RU2008131044A - Новое производное ариламидина, его соль и содержащий их противогрибковый агент - Google Patents
Новое производное ариламидина, его соль и содержащий их противогрибковый агент Download PDFInfo
- Publication number
- RU2008131044A RU2008131044A RU2008131044/04A RU2008131044A RU2008131044A RU 2008131044 A RU2008131044 A RU 2008131044A RU 2008131044/04 A RU2008131044/04 A RU 2008131044/04A RU 2008131044 A RU2008131044 A RU 2008131044A RU 2008131044 A RU2008131044 A RU 2008131044A
- Authority
- RU
- Russia
- Prior art keywords
- salt
- benzamidine
- piperidinyl
- propoxy
- phenoxy
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims abstract 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 229940121375 antifungal agent Drugs 0.000 claims abstract 2
- 239000003429 antifungal agent Substances 0.000 claims abstract 2
- DAIADFNENUPDES-UHFFFAOYSA-N butyl n-[amino-[4-[3-[1-[3-[4-(n'-butoxycarbonylcarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]phenyl]methylidene]carbamate Chemical compound C1=CC(C(N)=NC(=O)OCCCC)=CC=C1OCCCC1CCN(CCCOC=2C=CC(=CC=2)C(N)=NC(=O)OCCCC)CC1 DAIADFNENUPDES-UHFFFAOYSA-N 0.000 claims abstract 2
- BZMBWEDRPJFGEW-UHFFFAOYSA-N propan-2-yl n-[amino-[4-[3-[1-[3-[4-(n'-propan-2-yloxycarbonylcarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]phenyl]methylidene]carbamate Chemical compound C1=CC(C(N)=NC(=O)OC(C)C)=CC=C1OCCCC1CCN(CCCOC=2C=CC(=CC=2)C(N)=NC(=O)OC(C)C)CC1 BZMBWEDRPJFGEW-UHFFFAOYSA-N 0.000 claims abstract 2
- AGOLUMNZTYYZLK-UHFFFAOYSA-N propyl n-[amino-[4-[3-[1-[3-[4-(n'-propoxycarbonylcarbamimidoyl)phenoxy]propyl]piperidin-4-yl]propoxy]phenyl]methylidene]carbamate Chemical compound C1=CC(C(N)=NC(=O)OCCC)=CC=C1OCCCC1CCN(CCCOC=2C=CC(=CC=2)C(N)=NC(=O)OCCC)CC1 AGOLUMNZTYYZLK-UHFFFAOYSA-N 0.000 claims abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1. Производное ариламидина, представленное общей формулой, или его соль: ! [Формула 1] ! ! где R1 и R2 одинаково или различно представляют необязательно замещенную С3-4 алкильную группу. ! 2. Производное ариламидина или его соль по п.1, в котором R1 и R2 представляют одинаково С3-4 алкильную группу. ! 3. 4-{3-[4-(3-{4-[амино(пропоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(пропоксикарбонил)бензамидин или его соль. ! 4. 4-{3-[4-(3-{4-[амино(изопропоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(изопропоксикарбонил)бензамидин или его соль. ! 5. 4-{3-[4-(3-{4-[амино(бутоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(бутоксикарбонил)бензамидин или его соль. ! 6. Противогрибковый агент, содержащий производное ариламидина или его соль по любому одному из пп.1-5.
Claims (6)
1. Производное ариламидина, представленное общей формулой, или его соль:
[Формула 1]
где R1 и R2 одинаково или различно представляют необязательно замещенную С3-4 алкильную группу.
2. Производное ариламидина или его соль по п.1, в котором R1 и R2 представляют одинаково С3-4 алкильную группу.
3. 4-{3-[4-(3-{4-[амино(пропоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(пропоксикарбонил)бензамидин или его соль.
4. 4-{3-[4-(3-{4-[амино(изопропоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(изопропоксикарбонил)бензамидин или его соль.
5. 4-{3-[4-(3-{4-[амино(бутоксикарбонилимино)метил]фенокси}пропил)-1-пиперидинил]пропокси}-N'-(бутоксикарбонил)бензамидин или его соль.
