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AR058077A1 - Derivados de acidos fenoxiaceticos - Google Patents

Derivados de acidos fenoxiaceticos

Info

Publication number
AR058077A1
AR058077A1 ARP060104385A ARP060104385A AR058077A1 AR 058077 A1 AR058077 A1 AR 058077A1 AR P060104385 A ARP060104385 A AR P060104385A AR P060104385 A ARP060104385 A AR P060104385A AR 058077 A1 AR058077 A1 AR 058077A1
Authority
AR
Argentina
Prior art keywords
halogen
alkyl
optionally substituted
hydrogen
atoms
Prior art date
Application number
ARP060104385A
Other languages
English (en)
Inventor
Stephen Thom
Sultan Mohammadi Mansur
Timothy Luker
Mark Dickinson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0520324A external-priority patent/GB0520324D0/en
Priority claimed from GB0525082A external-priority patent/GB0525082D0/en
Priority claimed from GB0602800A external-priority patent/GB0602800D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR058077A1 publication Critical patent/AR058077A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

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Abstract

Reivindicacion 1: Un compuesto caracterizado porque es de formula 1 o una sal aceptable para uso farmacéutico del mismo: (Formula 1) en donde: A y D se seleccionan en forma independiente entre hidrogeno, halogeno, nitrilo, C1-3 alquilo, C1-3 alcoxi (los ultimos 2 grupos pueden estar opcionalmente sustituidos con uno o más átomos de halogeno); X es halogeno, o C1-3alquilo que está opcionalmente sustituido con uno o más átomos de halogeno; Y es un enlace; Z es un arilo o heteroarilo sustituido con uno o más seleccionados entre hidrogeno, halogeno, nitrilo, C1-6 alquilo, C1-6 alcoxi, SO2C1-6alquilo, heteroarilo; los ultimos cuatro grupos pueden estar opcionalmente sustituidos con átomos de halogeno, nitrilo o SO2C1-6alquilo; R1 y R2 representan en forma independiente un átomo de hidrogeno, o un grupo C1-3 alquilo; o R1 y R2 juntos pueden formar un anillo de entre 3 y 8 miembros que contiene opcionalmente uno o más átomos seleccionados entre O, S, NR3 y a su vez opcionalmente sustituido con uno o más C1-3 alquilo; y R3 es hidrogeno o C1-6 alquilo.
ARP060104385A 2005-10-06 2006-10-05 Derivados de acidos fenoxiaceticos AR058077A1 (es)

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GB0520324A GB0520324D0 (en) 2005-10-06 2005-10-06 Novel compounds
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GB0602800A GB0602800D0 (en) 2006-02-11 2006-02-11 Novel Compounds

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US8008350B2 (en) 2011-08-30
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US8415394B2 (en) 2013-04-09
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TW200745003A (en) 2007-12-16
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US20090036535A1 (en) 2009-02-05
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