RU2015119517A - Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 - Google Patents
Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 Download PDFInfo
- Publication number
- RU2015119517A RU2015119517A RU2015119517A RU2015119517A RU2015119517A RU 2015119517 A RU2015119517 A RU 2015119517A RU 2015119517 A RU2015119517 A RU 2015119517A RU 2015119517 A RU2015119517 A RU 2015119517A RU 2015119517 A RU2015119517 A RU 2015119517A
- Authority
- RU
- Russia
- Prior art keywords
- myocardial infarction
- hmgb1
- new method
- pharmaceutical composition
- treating myocardial
- Prior art date
Links
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 title claims abstract 6
- 102000055207 HMGB1 Human genes 0.000 title claims abstract 6
- 108700010013 HMGB1 Proteins 0.000 title claims abstract 6
- 101150021904 HMGB1 gene Proteins 0.000 title claims abstract 6
- 208000010125 myocardial infarction Diseases 0.000 title claims abstract 3
- 239000012634 fragment Substances 0.000 title 1
- 108010033276 Peptide Fragments Proteins 0.000 claims abstract 6
- 102000007079 Peptide Fragments Human genes 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1. Фармацевтическая композиция для применения в лечении инфаркта миокарда, содержащая пептидный фрагмент HMGB1.2. Фармацевтическая композиция по п. 1, где пептидный фрагмент HMGB1 представляет собой пептид, содержащий аминокислотную последовательность SEQ ID NO: 3.3. Фармацевтическая композиция по п. 1, где пептидный фрагмент HMGB1 представляет собой пептид, состоящий из аминокислотной последовательности SEQ ID NO: 3.
Claims (3)
1. Фармацевтическая композиция для применения в лечении инфаркта миокарда, содержащая пептидный фрагмент HMGB1.
2. Фармацевтическая композиция по п. 1, где пептидный фрагмент HMGB1 представляет собой пептид, содержащий аминокислотную последовательность SEQ ID NO: 3.
3. Фармацевтическая композиция по п. 1, где пептидный фрагмент HMGB1 представляет собой пептид, состоящий из аминокислотной последовательности SEQ ID NO: 3.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-235785 | 2012-10-25 | ||
| JP2012235785 | 2012-10-25 | ||
| PCT/JP2013/078758 WO2014065347A1 (ja) | 2012-10-25 | 2013-10-24 | Hmgb1断片を利用した新規心筋梗塞の治療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015119517A true RU2015119517A (ru) | 2016-12-20 |
| RU2647467C2 RU2647467C2 (ru) | 2018-03-15 |
Family
ID=50544720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015119517A RU2647467C2 (ru) | 2012-10-25 | 2013-10-24 | Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9623078B2 (ru) |
| EP (1) | EP2913058B1 (ru) |
| JP (1) | JP6253589B2 (ru) |
| KR (1) | KR102146815B1 (ru) |
| CN (1) | CN104884076B (ru) |
| AU (1) | AU2013335684B2 (ru) |
| BR (1) | BR112015009037A2 (ru) |
| CA (1) | CA2889275C (ru) |
| DK (1) | DK2913058T3 (ru) |
| ES (1) | ES2660420T3 (ru) |
| MX (1) | MX361259B (ru) |
| PL (1) | PL2913058T3 (ru) |
| RU (1) | RU2647467C2 (ru) |
| SG (1) | SG11201503236RA (ru) |
| TR (1) | TR201802122T4 (ru) |
| WO (1) | WO2014065347A1 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160070169A (ko) | 2008-04-30 | 2016-06-17 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
| EP2494977B1 (en) | 2009-10-28 | 2018-06-13 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
| WO2012147470A1 (ja) | 2011-04-26 | 2012-11-01 | 株式会社ジェノミックス | 組織再生を誘導するためのペプチドとその利用 |
| AU2013335685B2 (en) | 2012-10-25 | 2017-10-12 | Osaka University | Novel method for treating spinal cord injury using HMGB1 fragment |
| JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Ｈｍｇｂ１断片を利用した新規心筋梗塞の治療法 |
| EP3556378B1 (en) * | 2017-01-27 | 2025-03-12 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| CN110621331A (zh) | 2017-04-07 | 2019-12-27 | 斯特姆里姆有限公司 | 纤维化疾病的治疗药物 |
| KR102681936B1 (ko) * | 2017-04-25 | 2024-07-04 | 시오노기세이야쿠가부시키가이샤 | 조직 재생을 유도하기 위한 펩티드와 그 이용 |
| AU2018376452A1 (en) | 2017-12-01 | 2020-06-25 | Osaka University | Ectodermal mesenchymal stem cells and method for producing same |
