ES488796A0 - A MONACOLINE K PREPARATION PROCEDURE. - Google Patents
A MONACOLINE K PREPARATION PROCEDURE.Info
- Publication number
- ES488796A0 ES488796A0 ES488796A ES488796A ES488796A0 ES 488796 A0 ES488796 A0 ES 488796A0 ES 488796 A ES488796 A ES 488796A ES 488796 A ES488796 A ES 488796A ES 488796 A0 ES488796 A0 ES 488796A0
- Authority
- ES
- Spain
- Prior art keywords
- monacoline
- preparation procedure
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FVIGODVHAVLZOO-UHFFFAOYSA-N Dixanthogen Chemical compound CCOC(=S)SSC(=S)OCC FVIGODVHAVLZOO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54017856A JPS5925599B2 (en) | 1979-02-20 | 1979-02-20 | New physiologically active substance monacolin K and its production method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES488796A0 true ES488796A0 (en) | 1981-02-16 |
| ES8103171A1 ES8103171A1 (en) | 1981-02-16 |
Family
ID=11955290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES488796A Expired ES8103171A1 (en) | 1979-02-20 | 1980-02-20 | A MONACOLINE K PREPARATION PROCEDURE. |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5925599B2 (en) |
| KR (1) | KR830002801B1 (en) |
| AT (1) | AT373915B (en) |
| AU (1) | AU532626B2 (en) |
| BE (1) | BE881825A (en) |
| CA (1) | CA1129794A (en) |
| CH (1) | CH645890A5 (en) |
| DD (1) | DD154494A5 (en) |
| DE (2) | DE3051175C2 (en) |
| DK (2) | DK149095C (en) |
| ES (1) | ES8103171A1 (en) |
| FI (1) | FI66427C (en) |
| FR (1) | FR2449685B1 (en) |
| GB (1) | GB2046737B (en) |
| HU (1) | HU182069B (en) |
| IE (1) | IE49743B1 (en) |
| IT (1) | IT1175260B (en) |
| MX (1) | MX6314E (en) |
| NL (1) | NL191540C (en) |
| NO (1) | NO153974C (en) |
| NZ (1) | NZ192919A (en) |
| PH (1) | PH15145A (en) |
| PL (1) | PL124304B1 (en) |
| SE (1) | SE453301B (en) |
| SG (1) | SG6784G (en) |
| SU (2) | SU1158048A3 (en) |
| ZA (1) | ZA80962B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| JPH0692381B2 (en) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | MB-530A derivative |
| JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| DK149080C (en) * | 1980-06-06 | 1986-07-28 | Sankyo Co | METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES |
| JPS5835144A (en) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb-530b derivative and its preparation |
| US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
| WO1993017991A1 (en) * | 1992-03-04 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
| NZ247617A (en) | 1992-05-15 | 1995-07-26 | Sankyo Co | Octahydronaphthalene oxime derivatives and pharmaceutical compositions |
| US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
| HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| JP2001527424A (en) | 1998-03-20 | 2001-12-25 | ビオガル・ジョージィセルジャール・エル・テー | Metabolic control fermentation procedure for producing lovastatin hydroxy acid |
| JP3740062B2 (en) | 2000-02-24 | 2006-01-25 | テバ ジョジセルジャール レースベニュタールシャシャーグ | Purification method of culture solution |
| AU4183301A (en) | 2000-03-03 | 2001-09-17 | Biogal Gyogyszergyar | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
| KR20010095780A (en) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | Embryo monascus |
| IN192861B (en) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| WO2002063976A1 (en) * | 2001-02-09 | 2002-08-22 | Unilever N.V. | Food product comprising soy protein and statins |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| KR20020093147A (en) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | Preventive and Dietary Supplement for adult chronic disease |
| KR100710500B1 (en) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | Method for producing Monacholine K using red yeast bacteria |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| RO128803A0 (en) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | COMPOSITION FOR TREATMENT OR PREVENTION OF DISLIPIDEMS |
| CN110331151A (en) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | The construction method of purple Monascus mokH gene overexpression bacterial strain |
| CN111297938A (en) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | Method for detecting lovastatin in composition for assisting in reducing blood fat |
| JP2022135089A (en) * | 2021-03-04 | 2022-09-15 | 小林製薬株式会社 | cholesterol lowering agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (en) * | 1974-06-07 | 1981-03-18 | ||
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/en not_active Expired
-
1980
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/en not_active Expired
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 NL NL8001041A patent/NL191540C/en not_active IP Right Cessation
- 1980-02-20 ES ES488796A patent/ES8103171A1/en not_active Expired
- 1980-02-20 FI FI800506A patent/FI66427C/en not_active IP Right Cessation
- 1980-02-20 BE BE0/199476A patent/BE881825A/en not_active IP Right Cessation
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 CH CH136680A patent/CH645890A5/en not_active IP Right Cessation
- 1980-02-20 SE SE8001339A patent/SE453301B/en not_active IP Right Cessation
- 1980-02-20 FR FR8003662A patent/FR2449685B1/en not_active Expired
- 1980-02-20 DE DE3006216A patent/DE3006216C2/en not_active Expired
- 1980-02-20 IT IT67262/80A patent/IT1175260B/en active
- 1980-02-20 HU HU80397A patent/HU182069B/en unknown
- 1980-02-20 AT AT0092980A patent/AT373915B/en not_active IP Right Cessation
- 1980-02-20 SU SU802887300A patent/SU1158048A3/en active
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 PL PL1980222120A patent/PL124304B1/en unknown
- 1980-02-20 DK DK73080A patent/DK149095C/en not_active IP Right Cessation
- 1980-02-20 DD DD80219159A patent/DD154494A5/en unknown
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/en unknown
- 1980-02-20 MX MX808652U patent/MX6314E/en unknown
- 1980-02-20 NO NO800451A patent/NO153974C/en unknown
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-09-12 SU SU802977031A patent/SU969702A1/en active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889D0/en not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20010217 |