SG47482A1 - N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran carboxamide derivatives - Google Patents

N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran carboxamide derivatives

Info

Publication number: SG47482A1
Authority: SG; Singapore
Prior art keywords: aryl; alkyl; alk; cycloalkyl; piperidinyl
Prior art date: 1990-03-06

Application number

SG1996002170A

Other languages

English (en)

Inventor

Georges Henri Paul Van Daele

Jean-Paul Rene Marie Bosmans

Michel Anna Jozef De Cleyn

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-06

Filing date

1991-02-22

Publication date

1998-04-17

1991-02-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1998-04-17 Publication of SG47482A1 publication Critical patent/SG47482A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Cosmetics (AREA)

SG1996002170A 1990-03-06 1991-02-22 N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran carboxamide derivatives SG47482A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909005014A GB9005014D0 (en)	1990-03-06	1990-03-06	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (1)

Publication Number	Publication Date
SG47482A1 true SG47482A1 (en)	1998-04-17

Family

ID=10672103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996002170A SG47482A1 (en)	1990-03-06	1991-02-22	N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran carboxamide derivatives

Country Status (38)

Country	Link
US (2)	US5185335A (xx)
EP (1)	EP0445862B1 (xx)
JP (1)	JP2601566B2 (xx)
KR (1)	KR0177521B1 (xx)
CN (1)	CN1038936C (xx)
AT (1)	ATE191912T1 (xx)
AU (1)	AU636012B2 (xx)
BG (1)	BG60381B1 (xx)
CA (1)	CA2037575C (xx)
CY (1)	CY2235B1 (xx)
CZ (1)	CZ286617B6 (xx)
DE (1)	DE69132119T2 (xx)
DK (1)	DK0445862T3 (xx)
ES (1)	ES2147175T3 (xx)
FI (1)	FI101622B1 (xx)
GB (1)	GB9005014D0 (xx)
GR (1)	GR3033461T3 (xx)
HR (1)	HRP930483B1 (xx)
HU (2)	HU221627B1 (xx)
IE (1)	IE910710A1 (xx)
IL (1)	IL97018A (xx)
LT (1)	LT3708B (xx)
LV (1)	LV10085B (xx)
MA (1)	MA22076A1 (xx)
MY (1)	MY108831A (xx)
NO (1)	NO177424C (xx)
NZ (1)	NZ237189A (xx)
PL (6)	PL168693B1 (xx)
PT (1)	PT96937B (xx)
RU (1)	RU2070884C1 (xx)
SG (1)	SG47482A1 (xx)
SI (1)	SI9110396B (xx)
SK (2)	SK282407B6 (xx)
TN (1)	TNSN91010A1 (xx)
UA (1)	UA25969A1 (xx)
YU (1)	YU48854B (xx)
ZA (1)	ZA911611B (xx)
ZW (1)	ZW2391A1 (xx)

