[go: up one dir, main page]

DK21889D0 - APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA - Google Patents

APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA

Info

Publication number
DK21889D0
DK21889D0 DK021889A DK21889A DK21889D0 DK 21889 D0 DK21889 D0 DK 21889D0 DK 021889 A DK021889 A DK 021889A DK 21889 A DK21889 A DK 21889A DK 21889 D0 DK21889 D0 DK 21889D0
Authority
DK
Denmark
Prior art keywords
carboxylic acid
monacolin
medicine
salts
preparation
Prior art date
Application number
DK021889A
Other languages
Danish (da)
Other versions
DK21889A (en
Inventor
Akira Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK21889A publication Critical patent/DK21889A/en
Publication of DK21889D0 publication Critical patent/DK21889D0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK021889A 1979-02-20 1989-01-18 APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA DK21889D0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (en) 1979-02-20 1979-02-20 New physiologically active substance monacolin K and its production method

Publications (2)

Publication Number Publication Date
DK21889A DK21889A (en) 1989-01-18
DK21889D0 true DK21889D0 (en) 1989-01-18

Family

ID=11955290

Family Applications (2)

Application Number Title Priority Date Filing Date
DK73080A DK149095C (en) 1979-02-20 1980-02-20 PROCEDURE FOR PREPARING A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND called MONACOLIN K
DK021889A DK21889D0 (en) 1979-02-20 1989-01-18 APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK73080A DK149095C (en) 1979-02-20 1980-02-20 PROCEDURE FOR PREPARING A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND called MONACOLIN K

Country Status (27)

Country Link
JP (1) JPS5925599B2 (en)
KR (1) KR830002801B1 (en)
AT (1) AT373915B (en)
AU (1) AU532626B2 (en)
BE (1) BE881825A (en)
CA (1) CA1129794A (en)
CH (1) CH645890A5 (en)
DD (1) DD154494A5 (en)
DE (2) DE3051175C2 (en)
DK (2) DK149095C (en)
ES (1) ES8103171A1 (en)
FI (1) FI66427C (en)
FR (1) FR2449685B1 (en)
GB (1) GB2046737B (en)
HU (1) HU182069B (en)
IE (1) IE49743B1 (en)
IT (1) IT1175260B (en)
MX (1) MX6314E (en)
NL (1) NL191540C (en)
NO (1) NO153974C (en)
NZ (1) NZ192919A (en)
PH (1) PH15145A (en)
PL (1) PL124304B1 (en)
SE (1) SE453301B (en)
SG (1) SG6784G (en)
SU (2) SU1158048A3 (en)
ZA (1) ZA80962B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (en) * 1980-03-31 1994-11-16 三共株式会社 MB-530A derivative
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (en) * 1980-06-06 1986-07-28 Sankyo Co METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
JPS5835144A (en) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb-530b derivative and its preparation
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
JP2001527424A (en) 1998-03-20 2001-12-25 ビオガル・ジョージィセルジャール・エル・テー Metabolic control fermentation procedure for producing lovastatin hydroxy acid
JP3740062B2 (en) 2000-02-24 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ Purification method of culture solution
AU4183301A (en) 2000-03-03 2001-09-17 Biogal Gyogyszergyar A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
KR20010095780A (en) * 2000-04-12 2001-11-07 나가오카 마사시 Embryo monascus
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
WO2002063976A1 (en) * 2001-02-09 2002-08-22 Unilever N.V. Food product comprising soy protein and statins
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (en) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 Preventive and Dietary Supplement for adult chronic disease
KR100710500B1 (en) 2005-05-18 2007-04-24 고려대학교 산학협력단 Method for producing Monacholine K using red yeast bacteria
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (en) 2012-10-12 2013-09-30 Ion Gigel Fulga COMPOSITION FOR TREATMENT OR PREVENTION OF DISLIPIDEMS
CN110331151A (en) * 2019-04-11 2019-10-15 北京工商大学 The construction method of purple Monascus mokH gene overexpression bacterial strain
CN111297938A (en) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 Method for detecting lovastatin in composition for assisting in reducing blood fat
JP2022135089A (en) * 2021-03-04 2022-09-15 小林製薬株式会社 cholesterol lowering agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI66427B (en) 1984-06-29
FR2449685B1 (en) 1985-06-28
DK149095C (en) 1986-06-16
HU182069B (en) 1983-12-28
AU532626B2 (en) 1983-10-06
DE3006216C2 (en) 1985-10-31
GB2046737A (en) 1980-11-19
DE3051175C2 (en) 1989-12-21
FI66427C (en) 1984-10-10
FR2449685A1 (en) 1980-09-19
PH15145A (en) 1982-08-24
SE453301B (en) 1988-01-25
DK21889A (en) 1989-01-18
FI800506A7 (en) 1980-08-21
NO153974C (en) 1986-06-25
IT1175260B (en) 1987-07-01
JPS5925599B2 (en) 1984-06-19
NO800451L (en) 1980-08-21
JPS55111790A (en) 1980-08-28
ATA92980A (en) 1983-07-15
CH645890A5 (en) 1984-10-31
NL191540C (en) 1995-09-04
NZ192919A (en) 1984-07-06
SU1158048A3 (en) 1985-05-23
AT373915B (en) 1984-03-12
PL222120A1 (en) 1980-10-20
DK149095B (en) 1986-01-20
CA1129794A (en) 1982-08-17
DK73080A (en) 1980-08-21
ES488796A0 (en) 1981-02-16
ES8103171A1 (en) 1981-02-16
PL124304B1 (en) 1983-01-31
IE49743B1 (en) 1985-12-11
KR830002801B1 (en) 1983-12-16
MX6314E (en) 1985-04-01
NL8001041A (en) 1980-08-22
BE881825A (en) 1980-08-20
NO153974B (en) 1986-03-17
IT8067262A0 (en) 1980-02-20
AU5567380A (en) 1980-08-28
SU969702A1 (en) 1982-10-30
DE3006216A1 (en) 1980-09-04
SG6784G (en) 1985-02-08
SE8001339L (en) 1980-08-21
KR830002030A (en) 1983-05-21
GB2046737B (en) 1983-01-12
ZA80962B (en) 1981-03-25
NL191540B (en) 1995-05-01
IE800321L (en) 1980-08-20
DD154494A5 (en) 1982-03-24

