RU2009102012A - METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA - Google Patents
METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA Download PDFInfo
- Publication number
- RU2009102012A RU2009102012A RU2009102012/10A RU2009102012A RU2009102012A RU 2009102012 A RU2009102012 A RU 2009102012A RU 2009102012/10 A RU2009102012/10 A RU 2009102012/10A RU 2009102012 A RU2009102012 A RU 2009102012A RU 2009102012 A RU2009102012 A RU 2009102012A
- Authority
- RU
- Russia
- Prior art keywords
- bacterium
- amino acid
- family
- gene
- glutamate
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims abstract 21
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title claims abstract 9
- 229930195712 glutamate Natural products 0.000 title claims abstract 9
- 241000588921 Enterobacteriaceae Species 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 150000008575 L-amino acids Chemical class 0.000 claims abstract 12
- 230000014509 gene expression Effects 0.000 claims abstract 8
- 230000001965 increasing effect Effects 0.000 claims abstract 6
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims abstract 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract 4
- 229930064664 L-arginine Natural products 0.000 claims abstract 4
- 235000014852 L-arginine Nutrition 0.000 claims abstract 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims abstract 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract 4
- 229930182816 L-glutamine Natural products 0.000 claims abstract 4
- 229930182821 L-proline Natural products 0.000 claims abstract 4
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims abstract 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims abstract 4
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960002173 citrulline Drugs 0.000 claims abstract 4
- 235000013477 citrulline Nutrition 0.000 claims abstract 4
- 230000000694 effects Effects 0.000 claims abstract 4
- 101150081163 glnA gene Proteins 0.000 claims abstract 4
- 229960003104 ornithine Drugs 0.000 claims abstract 4
- 229960002429 proline Drugs 0.000 claims abstract 4
- 241000588722 Escherichia Species 0.000 claims abstract 2
- 241000520272 Pantoea Species 0.000 claims abstract 2
- 239000012531 culture fluid Substances 0.000 claims abstract 2
- 230000002708 enhancing effect Effects 0.000 claims abstract 2
- 108020002326 glutamine synthetase Proteins 0.000 claims abstract 2
- 102000005396 glutamine synthetase Human genes 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 235000015097 nutrients Nutrition 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1. Бактерия семейства Enterobacteriaceae - продуцент L-аминокислоты, принадлежащей к семейству глутамата, модифицированная таким образом, что активность глутаминсинтетазы в указанной бактерии увеличена. ! 2. Бактерия по п.1, отличающаяся тем, что указанная активность увеличена за счет усиления экспрессии гена glnA. ! 3. Бактерия по п.2, отличающаяся тем, что экспрессия указанного гена glnA усилена за счет увеличения числа копий гена или модификации последовательности, контролирующей экспрессию гена, в результате которой экспрессия гена усиливается. ! 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia. ! 5. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea. ! 6. Бактерия-продуцент L-аминокислоты по любому из пп.1-5, отличающаяся тем, что указанная L-аминокислота, принадлежащая к семейству глутамата, выбрана из группы, состоящей из L-глутамина, L-пролина, L-аргинина, орнитина и цитруллина. ! 7. Способ получения L-аминокислоты, принадлежащей к семейству глутамата, включающий: ! - выращивание бактерии по п.1 в питательной среде, и ! - выделение указанной L-аминокислоты из культуральной жидкости. ! 8. Способ по п.7, отличающийся тем, что указанная L-аминокислота, принадлежащая к семейству глутамата, выбрана из группы, состоящей из L-глутамина, L-пролина, L-аргинина, орнитина и цитруллина. 1. A bacterium of the Enterobacteriaceae family - a producer of the L-amino acid belonging to the glutamate family, modified in such a way that the activity of glutamine synthetase in the specified bacterium is increased. ! 2. The bacterium according to claim 1, characterized in that said activity is increased by enhancing the expression of the glnA gene. ! 3. The bacterium according to claim 2, characterized in that the expression of said glnA gene is enhanced by increasing the number of copies of the gene or by modifying the sequence that controls gene expression, as a result of which gene expression is enhanced. ! 4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. ! 5. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. ! 6. A bacterium producing L-amino acids according to any one of claims 1 to 5, characterized in that said L-amino acid belonging to the glutamate family is selected from the group consisting of L-glutamine, L-proline, L-arginine, ornithine and citrulline. ! 