Ceased
- 1996-03-22 CN CN96192775A patent/CN1065536C/zh not_active Expired - Lifetime
- 1996-03-22 PT PT03077455T patent/PT1445259E/pt unknown
- 1996-03-22 DK DK03077455T patent/DK1445259T3/da active
- 1996-03-22 SI SI9620040A patent/SI9620040B/sl not_active IP Right Cessation
- 1996-03-22 CH CH02245/97A patent/CH690579A5/de not_active IP Right Cessation
- 1996-03-22 SK SK1218-97A patent/SK284143B6/sk not_active IP Right Cessation
- 1996-03-22 TW TW085103500A patent/TW442488B/zh not_active IP Right Cessation
- 1996-03-22 FI FI973750A patent/FI973750L/fi unknown
- 1996-03-22 ES ES96302000T patent/ES2159346T3/es not_active Expired - Lifetime
- 1996-03-22 EP EP96302000A patent/EP0733635B1/en not_active Expired - Lifetime
- 1996-03-22 ES ES03077455T patent/ES2266719T3/es not_active Expired - Lifetime
- 1996-03-22 KR KR1019970706591A patent/KR100399688B1/ko not_active Ceased
- 1996-03-22 TR TR97/01017T patent/TR199701017T1/xx unknown
- 1996-03-22 EP EP03077455A patent/EP1445259B1/en not_active Expired - Lifetime
- 1996-03-22 ZA ZA9602344A patent/ZA962344B/xx unknown
- 1996-03-22 SI SI9630345T patent/SI0733635T1/xx unknown
- 1996-03-22 SI SI9630743T patent/SI1445259T1/sl unknown
- 1996-03-22 CA CA002214005A patent/CA2214005C/en not_active Expired - Fee Related
- 1996-03-22 EP EP00203573A patent/EP1095941B1/en not_active Expired - Lifetime
- 1996-03-22 NZ NZ306110A patent/NZ306110A/en not_active IP Right Cessation
- 1996-03-22 AT AT00203573T patent/ATE251627T1/de active
- 1996-03-22 GB GB9719819A patent/GB2313835B/en not_active Expired - Fee Related
- 1996-03-22 PE PE1996000203A patent/PE44897A1/es not_active IP Right Cessation
- 1996-03-22 AR ARP960101876A patent/AR002719A1/es unknown
- 1996-03-22 EE EE9700232A patent/EE03489B1/xx not_active IP Right Cessation
- 1996-03-22 AP APAP/P/1997/001065A patent/AP828A/en active
- 1996-03-22 PT PT96302000T patent/PT733635E/pt unknown
- 1996-03-22 MY MYPI96001085A patent/MY114701A/en unknown
- 1996-03-22 DK DK00203573T patent/DK1095941T3/da active
- 1996-03-22 LU LU90096A patent/LU90096B1/fr active
- 1996-03-22 AT AT96302000T patent/ATE204280T1/de active
- 1996-03-22 SI SI9630636T patent/SI1095941T1/xx unknown
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- 1996-03-22 CZ CZ19973000A patent/CZ292688B6/cs not_active IP Right Cessation
- 1996-05-09 SV SV1996000031A patent/SV1996000031A/es not_active Application Discontinuation
- 1996-07-25 US US08/686,989 patent/US5736541A/en not_active Expired - Lifetime
- 1996-10-18 PA PA19968353701A patent/PA8353701A1/es unknown
1997
- 1997-09-05 SE SE9703205A patent/SE9703205L/xx not_active Application Discontinuation
- 1997-09-08 LV LVP-97-163A patent/LV12018B/en unknown
- 1997-09-16 LT LT97-148A patent/LT4349B/lt not_active IP Right Cessation
- 1997-09-22 BG BG101900A patent/BG62619B1/bg unknown
- 1997-09-22 IS IS4564A patent/IS1896B/is unknown
- 1997-09-22 NO NO19974365A patent/NO314663B1/no not_active IP Right Cessation
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Also Published As

