RU2018126361A - Композиции, содержащие 15-hepe, и способы их применения - Google Patents
Композиции, содержащие 15-hepe, и способы их применения Download PDFInfo
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- RU2018126361A RU2018126361A RU2018126361A RU2018126361A RU2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A RU 2018126361 A RU2018126361 A RU 2018126361A
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Diabetes (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Claims (22)
1. Фармацевтическая композиция, содержащая 15-HEPE или ее фармацевтически приемлемое производное.
2. Композиция по п.1, отличающаяся тем, что указанная фармацевтическая композиция содержит от 100 мг до 1000 мг 15-HEPE или ее фармацевтически приемлемого производного.
3. Композиция по п.1, отличающаяся тем, что указанное фармацевтически приемлемое производное содержит сложный эфир, конъюгат, соль или их комбинацию.
4. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет форму свободной кислоты.
5. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет этерифицированную форму.
6. Композиция по п.5, отличающаяся тем, что указанная этерифицированная форма представляет собой форму сложного метилового эфира, сложного этилового эфира или их комбинацию.
7. Композиция по п.5, отличающаяся тем, что указанная этерифицированная форма представляет собой форму триглицерида.
8. Композиция по п.1, отличающаяся тем, что 15-HEPE имеет форму соли.
9. Композиция по п.1, отличающаяся тем, что 15-HEPE содержит 15(S)-HEPE и/или 15(R)-HEPE.
10. Композиция по п.1, отличающаяся тем, что 15-HEPE состоит из 15(S)-HEPE.
11. Композиция по п.1, отличающаяся тем, что 15-HEPE состоит из 15(R)-HEPE.
12. Способ лечения заболевания у субъекта, нуждающегося в этом, включающий введение указанному субъекту эффективного количества композиции, содержащей 15-HEPE или ее фармацевтически приемлемое производное.
13. Способ по п.12, отличающийся тем, что указанное заболевание выбрано из группы, состоящей из нарушения чувствительности к инсулину, псориаза, фиброза, ракового заболевания, нейродегенеративных нарушений, воспалительных заболеваний, дифференцировки адипоцитов, проблем с зачатием или репродуктивной способностью, боли и ожирения.
14. Способ по п.13, отличающийся тем, что указанное раковое заболевание представляет собой рак кожи.
15. Способ по п.14, отличающийся тем, что указанный рак кожи представляет собой меланому.
16. Способ по п.13, отличающийся тем, что указанное нейродегенеративное нарушение представляет собой болезнь Хантингтона.
17. Способ по п.13, отличающийся тем, что указанный фиброз представляет собой идиопатический фиброз легких.
18. Способ по п.12, отличающийся тем, что указанное фармацевтически приемлемое производное включает сложный эфир, конъюгат, соль или их комбинацию.
19. Способ по п.12, отличающийся тем, что указанное заболевание ослабляется по сравнению со вторым субъектом, которому не вводили композицию и необязательно вводили плацебо.
20. Способ по п.12, отличающийся тем, что указанное эффективное количество композиции, содержащей 15-HEPE или ее фармацевтически приемлемое производное, составляет от примерно 100 мг до примерно 2000 мг.
21. Способ увеличения всасывания 15-HEPE, включающий введение композиции, содержащей 15-HEPE или ее производное, субъекту, нуждающемуся в этом, после приема пищи.
22. Способ по п.21, отличающийся тем, что указанное фармацевтически приемлемое производное включает сложный эфир, конъюгат, соль или их комбинацию.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562269280P | 2015-12-18 | 2015-12-18 | |
| US62/269,280 | 2015-12-18 | ||
| PCT/IB2016/001878 WO2017103671A1 (en) | 2015-12-18 | 2016-12-19 | Compositions comprising 15-hepe and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020137883A Division RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018126361A true RU2018126361A (ru) | 2020-01-22 |
| RU2018126361A3 RU2018126361A3 (ru) | 2020-01-22 |
| RU2737089C2 RU2737089C2 (ru) | 2020-11-24 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018126361A RU2737089C2 (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
| RU2020137883A RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020137883A RU2020137883A (ru) | 2015-12-18 | 2016-12-19 | Композиции, содержащие 15-hepe, и способы их применения |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9855238B2 (ru) |
| EP (2) | EP4218736A3 (ru) |
| JP (4) | JP2018537513A (ru) |
| KR (6) | KR20220038818A (ru) |
| CN (2) | CN108697680A (ru) |
| AR (2) | AR107143A1 (ru) |
| AU (4) | AU2016370626B2 (ru) |
| BR (1) | BR122023026625A2 (ru) |
| CA (2) | CA3129008A1 (ru) |
| ES (1) | ES2948444T3 (ru) |
| IL (3) | IL318963A (ru) |
| MX (2) | MX379262B (ru) |
| NZ (1) | NZ744323A (ru) |
| PH (1) | PH12018501279A1 (ru) |
| RU (2) | RU2737089C2 (ru) |
| SG (1) | SG11201805149XA (ru) |
| WO (1) | WO2017103671A1 (ru) |
| ZA (2) | ZA201804779B (ru) |
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| EP3878835A1 (en) | 2013-11-15 | 2021-09-15 | DS Biopharma Limited | Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids |
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| EP3294282A1 (en) | 2015-05-13 | 2018-03-21 | DS Biopharma Limited | Compositions comprising 15-oxo-epa or 15-oxo-dgla and methods of making and using same |
| CN108025181A (zh) | 2015-07-21 | 2018-05-11 | 艾菲穆恩有限公司 | 用于治疗或预防癌症和神经疾病的包括15-hepe的组合物 |
| IL318963A (en) | 2015-12-18 | 2025-04-01 | Afimmune Ltd | Compositions comprising 15-hydroxy-eicosapentaenoic acid and methods of using them |
| CN113116878A (zh) * | 2020-01-10 | 2021-07-16 | 南京大学 | 15s-hepe用于增强t细胞介导的肿瘤免疫治疗的新用途 |
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| KR20160132372A (ko) * | 2014-01-10 | 2016-11-18 | 디그너티 사이언스 리미티드 | 15-hepe를 포함하는 약제학적 조성물 및 이를 이용하는 천식 및 폐 장애의 치료 방법 |
| MA41120A (fr) * | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| CN113893240A (zh) * | 2015-01-16 | 2022-01-07 | 艾菲穆恩有限公司 | 包含15-hepe的组合物和其使用方法 |
| EP3294282A1 (en) * | 2015-05-13 | 2018-03-21 | DS Biopharma Limited | Compositions comprising 15-oxo-epa or 15-oxo-dgla and methods of making and using same |
| CN108025181A (zh) * | 2015-07-21 | 2018-05-11 | 艾菲穆恩有限公司 | 用于治疗或预防癌症和神经疾病的包括15-hepe的组合物 |
| IL318963A (en) | 2015-12-18 | 2025-04-01 | Afimmune Ltd | Compositions comprising 15-hydroxy-eicosapentaenoic acid and methods of using them |
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