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RU2018126365A - Способ расщепления амидных связей - Google Patents

Способ расщепления амидных связей Download PDF

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Publication number
RU2018126365A
RU2018126365A RU2018126365A RU2018126365A RU2018126365A RU 2018126365 A RU2018126365 A RU 2018126365A RU 2018126365 A RU2018126365 A RU 2018126365A RU 2018126365 A RU2018126365 A RU 2018126365A RU 2018126365 A RU2018126365 A RU 2018126365A
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Russia
Prior art keywords
paragraphs
amide group
hydroxylamine
reaction
salt
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RU2018126365A
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English (en)
Inventor
Крейг Стивен ХАРРИС
ЦЗИН Лаура ЦЗИН
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Гальдерма С.А.
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Priority claimed from EP15202944.3A external-priority patent/EP3187510A1/en
Priority claimed from EP16172254.1A external-priority patent/EP3252082A1/en
Priority claimed from EP16172241.8A external-priority patent/EP3252081A1/en
Priority claimed from EP16172225.1A external-priority patent/EP3252080A1/en
Application filed by Гальдерма С.А. filed Critical Гальдерма С.А.
Publication of RU2018126365A publication Critical patent/RU2018126365A/ru

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Claims (21)

1. Способ расщепления амидных связей, включающий
a) обеспечение молекулы, содержащей амидную группу, где амидная группа является первичной, вторичной или третичной амидной группой;
b) проведение реакции молекулы, содержащей амидную группу, с гидроксиламином (NH2OH) или его солью для расщепления амидной связи амидной группы.
2. Способ по п. 1, отличающийся тем, что способ дополнительно включает:
c) выделение продукта, образовавшегося в реакции стадии b).
3. Способ по п. 1 или 2, отличающийся тем, что амидная группа является N-ациламидной группой, предпочтительно - N-ацетиламидной группой.
4. Способ по любому из пп. 1-3, отличающийся тем, что молекула, содержащая амидную группу, дополнительно содержит рН-чувствительный хиральный центр.
5. Способ по любому из пп. 1-4, отличающийся тем, что молекула, содержащая амидную группу, дополнительно содержит рН-чувствительную защитную группу.
6. Способ по любому из пп. 1-5, отличающийся тем, что стадия b) включает проведение реакции молекулы, содержащей амидную группу, с гидроксиламином или его солью при температуре, равной 100°С или менее.
7. Способ по любому из пп. 1-6, отличающийся тем, что стадия b) включает проведение реакции молекулы, содержащей амидную группу, с гидроксиламином или его солью в течение периода времени, лежащего в диапазоне от 2 часов до 200 часов.
8. Способ по любому из пп. 1-7, отличающийся тем, что стадия b) включает проведение реакции молекулы, содержащей амидную группу, с гидроксиламином в воде.
9. Способ по любому из пп. 1-8, отличающийся тем, что молярная концентрация гидроксиламина на стадии b) лежит в диапазоне от 5 М до 20 М.
10. Способ по любому из пп. 1-9, отличающийся тем, что стадия b) включает проведение реакции молекулы, содержащей амидную группу, с солью гидроксиламина.
11. Способ по п. 10, отличающийся тем, что соль гидроксиламина является солью гидроксиламина и йодистоводородной кислоты или трифторуксусной кислоты.
12. Способ по любому из пп. 1-11, отличающийся тем, что концентрация соли гидроксиламина на стадии b) лежит в диапазоне от 0,1 М до 5 М.
13. Способ по любому из пп. 1-12, отличающийся тем, что реакцию на стадии b) проводят в растворителе, способном по меньшей мере частично растворять соль гидроксиламина.
14. Способ по любому из пп. 1-13, отличающийся тем, что реакцию на стадии b) проводят при значении рН, лежащем в диапазоне от 4 до 12.
15. Способ по любому из пп. 1-14, отличающийся тем, что реакцию на стадии b) проводят при значении рН, лежащем в диапазоне от 9 до 11.
