RU2018108589A - Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr - Google Patents
Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr Download PDFInfo
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- RU2018108589A RU2018108589A RU2018108589A RU2018108589A RU2018108589A RU 2018108589 A RU2018108589 A RU 2018108589A RU 2018108589 A RU2018108589 A RU 2018108589A RU 2018108589 A RU2018108589 A RU 2018108589A RU 2018108589 A RU2018108589 A RU 2018108589A
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- Prior art keywords
- antitumor therapy
- carboplatin
- etoposide
- cisplatin
- ionizing radiation
- Prior art date
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- 208000002154 non-small cell lung carcinoma Diseases 0.000 title claims 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title claims 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title 1
- 201000002528 pancreatic cancer Diseases 0.000 title 1
- 208000008443 pancreatic carcinoma Diseases 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 claims 34
- 238000002560 therapeutic procedure Methods 0.000 claims 34
- 229960004562 carboplatin Drugs 0.000 claims 20
- 190000008236 carboplatin Chemical compound 0.000 claims 20
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 20
- 229960004316 cisplatin Drugs 0.000 claims 20
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 20
- 229960005420 etoposide Drugs 0.000 claims 20
- 230000005865 ionizing radiation Effects 0.000 claims 20
- 238000000034 method Methods 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Radiation-Therapy Devices (AREA)
Claims (45)
1. Способ лечения немелкоклеточного рака легкого у пациента, содержащий введение пациенту соединения с формулой:
в сочетании с противоопухолевой терапией, выбранной из цисплатина или карбоплатина, этопозида и ионизирующего излучения.
2. Способ по п.1, где противоопухолевая терапия представляет собой цисплатин или карбоплатин.
3. Способ по п.1, где противоопухолевая терапия представляет собой этопозид.
4. Способ по п.1, где противоопухолевая терапия представляет собой ионизирующее излучение.
5. Способ по п.1, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид.
6. Способ по п.1, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и ионизирующее излучение.
7. Способ по п.1, где противоопухолевая терапия представляет собой этопозид и ионизирующее излучение.
8. Способ по п.1, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид, и ионизирующее излучение.
9. Способ повышения чувствительности клеток рака немелкоклеточного рака легкого у пациента к противоопухолевой терапии, включающий введение пациенту соединения с формулой
VE-822
в сочетании с одной или более противоопухолевой терапией, выбранной из цисплатина или карбоплатина, этопозида и ионизирующего излучения.
10. Способ по п.9, где противоопухолевая терапия представляет собой цисплатин или карбоплатин.
11. Способ по п.9, где противоопухолевая терапия представляет собой этопозид.
12. Способ по п.9, где противоопухолевая терапия представляет собой ионизирующее излучение.
13. Способ по п.9, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид.
14. Способ по п.9, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и ионизирующее излучение.
15. Способ по п.9, где противоопухолевая терапия представляет собой этопозид и ионизирующее излучение.
16. Способ по п.9, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид, и ионизирующее излучение.
17. Применение соединения формулы
VE-822
в производстве лекарственного средства для лечения немелкоклеточного рака легкого, где
лекарственное средство вводится в сочетании с противоопухолевой терапией, выбранной из цисплатина или карбоплатина, этопозида и ионизирующего излучения.
18. Применение по п.17, где противоопухолевая терапия представляет собой цисплатин или карбоплатин.
19. Применение по п.17, где противоопухолевая терапия представляет собой этопозид.
20. Применение по п.17, где противоопухолевая терапия представляет собой ионизирующее излучение.
21. Применение по п.17, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид.
22. Применение по п.17, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и ионизирующее излучение.
23. Применение по п.17, где противоопухолевая терапия представляет собой этопозид и ионизирующее излучение.
24. Применение по п.17, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид, и ионизирующее излучение.
25. Применение соединения формулы
VE-822
в производстве лекарственного средства для повышения чувствительности клеток рака немелкоклеточного рака легкого у пациента к противоопухолевой терапии, где
лекарственное средство вводится в сочетании с противоопухолевой терапией, выбранной из цисплатина или карбоплатина, этопозида и ионизирующего излучения.
