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RU2016118861A - The method of obtaining nanocapsules of L-arginine - Google Patents

The method of obtaining nanocapsules of L-arginine Download PDF

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Publication number
RU2016118861A
RU2016118861A RU2016118861A RU2016118861A RU2016118861A RU 2016118861 A RU2016118861 A RU 2016118861A RU 2016118861 A RU2016118861 A RU 2016118861A RU 2016118861 A RU2016118861 A RU 2016118861A RU 2016118861 A RU2016118861 A RU 2016118861A
Authority
RU
Russia
Prior art keywords
arginine
obtaining nanocapsules
nanocapsules
carboxymethyl cellulose
sodium carboxymethyl
Prior art date
Application number
RU2016118861A
Other languages
Russian (ru)
Other versions
RU2642233C2 (en
Inventor
Александр Александрович Кролевец
Original Assignee
Александр Александрович Кролевец
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Александр Александрович Кролевец filed Critical Александр Александрович Кролевец
Priority to RU2016118861A priority Critical patent/RU2642233C2/en
Publication of RU2016118861A publication Critical patent/RU2016118861A/en
Application granted granted Critical
Publication of RU2642233C2 publication Critical patent/RU2642233C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Landscapes

  • Manufacturing Of Micro-Capsules (AREA)

Claims (1)

Способ получения нанокапсул L-аргинина в натрий карбоксиметилцеллюлозе, характеризующийся тем, что L-аргинин медленно добавляют в суспензию натрий карбоксиметилцеллюлозы в метаноле в присутствии 0,01 препарата Е472с в качестве поверхностно-активного вещества при перемешивании 1000 об/мин, затем приливают 10 мл петролейного эфира, полученную суспензию отфильтровывают и сушат при комнатной температуре, при этом соотношение ядро:оболочка составляет 1:1, или 1:3, или 5:1.A method of producing L-arginine nanocapsules in sodium carboxymethyl cellulose, characterized in that L-arginine is slowly added to a suspension of sodium carboxymethyl cellulose in methanol in the presence of 0.01 of the preparation E472c as a surfactant with stirring at 1000 rpm, then 10 ml of petroleum is added ether, the resulting suspension is filtered off and dried at room temperature, with a core: shell ratio of 1: 1, or 1: 3, or 5: 1.
RU2016118861A 2016-05-16 2016-05-16 Method of producing l-arginine nanocapsules RU2642233C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016118861A RU2642233C2 (en) 2016-05-16 2016-05-16 Method of producing l-arginine nanocapsules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016118861A RU2642233C2 (en) 2016-05-16 2016-05-16 Method of producing l-arginine nanocapsules

Publications (2)

Publication Number Publication Date
RU2016118861A true RU2016118861A (en) 2017-11-21
RU2642233C2 RU2642233C2 (en) 2018-01-24

Family

ID=60413477

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016118861A RU2642233C2 (en) 2016-05-16 2016-05-16 Method of producing l-arginine nanocapsules

Country Status (1)

Country Link
RU (1) RU2642233C2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2556202C1 (en) * 2014-03-18 2015-07-10 Александр Александрович Кролевец Method of obtaining l-arginine nanocapsules in sodium alginate
RU2557903C1 (en) * 2014-03-26 2015-07-27 Александр Александрович Кролевец Method of production of nanocapsules of l-arginine in pectin

Also Published As

Publication number Publication date
RU2642233C2 (en) 2018-01-24

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