16. Способ по п. 14, отличающийся тем, что рН реакционной смеси снижают до значения, лежащего в диапазоне от 4 до 9 посредством добавления агента, снижающего рН, выбранного из группы, состоящей из минеральных кислот, органических кислот и солей, снижающих рН, а также их комбинаций.
17. Способ по п. 16, отличающийся тем, что агент, снижающий рН, является солью, снижающей рН.
18. Применение гидроксиламина или его соли для расщепления амидной связи в молекуле, содержащей амидную группу.
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX395029B (es) * 2015-12-29 2025-03-24 Galderma Sa Metodo para desacetilacion de biopolimeros.
PT3623390T (pt) 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
WO2019002372A1 (en) * 2017-06-28 2019-01-03 Nestlé Skin Health Sa Method of preparing a hydrogel product
KR102705487B1 (ko) * 2017-12-22 2024-09-12 갈더마 홀딩 소시에떼 아노님 주사가능한 젤 생성물
EP3581168A1 (en) * 2018-06-15 2019-12-18 Universiteit Utrecht Holding B.V. Sustained release composition
AU2019340387C1 (en) 2018-09-10 2025-06-19 The Regents Of The University Of California Dithiolsaccharide mucolytic agents and uses thereof
CN109206537B (zh) * 2018-10-10 2021-04-09 华熙生物科技股份有限公司 一种乙酰化透明质酸钠的制备方法及其应用
EP3659632A1 (en) * 2018-11-29 2020-06-03 Nestlé Skin Health SA Post-crosslinking partial degradation of amide crosslinked hydrogels
ES3032689T3 (en) * 2018-12-21 2025-07-23 Galderma Holding SA Hydrogel compositions encapsulating solid particles
TWI894184B (zh) 2019-12-02 2025-08-21 瑞士商葛德瑪控股公司 高分子量美容組合物
EP4135772A4 (en) * 2020-04-17 2024-04-24 Brendan Patrick Purcell Controlled release hyaluronic acid compositions
AR127493A1 (es) 2021-10-29 2024-01-31 Alliance Sustainable Energy Pretratamiento de lignocelulosa utilizando procesos de álcali de dos etapas y refinación mecánica
WO2023148619A1 (en) 2022-02-01 2023-08-10 Galderma Holding SA Methods of producing crosslinked hyaluronic acid hydrogels
IT202200018585A1 (it) * 2022-09-12 2024-03-12 Glycocore Pharma S R L Procedimento di coniugazione dell’acido ialuronico e coniugati dell’acido ialuronico così ottenuti
WO2025091137A1 (en) 2023-11-02 2025-05-08 Volumina Medical Sa Implantable device compositions including ester bonds
WO2026022744A1 (en) 2024-07-24 2026-01-29 Galderma Holding SA High-durability glycosaminoglycan gels and methods of making the same

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU730695A1 (ru) * 1977-07-05 1980-04-30 Ордена Ленина Институт Элементоорганических Соединений Ан Ссср Способ получени хитозана
DE3684887D1 (de) 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
US4859581A (en) * 1986-03-10 1989-08-22 Board Of Regents, The University Of Texas System Endoglycosidase assay
JPS62265998A (ja) 1986-03-10 1987-11-18 ボ−ド　オブ　リ−ジエンツ　ザ　ユニヴア−シテイ　オブ　テキサス　システム ヘパラン硫酸エンドグリコシダーゼアッセイ
DE4200080A1 (de) 1992-01-03 1993-09-30 Reinmueller Johannes Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
DE4439575A1 (de) 1994-11-05 1996-05-09 Permselect Ges Fuer Zellstrukt Neue Vernetzungsprodukte auf Basis Hyaluronsäure
WO1997011958A1 (en) * 1995-09-29 1997-04-03 The Scripps Research Institute Protein signature analysis
FR2764514B1 (fr) 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
KR19990029749A (ko) 1997-09-17 1999-04-26 미우라 아끼라 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체
