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RU2016134390A - The method of obtaining nanocapsules AEKol - Google Patents

The method of obtaining nanocapsules AEKol Download PDF

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Publication number
RU2016134390A
RU2016134390A RU2016134390A RU2016134390A RU2016134390A RU 2016134390 A RU2016134390 A RU 2016134390A RU 2016134390 A RU2016134390 A RU 2016134390A RU 2016134390 A RU2016134390 A RU 2016134390A RU 2016134390 A RU2016134390 A RU 2016134390A
Authority
RU
Russia
Prior art keywords
aekol
nanocapsules
obtaining nanocapsules
konjac gum
shell
Prior art date
Application number
RU2016134390A
Other languages
Russian (ru)
Other versions
RU2016134390A3 (en
RU2648747C2 (en
Inventor
Александр Александрович Кролевец
Original Assignee
Александр Александрович Кролевец
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Александр Александрович Кролевец filed Critical Александр Александрович Кролевец
Priority to RU2016134390A priority Critical patent/RU2648747C2/en
Publication of RU2016134390A3 publication Critical patent/RU2016134390A3/ru
Publication of RU2016134390A publication Critical patent/RU2016134390A/en
Application granted granted Critical
Publication of RU2648747C2 publication Critical patent/RU2648747C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Claims (1)

Способ получения нанокапсул АЕКола, характеризующийся тем, что в качестве оболочки нанокапсул используется конжаковая камедь, при этом АЕКол прибавляют в суспензию конжаковой камеди в гексане в присутствии 0,01 г Е472с в качестве поверхностно-активного вещества, затем перемешивают при 1300 об/мин, после приливают 10 мл 1,2-дихлорэтана, после чего полученную суспензию отфильтровывают и сушат при комнатной температуре, при этом соотношение ядро/оболочка составляет 1:1 или 1:3 или 3:1 или 1:5.A method for producing AEKol nanocapsules, characterized in that konjac gum is used as a shell of nanocapsules, while AEKol is added to a suspension of konjac gum in hexane in the presence of 0.01 g E472c as a surfactant, then stirred at 1300 rpm, after 10 ml of 1,2-dichloroethane are poured, after which the suspension obtained is filtered off and dried at room temperature, with a core / shell ratio of 1: 1 or 1: 3 or 3: 1 or 1: 5.
RU2016134390A 2016-08-22 2016-08-22 Method of producing aecol nanocapsules RU2648747C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016134390A RU2648747C2 (en) 2016-08-22 2016-08-22 Method of producing aecol nanocapsules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016134390A RU2648747C2 (en) 2016-08-22 2016-08-22 Method of producing aecol nanocapsules

Publications (3)

Publication Number Publication Date
RU2016134390A3 RU2016134390A3 (en) 2018-03-05
RU2016134390A true RU2016134390A (en) 2018-03-05
RU2648747C2 RU2648747C2 (en) 2018-03-28

Family

ID=61597147

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016134390A RU2648747C2 (en) 2016-08-22 2016-08-22 Method of producing aecol nanocapsules

Country Status (1)

Country Link
RU (1) RU2648747C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA10198A (en) * 1994-01-05 1996-12-25 Науково-Виробнича Фірма "Флорі" Gastroenterological drug
WO2004064544A1 (en) * 2003-01-22 2004-08-05 Durafizz, Llc Microencapsulation for sustained delivery of carbon dioxide

Also Published As

Publication number Publication date
RU2016134390A3 (en) 2018-03-05
RU2648747C2 (en) 2018-03-28

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