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SG78336A1 - Pyrazolopyrimidines and pyrazolotriazines - Google Patents

Pyrazolopyrimidines and pyrazolotriazines

Info

Publication number
SG78336A1
SG78336A1 SG1999001080A SG1999001080A SG78336A1 SG 78336 A1 SG78336 A1 SG 78336A1 SG 1999001080 A SG1999001080 A SG 1999001080A SG 1999001080 A SG1999001080 A SG 1999001080A SG 78336 A1 SG78336 A1 SG 78336A1
Authority
SG
Singapore
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
SG1999001080A
Other languages
English (en)
Inventor
Michael Bos
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG78336A1 publication Critical patent/SG78336A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG1999001080A 1998-03-11 1999-03-09 Pyrazolopyrimidines and pyrazolotriazines SG78336A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (1)

Publication Number Publication Date
SG78336A1 true SG78336A1 (en) 2001-02-20

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1999001080A SG78336A1 (en) 1998-03-11 1999-03-09 Pyrazolopyrimidines and pyrazolotriazines

Country Status (33)

Country Link
US (1) US6194410B1 (fr)
EP (1) EP0941994B1 (fr)
JP (1) JP3231288B2 (fr)
KR (1) KR100313181B1 (fr)
CN (1) CN1118468C (fr)
AR (1) AR016453A1 (fr)
AT (1) ATE240332T1 (fr)
AU (1) AU752408B2 (fr)
BR (1) BR9901095A (fr)
CA (1) CA2265095C (fr)
CZ (1) CZ291514B6 (fr)
DE (1) DE69907784T2 (fr)
DK (1) DK0941994T3 (fr)
ES (1) ES2198095T3 (fr)
HR (1) HRP990077B1 (fr)
HU (1) HUP9900589A1 (fr)
ID (1) ID23575A (fr)
IL (1) IL128869A (fr)
MA (1) MA26612A1 (fr)
MY (1) MY119536A (fr)
NO (1) NO312297B1 (fr)
NZ (1) NZ334526A (fr)
PE (1) PE20000337A1 (fr)
PL (1) PL331875A1 (fr)
PT (1) PT941994E (fr)
RU (1) RU2218340C2 (fr)
SG (1) SG78336A1 (fr)
SI (1) SI0941994T1 (fr)
TR (1) TR199900531A2 (fr)
TW (1) TW585865B (fr)
UY (1) UY25419A1 (fr)
YU (1) YU12099A (fr)
ZA (1) ZA991946B (fr)

