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NO991150L - Pyrazolopyrimidiner og pyrazolotriaziner - Google Patents

Pyrazolopyrimidiner og pyrazolotriaziner

Info

Publication number
NO991150L
NO991150L NO991150A NO991150A NO991150L NO 991150 L NO991150 L NO 991150L NO 991150 A NO991150 A NO 991150A NO 991150 A NO991150 A NO 991150A NO 991150 L NO991150 L NO 991150L
Authority
NO
Norway
Prior art keywords
pyrazolotriazines
pyrazolopyrimidines
Prior art date
Application number
NO991150A
Other languages
English (en)
Other versions
NO991150D0 (no
NO312297B1 (no
Inventor
Michael Boes
Claus Riemer
Heinz Stadler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO991150D0 publication Critical patent/NO991150D0/no
Publication of NO991150L publication Critical patent/NO991150L/no
Publication of NO312297B1 publication Critical patent/NO312297B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO19991150A 1998-03-11 1999-03-10 Pyrazolopyrimidiner og pyrazolotriaziner, anvendelse og fremgangsmåte for fremstilling derav, samt medikament NO312297B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98104346 1998-03-11

Publications (3)

Publication Number Publication Date
NO991150D0 NO991150D0 (no) 1999-03-10
NO991150L true NO991150L (no) 1999-09-13
NO312297B1 NO312297B1 (no) 2002-04-22

Family

ID=8231568

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991150A NO312297B1 (no) 1998-03-11 1999-03-10 Pyrazolopyrimidiner og pyrazolotriaziner, anvendelse og fremgangsmåte for fremstilling derav, samt medikament

Country Status (33)

Country Link
US (1) US6194410B1 (no)
EP (1) EP0941994B1 (no)
JP (1) JP3231288B2 (no)
KR (1) KR100313181B1 (no)
CN (1) CN1118468C (no)
AR (1) AR016453A1 (no)
AT (1) ATE240332T1 (no)
AU (1) AU752408B2 (no)
BR (1) BR9901095A (no)
CA (1) CA2265095C (no)
CZ (1) CZ291514B6 (no)
DE (1) DE69907784T2 (no)
DK (1) DK0941994T3 (no)
ES (1) ES2198095T3 (no)
HR (1) HRP990077B1 (no)
HU (1) HUP9900589A1 (no)
ID (1) ID23575A (no)
IL (1) IL128869A (no)
MA (1) MA26612A1 (no)
MY (1) MY119536A (no)
NO (1) NO312297B1 (no)
NZ (1) NZ334526A (no)
PE (1) PE20000337A1 (no)
PL (1) PL331875A1 (no)
PT (1) PT941994E (no)
RU (1) RU2218340C2 (no)
SG (1) SG78336A1 (no)
SI (1) SI0941994T1 (no)
TR (1) TR199900531A3 (no)
TW (1) TW585865B (no)
UY (1) UY25419A1 (no)
YU (1) YU12099A (no)
ZA (1) ZA991946B (no)

Families Citing this family (48)