| EP3718561A4 (en) * | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapy for inflammatory bowel disease |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| US20220009976A1 (en) * | 2018-10-05 | 2022-01-13 | StemRIM Inc. | Peptide Possessing Mesenchymal-Stem-Cell Mobilizing Activity |
| AU2019367943A1 (en) | 2018-10-25 | 2021-05-27 | Osaka University | Therapeutic medication for cartilage disorder |
| AU2020385059A1 (en) | 2019-11-12 | 2022-06-02 | Oxford University Innovation Limited | Polypeptides related to HMGB1 useful for promoting tissue regeneration, compositions comprising same, and uses thereof |
| RU2718912C1 (ru) * | 2019-12-24 | 2020-04-15 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт общей патологии и физиологии" (ФГБНУ "НИИОПП") | Способ лечения и профилактики инфаркта миокарда с патологией легких |
| US20230173027A1 (en) * | 2020-04-20 | 2023-06-08 | Shionogi & Co., Ltd. | Formulation containing hmgb1 partial peptide |
| EP4341280A1 (en) | 2021-05-19 | 2024-03-27 | Oxford University Innovation Limited | Polypeptides related to hmgb1 useful for promoting tissue regeneration, compositions comprising same, and uses thereof |
| JP2025135028A (ja) * | 2022-06-30 | 2025-09-18 | 国立大学法人大阪大学 | 半月板の治療薬 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5238680B2 (ru) | 1972-12-27 | 1977-09-30 | ||
| US5658894A (en) | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
| US5661127A (en) * | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
| JP3018313B2 (ja) | 1996-02-23 | 2000-03-13 | 雪印乳業株式会社 | 骨形成促進及び骨吸収防止剤 |
| US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| AU778386B2 (en) | 1999-07-28 | 2004-12-02 | Board Of Trustees Of The Leland Stanford Junior University | Nicotine receptor agonists in stem cell and progenitor cell recruitment |
| EP1114862A3 (de) | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen |
| ES2302726T3 (es) | 2000-02-24 | 2008-08-01 | Invitrogen Corporation | Estimulacion y concentracion simultanea de celulas. |
| JP3421741B2 (ja) | 2000-05-18 | 2003-06-30 | 筑波大学長 | 人工骨髄、血球細胞の増殖方法 |
| US20040191246A1 (en) | 2003-02-26 | 2004-09-30 | Connelly Patrick R. | Process for in vivo treatment of specific biological targets in bodily fluid |
| US7754217B2 (en) | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| DE10121254A1 (de) | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | MRP8/MRP14 Heterodimers oder seiner Einzelkomponenten alleine oder in Kombination zur Behandlung und/oder Prävention von Hauterkrankungen, Wunden und/oder Wundheilungsstörungen, die durch eine verringerte Menge an MRP8/MRP14 Heterodimeren gekennzeichnet sind |
| EP1390058A2 (en) | 2001-04-30 | 2004-02-25 | Switch Biotech Aktiengesellschaft | Mrp8/mrp14 heterodimer, or its individual components in combination, for treating and/or preventing skin diseases, wounds and/or wound-healing disturbances |
| JP2005512507A (ja) | 2001-05-15 | 2005-05-12 | ノース・ショア−ロング・アイランド・ジューイッシュ・リサーチ・インスティテュート | 抗炎症剤としてのｈｍｇフラグメントの使用 |
| US7220723B2 (en) | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| ITMI20011986A1 (it) | 2001-09-25 | 2003-03-25 | San Raffaele Centro Fond | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
| KR100704158B1 (ko) | 2001-11-19 | 2007-04-05 | 교와 핫꼬 고교 가부시끼가이샤 | 다분화능 줄기세포를 조직으로부터 말초혈로 동원하는약제 |
| DK1921133T3 (en) | 2001-12-07 | 2015-08-24 | Cytori Therapeutics Inc | System for processing lipoaspiratceller |
| MXPA05000302A (es) * | 2002-07-03 | 2005-08-19 | San Raffaele Centro Fond | Uso de hmgb1 en el tratamiento de dano de tejido y/o para promover la reparacion de tejido. |
| CA2489860C (en) | 2002-07-05 | 2015-02-10 | Universite Laval | Use of an antibody against s100a8 or s100a9 as chemotactic factor inhibitor for modulating inflammatory reactions |
| GB0226251D0 (en) | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
| CA2506328A1 (en) | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
| CA2512512A1 (en) | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Uses of hmgb, hmgn, hmga proteins |