Publication number	Publication date
LU90096B1 (fr)	1997-07-22
CA2214005C (en)	2001-07-03
NO314663B1 (no)	2003-04-28
SV1996000031A (es)	1998-03-27
SE9703205D0 (sv)	1997-09-05
ES2208220T3 (es)	2004-06-16
YU17796A (sh)	1999-03-04
IS1896B (is)	2003-10-20
NO974365L (no)	1997-09-22
DE69614426T2 (de)	2002-05-23
RO118872B1 (ro)	2003-12-30
AU706471B2 (en)	1999-06-17
HUP9802824A2 (hu)	1999-06-28
JPH11502535A (ja)	1999-03-02
FI973750A7 (fi)	1997-09-22
AU5427996A (en)	1996-10-16
ATE251627T1 (de)	2003-10-15
CA2214005A1 (en)	1996-10-03
SI0733635T1 (en)	2002-06-30
IL117610A (en)	2001-08-26
EP0733635A1 (en)	1996-09-25
ES2266719T3 (es)	2007-03-01
SE9703205L (sv)	1997-09-05
GB2313835A (en)	1997-12-10
ATE331719T1 (de)	2006-07-15
NZ306110A (en)	1998-09-24
TW442488B (en)	2001-06-23
AR002719A1 (es)	1998-04-29
KR19980703188A (ko)	1998-10-15
HU224989B1 (en)	2006-05-29
PA8353701A1 (es)	1998-09-18
PT1445259E (pt)	2006-10-31
DK1095941T3 (da)	2004-02-16
PT1095941E (pt)	2004-02-27
HUP9802824A3 (en)	2000-01-28
LV12018A (lv)	1998-04-20
CO4650278A1 (es)	1998-09-03
NO974365D0 (no)	1997-09-22
WO1996030375A1 (en)	1996-10-03
CN1179160A (zh)	1998-04-15
GB9719819D0 (en)	1997-11-19
LV12018B (en)	1998-09-20
EE03489B1 (et)	2001-08-15
MX9707183A (es)	1997-11-29
EP1095941A1 (en)	2001-05-02
SI1445259T1 (sl)	2006-10-31
HK1013988A1 (en)	1999-09-17
DE69630324T2 (de)	2004-07-29
SI1095941T1 (en)	2003-12-31
AT406771B (de)	2000-08-25
EG23659A (en)	2007-03-26
US5736541A (en)	1998-04-07
EP0733635B1 (en)	2001-08-16
EP1095941B1 (en)	2003-10-08
DE19681286T1 (de)	1998-04-02
UA44765C2 (uk)	2002-03-15
GB2313835B (en)	1998-09-16
CZ300097A3 (en)	1997-12-17
YU49478B (sh)	2006-05-25
PL322501A1 (en)	1998-02-02
DK108997A (da)	1997-11-12
BG101900A (en)	1999-03-31
BG62619B1 (bg)	2000-03-31
AP9701065A0 (en)	1997-10-31
AR010448A1 (es)	2000-06-28
LT4349B (lt)	1998-05-25
IL117610A0 (en)	1996-07-23
PL183723B1 (pl)	2002-07-31
BR9607790A (pt)	1998-07-07
PE44897A1 (es)	1997-10-22
EE9700232A (et)	1998-04-15
ATE204280T1 (de)	2001-09-15
KR100399688B1 (ko)	2004-02-18
DK0733635T3 (da)	2001-10-08
FI973750A0 (fi)	1997-09-22
DE69636313T2 (de)	2007-05-31
OA10510A (en)	2002-04-24
DE69636313D1 (de)	2006-08-10
EA199700262A1 (ru)	1998-02-26
LT97148A (lt)	1998-01-26
IS4564A (is)	1997-09-22
SK284143B6 (sk)	2004-10-05
DK1445259T3 (da)	2006-10-16
ATA902196A (de)	2000-01-15
EA000149B1 (ru)	1998-10-29
TW513432B (en)	2002-12-11
TR199701017T1 (xx)	1998-01-21
PT733635E (pt)	2001-12-28
ZA962342B (en)	1997-09-22
SK121897A3 (en)	1998-03-04
CH690579A5 (de)	2000-10-31
EP1445259B1 (en)	2006-06-28
DE69630324D1 (de)	2003-11-13
AP828A (en)	2000-04-28
EP1445259A1 (en)	2004-08-11
DE69614426D1 (de)	2001-09-20
SI9620040A (sl)	1998-06-30
ES2159346T3 (es)	2001-10-01
CZ292688B6 (cs)	2003-11-12
MY114701A (en)	2002-12-31
FI973750L (fi)	1997-09-22
ZA962344B (en)	1997-09-22
CN1065536C (zh)	2001-05-09

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2005-01-10	IF	Valid on the event date
2014-12-31	KO00	Lapse of patent	Effective date: 20141104