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AU4331500A (en) * 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DE19956791A1 (de) * 1999-11-25 2001-05-31 Merck Patent Gmbh Neue Sulfonyloxazolamine
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
ES2282401T3 (es) * 2001-03-13 2007-10-16 Bristol-Myers Squibb Pharma Company 4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
DE60218037T2 (de) 2001-06-07 2007-08-23 F. Hoffmann-La Roche Ag Neue indolderivate mit affinität zum 5-ht6-rezeptor
BR0210411A (pt) 2001-06-15 2004-08-17 Hoffmann La Roche Derivados 4-piperazinilindol com afinidade para o receptor 5-ht6
JP2005527463A (ja) * 2001-08-07 2005-09-15 スミスクライン ビーチャム パブリック リミテッド カンパニー Cns疾患を治療するための5−ht6受容体アフィニティーを有する3−アリールスルホニル−7−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン
PT1455779E (pt) * 2001-12-20 2006-11-30 Wyeth Corp Derivados de indolilalquilamina como ligandos da 5-hidroxitriptamina-6
US6642381B2 (en) * 2001-12-27 2003-11-04 Hoffman-La Roche Inc. Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
US6875771B2 (en) 2002-07-26 2005-04-05 Bristol-Myers Squibb Company Pyridopyrimidine derivatives as 5-HT6 antagonists
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY138201A (en) * 2002-09-04 2009-05-29 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
MXPA05008441A (es) * 2003-02-14 2005-10-19 Wyeth Corp Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6.
KR20050115252A (ko) 2003-02-28 2005-12-07 데이진 화-마 가부시키가이샤 피라졸로[1,5-a]피리미딘 유도체
GB0305559D0 (en) * 2003-03-11 2003-04-16 Teijin Ltd Compounds
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US20080287405A1 (en) * 2004-05-14 2008-11-20 Thannickal Victor J Compositions and Methods Relating to Protein Kinase Inhibitors
MX337817B (es) * 2004-11-04 2011-11-04 Vertex Pharma Pirazolo [1,5-a] pirimidinas de utilidad como inhibidores de proteina quinasas.
RU2390523C2 (ru) * 2005-10-21 2010-05-27 Мицубиси Танабе Фарма Корпорейшн ПРОИЗВОДНОЕ ПИРАЗОЛ[1,5-a]ПИРИМИДИНА
RU2330854C2 (ru) * 2006-03-15 2008-08-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУВПО "ПГФА Росздрава") Способ получения конденсированных гем-диметилзамещенных амино-1,3,5-триазинов
EP2248817B1 (en) * 2008-01-24 2015-01-07 Alla Chem, LLC. Substituted 2-amino-3-sulfonyl-pyrazolo[1,5-a] pyrimidines/antagonists of serotonin 5-ht6 receptors, methods for the production and the use thereof
EP2248814A4 (en) * 2008-01-24 2011-01-12 Alla Chem Llc SUBSTITUTED CYCLOALKAN [E AND D] PYRAZOLO [1,5-A] PYRIMIDINES / ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS AND PROCESS FOR THEIR PREPARATION AND THEIR USE
RU2369600C1 (ru) * 2008-01-24 2009-10-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
JP5584626B2 (ja) * 2008-01-24 2014-09-03 アンドレイ・アレクサンドロビッチ・イワシェンコ 2−アルキルアミノ−3−(アリールスルホニル)−シクロアルキル[e又はd]ピラゾロ[1,5−a]ピリミジン−セロトニン5−HT6受容体アンタゴニスト、その調製の方法及び使用
RU2384581C2 (ru) 2008-05-07 2010-03-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2-АМИНО-3-СУЛЬФОНИЛ-ТЕТРАГИДРО-ПИРАЗОЛО[1,5-a]ПИРИДО-ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
EP3020719B1 (en) 2008-10-06 2017-09-20 Alla Chem, LLC. Substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines, serotonin 5-ht6 receptor antagonists and methods for the production and use thereof and methods for the production and use thereof
EP2384328B1 (en) 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
RU2443697C1 (ru) 2010-12-21 2012-02-27 Александр Васильевич Иващенко Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения
CN104023728B (zh) 2011-09-30 2016-11-02 益普生制药股份有限公司 大环lrrk2激酶抑制剂
MX381849B (es) * 2012-03-09 2025-03-13 Lexicon Pharmaceuticals Inc Compuestos a base de pirazol[1,5-a]pirimidina, composiciones que los comprenden, y métodos para su uso.
TW201542550A (zh) * 2013-09-06 2015-11-16 Lexicon Pharmaceuticals Inc 吡唑并[1,5-a]嘧啶基化合物、包含彼之組合物以及使用彼之方法
TW201620911A (zh) * 2014-03-17 2016-06-16 雷西肯製藥股份有限公司 銜接子關聯激酶1之抑制劑、包含其之組成物、及其使用方法
CA2960777A1 (en) 2014-09-17 2016-03-24 Oncodesign S.A. Macrocyclic lrrk2 kinase inhibitors
EP3268000B1 (en) 2015-03-09 2021-08-04 Aurigene Discovery Technologies Limited Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
EP3371188B1 (en) 2015-11-02 2019-10-23 Janssen Pharmaceutica NV [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
TWI764950B (zh) 2016-11-02 2022-05-21 比利時商健生藥品公司 Pde2抑制劑
CN109890824B (zh) 2016-11-02 2022-05-24 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
AU2017353315B2 (en) 2016-11-02 2021-09-16 Janssen Pharmaceutica Nv (1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors
MA55909A (fr) 2019-05-05 2022-03-16 Qilu Regor Therapeutics Inc Inhibiteurs de cdk
CN112142744A (zh) * 2019-06-28 2020-12-29 上海瑛派药业有限公司 取代的稠合杂芳双环化合物作为激酶抑制剂及其应用
PH12022551623A1 (en) 2020-01-13 2023-11-29 Verge Analytics Inc Substituted pyrazolo-pyrimidines and uses thereof