Similar Documents

Publication Publication Date Title
DK21889A (en) APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA
DK160099C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF OPTICALLY ACTIVE OR RACEMIC 6-SUBSTITUTED 2-PENEM-3-CARBOXYLIC ACID COMPOUNDS OR PHARMACEUTICAL APPLICABLE SALTS THEREOF
DK151623C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N-SUBSTITUTED MORANOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
NO155055C (en) ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE BETA-CARBOLIN-3-CARBOXYLIC ACID DERIVATIVES.
NO150106C (en) APPLICATION OF AN N-ACYL-ALFA AMINO ACID AS EMULSANT FOR THE PREPARATION OF EMULSIONS
DK145376C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N- (1'-BENZYL-2'-PYRROLIDINYLMETHYL) -BENZAMIDES OR ACID ADDITION SALTS, QUATERNARY AMMONIUM SALT OR OPTICALLY ACTIVE ISOMERS THEREOF
DK149569C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ISOQUINOLINE ACETIC ACID COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK125179A (en) PROCEDURE FOR THE PREPARATION OF DISUBSTITUTED 3-CEPHEM-4-CATBOXYL ACID DERIVATIVES
DK322380A (en) PROCEDURE FOR THE PREPARATION OF MONACOLIN K SALTS OR ESTERS
DK335279A (en) PROCEDURE FOR THE PREPARATION OF SPIROFURANO HYDANTOIN COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE METAL SALTS THEREOF
AR219859A1 (en) PROCEDURE FOR THE ELIMINATION OF ASCORBIC ACID FROM AQUEOUS SOLUTIONS
DK159079A (en) PROCEDURE FOR THE PREPARATION OF 4-AMINO-2-PIPERIDINOQUINAZOLINE DERIVATIVES OR ACID ADDITIONAL SALTS THEREOF
DK149841C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ALFA-FLUOR-METHYL-ALFA AMINOALCANIC ACIDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK321482A (en) PROCEDURE FOR THE PREPARATION OF 1-IMIDAZOLYL-2-PHENYL-8-PIPERAZINYLPHENOXY-OCTAN-2-OL COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK165005C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4,5-DIHYDRO-4-OXOFURAN-2-CARBOXYLIC ACID DERIVATIVES OR THERAPEUTIC ACCEPTABLE SALTS THEREOF
DK430379A (en) PROCEDURE FOR THE PREPARATION OF 2,6-DIAMINONEBULARIN OR ACID ADDITION SALTS THEREOF
DK152427C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-THIOMETHYLPYRIDINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK160874C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ERGOL-8-ONE OR ERGOLIN COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
NO854414L (en) PROCEDURE FOR THE PREPARATION OF THE KINKONIDIN SALT OF D-2- (6-METOXY-2-Naphthyl) -Propionic Acid.
DK157021C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2,3-POLYMETHYLENE-4-OXO-4H-PYRIDO- OR -AZEPINOOE1,2-AAAPYRIMIDINES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS OR QUATERA SALTS
RO81506A (en) PROCEDURE FOR PREPARATION OF 1,3,4-TIADIAZOL-2-CARBOXYLIC ACID DERIVATIVES
DK148036C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF EPIMERE 4 '' - AMINO-ERYTHROMYCIN COMPOUNDS OR ACID ADDITION SALTS.
DK317678A (en) PROCEDURE FOR THE PREPARATION OF 3- (1-PYRAZOLYL) -PYRIDAZINDF ERIVATES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITIONAL SALTS THEREOF
FI791183A7 (en) A method for the preparation of novel oximoximes derived from 3-azidomethyl-7-aminothiazolyl-acetamidocephalosporanic acid.
DK153539C (en) PROCEDURE FOR THE PREPARATION OF 3,3-DIMETHYL-2-OXOCHORIC ACID OR SALTS THEREOF

Legal Events

Date Code Title Description
ARF Application refused