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SE8001339L - ANTIHYPERCOLESTEREMIC MEDICINE, MONACOLINE K AND PREPARATION OF THEREOF - Google Patents

ANTIHYPERCOLESTEREMIC MEDICINE, MONACOLINE K AND PREPARATION OF THEREOF

Info

Publication number
SE8001339L
SE8001339L SE8001339A SE8001339A SE8001339L SE 8001339 L SE8001339 L SE 8001339L SE 8001339 A SE8001339 A SE 8001339A SE 8001339 A SE8001339 A SE 8001339A SE 8001339 L SE8001339 L SE 8001339L
Authority
SE
Sweden
Prior art keywords
antihypercolesteremic
monacoline
medicine
preparation
monascus
Prior art date
Application number
SE8001339A
Other languages
Swedish (sv)
Other versions
SE453301B (en
Inventor
A Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of SE8001339L publication Critical patent/SE8001339L/en
Publication of SE453301B publication Critical patent/SE453301B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A new compound which we refer to as Monacolin K, has the molecular formula C24H36O5 and has been found to have valuable antihypercholesteraemic activity. It can be produced by cultivating suitable micro-organisms from the genus Monascus, especially Monascus ruber strain 1005 (FERM 4822).
SE8001339A 1979-02-20 1980-02-20 ANTIHYPERCOLESTEROLEMIC MEDICINE, MONACOLINE K, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SE453301B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (en) 1979-02-20 1979-02-20 New physiologically active substance monacolin K and its production method

Publications (2)

Publication Number Publication Date
SE8001339L true SE8001339L (en) 1980-08-21
SE453301B SE453301B (en) 1988-01-25

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8001339A SE453301B (en) 1979-02-20 1980-02-20 ANTIHYPERCOLESTEROLEMIC MEDICINE, MONACOLINE K, PROCEDURES FOR PREPARING THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Country Status (27)

Country Link
JP (1) JPS5925599B2 (en)
KR (1) KR830002801B1 (en)
AT (1) AT373915B (en)
AU (1) AU532626B2 (en)
BE (1) BE881825A (en)
CA (1) CA1129794A (en)
CH (1) CH645890A5 (en)
DD (1) DD154494A5 (en)
DE (2) DE3051175C2 (en)
DK (2) DK149095C (en)
ES (1) ES8103171A1 (en)
FI (1) FI66427C (en)
FR (1) FR2449685B1 (en)
GB (1) GB2046737B (en)
HU (1) HU182069B (en)
IE (1) IE49743B1 (en)
IT (1) IT1175260B (en)
MX (1) MX6314E (en)
NL (1) NL191540C (en)
NO (1) NO153974C (en)
NZ (1) NZ192919A (en)
PH (1) PH15145A (en)
PL (1) PL124304B1 (en)
SE (1) SE453301B (en)
SG (1) SG6784G (en)
SU (2) SU1158048A3 (en)
ZA (1) ZA80962B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (en) * 1980-03-31 1994-11-16 三共株式会社 MB-530A derivative
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (en) * 1980-06-06 1986-07-28 Sankyo Co METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
JPS5835144A (en) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb-530b derivative and its preparation
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
FI932188L (en) 1992-05-15 1993-11-16 Sankyo Co OCTAHYDRONAPTHALENOXIME DERIVATIVES FOER INHIBERING AV CHOLESTEROLBIOSYNTESEN, DERAS FRAMSTAELLNING OCH ANVAENDNING
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
UA73074C2 (en) 1998-03-20 2005-06-15 Method of controlled fermentation for production of lovastatin as hydroxy-acid
HUP0300073A3 (en) 2000-02-24 2004-10-28 Teva Gyogyszergyar Zartkoeruee Method of purifying a fermentation broth
JP2003525935A (en) 2000-03-03 2003-09-02 ビオガル ジョジセルジャール アール テー． Method for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
KR20010095780A (en) * 2000-04-12 2001-11-07 나가오카 마사시 Embryo monascus
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
ATE356554T1 (en) 2001-02-09 2007-04-15 Unilever Nv FOODS CONTAINING SOY PROTEIN AND STATIN
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (en) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 Preventive and Dietary Supplement for adult chronic disease
KR100710500B1 (en) 2005-05-18 2007-04-24 고려대학교 산학협력단 Method for producing Monacholine Ｋ using red yeast bacteria
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (en) 2012-10-12 2013-09-30 Ion Gigel Fulga COMPOSITION FOR TREATMENT OR PREVENTION OF DISLIPIDEMS
CN110331151A (en) * 2019-04-11 2019-10-15 北京工商大学 The construction method of purple Monascus mokH gene overexpression bacterial strain
CN111297938A (en) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 Method for detecting lovastatin in composition for assisting in reducing blood fat
JP2022135089A (en) * 2021-03-04 2022-09-15 小林製薬株式会社 cholesterol lowering agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
SU969702A1 (en) 1982-10-30
SE453301B (en) 1988-01-25
NL191540C (en) 1995-09-04
PL222120A1 (en) 1980-10-20
DE3006216A1 (en) 1980-09-04
ZA80962B (en) 1981-03-25
IE49743B1 (en) 1985-12-11
BE881825A (en) 1980-08-20
IT1175260B (en) 1987-07-01
ES488796A0 (en) 1981-02-16
KR830002801B1 (en) 1983-12-16
DK73080A (en) 1980-08-21
PH15145A (en) 1982-08-24
AU532626B2 (en) 1983-10-06
NO153974C (en) 1986-06-25
DK149095B (en) 1986-01-20
GB2046737B (en) 1983-01-12
CA1129794A (en) 1982-08-17
DK21889D0 (en) 1989-01-18
FI800506A7 (en) 1980-08-21
DD154494A5 (en) 1982-03-24
NL191540B (en) 1995-05-01
AT373915B (en) 1984-03-12
ATA92980A (en) 1983-07-15
GB2046737A (en) 1980-11-19
HU182069B (en) 1983-12-28
DE3006216C2 (en) 1985-10-31
FI66427B (en) 1984-06-29
NO153974B (en) 1986-03-17
NO800451L (en) 1980-08-21
JPS55111790A (en) 1980-08-28
MX6314E (en) 1985-04-01
AU5567380A (en) 1980-08-28
FR2449685B1 (en) 1985-06-28
DK149095C (en) 1986-06-16
IE800321L (en) 1980-08-20
SG6784G (en) 1985-02-08
DK21889A (en) 1989-01-18
NZ192919A (en) 1984-07-06
JPS5925599B2 (en) 1984-06-19
KR830002030A (en) 1983-05-21
NL8001041A (en) 1980-08-22
SU1158048A3 (en) 1985-05-23
CH645890A5 (en) 1984-10-31
PL124304B1 (en) 1983-01-31
ES8103171A1 (en) 1981-02-16
DE3051175C2 (en) 1989-12-21
FI66427C (en) 1984-10-10
FR2449685A1 (en) 1980-09-19
IT8067262A0 (en) 1980-02-20

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