RU2015119280A - The method of producing nanocapsules of rosuvastatin in carrageenan - Google Patents
The method of producing nanocapsules of rosuvastatin in carrageenan Download PDFInfo
- Publication number
- RU2015119280A RU2015119280A RU2015119280A RU2015119280A RU2015119280A RU 2015119280 A RU2015119280 A RU 2015119280A RU 2015119280 A RU2015119280 A RU 2015119280A RU 2015119280 A RU2015119280 A RU 2015119280A RU 2015119280 A RU2015119280 A RU 2015119280A
- Authority
- RU
- Russia
- Prior art keywords
- rosuvastatin
- carrageenan
- nanocapsules
- suspension
- producing
- Prior art date
Links
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title claims abstract 5
- 229960000672 rosuvastatin Drugs 0.000 title claims abstract 5
- 235000010418 carrageenan Nutrition 0.000 title claims abstract 3
- 239000000679 carrageenan Substances 0.000 title claims abstract 3
- 229940113118 carrageenan Drugs 0.000 title claims abstract 3
- 229920001525 carrageenan Polymers 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims abstract 3
- 239000002088 nanocapsule Substances 0.000 title claims abstract 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 title claims abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000000725 suspension Substances 0.000 claims abstract 4
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000001793 Citric acid esters of mono and diglycerides of fatty acids Substances 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract 2
- 238000003756 stirring Methods 0.000 claims abstract 2
Landscapes
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
Abstract
Способ получения нанокапсул розувастатина, характеризующийся тем, что розувастатин медленно добавляют в суспензию каррагинана в гексане, в присутствии 0,005 г препарата Е472с при перемешивании 1000 об/мин, при массовом соотношении оболочка:ядро 3:1 или 1:5, затем приливают 5 мл 1,2-дихлорэтана, полученную суспензию отфильтровывают и сушат при комнатной температуре.A method of producing rosuvastatin nanocapsules, characterized in that rosuvastatin is slowly added to a suspension of carrageenan in hexane, in the presence of 0.005 g of the preparation E472c with stirring at 1000 rpm, with a shell: core mass ratio of 3: 1 or 1: 5, then 5 ml of 1 , 2-dichloroethane, the resulting suspension is filtered off and dried at room temperature.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015119280A RU2614734C2 (en) | 2015-05-21 | 2015-05-21 | Method of producing nanocapsules of rosuvastatin in carrageenan |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015119280A RU2614734C2 (en) | 2015-05-21 | 2015-05-21 | Method of producing nanocapsules of rosuvastatin in carrageenan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015119280A true RU2015119280A (en) | 2016-12-10 |
| RU2614734C2 RU2614734C2 (en) | 2017-03-28 |
Family
ID=57759693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015119280A RU2614734C2 (en) | 2015-05-21 | 2015-05-21 | Method of producing nanocapsules of rosuvastatin in carrageenan |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2614734C2 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2134967C1 (en) * | 1997-05-30 | 1999-08-27 | Шестаков Константин Алексеевич | Method of preparing microcapsulated preparations containing pyrethroid insecticides |
| ES2255426B1 (en) * | 2004-10-19 | 2007-08-16 | Gp Pharm, S.A. | PHARMACEUTICAL FORMULATION THAT INCLUDES MICROCAPSULES OF STATINS SUSPENDED IN ESTER ALKYLS OF POLYINSATURATED FATTY ACIDS (PUFA). |
-
2015
- 2015-05-21 RU RU2015119280A patent/RU2614734C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2614734C2 (en) | 2017-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20180522 |