6. Противогрибковый агент, содержащий производное ариламидина или его соль по любому одному из пп.1-5.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005-380547 | 2005-12-29 | ||
| JP2005380547 | 2005-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008131044A true RU2008131044A (ru) | 2010-02-10 |
| RU2415839C2 RU2415839C2 (ru) | 2011-04-10 |
Family
ID=38218090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008131044/04A RU2415839C2 (ru) | 2005-12-29 | 2006-12-27 | Новое производное ариламидина, его соль и содержащий их противогрибковый агент |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8536343B2 (ru) |
| EP (1) | EP1967190B1 (ru) |
| JP (1) | JP5038155B2 (ru) |
| KR (1) | KR101359363B1 (ru) |
| CN (1) | CN101351204B (ru) |
| AU (1) | AU2006330408B2 (ru) |
| BR (1) | BRPI0620732A2 (ru) |
| CA (1) | CA2634846C (ru) |
| CY (1) | CY1110857T1 (ru) |
| DE (1) | DE602006016010D1 (ru) |
| DK (1) | DK1967190T3 (ru) |
| ES (1) | ES2349146T3 (ru) |
| IL (1) | IL192380A0 (ru) |
| NO (1) | NO20082698L (ru) |
| NZ (1) | NZ569317A (ru) |
| PL (1) | PL1967190T3 (ru) |
| PT (1) | PT1967190E (ru) |
| RU (1) | RU2415839C2 (ru) |
| SI (1) | SI1967190T1 (ru) |
| WO (1) | WO2007074868A1 (ru) |
| ZA (1) | ZA200805604B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2070536T3 (da) | 2006-10-06 | 2012-04-10 | Toyama Chemical Co Ltd | Farmaceutisk sammensætning med et phenylamidin-derivat og fremgangsmåde til anvendelse af den farmaceutiske sammensætning i kombination med et antifungalt middel |
| TWI395735B (zh) * | 2007-07-04 | 2013-05-11 | Toyama Chemical Co Ltd | ４－｛３－〔４－（３－｛４－〔胺基（丁氧基羰基亞胺基）甲基〕苯氧基｝丙基）－１－哌啶基〕丙氧基｝－ｎ’－（丁氧基羰基）苄脒之新穎結晶 |
| MX379125B (es) | 2012-09-14 | 2025-03-10 | Supernus Pharmaceuticals Inc | Métodos para producir molindona y sus sales. |
| WO2015087857A1 (ja) * | 2013-12-10 | 2015-06-18 | 日本曹達株式会社 | アリールアミジン化合物および殺菌剤 |
| WO2016047550A1 (ja) * | 2014-09-24 | 2016-03-31 | 日本曹達株式会社 | アリールアミジン化合物を含有する農園芸用殺菌剤 |
| WO2016195077A1 (ja) * | 2015-06-03 | 2016-12-08 | 日本曹達株式会社 | グアニジン化合物および殺菌剤 |
| WO2021090739A1 (en) * | 2019-11-04 | 2021-05-14 | Fujifilm Toyama Chemical Co., Ltd. | Composition and method for treating candida auris infection |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3281522B2 (ja) | 1994-12-01 | 2002-05-13 | 富山化学工業株式会社 | 新規な２，３−ジケトピペラジン誘導体またはその塩 |
| WO1996016947A1 (en) * | 1994-12-01 | 1996-06-06 | Toyama Chemical Co., Ltd. | Novel 2,3-diketopiperazine derivative or salt thereof |
| US6319944B1 (en) | 1999-05-10 | 2001-11-20 | Merck & Co., Inc. | Aryl amidines, compositions containing such compounds and methods of use |
| AU779923B2 (en) * | 1999-07-08 | 2005-02-17 | Georgia State University | Novel prodrugs for antimicrobial amidines |
| WO2003024451A1 (de) | 2001-09-08 | 2003-03-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 2-(2-phenylethyl)-benzimidazol-5-carboxamid- derivative und ihre verwendung als tryptase_ inhibitoren |
| ATE517080T1 (de) | 2002-03-06 | 2011-08-15 | Toyama Chemical Co Ltd | Neues arylamidinderivat bzw. salz davon |