26. Применение по п.25, где противоопухолевая терапия представляет собой цисплатин или карбоплатин.
27. Применение по п.25, где противоопухолевая терапия представляет собой этопозид.
28. Применение по п.25, где противоопухолевая терапия представляет собой ионизирующее излучение.
29. Применение по п.25, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид.
30. Применение по п.25, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и ионизирующее излучение.
31. Применение по п.25, где противоопухолевая терапия представляет собой этопозид и ионизирующее излучение.
32. Применение по п.25, где противоопухолевая терапия представляет собой цисплатин или карбоплатин, и этопозид, и ионизирующее излучение.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542084P | 2011-09-30 | 2011-09-30 | |
| US61/542,084 | 2011-09-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117666A Division RU2648507C2 (ru) | 2011-09-30 | 2012-10-01 | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018108589A true RU2018108589A (ru) | 2019-02-25 |
| RU2018108589A3 RU2018108589A3 (ru) | 2021-12-03 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117666A RU2648507C2 (ru) | 2011-09-30 | 2012-10-01 | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
| RU2018108589A RU2018108589A (ru) | 2011-09-30 | 2012-10-01 | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014117666A RU2648507C2 (ru) | 2011-09-30 | 2012-10-01 | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20130089626A1 (ru) |
| EP (2) | EP3733185B1 (ru) |
| JP (4) | JP6162126B2 (ru) |
| KR (1) | KR102056586B1 (ru) |
| CN (3) | CN108685922A (ru) |
| AU (3) | AU2012315384B2 (ru) |
| BR (1) | BR112014007690B1 (ru) |
| CA (2) | CA3089792C (ru) |
| ES (2) | ES2940121T3 (ru) |
| IL (1) | IL231813B (ru) |
| IN (1) | IN2014CN02501A (ru) |
| MX (2) | MX373340B (ru) |
| RU (2) | RU2648507C2 (ru) |
| SG (2) | SG11201401095YA (ru) |
| WO (1) | WO2013049859A1 (ru) |
| ZA (1) | ZA201402627B (ru) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106518856B (zh) | 2008-12-19 | 2020-04-28 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的化合物 |
| SG185524A1 (en) | 2010-05-12 | 2012-12-28 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
| US9062008B2 (en) | 2010-05-12 | 2015-06-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| MX2012013082A (es) | 2010-05-12 | 2013-05-09 | Vertex Pharma | Derivados de 2-aminopiridina utiles como iinhibidores de cinasa atr. |
| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| JP2013526540A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| US8969356B2 (en) | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8623869B2 (en) | 2010-06-23 | 2014-01-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| CA2832100A1 (en) | 2011-04-05 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of tra kinase |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| US9096602B2 (en) | 2011-06-22 | 2015-08-04 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors |
| JP2014520161A (ja) | 2011-06-22 | 2014-08-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN103958507A (zh) | 2011-09-30 | 2014-07-30 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物 |
| EP3733185B1 (en) | 2011-09-30 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Treating non-small cell lung cancer with atr inhibitors |
| WO2013049719A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CA2850566C (en) | 2011-09-30 | 2022-05-03 | Vertex Pharmaceuticals Incorporated | Process for making 4-[chloro-n-hydroxycarbonimidoyl]phenyl derivative |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013071093A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| US8846918B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013071088A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2833973B1 (en) * | 2012-04-05 | 2017-09-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| US8999632B2 (en) | 2012-10-04 | 2015-04-07 | Vertex Pharmaceuticals Incorporated | Method for measuring ATR inhibition mediated increases in DNA damage |
| US8912198B2 (en) | 2012-10-16 | 2014-12-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| DK3418281T3 (da) | 2012-12-07 | 2020-12-07 | Vertex Pharma | Pyrazolo[1,5-a]pyrimidiner, der er anvendelige som inhibitorer af atr-kinase til behandling af cancersygdomme |
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