JP4385152B2 (ja) 1997-09-17 2009-12-16 三菱化学株式会社 ２価反応性水溶性高分子誘導体及びそれを含有する複合体
EP1048301A4 (en) 1998-01-16 2005-03-09 Takeda Chemical Industries Ltd COMPOSITIONS WITH DELAYED ACTIVE INGREDIENTS, PROCESS FOR THEIR PREPARATION AND THEIR USE
FR2777193B1 (fr) 1998-04-14 2001-06-08 Coletica Particule a groupement hydroxamique chelatante d'ions metalliques et leur utilisation en cosmetique ou en pharmacie
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
GB9902412D0 (en) 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
US20030022257A1 (en) 2000-07-21 2003-01-30 Macina Roberto A. Compositions and methods relating to lung specific genes
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
KR100375299B1 (ko) * 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
EP1409728A2 (en) 2001-04-09 2004-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-enzymatic liposome-linked closely spaced array electrodes assay (nel-ela) for detecting and quantifying nucleic acids
EP1448991A2 (en) 2001-04-09 2004-08-25 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Activated enzyme-linked detection systems for detecting and quantifying nucleid acids, antigens, antibodies and other analytes
EP1411861B1 (en) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
FR2826657B1 (fr) 2001-06-29 2003-09-05 Rhodia Chimie Sa Polymeres derives de polysaccharides comprenant une ou plusieurs fonctions oxime ou amine et utilisations desdits polymeres
US8524884B2 (en) 2001-10-30 2013-09-03 Colorado State University Research Foundation Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
KR20040009891A (ko) 2002-07-26 2004-01-31 주식회사 엘지생명과학 히알루론산의 유도체 겔 및 그 제조방법
PT102888B (pt) 2002-12-23 2005-04-29 Filipe Manuel Rodrigues Aguiar Processo industrial de producao de acido polilactico (pla) obtido por esterificacao e polimerizacao de acido lactico purificado, sendo o referido acido produzido atraves de um processo fermentativo
TWI251596B (en) 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
US7115388B2 (en) 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
US20160106717A1 (en) 2004-09-24 2016-04-21 Gen Pharma Holdings LLC Cai-based systems and methods for the localized treatment of uveitis
DE102005055385A1 (de) 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
JP2009507103A (ja) 2005-09-02 2009-02-19 コルバー・ライフサイエンス・リミテツド 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法
ATE540705T1 (de) 2005-09-21 2012-01-15 Surmodics Inc Überzüge und artikel mit natürlichen biologisch abbaubaren polysacchariden
US7785624B2 (en) 2006-03-02 2010-08-31 Inspire Pharmaceuticals, Inc. Pharmaceutical latrunculin formulations
DE102006013594A1 (de) 2006-03-22 2007-09-27 Biopolymer Gmbh & Co. Kg Quervernetzte Gele von Hyaluronsäure und deren Verwendung
CN101511876A (zh) * 2006-07-11 2009-08-19 犹他大学研究基金会 用亲电子基团修饰的大分子及其制备和使用方法
FR2909560B1 (fr) 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique Gel d'acide hyaluronique pour injection intradermique
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
WO2010065784A2 (en) * 2008-12-03 2010-06-10 Jakk Group, Inc. Methods, devices, and compositions for dermal filling
US10105197B1 (en) 2009-03-26 2018-10-23 Fernando Colon Method of treatment for periodontal pockets