7. A method for producing an L-amino acid belonging to the glutamate family, comprising:! - growing bacteria according to claim 1 in a nutrient medium, and! - the allocation of the specified L-amino acids from the culture fluid. ! 8. The method according to claim 7, characterized in that said L-amino acid belonging to the glutamate family is selected from the group consisting of L-glutamine, L-proline, L-arginine, ornithine and citrulline.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009102012/10A RU2420586C2 (en) | 2009-01-23 | 2009-01-23 | Method of producing l-amino acid of glutamate family with using escherichia bacterium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009102012/10A RU2420586C2 (en) | 2009-01-23 | 2009-01-23 | Method of producing l-amino acid of glutamate family with using escherichia bacterium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009102012A true RU2009102012A (en) | 2010-07-27 |
| RU2420586C2 RU2420586C2 (en) | 2011-06-10 |
Family
ID=42697855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009102012/10A RU2420586C2 (en) | 2009-01-23 | 2009-01-23 | Method of producing l-amino acid of glutamate family with using escherichia bacterium |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2420586C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2496867C2 (en) * | 2011-04-25 | 2013-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | Method to produce l-amino acid of glutamate family using coryneformic bacterium |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4560998B2 (en) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | Method for producing L-glutamine by fermentation and L-glutamine producing bacteria |
| RU2230114C2 (en) * | 2001-11-30 | 2004-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Mutant glutamine synthetase, dna fragment, strain of escherichia coli as p roducer of l-glutamine and method for preparing l-amino acids |
-
2009
- 2009-01-23 RU RU2009102012/10A patent/RU2420586C2/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2496867C2 (en) * | 2011-04-25 | 2013-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | Method to produce l-amino acid of glutamate family using coryneformic bacterium |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2420586C2 (en) | 2011-06-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2011116147A (en) | METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE FAMILY USING THE CORINEFORM BACTERIA | |
| DE602007005233D1 (en) | PROCESS FOR THE PREPARATION OF L-AMINO ACID | |
| BR112014031658A2 (en) | Mixotrophic method of aquaculture | |
| MX389212B (en) | METHODS AND COMPOSITIONS OF MICROBIAL FERMENTATION. | |
| MY163228A (en) | Process for Producing 3-Hydroxybutyric Acid or Salt Thereof | |
| ATE554159T1 (en) | MICROORGANISM CAPABILITY FOR THE PRODUCTION OF L-AMINO ACID AND METHOD FOR THE PRODUCTION OF L-AMINO ACID | |
| RU2009136544A (en) | METHOD FOR PRODUCING L-CISTEINE USING THE ENTEROBACTERIACEAE FAMILY BACTERIA | |
| EA201491785A1 (en) | METHOD OF ENZYMATION | |
| JP2013517777A5 (en) | ||
| EA201000901A1 (en) | METHOD FOR CULTIVATING MICROORGANISMS RELATING TO THRAUSTOCHYTRIALES ORDER | |
| RU2007131007A (en) | METHOD FOR PRODUCING L-AMINO ACID USING THE Enterobacteriaceae Bacteria in Which Expression of the yahN Gene Is Weakened | |
| BR112016005456A2 (en) | A manufacturing method of L-amino acid from the seaweed origin biomass | |
| RU2010122647A (en) | METHOD FOR PRODUCING L-ARGININE AND L-CITRULLIN USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF THE pepA GENE IS DECREASED | |
| RU2010107899A (en) | FAMILY BACTERIA ENTEROBACTERIACEAE-PRODUCER L-CYSTEINE | |
| RU2017142878A (en) | Microorganism of the genus Escherichia, which has L-tryptophan productivity, and method for producing L-tryptophan using it | |
| MX379133B (en) | Novel bacterium of bacillus genus and uses thereof | |
| BR112013020216A2 (en) | PROCESS FOR PRODUCING TARGET SUBSTANCE THROUGH THE FERMENTATION PROCESS | |
| RU2012135337A (en) | METHOD FOR PRODUCING L-ARGININE USING A BACTERIA OF THE Enterobacteriaceae Family Containing Impaired N-Acetylornithindeacetylase | |
| RU2010122646A (en) | METHOD FOR PRODUCING L-AMINO ACID USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES CODING THE LYSINE / ARGININE / ORNITINE TRANSPORTER IS DECREASED | |
| RU2009102012A (en) | METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA | |
| RU2011134436A (en) | METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY | |
| RU2016141594A (en) | A microorganism having the ability to produce L-lysine, and a method for producing L-lysine using this microorganism | |
| RU2003126289A (en) | METHOD FOR PRODUCING L-AMINO ACIDS USING BACTERIA OF THE ENTEROBACTERIACEAE FAMILY CONTAINING INACTIVATED NIR OPERON | |
| RU2009102011A (en) | METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE, L-THREONINE OR L-VALINE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA | |
| RU2010146281A (en) | BACTERIA OF THE GENUS Escherichia Possessing Enhanced Expression of the ACEEF-lpdA GENES OPERON AND METHOD FOR PRODUCING SUITIC ACID USING SUCH BACTERIA |