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WO2000059907A2 (fr) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines antagonistes de corticoliberine (crf)
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PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
CA2440553C (fr) * 2001-03-13 2010-06-08 Paul J. Gilligan 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, ses enantiomeres et sels pharmaceutiquement acceptables en tant que ligands du recepteur de la corticoliberine
EP1401813B1 (fr) 2001-06-07 2007-02-07 F. Hoffman-la Roche AG Nouveaux derives de l'indole a affinite pour le recepteur 5-ht6
MXPA03011638A (es) 2001-06-15 2004-04-02 Hoffmann La Roche Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
EP1414442A1 (fr) * 2001-08-07 2004-05-06 Smithkline Beecham Plc 3-arylsulfonyl-7-piperazinyl- indols, -benzofurans et benzothiophenes a affinite avec les recepteurs 5-ht6 pour le traitement de troubles du snc
JP4335684B2 (ja) * 2001-12-20 2009-09-30 ワイス 5−ヒドロキシトリプタミン−6リガンドとしてのインドリルアルキルアミン誘導体
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
AR041137A1 (es) * 2002-09-04 2005-05-04 Pharmacopeia Drug Discovery Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
EP1592690A1 (fr) * 2003-02-14 2005-11-09 Wyeth Derives de heterocyclyl-3-sulfonylazaindole ou -azaindazole utilises comme ligands de la 5-hydroxytryptamine-6
CA2516824A1 (fr) 2003-02-28 2004-09-10 Teijin Pharma Limited Derives de pyrazolo[1,5-a]pyrimidine
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005112936A1 (fr) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions et methodes associees aux inhibiteurs de la proteine kinase
CN101094853B (zh) * 2004-11-04 2011-07-13 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑并[1,5-a]嘧啶
RU2390523C2 (ru) * 2005-10-21 2010-05-27 Мицубиси Танабе Фарма Корпорейшн ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
EA017968B1 (ru) * 2008-01-24 2013-04-30 Андрей Александрович ИВАЩЕНКО ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP2248814A4 (fr) 2008-01-24 2011-01-12 Alla Chem Llc Cyclo-alcanoýe et d¨pyrazoloý1,5-a¨pyrimidines substituées fonctionnant comme des antagonistes des récepteurs 5-ht6 de sérotonine, procédés de fabrication et d'utilisation
RU2369600C1 (ru) * 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
EA017805B1 (ru) * 2008-01-24 2013-03-29 Андрей Александрович ИВАЩЕНКО 2-АЛКИЛАМИНО-3-АРИЛСУЛЬФОНИЛЦИКЛОАЛКАНО[e ИЛИ d]ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТРЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EA017630B1 (ru) * 2008-10-06 2013-01-30 Андрей Александрович ИВАЩЕНКО ЗАМЕЩЕННЫЕ 3-АРИЛСУЛЬФОНИЛПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ, АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT-РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
WO2010060952A1 (fr) * 2008-11-27 2010-06-03 Boehringer Ingelheim International Gmbh Dérivés de 6,7,8,9-tétrahydro-5h-1,4,7,10a-tétraaza-cyclohept[f]indène, compositions pharmaceutiques contenant ces composés, leur utilisation et procédés pour préparer ceux-ci
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
AU2011331301A1 (en) 2010-11-15 2013-05-23 Katholieke Universiteit Leuven Antiviral condensed heterocyclic compounds
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
PT2760453T (pt) 2011-09-30 2016-08-02 Ipsen Pharma Sas Inibidores macrocíclicos da cinase lrrk2
AU2013230128B2 (en) * 2012-03-09 2017-08-17 Lexicon Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶1之抑制劑、包含其之組成物、及其使用方法
EA032838B1 (ru) 2014-09-17 2019-07-31 Онкодизайн С.А. Макроциклические ингибиторы lrrk2-киназы
US11186576B2 (en) 2015-03-09 2021-11-30 Aurigene Discovery Technologies Limited Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
WO2017052394A1 (fr) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Composés d'imidazopyridine et leur utilisation comme ligands du récepteur 5-ht6
HK1256751A1 (zh) 2015-11-02 2019-10-04 Janssen Pharmaceutica Nv [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物
CN109890824B (zh) 2016-11-02 2022-05-24 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
EP3535269B1 (fr) 2016-11-02 2020-12-09 Janssen Pharmaceutica NV Composés de [1,2,4]triazolo[1,5-a]pyrimidine comme inhibiteurs de pde2
EP3535267B1 (fr) 2016-11-02 2020-12-30 Janssen Pharmaceutica NV Dérivés de [1,2,4]triazolo[1,5-a]pyrimidine comme inhibiteurs de pde2
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ATE296811T1 (de) 1997-07-11 2005-06-15 Smithkline Beecham Plc Sulfonamid-derivate als 5-ht6 receptor antagonisten und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HRP990077B1 (en) 2003-08-31
CA2265095A1 (fr) 1999-09-11
MA26612A1 (fr) 2004-12-20
RU2218340C2 (ru) 2003-12-10
DE69907784D1 (de) 2003-06-18
KR100313181B1 (ko) 2001-11-05
IL128869A (en) 2003-09-17
SI0941994T1 (en) 2003-10-31
MY119536A (en) 2005-06-30
ZA991946B (en) 1999-09-13
NZ334526A (en) 2000-07-28
KR19990077741A (ko) 1999-10-25
TR199900531A3 (tr) 1999-10-21
PL331875A1 (en) 1999-09-13
JP3231288B2 (ja) 2001-11-19
ID23575A (id) 2000-05-04
PE20000337A1 (es) 2000-05-13
CZ82599A3 (cs) 1999-09-15
CZ291514B6 (cs) 2003-03-12
HK1023343A1 (en) 2000-09-08
JP2000186090A (ja) 2000-07-04
CN1236780A (zh) 1999-12-01
PT941994E (pt) 2003-09-30
CA2265095C (fr) 2008-07-22
HRP990077A2 (en) 2000-02-29
NO991150D0 (no) 1999-03-10
AR016453A1 (es) 2001-07-04
EP0941994A1 (fr) 1999-09-15
DK0941994T3 (da) 2003-09-08
EP0941994B1 (fr) 2003-05-14
US6194410B1 (en) 2001-02-27
CN1118468C (zh) 2003-08-20
BR9901095A (pt) 2000-05-02
YU12099A (sh) 2000-10-30
HUP9900589A1 (hu) 2000-03-28
ES2198095T3 (es) 2004-01-16
NO991150L (no) 1999-09-13
UY25419A1 (es) 2001-11-30
TR199900531A2 (xx) 1999-10-21
NO312297B1 (no) 2002-04-22
HU9900589D0 (en) 1999-05-28
AU2038399A (en) 1999-09-23
DE69907784T2 (de) 2004-03-25
ATE240332T1 (de) 2003-05-15
AU752408B2 (en) 2002-09-19
IL128869A0 (en) 2000-01-31
TW585865B (en) 2004-05-01

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