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DE3825043A1 (de) 1988-07-20 1990-02-15 Schering Ag 3-methylsulfonyl-pyrazolo(1,5-a)pyrimidin-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwuchsregulierender und fungizider wirkung
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
AU7001396A (en) 1995-09-22 1997-04-09 Takeda Chemical Industries Ltd. Triazole compounds, their production and use
JP2001506995A (ja) 1996-12-19 2001-05-29 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー N−ピペラジン−1−イルフェニル−ベンズアミド誘導体
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
ATE296811T1 (de) 1997-07-11 2005-06-15 Smithkline Beecham Plc Sulfonamid-derivate als 5-ht6 receptor antagonisten und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HRP990077A2 (en) 2000-02-29
CA2265095C (en) 2008-07-22
EP0941994B1 (en) 2003-05-14
DE69907784D1 (de) 2003-06-18
SG78336A1 (en) 2001-02-20
CN1118468C (zh) 2003-08-20
SI0941994T1 (en) 2003-10-31
AU752408B2 (en) 2002-09-19
BR9901095A (pt) 2000-05-02
TR199900531A2 (xx) 1999-10-21
UY25419A1 (es) 2001-11-30
PE20000337A1 (es) 2000-05-13
TW585865B (en) 2004-05-01
CN1236780A (zh) 1999-12-01
ZA991946B (en) 1999-09-13
JP3231288B2 (ja) 2001-11-19
IL128869A (en) 2003-09-17
KR19990077741A (ko) 1999-10-25
CZ82599A3 (cs) 1999-09-15
MA26612A1 (fr) 2004-12-20
NO991150D0 (no) 1999-03-10
TR199900531A3 (tr) 1999-10-21
IL128869A0 (en) 2000-01-31
KR100313181B1 (ko) 2001-11-05
NO312297B1 (no) 2002-04-22
PT941994E (pt) 2003-09-30
EP0941994A1 (en) 1999-09-15
HK1023343A1 (en) 2000-09-08
ID23575A (id) 2000-05-04
HUP9900589A1 (hu) 2000-03-28
JP2000186090A (ja) 2000-07-04
MY119536A (en) 2005-06-30
CA2265095A1 (en) 1999-09-11
PL331875A1 (en) 1999-09-13
DE69907784T2 (de) 2004-03-25
HRP990077B1 (en) 2003-08-31
AR016453A1 (es) 2001-07-04
RU2218340C2 (ru) 2003-12-10
NZ334526A (en) 2000-07-28
YU12099A (sh) 2000-10-30
HU9900589D0 (en) 1999-05-28
AU2038399A (en) 1999-09-23
US6194410B1 (en) 2001-02-27
ES2198095T3 (es) 2004-01-16
CZ291514B6 (cs) 2003-03-12
DK0941994T3 (da) 2003-09-08
ATE240332T1 (de) 2003-05-15

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