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SG49153A1 (en) *	1991-09-12	1998-05-18	Smithkline Beecham Plc	5-HT4 receptor antagonists
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US5595872A (en) *	1992-03-06	1997-01-21	Bristol-Myers Squibb Company	Nucleic acids encoding microsomal trigyceride transfer protein
GB9219163D0 (en) *	1992-09-10	1992-10-28	Smithkline Beecham Plc	Pharmaceuticals
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MX9306311A (es) *	1992-10-13	1994-04-29	Smithkline Beecham Plc	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
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GB9301660D0 (en) *	1993-01-28	1993-03-17	Smithkline Beecham Plc	Pharmaceuticals
US5739135A (en) *	1993-09-03	1998-04-14	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method
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JPH0873463A (ja)	1994-07-05	1996-03-19	Sanwa Kagaku Kenkyusho Co Ltd	ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
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PL182502B1 (pl) *	1994-09-27	2002-01-31	Janssen Pharmaceutica Nv	Nowe związki, pochodne bicyklicznego benzoesanu N-podstawionego piperydynylu, środek farmaceutyczny i sposób wytwarzania pochodnych bicyklicznego benzoesanu N-podstawionego piperydynylu
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US6096763A (en) *	1995-02-23	2000-08-01	Merck & Co., Inc.	α1a adrenergic receptor antagonists
TW360653B (en) *	1995-03-01	1999-06-11	Janssen Pharmaceutica Nv	A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
GB9507882D0 (en) *	1995-04-18	1995-05-31	Pharmacia Spa	Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
GB2308362A (en) *	1995-12-19	1997-06-25	Lilly Industries Ltd	Pharmaceutical indole derivatives
TW402591B (en) *	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
US6294555B1 (en)	1998-04-28	2001-09-25	Dainippon Pharmaceutical Co., Ltd.	1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
EP1077973A2 (en) *	1998-05-14	2001-02-28	Egis Gyogyszergyar Rt.	Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
WO2000015636A1 (en) *	1998-09-10	2000-03-23	F. Hoffmann-La Roche Ag	Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
NZ511117A (en) *	1998-11-23	2002-11-26	Janssen Pharmaceutica Nv	Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
TW592709B (en) *	1999-04-29	2004-06-21	Janssen Pharmaceutica Nv	Prucalopride oral solution
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds
CN1288730A (zh) *	1999-09-07	2001-03-28	麦克内尔-Ppc股份有限公司	轻泻组合物
GB0011838D0 (en) *	2000-05-17	2000-07-05	Astrazeneca Ab	Chemical compounds
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0107228D0 (en)	2001-03-22	2001-05-16	Astrazeneca Ab	Chemical compounds
SE0103818D0 (sv)	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
CA2471729C (en) *	2002-01-16	2010-03-23	Janssen Pharmaceutica N.V.	Prucalopride-n-oxide
PT1489078E (pt) *	2002-03-28	2010-02-24	Mitsubishi Tanabe Pharma Corp	Derivados de benzofurano
TW200409637A (en)	2002-06-26	2004-06-16	Glaxo Group Ltd	Compounds
SE0301369D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
DE10349113A1 (de) *	2003-10-17	2005-05-12	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Aminocrotonylverbindungen
JP2007525503A (ja) *	2004-02-27	2007-09-06	バーテックス　ファーマシューティカルズ　インコーポレイテッド	カスパーゼインヒビターおよびそれらの使用
GB0525661D0 (en) *	2005-12-16	2006-01-25	Glaxo Group Ltd	Novel compounds
EP2007756B1 (en) *	2006-04-07	2015-08-26	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
CN102477002B (zh) *	2010-11-26	2015-04-15	苏州凯达生物医药技术有限公司	3-氨基-2,2-双甲基丙酰胺的制备方法
AU2012221927B2 (en)	2011-02-25	2016-04-28	Yuhan Corporation	Diaminopyrimidine derivatives and processes for the preparation thereof
GB201103397D0 (xx)	2011-02-28	2011-04-13	Shire Movetis N V
KR101256908B1 (ko)	2011-04-28	2013-04-23	(주)에이치비메디컬스	주름제거용 충전체
CN102295594B (zh) *	2011-07-12	2016-01-20	上海医药工业研究院	4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
WO2013024164A1 (en)	2011-08-18	2013-02-21	Shire Ag	Combinations of a 5-ht4 receptor agonist and a pde4 inhibitor for use in therapy
KR101657616B1 (ko)	2013-05-24	2016-09-19	주식회사유한양행	피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
WO2017137910A1 (en)	2016-02-11	2017-08-17	Symed Labs Limited	Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN110963999B (zh) *	2019-11-27	2021-05-11	广东东阳光药业有限公司	2,3-二氢苯并呋喃酰胺衍生物及其用途
MY210588A (en) *	2020-05-04	2025-10-01	Takeda Pharmaceuticals Co	Luminally-acting n-(piperidin-4-yl)benzamide derivatives