US20100255068A1 (en) 2009-04-02 2010-10-07 Allergan, Inc. Hair-like shaped hydrogels for soft tissue augmentation
CN102070786B (zh) * 2009-11-19 2012-05-30 中国农业科学院农产品加工研究所 一种透明质酸-海藻酸钠复合水凝胶及其制备方法
US8197849B2 (en) * 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
KR101831918B1 (ko) 2010-06-11 2018-02-27 한국원자력의학원 히알루론산의 탈아세틸화 가수분해효소, 및 이에 의해 탈아세틸화된 히알루론산 및 이의 유도체
WO2012026468A1 (ja) * 2010-08-23 2012-03-01 電気化学工業株式会社 架橋ヒアルロン酸組成物及び自己架橋ヒアルロン酸粒子
HUE033169T2 (en) 2011-03-03 2017-11-28 Chugai Pharmaceutical Co Ltd Amino carboxylic acid modified hyaluronic acid derivative
ES2686927T3 (es) * 2011-09-07 2018-10-22 Prolynx Llc Hidrogeles con reticulación biodegradable
KR102052775B1 (ko) 2011-12-08 2019-12-04 알러간 인더스트리 에스에이에스 진피 필러 조성물
US8887243B2 (en) 2012-01-30 2014-11-11 Cisco Technology, Inc. Integrated security platform
CZ304512B6 (cs) * 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CN102952281B (zh) * 2012-09-13 2014-03-19 江苏隆源生物科技有限公司 一种壳寡糖和透明质酸交联凝胶的制备方法
FR2997085B1 (fr) * 2012-10-24 2015-05-29 Teoxane Procede de preparation d'un gel reticule
FR2997014B1 (fr) 2012-10-24 2015-03-20 Teoxane Composition sterile dermo-injectable
US9597826B2 (en) * 2012-10-30 2017-03-21 Bell Helicopter Textron Inc. Method of repairing, splicing, joining, machining, and stabilizing honeycomb core using pourable structural foam and a structure incorporating the same
EP2727597A1 (en) 2012-11-06 2014-05-07 Centre National de la Recherche Scientifique (CNRS) Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
CN104140541A (zh) * 2013-05-10 2014-11-12 北京化工大学 注射型透明质酸水凝胶的制备方法及其应用
AU2014288252A1 (en) * 2013-07-08 2016-02-11 Denka Company Limited Core-shell crosslinked hyaluronic acid gel particles, production method for same, and medical material
US9518630B2 (en) * 2013-08-01 2016-12-13 Specialized Bicycle Components, Inc. Bicycle air spring
KR20160035081A (ko) * 2013-08-07 2016-03-30 애로우헤드 리서치 코오포레이션 생체 내에서 RNAi 유발제를 종양 세포로 전달하기 위한 폴리콘주게이트
EP3041830B1 (en) 2013-09-03 2023-10-25 Agency For Science, Technology And Research Polymer-flavonoid conjugates and hydrogels for biomedical applications
CN105705137B (zh) 2013-09-27 2020-03-27 安特易斯有限公司 获得基于含有以粉末形式添加的利多卡因和碱剂的透明质酸且热灭菌的可注射水凝胶的方法
CN103788222B (zh) 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法
WO2015181365A1 (en) * 2014-05-29 2015-12-03 Galderma S.A. Cyclodextrin-grafted hyaluronic acid crosslinked with dextran and uses thereof
RU2016150853A (ru) * 2014-05-29 2018-07-02 Гальдерма С.А. Поперечно-сшитая гиалуроновая кислота с привитым декстраном
CN104194066B (zh) 2014-09-15 2016-08-24 中国科学院上海硅酸盐研究所 氧化硅-壳聚糖复合气凝胶及其制备方法
CN105288594A (zh) * 2015-11-30 2016-02-03 武汉理工大学 一种被可注射水凝胶包裹的生长因子多孔微球复合系统
MX395029B (es) 2015-12-29 2025-03-24 Galderma Sa Metodo para desacetilacion de biopolimeros.
WO2019001784A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa Hyaluronic acid gel with a divalent cation
WO2019002370A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa GLYCOSAMINOGLYCANES RETICULATED AND FUNCTIONALIZED
WO2019002368A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa GLYCOSAMINOGLYCANES RETICULATED AND FUNCTIONALIZED
US10889894B2 (en) * 2018-08-06 2021-01-12 Applied Materials, Inc. Faceplate with embedded heater

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