| WO2004084928A1 (en) | 2003-03-28 | 2004-10-07 | UNIVERSITé LAVAL | S100 protein as neutrophil activator for alleviating neutropenia in cancer treatment |
| US20050014255A1 (en) | 2003-05-29 | 2005-01-20 | Board Of Regents, The University Of Texas System | Stem cells for clinical and commercial uses |
| WO2005025604A2 (en) | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Use of hmgb and hmgb fragments to decrease specific immune response |
| ITRM20040058A1 (it) | 2004-02-03 | 2004-05-03 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di regolare la proliferazione delle cellule muscolari lisce ed endoteliali. |
| EP1768693A1 (en) | 2004-07-20 | 2007-04-04 | Provincia Italiana Della Congregazione Dei Figli Dell'Immacolata Concezione - Istituto Dermopatico Dell'Immacolata | Use of hmgb1 for wound healing |
| MX2007001155A (es) | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| BRPI0514835A (pt) | 2004-09-03 | 2008-06-24 | Creabilis Therapeutics Spa | variante de polipetìdeo de box de domìnio de ligação por alta afinidade de hmbg1 humano e/ou não humano ou de fragmento biologicamente ativo de box-a de hmgb1, molécula de ácido nucléico, uso, composição farmacêutica e dispositivo médico |
| KR100593397B1 (ko) | 2004-10-27 | 2006-06-28 | 한국원자력연구소 | 중배엽 줄기세포 및/또는 ｐ 물질을 함유하는 상처 치유또는 상처 치유 촉진제, 또는 세포 치료제 |
| WO2006047820A1 (en) | 2004-11-01 | 2006-05-11 | Newsouth Innovations Pty Limited | Use of calgranulin a and b in the promotion and inhibition of mineralized tissue formation |
| ITRM20050032A1 (it) | 2005-01-21 | 2006-07-22 | Marco E Bianchi | Inibitori ed antagonisti di hmgb1 in grado di inibire la patogenesi e la progressione della malattia aterosclerotica. |
| WO2006080434A1 (ja) | 2005-01-27 | 2006-08-03 | Japan Health Sciences Foundation | 間葉系幹細胞を含む細胞シート |
| MX2007011218A (es) | 2005-03-23 | 2007-10-17 | Biosafe Sa | Sistema integrado para colectar, procesar y transplantar subconjuntos de celulas, incluyendo celulas madre adultas para medicina regenerativa. |
| WO2006114805A2 (en) | 2005-04-28 | 2006-11-02 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb2 and hmgb3 proteins for medical applications |
| WO2007015546A1 (ja) | 2005-08-04 | 2007-02-08 | Genomix Co., Ltd | 間葉系幹細胞誘導剤及び組織再生促進剤並びに間葉系幹細胞の調製方法 |
| WO2007031100A1 (en) | 2005-09-14 | 2007-03-22 | Ostini, Marco | Active immunotherapy of life-threatening systemic inflammation |
| US7829097B2 (en) * | 2006-02-06 | 2010-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of HMGB1 for protection against ischemia reperfusion injury |
| JP4982739B2 (ja) | 2006-06-01 | 2012-07-25 | 国立大学法人 東京医科歯科大学 | ポリグルタミン病の予防・治療剤 |
| EP2046834B9 (en) | 2006-08-11 | 2013-04-10 | Ono Pharmaceutical Co., Ltd. | Monoclonal antibodies against stromal derived factor-1 (sdf-1) |
| WO2008053892A1 (en) | 2006-10-30 | 2008-05-08 | Genomix Co., Ltd. | Pharmaceutical for promoting functional regeneration of damaged tissue |
| KR20160070169A (ko) | 2008-04-30 | 2016-06-17 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
| JP5660889B2 (ja) | 2008-04-30 | 2015-01-28 | 株式会社ジェノミックス | 末梢循環への骨髄由来多能性幹細胞動員薬 |
| WO2009133940A1 (ja) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | 損傷組織の機能的再生促進医薬 |
| EP2488209B1 (en) | 2009-10-16 | 2016-09-28 | Rutgers, the State University of New Jersey | Method for treating chronic nerve tissue injury using a cell therapy strategy |
| EP2494977B1 (en) | 2009-10-28 | 2018-06-13 | Genomix Co., Ltd. | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
| WO2012147470A1 (ja) * | 2011-04-26 | 2012-11-01 | 株式会社ジェノミックス | 組織再生を誘導するためのペプチドとその利用 |
| CN102443064A (zh) | 2011-11-03 | 2012-05-09 | 刘誉 | 一种基于凝血酶活性的双靶向作用的嵌合多肽及其应用 |
| JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Ｈｍｇｂ１断片を利用した新規心筋梗塞の治療法 |
| AU2013335685B2 (en) | 2012-10-25 | 2017-10-12 | Osaka University | Novel method for treating spinal cord injury using HMGB1 fragment |
-
2013
- 2013-10-24 JP JP2014543334A patent/JP6253589B2/ja active Active
- 2013-10-24 US US14/436,906 patent/US9623078B2/en active Active