| JP4937506B2 (ja) | 2003-09-05 | 2012-05-23 | 富山化学工業株式会社 | 新規なアリールアミジン誘導体またはその塩 |
| PT1767526E (pt) | 2004-06-30 | 2012-12-10 | Toyama Chemical Co Ltd | Derivado de arilamidina, os seus sais e um antifúngico que os contenha |
| EP1867332B1 (en) | 2005-04-07 | 2011-08-24 | Toyama Chemical Co., Ltd. | Pharmaceutical composition and method using antifungal agent in combination |
-
2006
- 2006-12-27 ZA ZA200805604A patent/ZA200805604B/xx unknown
- 2006-12-27 DK DK06843443.0T patent/DK1967190T3/da active
- 2006-12-27 KR KR1020087018282A patent/KR101359363B1/ko not_active Expired - Fee Related
- 2006-12-27 NZ NZ569317A patent/NZ569317A/en unknown
- 2006-12-27 BR BRPI0620732-4A patent/BRPI0620732A2/pt not_active IP Right Cessation
- 2006-12-27 EP EP06843443A patent/EP1967190B1/en not_active Not-in-force
- 2006-12-27 US US12/159,527 patent/US8536343B2/en not_active Expired - Fee Related
- 2006-12-27 WO PCT/JP2006/326061 patent/WO2007074868A1/ja not_active Ceased
- 2006-12-27 CA CA2634846A patent/CA2634846C/en not_active Expired - Fee Related
- 2006-12-27 RU RU2008131044/04A patent/RU2415839C2/ru not_active IP Right Cessation
- 2006-12-27 JP JP2007552006A patent/JP5038155B2/ja not_active Expired - Fee Related
- 2006-12-27 AU AU2006330408A patent/AU2006330408B2/en not_active Ceased
- 2006-12-27 CN CN2006800497554A patent/CN101351204B/zh not_active Expired - Fee Related
- 2006-12-27 SI SI200630810T patent/SI1967190T1/sl unknown
- 2006-12-27 PT PT06843443T patent/PT1967190E/pt unknown
- 2006-12-27 DE DE602006016010T patent/DE602006016010D1/de active Active
- 2006-12-27 PL PL06843443T patent/PL1967190T3/pl unknown
- 2006-12-27 ES ES06843443T patent/ES2349146T3/es active Active
-
2008
- 2008-06-12 NO NO20082698A patent/NO20082698L/no not_active Application Discontinuation
- 2008-06-22 IL IL192380A patent/IL192380A0/en not_active IP Right Cessation
-
2010
- 2010-10-27 CY CY20101100969T patent/CY1110857T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1967190E (pt) | 2010-10-14 |
| AU2006330408B2 (en) | 2011-10-13 |
| RU2415839C2 (ru) | 2011-04-10 |
| BRPI0620732A2 (pt) | 2011-11-22 |
| CN101351204A (zh) | 2009-01-21 |
| JP5038155B2 (ja) | 2012-10-03 |
| WO2007074868A1 (ja) | 2007-07-05 |
| ES2349146T3 (es) | 2010-12-28 |
| NZ569317A (en) | 2010-08-27 |
| ZA200805604B (en) | 2009-12-30 |
| DE602006016010D1 (de) | 2010-09-16 |
| CA2634846C (en) | 2013-02-19 |
| EP1967190B1 (en) | 2010-08-04 |
| IL192380A0 (en) | 2008-12-29 |
| EP1967190A1 (en) | 2008-09-10 |
| PL1967190T3 (pl) | 2011-01-31 |
| JPWO2007074868A1 (ja) | 2009-06-04 |
| SI1967190T1 (sl) | 2010-12-31 |
| NO20082698L (no) | 2008-09-05 |
| EP1967190A4 (en) | 2009-08-26 |
| AU2006330408A1 (en) | 2007-07-05 |
| DK1967190T3 (da) | 2010-11-22 |
| US8536343B2 (en) | 2013-09-17 |
| KR101359363B1 (ko) | 2014-02-07 |
| CA2634846A1 (en) | 2007-07-05 |
| US20100016602A1 (en) | 2010-01-21 |
| CN101351204B (zh) | 2011-01-12 |
| CY1110857T1 (el) | 2015-06-10 |
| KR20080080227A (ko) | 2008-09-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151228 |