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RU2008128244A - Способы идентификации опухолей, восприимчивых к лечению антителами против erbb2 - Google Patents

Способы идентификации опухолей, восприимчивых к лечению антителами против erbb2 Download PDF

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Publication number
RU2008128244A
RU2008128244A RU2008128244/13A RU2008128244A RU2008128244A RU 2008128244 A RU2008128244 A RU 2008128244A RU 2008128244/13 A RU2008128244/13 A RU 2008128244/13A RU 2008128244 A RU2008128244 A RU 2008128244A RU 2008128244 A RU2008128244 A RU 2008128244A
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Russia
Prior art keywords
rhumab
treatment
identification
methods
antibodies against
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RU2008128244/13A
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English (en)
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Ханс КОЛЛЬ (DE)
Ханс КОЛЛЬ
Биргит БОССЕНМАЙЕР (DE)
Биргит БОССЕНМАЙЕР
Ханс-Йоахим МЮЛЛЕР (DE)
Ханс-Йоахим Мюллер
Марк К. СЛИВКОВСКИ (US)
Марк К. СЛИВКОВСКИ
Стефен Майкл КЕЛСИ (US)
Стефен Майкл КЕЛСИ
Original Assignee
Дженентек, Инк. (Us)
Дженентек, Инк.
Ф. Хоффманн-Ля Рош Аг (Ch)
Ф. Хоффманн-Ля Рош Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30118578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2008128244(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дженентек, Инк. (Us), Дженентек, Инк., Ф. Хоффманн-Ля Рош Аг (Ch), Ф. Хоффманн-Ля Рош Аг filed Critical Дженентек, Инк. (Us)
Publication of RU2008128244A publication Critical patent/RU2008128244A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G01N33/5759—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1. Применение рекомбинантного гуманизированного моноклонального антитела 2С4 (rhuMAb 2C4) для получения лекарственного средства для лечения злокачественной опухоли, при этом лекарственное средство обеспечивает фиксированную дозу rhuMAb 2C4, составляющую 420 мг или 840 мг. ! 2. Изделие производства, включающее в себя емкость, содержащую рекомбинантное гуманизированное моноклональное антитело2С4 (rhuMAb 2C4) и инструкции по введению пациенту, страдающему от опухоли, указанного антитела в фиксированной дозе rhuMAb 2C4, составляющую 420 мг или 840 мг.

Claims (2)

1. Применение рекомбинантного гуманизированного моноклонального антитела 2С4 (rhuMAb 2C4) для получения лекарственного средства для лечения злокачественной опухоли, при этом лекарственное средство обеспечивает фиксированную дозу rhuMAb 2C4, составляющую 420 мг или 840 мг.
2. Изделие производства, включающее в себя емкость, содержащую рекомбинантное гуманизированное моноклональное антитело2С4 (rhuMAb 2C4) и инструкции по введению пациенту, страдающему от опухоли, указанного антитела в фиксированной дозе rhuMAb 2C4, составляющую 420 мг или 840 мг.
RU2008128244/13A 2002-07-15 2008-07-10 Способы идентификации опухолей, восприимчивых к лечению антителами против erbb2 RU2008128244A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39629002P 2002-07-15 2002-07-15
US60/396,290 2002-07-15
US48004303P 2003-06-20 2003-06-20
US60/480,043 2003-06-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2005103824/13A Division RU2338751C2 (ru) 2002-07-15 2003-07-11 СПОСОБЫ ИДЕНТИФИКАЦИИ ОПУХОЛЕЙ, ВОСПРИИМЧИВЫХ К ЛЕЧЕНИЮ АНТИТЕЛАМИ ПРОТИВ ErbB2

Publications (1)

Publication Number Publication Date
RU2008128244A true RU2008128244A (ru) 2010-01-20

Family

ID=30118578

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2005103824/13A RU2338751C2 (ru) 2002-07-15 2003-07-11 СПОСОБЫ ИДЕНТИФИКАЦИИ ОПУХОЛЕЙ, ВОСПРИИМЧИВЫХ К ЛЕЧЕНИЮ АНТИТЕЛАМИ ПРОТИВ ErbB2
RU2008128244/13A RU2008128244A (ru) 2002-07-15 2008-07-10 Способы идентификации опухолей, восприимчивых к лечению антителами против erbb2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2005103824/13A RU2338751C2 (ru) 2002-07-15 2003-07-11 СПОСОБЫ ИДЕНТИФИКАЦИИ ОПУХОЛЕЙ, ВОСПРИИМЧИВЫХ К ЛЕЧЕНИЮ АНТИТЕЛАМИ ПРОТИВ ErbB2

Country Status (20)

Country Link
US (2) US20040106161A1 (ru)
EP (2) EP2263691B1 (ru)
JP (3) JP5069843B2 (ru)
CN (2) CN102295703A (ru)
AT (1) ATE535254T1 (ru)
AU (2) AU2003273218C1 (ru)
BR (1) BR0312534A (ru)
CA (1) CA2490758C (ru)
CY (2) CY1112631T1 (ru)
DK (2) DK1585966T3 (ru)
ES (2) ES2392525T3 (ru)
HU (1) HUP0600340A3 (ru)
IL (2) IL165952A (ru)
MX (1) MXPA05000403A (ru)
NO (1) NO337855B1 (ru)
NZ (1) NZ537660A (ru)
PL (1) PL214010B1 (ru)
PT (2) PT1585966E (ru)
RU (2) RU2338751C2 (ru)
WO (1) WO2004008099A2 (ru)

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