RU2009102011A - METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE, L-THREONINE OR L-VALINE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA - Google Patents
METHOD FOR PRODUCING L-AMINO ACID OF THE GLUTAMATE, L-THREONINE OR L-VALINE FAMILY USING THE ENTEROBACTERIACEAE FAMILY BACTERIA Download PDFInfo
- Publication number
- RU2009102011A RU2009102011A RU2009102011/10A RU2009102011A RU2009102011A RU 2009102011 A RU2009102011 A RU 2009102011A RU 2009102011/10 A RU2009102011/10 A RU 2009102011/10A RU 2009102011 A RU2009102011 A RU 2009102011A RU 2009102011 A RU2009102011 A RU 2009102011A
- Authority
- RU
- Russia
- Prior art keywords
- bacterium
- family
- specified
- amino acid
- glutamate
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims abstract 21
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title claims abstract 17
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 title claims abstract 9
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 title claims abstract 9
- 229930195712 glutamate Natural products 0.000 title claims abstract 9
- 241000588921 Enterobacteriaceae Species 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 150000008575 L-amino acids Chemical class 0.000 claims abstract 12
- 229940049906 glutamate Drugs 0.000 claims abstract 8
- 230000001965 increasing effect Effects 0.000 claims abstract 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 101150099894 GDHA gene Proteins 0.000 claims abstract 4
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims abstract 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract 4
- 229930064664 L-arginine Natural products 0.000 claims abstract 4
- 235000014852 L-arginine Nutrition 0.000 claims abstract 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims abstract 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract 4
- 229930182816 L-glutamine Natural products 0.000 claims abstract 4
- 229930182821 L-proline Natural products 0.000 claims abstract 4
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims abstract 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims abstract 4
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000004473 Threonine Substances 0.000 claims abstract 4
- 229960002173 citrulline Drugs 0.000 claims abstract 4
- 235000013477 citrulline Nutrition 0.000 claims abstract 4
- 230000000694 effects Effects 0.000 claims abstract 4
- 229960002989 glutamic acid Drugs 0.000 claims abstract 4
- 229960002743 glutamine Drugs 0.000 claims abstract 4
- 229960003104 ornithine Drugs 0.000 claims abstract 4
- 229960002429 proline Drugs 0.000 claims abstract 4
- 229960002898 threonine Drugs 0.000 claims abstract 4
- 229960004295 valine Drugs 0.000 claims abstract 4
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims abstract 2
- 241000588722 Escherichia Species 0.000 claims abstract 2
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims abstract 2
- 241000520272 Pantoea Species 0.000 claims abstract 2
- 239000012531 culture fluid Substances 0.000 claims abstract 2
- 230000002708 enhancing effect Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 235000015097 nutrients Nutrition 0.000 claims abstract 2
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1. Бактерия семейства Enterobacteriaceae - продуцент L-аминокислоты, принадлежащей к семейству глутамата; L-треонина или L-валина, модифицированная таким образом, что активность глутаматдегидрогеназы в указанной бактерии увеличена. ! 2. Бактерия по п.1, отличающаяся тем, что указанная активность увеличена за счет усиления экспрессии гена gdhA. ! 3. Бактерия по п.2, отличающаяся тем, что экспрессия указанного гена gdhA усилена за счет увеличения числа копий гена или модификации последовательности, контролирующей экспрессию гена, приводящей к усилению экспрессии указанного гена. ! 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Escherichia. ! 5. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к роду Pantoea. ! 6. Бактерия-продуцент L-аминокислоты по любому из пп.1-5, отличающаяся тем, что указанная L-аминокислота, принадлежащая к семейству глутамата, выбрана из группы, состоящей из L-глутаминовой кислоты, L-глутамина, L-пролина, L-аргинина, орнитина и цитруллина. ! 