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1990
- 1990-03-06 GB GB909005014A patent/GB9005014D0/en active Pending
1991
- 1991-02-04 US US07/650,328 patent/US5185335A/en not_active Expired - Lifetime
- 1991-02-21 NZ NZ237189A patent/NZ237189A/xx unknown
- 1991-02-22 SK SK1623-98A patent/SK282407B6/sk not_active IP Right Cessation
- 1991-02-22 SG SG1996002170A patent/SG47482A1/en unknown
- 1991-02-22 SK SK460-91A patent/SK282406B6/sk not_active IP Right Cessation
- 1991-02-22 DK DK91200382T patent/DK0445862T3/da active
- 1991-02-22 DE DE69132119T patent/DE69132119T2/de not_active Expired - Lifetime
- 1991-02-22 AT AT91200382T patent/ATE191912T1/de not_active IP Right Cessation
- 1991-02-22 EP EP91200382A patent/EP0445862B1/en not_active Expired - Lifetime
- 1991-02-22 CZ CS1991460A patent/CZ286617B6/cs not_active IP Right Cessation
- 1991-02-22 ES ES91200382T patent/ES2147175T3/es not_active Expired - Lifetime
- 1991-02-28 JP JP3058048A patent/JP2601566B2/ja not_active Expired - Lifetime
- 1991-03-02 KR KR1019910003440A patent/KR0177521B1/ko not_active Expired - Lifetime
- 1991-03-04 IE IE071091A patent/IE910710A1/en not_active IP Right Cessation
- 1991-03-04 MY MYPI91000336A patent/MY108831A/en unknown
- 1991-03-04 AU AU72079/91A patent/AU636012B2/en not_active Expired
- 1991-03-05 CA CA002037575A patent/CA2037575C/en not_active Expired - Lifetime
- 1991-03-05 FI FI911096A patent/FI101622B1/fi active
- 1991-03-05 HU HU9100706A patent/HU221627B1/hu unknown
- 1991-03-05 NO NO910863A patent/NO177424C/no not_active IP Right Cessation
- 1991-03-05 ZW ZW23/91A patent/ZW2391A1/xx unknown
- 1991-03-05 UA UA4894778A patent/UA25969A1/uk unknown
- 1991-03-05 RU SU914894778A patent/RU2070884C1/ru active
- 1991-03-05 PT PT96937A patent/PT96937B/pt not_active IP Right Cessation
- 1991-03-05 BG BG93979A patent/BG60381B1/bg unknown
- 1991-03-05 ZA ZA911611A patent/ZA911611B/xx unknown
- 1991-03-06 PL PL91308054A patent/PL168693B1/pl unknown
- 1991-03-06 TN TNTNSN91010A patent/TNSN91010A1/fr unknown
- 1991-03-06 PL PL91289323A patent/PL168811B1/pl unknown
- 1991-03-06 YU YU39691A patent/YU48854B/sh unknown
- 1991-03-06 PL PL91308055A patent/PL168356B1/pl unknown
- 1991-03-06 PL PL91308052A patent/PL168384B1/pl unknown
- 1991-03-06 SI SI9110396A patent/SI9110396B/sl unknown
- 1991-03-06 CN CN91101360A patent/CN1038936C/zh not_active Expired - Lifetime
- 1991-03-06 PL PL91308053A patent/PL168686B1/pl unknown
- 1991-03-06 PL PL91309550A patent/PL169238B1/pl unknown
- 1991-03-06 MA MA22349A patent/MA22076A1/fr unknown
- 1991-10-24 IL IL9701891A patent/IL97018A/en not_active IP Right Cessation
1992
- 1992-11-17 US US07/977,314 patent/US5262418A/en not_active Expired - Lifetime
- 1992-11-27 LV LVP-92-232A patent/LV10085B/en unknown
1993
- 1993-03-23 HR HR930483A patent/HRP930483B1/xx not_active IP Right Cessation
- 1993-08-10 LT LTIP846A patent/LT3708B/lt not_active IP Right Cessation
1995
- 1995-06-16 HU HU95P/P00241P patent/HU211350A9/hu unknown
2000
- 2000-05-19 GR GR20000401151T patent/GR3033461T3/el not_active IP Right Cessation
- 2000-06-16 CY CY0000025A patent/CY2235B1/xx unknown