- 2013-10-24 BR BR112015009037A patent/BR112015009037A2/pt not_active Application Discontinuation
- 2013-10-24 MX MX2015005252A patent/MX361259B/es active IP Right Grant
- 2013-10-24 CN CN201380067948.2A patent/CN104884076B/zh active Active
- 2013-10-24 AU AU2013335684A patent/AU2013335684B2/en active Active
- 2013-10-24 DK DK13849289.7T patent/DK2913058T3/en active
- 2013-10-24 SG SG11201503236RA patent/SG11201503236RA/en unknown
- 2013-10-24 ES ES13849289.7T patent/ES2660420T3/es active Active
- 2013-10-24 RU RU2015119517A patent/RU2647467C2/ru active
- 2013-10-24 EP EP13849289.7A patent/EP2913058B1/en active Active
- 2013-10-24 WO PCT/JP2013/078758 patent/WO2014065347A1/ja not_active Ceased
- 2013-10-24 KR KR1020157013590A patent/KR102146815B1/ko active Active
- 2013-10-24 TR TR2018/02122T patent/TR201802122T4/tr unknown
- 2013-10-24 PL PL13849289T patent/PL2913058T3/pl unknown
- 2013-10-24 CA CA2889275A patent/CA2889275C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1211488A1 (en) | 2016-05-27 |
| CN104884076B (zh) | 2017-10-03 |
| AU2013335684A1 (en) | 2015-05-14 |
| HK1212887A1 (en) | 2016-06-24 |
| US20150273017A1 (en) | 2015-10-01 |
| ES2660420T3 (es) | 2018-03-22 |
| KR102146815B1 (ko) | 2020-08-21 |
| US9623078B2 (en) | 2017-04-18 |
| EP2913058A4 (en) | 2016-04-13 |
| JP6253589B2 (ja) | 2017-12-27 |
| AU2013335684B2 (en) | 2017-06-29 |
| TR201802122T4 (tr) | 2018-03-21 |
| KR20150103660A (ko) | 2015-09-11 |
| JPWO2014065347A1 (ja) | 2016-09-08 |
| SG11201503236RA (en) | 2015-06-29 |
| DK2913058T3 (en) | 2018-02-19 |
| CA2889275A1 (en) | 2014-05-01 |
| CN104884076A (zh) | 2015-09-02 |
| MX2015005252A (es) | 2015-10-29 |
| WO2014065347A1 (ja) | 2014-05-01 |
| PL2913058T3 (pl) | 2018-04-30 |
| EP2913058A1 (en) | 2015-09-02 |
| RU2647467C2 (ru) | 2018-03-15 |
| MX361259B (es) | 2018-11-30 |
| CA2889275C (en) | 2021-06-15 |
| BR112015009037A2 (pt) | 2017-11-14 |
| EP2913058B1 (en) | 2017-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015119517A (ru) | Новый способ лечения инфаркта миокарда с применением фрагмента hmgb1 | |
| RU2015119523A (ru) | Новый способ лечения повреждения спинного мозга с применением фрагмента hmgb1 | |
| MY195318A (en) | Multispecific Antibody Constructs | |
| NZ704662A (en) | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid | |
| IN2014KN01713A (ru) | ||
| IN2014KN01714A (ru) | ||
| MX360211B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| RU2014143639A (ru) | Регулируемые протеазой антитела | |
| MY166282A (en) | Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses | |
| MX2012008999A (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX2012008998A (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX342291B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| MX340016B (es) | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. | |
| NZ628446A (en) | Fibronectin based scaffold domain proteins that bind to myostatin | |
| MX2012007850A (es) | Composiciones y metodo para tratar gliobastoma (gbm). | |
| EA201270225A1 (ru) | СОЕДИНЕНИЯ ДЛЯ УМЕНЬШЕНИЯ ПРОДУКЦИИ β-АМИЛОИДА | |
| MX391136B (es) | FRAGMENTOS DE OspA ESTABILIZADOS CON CISTEÍNA Y MÉTODO DE USO | |
| RU2015112625A (ru) | Пептид, применение пептида для лечения сердечно-сосудистых заболеваний, нуклеотидная последовательность, вектор экспрессии, хозяйская клетка, фармацевтическая композиция | |
| JP2012529293A5 (ru) | ||
| EA201590845A1 (ru) | Варианты fc-гамма-рецептора iib | |
| EA201492068A1 (ru) | Гидрохлоридная соль пептида и ее применение в комбинации с другими пептидами в иммунотерапии | |
| EA201590601A1 (ru) | Применение pedf-производных полипептидов для лечения остеоартрита | |
| RU2013111675A (ru) | Рекомбинантный fc-гибридный белок пятого домена фибронектина типа iii dcc | |
| SG195302A1 (en) | Shk-based pharmaceutical compositions and methods of manufacturing and using the same | |
| TR201907379T4 (tr) | Yeni anti-insan PAI-1 antikoru. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Correction of name of patent owner |