7. Способ получения L-аминокислоты, принадлежащей к семейству глутамата; L-треонина или L-валина, включающий: ! выращивание бактерии по п.1 в питательной среде, и ! выделение указанной L-аминокислоты из культуральной жидкости. ! 8. Способ по п.7, отличающийся тем, что указанная L-аминокислота, принадлежащая к семейству глутамата, выбрана из группы, состоящей из L-глутаминовой кислоты, L-глутамина, L-пролина, L-аргинина, орнитина и цитруллина. 1. A bacterium of the Enterobacteriaceae family - a producer of the L-amino acid belonging to the glutamate family; L-threonine or L-valine, modified so that the activity of glutamate dehydrogenase in the specified bacteria is increased. ! 2. The bacterium according to claim 1, characterized in that said activity is increased by enhancing the expression of the gdhA gene. ! 3. The bacterium according to claim 2, characterized in that the expression of the specified gdhA gene is enhanced by increasing the number of copies of the gene or modifying the sequence that controls the expression of the gene, leading to increased expression of the specified gene. ! 4. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Escherichia. ! 5. The bacterium according to claim 1, characterized in that said bacterium belongs to the genus Pantoea. ! 6. The bacterium producing L-amino acids according to any one of claims 1 to 5, characterized in that said L-amino acid belonging to the glutamate family is selected from the group consisting of L-glutamic acid, L-glutamine, L-proline, L-arginine, ornithine and citrulline. ! 7. A method for producing an L-amino acid belonging to the glutamate family; L-threonine or L-valine, including:! growing bacteria according to claim 1 in a nutrient medium, and! the allocation of the specified L-amino acids from the culture fluid. ! 8. The method according to claim 7, characterized in that the specified L-amino acid belonging to the glutamate family is selected from the group consisting of L-glutamic acid, L-glutamine, L-proline, L-arginine, ornithine and citrulline.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009102011/10A RU2418064C2 (en) | 2009-01-23 | 2009-01-23 | METHOD OF OBTAINING L-AMINO ACID OF GLUTAMATE FAMILY, OR L-BALINE WITH APPLICATION OF BACTERIUM BELONGING TO GENUS Escherichia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2009102011/10A RU2418064C2 (en) | 2009-01-23 | 2009-01-23 | METHOD OF OBTAINING L-AMINO ACID OF GLUTAMATE FAMILY, OR L-BALINE WITH APPLICATION OF BACTERIUM BELONGING TO GENUS Escherichia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009102011A true RU2009102011A (en) | 2010-07-27 |
| RU2418064C2 RU2418064C2 (en) | 2011-05-10 |
Family
ID=42697854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009102011/10A RU2418064C2 (en) | 2009-01-23 | 2009-01-23 | METHOD OF OBTAINING L-AMINO ACID OF GLUTAMATE FAMILY, OR L-BALINE WITH APPLICATION OF BACTERIUM BELONGING TO GENUS Escherichia |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2418064C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119082065B (en) * | 2024-11-08 | 2025-03-25 | 内蒙古伊品生物科技有限公司 | Application of glutamate dehydrogenase from Salmonella typhimurium and related biomaterials in amino acid synthesis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3880636B2 (en) * | 1994-01-10 | 2007-02-14 | 味の素株式会社 | Method for producing L-glutamic acid by fermentation |
| FR2747131B1 (en) * | 1996-04-09 | 1998-06-26 | Orsan | PROCESS FOR PRODUCTION OF AMINO ACID BY FERMENTATION OF CORYNEBACTERIA EXPRESSING TREHALASE ACTIVITY |
| AU746542B2 (en) * | 1998-03-18 | 2002-05-02 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| RU2207371C2 (en) * | 2000-09-26 | 2003-06-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Method for preparing l-amino acids of l-glutamic acid family, strain of bacterium escherichia coli as producer of l-amino acid (variants) |
| JP4560998B2 (en) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | Method for producing L-glutamine by fermentation and L-glutamine producing bacteria |
-
2009
- 2009-01-23 RU RU2009102011/10A patent/RU2418064C2/en active
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| Publication number | Publication date |
|---|---|
| RU2418064C2 (en) | 2011-05-10 |
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