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RU2013119705A - Применение производного рапамицина - Google Patents

Применение производного рапамицина Download PDF

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Publication number
RU2013119705A
RU2013119705A RU2013119705/15A RU2013119705A RU2013119705A RU 2013119705 A RU2013119705 A RU 2013119705A RU 2013119705/15 A RU2013119705/15 A RU 2013119705/15A RU 2013119705 A RU2013119705 A RU 2013119705A RU 2013119705 A RU2013119705 A RU 2013119705A
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RU
Russia
Prior art keywords
hydroxyethyl
rapamycin
pharmaceutical composition
solid
administered
Prior art date
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RU2013119705/15A
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English (en)
Other versions
RU2665138C2 (ru
Inventor
ЛАНЕ Хейди
О'РЕЙЛЛИ Теренс
Марджори ВУД Джинетта
Original Assignee
Новартис Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26245731&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2013119705(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0104072A external-priority patent/GB0104072D0/en
Priority claimed from GB0124957A external-priority patent/GB0124957D0/en
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2013119705A publication Critical patent/RU2013119705A/ru
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Publication of RU2665138C2 publication Critical patent/RU2665138C2/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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Abstract

1. Применение 40-O-(2-гидроксиэтил)-рапамицина для получения фармацевтической композиции для лечения солидных опухолей экскреторной системы.2. Применение 40-O-(2-гидроксиэтил)-рапамицина по п.1, в котором солидной опухолью экскреторной системы является карцинома экскреторной системы.3. Применение 40-O-(2-гидроксиэтил)-рапамицина по любому из пп.1 или 2, где единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.4. Применение фармацевтической композиции, содержащей 40-O-(2-гидроксиэтил) рапамицин и по меньшей мере один фармацевтически приемлемый наполнитель или носитель для лечения солидных опухолей экскреторной системы.5. Применение фармацевтической композиции по п.4, в котором солидной опухолью экскреторной системы является карцинома экскреторной системы.6. Применение фармацевтической композиции по п.4 или 5, где единичной дозой 40-O-(2-гидроксиэтил)-рапамицина вводимого составляет от 0,1 мг до 15 мг.7. Применение 40-O-(2-гидроксиэтил)-рапамицина для приготовления фармацевтической композиции для лечения солидных опухолей поджелудочной железы.8. Применение 40-O-(2-гидроксиэтил)-рапамицина по п.7, в котором единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.9. Применение фармацевтической композиции, содержащей 40-O-(2-гидроксиэтил) рапамицин и по меньшей мере один фармацевтически приемлемый наполнитель или носитель для лечения солидных опухолей поджелудочной железы.10. Применение фармацевтической композиции по п.9, где единичной доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.11. Применение 40-O-(2-гидроксиэтил)-рапамицина для получения фармацевтической композ

Claims (16)

1. Применение 40-O-(2-гидроксиэтил)-рапамицина для получения фармацевтической композиции для лечения солидных опухолей экскреторной системы.
2. Применение 40-O-(2-гидроксиэтил)-рапамицина по п.1, в котором солидной опухолью экскреторной системы является карцинома экскреторной системы.
3. Применение 40-O-(2-гидроксиэтил)-рапамицина по любому из пп.1 или 2, где единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.
4. Применение фармацевтической композиции, содержащей 40-O-(2-гидроксиэтил) рапамицин и по меньшей мере один фармацевтически приемлемый наполнитель или носитель для лечения солидных опухолей экскреторной системы.
5. Применение фармацевтической композиции по п.4, в котором солидной опухолью экскреторной системы является карцинома экскреторной системы.
6. Применение фармацевтической композиции по п.4 или 5, где единичной дозой 40-O-(2-гидроксиэтил)-рапамицина вводимого составляет от 0,1 мг до 15 мг.
7. Применение 40-O-(2-гидроксиэтил)-рапамицина для приготовления фармацевтической композиции для лечения солидных опухолей поджелудочной железы.
8. Применение 40-O-(2-гидроксиэтил)-рапамицина по п.7, в котором единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.
9. Применение фармацевтической композиции, содержащей 40-O-(2-гидроксиэтил) рапамицин и по меньшей мере один фармацевтически приемлемый наполнитель или носитель для лечения солидных опухолей поджелудочной железы.
10. Применение фармацевтической композиции по п.9, где единичной доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.
11. Применение 40-O-(2-гидроксиэтил)-рапамицина для получения фармацевтической композиции для лечения солидных опухолей мозга.
12. Применение 40-O-(2-гидроксиэтил)-рапамицина по п.11, в котором солидной опухолью мозга является рак мозга.
13. Применение 40-O-(2-гидроксиэтил)-рапамицина по п. 11 или 12, где единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.
14. Применение фармацевтической композиции, содержащей 40-O-(2-гидроксиэтил) рапамицин и по меньшей мере один фармацевтически приемлемый наполнитель или носитель для лечения солидных опухолей мозга.
15. Применение фармацевтической композиции по п.14, в котором солидной опухолью мозга является рак мозга.
16. Применение фармацевтической композиции по п.14 или 15, где единичная доза вводимого 40-O-(2-гидроксиэтил)-рапамицина составляет от 0,1 мг до 15 мг.
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