SG110069A1 - New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates - Google Patents

New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

Info

Publication number: SG110069A1
Authority: SG; Singapore
Prior art keywords: carboxymethyl; synthesis; acid; tetraesters; hydrates
Prior art date: 2002-09-24

Application number

SG200305553A

Other languages

English (en)

Inventor

Vaysse-Ludot Lucile

Lecouve Jean-Pierre

Langlois Pascal

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-24

Publication date

2005-04-28

2003-09-24 Application filed by Servier Lab filed Critical Servier Lab

2005-04-28 Publication of SG110069A1 publication Critical patent/SG110069A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SG200305553A 2002-09-24 2003-09-24 New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates SG110069A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number	Publication Date
SG110069A1 true SG110069A1 (en)	2005-04-28

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200305553A SG110069A1 (en)	2002-09-24	2003-09-24	New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates

Country Status (38)

Country	Link
US (1)	US7091364B2 (me)
EP (1)	EP1403265B1 (me)
JP (1)	JP4136866B2 (me)
KR (1)	KR100551502B1 (me)
CN (1)	CN1280286C (me)
AP (1)	AP1972A (me)
AR (1)	AR041357A1 (me)
AT (1)	ATE449767T1 (me)
AU (2)	AU2003299095A1 (me)
BR (1)	BR0304203A (me)
CA (1)	CA2442881C (me)
CY (1)	CY1109831T1 (me)
DE (1)	DE60330213D1 (me)
DK (1)	DK1403265T3 (me)
EA (1)	EA007108B1 (me)
EC (1)	ECSP055743A (me)
ES (1)	ES2337348T3 (me)
FR (1)	FR2844797B1 (me)
GE (1)	GEP20074139B (me)
HR (1)	HRP20050361B1 (me)
IL (1)	IL167315A (me)
IS (1)	IS2728B (me)
MA (1)	MA26100A1 (me)
ME (1)	ME00453B (me)
MX (1)	MXPA03008647A (me)
MY (1)	MY134924A (me)
NO (1)	NO328626B1 (me)
NZ (1)	NZ528401A (me)
OA (1)	OA12932A (me)
PL (1)	PL215879B1 (me)
PT (1)	PT1403265E (me)
RS (1)	RS51551B (me)
SG (1)	SG110069A1 (me)
SI (1)	SI1403265T1 (me)
TN (1)	TNSN05088A1 (me)
UA (1)	UA79157C2 (me)
WO (1)	WO2004029034A1 (me)
ZA (1)	ZA200307411B (me)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
US20060275503A1 (en) *	2003-05-07	2006-12-07	Nordic Bone A/S	Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions
PL1534305T3 (pl) *	2003-05-07	2007-03-30	Osteologix As	Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
KR101165614B1 (ko)	2004-02-26	2012-07-18	오스테올로지스 에이에스	괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
BRPI0512357A (pt)	2004-06-25	2008-03-04	Strontin Aps	composições compreendendo estrÈncio e vitamina d e usos destas
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (en)	2013-01-21	2015-05-13	Galenicum Health S.L.	Pharmaceutical compositions comprising an acid salt
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
CN1280286C (zh)	2006-10-18
US7091364B2 (en)	2006-08-15
FR2844797A1 (fr)	2004-03-26
ME00453B (me)	2011-10-10
IS7803A (is)	2005-04-18
IS2728B (is)	2011-04-15
OA12932A (en)	2006-10-13
AU2003248280B2 (en)	2009-01-08
FR2844797B1 (fr)	2004-10-22
HRP20050361A2 (en)	2005-06-30
JP2004269496A (ja)	2004-09-30
SI1403265T1 (sl)	2010-01-29
NZ528401A (en)	2004-05-28
PL215879B1 (pl)	2014-02-28
EA200300927A1 (ru)	2004-04-29
CA2442881C (fr)	2010-06-29
NO328626B1 (no)	2010-04-12
AU2003299095A1 (en)	2004-04-19
ECSP055743A (es)	2005-07-06
HK1061846A1 (en)	2004-10-08
EP1403265A1 (fr)	2004-03-31
EP1403265B1 (fr)	2009-11-25
AP1972A (en)	2009-03-12
MA26100A1 (fr)	2004-04-01
ES2337348T3 (es)	2010-04-23
RS51551B (sr)	2011-06-30
CN1500784A (zh)	2004-06-02
US20040059134A1 (en)	2004-03-25
PT1403265E (pt)	2009-12-16
EA007108B1 (ru)	2006-06-30
KR20040026626A (ko)	2004-03-31
IL167315A (en)	2009-08-03
CY1109831T1 (el)	2014-09-10
DE60330213D1 (de)	2010-01-07
MY134924A (en)	2008-01-31
WO2004029034A1 (fr)	2004-04-08
HRP20050361B1 (hr)	2014-03-14
ZA200307411B (en)	2004-07-07
KR100551502B1 (ko)	2006-02-13
MXPA03008647A (es)	2005-04-19
NO20034236D0 (no)	2003-09-23
RS20050241A (sr)	2007-06-04
AR041357A1 (es)	2005-05-11
JP4136866B2 (ja)	2008-08-20
NO20034236L (no)	2004-03-25
AU2003248280A1 (en)	2004-04-08
TNSN05088A1 (fr)	2007-05-14
ATE449767T1 (de)	2009-12-15
BR0304203A (pt)	2004-08-24
UA79157C2 (en)	2007-05-25
AP2005003255A0 (en)	2005-03-31
CA2442881A1 (fr)	2004-03-24
GEP20074139B (en)	2007-06-25
PL362366A1 (en)	2004-04-05
DK1403265T3 (da)	2010-04-06

Publication	Publication Date	Title
SG110069A1 (en)	2005-04-28	New process for the industrial synthesis of tetraesters of 5-[bis(carboxymethyl)amino]-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates
GEP20074135B (en)	2007-06-25	Process for the synthesis of (is)-4,5-dimethoxy-1-(methylaminomethyl)- benzocyclobutane and addition salts thereof, and to the application thereof in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AP1910A (en)	2008-10-30	New process for the industrial synthesis of strontium ranelate and its hydrates
UA97638C2 (ru)	2012-03-12	Способ синтеза ранелата стронция и его гидратов
AP1942A (en)	2009-01-28	New process for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid, and application to the synthesis of bivalent salts of ranelic acid and their hydrates.
MXPA05013751A (es)	2006-03-08	Procedimiento e intermediarios para la preparacion de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida o sus sales.
TNSN06338A1 (en)	2008-02-22	Substantially pure 2-{[2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carbonyl]-amino}-3-(phenylpyridin-2-yl-amino)-propionic acid as an ikb kinase inhibitor
GB2400100B (en)	2006-04-12	Metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid
GEP20063955B (en)	2006-10-25	New process for the synthesis of (7-methoxy-3,4-dihydro-1-nap hthalenyl) acetonitrile and its application in the synthesis of agomelatine
GB0212410D0 (en)	2002-07-10	Organic compounds
MX2009007598A (es)	2009-07-27	Hexahidrato de enrofloxacino.
GEP20084463B (en)	2008-08-25	Use of the distrontium salt of the acid 2-[n,n-di(carboxy methyl) amino]-3-cyano-4-carboxymethyl-thiophene-5-carboxylate for the production of medicaments for the treatment of gastro-duodenal pain
CR7762A (es)	2005-06-13	Sintesis de esteres de acido tiofenocarboxilico para la preparacion de sales del acido ranelico
CU23386A3 (es)	2009-06-25	Nuevo metodo para la sintesis industrial de ranelato de estroncio y los hidratos del mismo