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RU2012103976A - 2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazole [3,4-b] pyridine-5-yl) -2-oxo-n-arylacetamides and a method for their preparation - Google Patents

2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazole [3,4-b] pyridine-5-yl) -2-oxo-n-arylacetamides and a method for their preparation Download PDF

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RU2012103976A
RU2012103976A RU2012103976/04A RU2012103976A RU2012103976A RU 2012103976 A RU2012103976 A RU 2012103976A RU 2012103976/04 A RU2012103976/04 A RU 2012103976/04A RU 2012103976 A RU2012103976 A RU 2012103976A RU 2012103976 A RU2012103976 A RU 2012103976A
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aryl
phenyl
methyl
aroyl
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Павел Сергеевич Силайчев
Андрей Николаевич Масливец
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Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет"
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Abstract

1. 2-(6-Арил-4-ароил-3-метил-1-фенил-1Н-пиразоло[3,4-b]пиридин-5-ил)-2-оксо-N-арилацетамиды формулыгде Ar- Ph, СНМе 4, СН(Ме)2,5; Ar- Ph, СНМе 4, CHOMe 4, CHBr 4.2. Способ получения 2-(6-Арил-4-ароил-3-метил-1-фенил-1Н-пиразоло[3,4-b]пиридин-5-ил)-2-оксо-N-арилацетамидов общей формулыгде Ar- Ph, СНМе 4, СН(Ме)2,5; Ar- Ph, СНМе 4, CHOMe 4, CHBr 4,отличающийся тем, что 1-арил-4,5-диароли-1Н-пиррол-2,3-дионы подвергают взаимодействию с 5-амино-3-метил-1-фенил-1H-пиразолом в среде инертного апротонного растворителя с последующим выделением целевых продуктов.3. Способ по п.2, отличающийся тем, что процесс ведут при температуре 78-82°С.4. Способ по п.2, отличающийся тем, что в качестве растворителя используют абсолютный бензол или 1,2-дихлорэтан.1. 2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazolo [3,4-b] pyridin-5-yl) -2-oxo-N-aryl acetamides of the formula where Ar-Ph, CHMe 4, CH (Me) 2.5; Ar-Ph, CHMe 4, CHOMe 4, CHBr 4.2. The method of obtaining 2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazolo [3,4-b] pyridin-5-yl) -2-oxo-N-arylacetamides of the general formula where Ar-Ph CHMe 4; CH (Me) 2.5; Ar-Ph, CHMe 4, CHOMe 4, CHBr 4, characterized in that 1-aryl-4,5-diaroli-1H-pyrrole-2,3-dione are reacted with 5-amino-3-methyl-1-phenyl -1H-pyrazole in an inert aprotic solvent, followed by isolation of the desired products. 3. The method according to claim 2, characterized in that the process is conducted at a temperature of 78-82 ° C. The method according to claim 2, characterized in that absolute benzene or 1,2-dichloroethane is used as the solvent.

Claims (4)

1. 2-(6-Арил-4-ароил-3-метил-1-фенил-1Н-пиразоло[3,4-b]пиридин-5-ил)-2-оксо-N-арилацетамиды формулы1. 2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazolo [3,4-b] pyridin-5-yl) -2-oxo-N-aryl acetamides of the formula
Figure 00000001
Figure 00000001
 где Ar1 - Ph, С6Н4Ме 4, С6Н3(Ме)2 2,5; Ar2 - Ph, С6Н4Ме 4, C6H4OMe 4, C6H4Br 4.where Ar 1 is Ph, C 6 H 4 Me 4, C 6 H 3 (Me) 2 2.5; Ar 2 - Ph, C 6 H 4 Me 4, C 6 H 4 OMe 4, C 6 H 4 Br 4. 2. Способ получения 2-(6-Арил-4-ароил-3-метил-1-фенил-1Н-пиразоло[3,4-b]пиридин-5-ил)-2-оксо-N-арилацетамидов общей формулы2. The method of obtaining 2- (6-Aryl-4-aroyl-3-methyl-1-phenyl-1H-pyrazolo [3,4-b] pyridin-5-yl) -2-oxo-N-arylacetamides of the General formula
Figure 00000001
Figure 00000001
 где Ar1 - Ph, С6Н4Ме 4, С6Н3(Ме)2 2,5; Ar2 - Ph, С6Н4Ме 4, C6H4OMe 4, C6H4Br 4,where Ar 1 is Ph, C 6 H 4 Me 4, C 6 H 3 (Me) 2 2.5; Ar 2 - Ph, C 6 H 4 Me 4, C 6 H 4 OMe 4, C 6 H 4 Br 4, отличающийся тем, что 1-арил-4,5-диароли-1Н-пиррол-2,3-дионы подвергают взаимодействию с 5-амино-3-метил-1-фенил-1H-пиразолом в среде инертного апротонного растворителя с последующим выделением целевых продуктов.characterized in that 1-aryl-4,5-diaroli-1H-pyrrole-2,3-dions are reacted with 5-amino-3-methyl-1-phenyl-1H-pyrazole in an inert aprotic solvent, followed by isolation of the desired products. 3. Способ по п.2, отличающийся тем, что процесс ведут при температуре 78-82°С.3. The method according to claim 2, characterized in that the process is conducted at a temperature of 78-82 ° C. 4. Способ по п.2, отличающийся тем, что в качестве растворителя используют абсолютный бензол или 1,2-дихлорэтан. 4. The method according to claim 2, characterized in that absolute benzene or 1,2-dichloroethane is used as the solvent.
RU2012103976/04A 2012-02-07 2012-02-07 2-(6-ARYL-4-AROYL-3-METHYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDIN-5-YL)-2-OXO-N-ARYLACETAMIDES AND METHODS FOR PRODUCTION THEREOF RU2501800C2 (en)

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