Also Published As

Publication number	Publication date
CA2037575C (en)	2003-09-16
SK282407B6 (sk)	2002-01-07
NO910863D0 (no)	1991-03-05
LT3708B (en)	1996-02-26
ZA911611B (en)	1992-11-25
JPH04211685A (ja)	1992-08-03
ES2147175T3 (es)	2000-09-01
BG60381B1 (bg)	1995-01-31
UA25969A1 (uk)	1999-02-26
CZ286617B6 (cs)	2000-05-17
TNSN91010A1 (fr)	1992-10-25
HRP930483A2 (en)	1995-12-31
FI911096A7 (fi)	1991-09-07
HU221627B1 (hu)	2002-12-28
PL168356B1 (pl)	1996-02-29
KR0177521B1 (ko)	1999-03-20
IL97018A (en)	1995-11-27
PL169238B1 (pl)	1996-06-28
YU39691A (sh)	1994-06-10
SI9110396B (sl)	2000-06-30
CN1054598A (zh)	1991-09-18
EP0445862B1 (en)	2000-04-19
PL168693B1 (pl)	1996-03-29
FI101622B (fi)	1998-07-31
EP0445862A2 (en)	1991-09-11
PL168384B1 (en)	1996-02-29
FI911096A0 (fi)	1991-03-05
AU636012B2 (en)	1993-04-08
PT96937B (pt)	1998-07-31
LV10085A (lv)	1994-05-10
SK282406B6 (sk)	2002-01-07
PT96937A (pt)	1991-10-31
NO177424C (no)	1995-09-13
HUT60733A (en)	1992-10-28
CS46091A3 (en)	1991-10-15
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HU211350A9 (en)	1995-11-28
HU910706D0 (en)	1991-09-30
YU48854B (sh)	2002-06-19
CA2037575A1 (en)	1991-09-07
CN1038936C (zh)	1998-07-01
SI9110396A (en)	1997-12-31
IL97018A0 (en)	1992-03-29
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ATE191912T1 (de)	2000-05-15
NO910863L (no)	1991-09-09
MY108831A (en)	1996-11-30
LV10085B (en)	1995-02-20
US5185335A (en)	1993-02-09
KR910016744A (ko)	1991-11-05
HK1010727A1 (en)	1999-06-25
DK0445862T3 (da)	2000-09-04
DE69132119T2 (de)	2000-12-21
BG93979A (bg)	1993-12-24
MA22076A1 (fr)	1991-10-01
PL168686B1 (pl)	1996-03-29
NZ237189A (en)	1992-11-25
GB9005014D0 (en)	1990-05-02
US5262418A (en)	1993-11-16
PL168811B1 (pl)	1996-04-30
ZW2391A1 (en)	1992-09-07
AU7207991A (en)	1991-09-12
RU2070884C1 (ru)	1996-12-27
HRP930483B1 (en)	2001-04-30
JP2601566B2 (ja)	1997-04-16
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FI101622B1 (fi)	1998-07-31

Publication	Publication Date	Title
AU636012B2 (en)	1993-04-08	N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2h-benzopyran )carboxamide derivatives
NZ507119A (en)	2002-08-28	1-[(4-Piperidinyl)methyl]-4-piperidine derivatives useful for treating gastrointestinal disorders
MY117803A (en)	2004-08-30	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
BG103144A (en)	1999-09-30	Cysteineprotease inhibitors
HU9601106D0 (en)	1996-07-29	Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands
DE3868301D1 (de)	1992-03-19	2-(methyl(4-piperidinyl))-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indolderivate, ihre herstellung und therapeutische verwendung.
MY121852A (en)	2006-02-28	4-(aminoethyl)-piperidine benzamides for treating gastrointestinal disorders
NZ333513A (en)	2000-04-28	1,4-di-substituted piperidines and medicaments useful as muscarinic antagonists
ZA951281B (en)	1996-02-16	Cosmetic or pharmaceutical compositions consisting of liposomes
MY133108A (en)	2007-10-31	Muscarinic antagonists
MY117680A (en)	2004-07-31	1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)- piperidine derivatives
ATE72431T1 (de)	1992-02-15	5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
NO975903L (no)	1998-06-17	N-benzylpiperazin-forbindelser, fremgangsmÕte ved fremstilling derav, samt farmas°ytiske blandinger
MX9701165A (es)	1997-05-31	Triazolinonas sustituidas como agentes para la proteccion de plantas.
EA200200197A1 (ru)	2002-06-27	Производные стрептограминов, способ их получения и содержащие их композиции
TW354295B (en)	1999-03-11	Phenyl-oxo-alkyl-(4-piperidinyl) benzoate derivatives