RU2008147739A - COMBINED ANTI-TUBERCULOSIS PHARMACEUTICAL COMPOSITION - Google Patents
COMBINED ANTI-TUBERCULOSIS PHARMACEUTICAL COMPOSITION Download PDFInfo
- Publication number
- RU2008147739A RU2008147739A RU2008147739/15A RU2008147739A RU2008147739A RU 2008147739 A RU2008147739 A RU 2008147739A RU 2008147739/15 A RU2008147739/15 A RU 2008147739/15A RU 2008147739 A RU2008147739 A RU 2008147739A RU 2008147739 A RU2008147739 A RU 2008147739A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- isoniazid
- ethyl
- active principle
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 9
- 230000002365 anti-tubercular Effects 0.000 title claims abstract 3
- FVVDKUPCWXUVNP-UHFFFAOYSA-M Aminosalicylate sodium anhydrous Chemical compound [Na+].NC1=CC=C(C([O-])=O)C(O)=C1 FVVDKUPCWXUVNP-UHFFFAOYSA-M 0.000 claims abstract 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract 4
- -1 diethyl ethyl ethyl Chemical group 0.000 claims abstract 4
- 229960003350 isoniazid Drugs 0.000 claims abstract 4
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims abstract 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N phthalic acid di-n-ethyl ester Natural products CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims abstract 4
- 229940046927 sodium aminosalicylate Drugs 0.000 claims abstract 4
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract 2
- 229920002472 Starch Polymers 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims abstract 2
- 239000003086 colorant Substances 0.000 claims abstract 2
- 229920001577 copolymer Polymers 0.000 claims abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract 2
- 239000000796 flavoring agent Substances 0.000 claims abstract 2
- 235000019634 flavors Nutrition 0.000 claims abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004615 ingredient Substances 0.000 claims abstract 2
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract 2
- 239000000377 silicon dioxide Substances 0.000 claims abstract 2
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract 2
- 239000011734 sodium Substances 0.000 claims abstract 2
- 229910052708 sodium Inorganic materials 0.000 claims abstract 2
- 235000015424 sodium Nutrition 0.000 claims abstract 2
- 239000007909 solid dosage form Substances 0.000 claims abstract 2
- 239000008107 starch Substances 0.000 claims abstract 2
- 235000019698 starch Nutrition 0.000 claims abstract 2
- 239000000454 talc Substances 0.000 claims abstract 2
- 229910052623 talc Inorganic materials 0.000 claims abstract 2
- 235000012222 talc Nutrition 0.000 claims abstract 2
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Комбинированная противотуберкулезная фармацевтическая композиция в виде твердой лекарственной формы, включающая терапевтически эффективное количество действующего начала, в качестве которого содержит комбинацию натрия аминосалицилата и изониазида при следующем соотношении ингредиентов действующего начала, мас.%: ! Натрия аминосалицилат 36,8-90,41 Изониазид 1,08-3,38 !2. Фармацевтическая композиция по п.1, характеризующаяся тем, что она выполнена в форме таблетки. ! 3. Фармацевтическая композиция по п.2, характеризующаяся тем, что она содержит в качестве вспомогательных веществ этилцеллюлозу, целлюлозу микрокристаллическую, поливинилпирролидон, карбоксиметилкрахмал натрия, кремния диоксил коллоидный, тальк, магния стеарат, гидроксипропилметилцеллюлозу, диэтилфталат, полиэтиленгликоль, триэтилцитрат, титана диоксид, матакриловой кислоты сополимер, различные красители, ароматизаторы и/или вкусовые добавки. ! 4. Фармацевтическая композиция по п.2 или 3, характеризующаяся тем, что она имеет оболочку. 1. The combined anti-tuberculosis pharmaceutical composition in the form of a solid dosage form, comprising a therapeutically effective amount of the active principle, which contains a combination of sodium aminosalicylate and isoniazid in the following ratio of ingredients of the active principle, wt.%:! Sodium aminosalicylate 36.8-90.41 Isoniazid 1.08-3.38! 2. The pharmaceutical composition according to claim 1, characterized in that it is made in the form of tablets. ! 3. The pharmaceutical composition according to claim 2, characterized in that it contains ethyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, sodium carboxymethyl starch, silicon dioxide colloidal, talc, magnesium stearate, hydroxypropyl methyl cellulose, diethyl ethyl ethyl phthalate, diethyl ethyl phthalate acid copolymer, various colorants, flavors and / or flavorings. ! 4. The pharmaceutical composition according to claim 2 or 3, characterized in that it has a shell.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008147739/15A RU2417087C2 (en) | 2008-12-03 | 2008-12-03 | Combined antituberculous pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008147739/15A RU2417087C2 (en) | 2008-12-03 | 2008-12-03 | Combined antituberculous pharmaceutical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008147739A true RU2008147739A (en) | 2010-06-10 |
| RU2417087C2 RU2417087C2 (en) | 2011-04-27 |
Family
ID=42681250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008147739/15A RU2417087C2 (en) | 2008-12-03 | 2008-12-03 | Combined antituberculous pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2417087C2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102344412A (en) * | 2010-07-30 | 2012-02-08 | 重庆华邦胜凯制药有限公司 | Preparation method of isoniazid para-aminosalicylate |
| PL446974A1 (en) * | 2023-12-04 | 2025-06-09 | Politechnika Śląska | Method of producing micellar ionic conjugates based on graft polymers for co-delivery of anti-tuberculosis drugs and their use |
| PL446972A1 (en) * | 2023-12-04 | 2025-06-09 | Politechnika Śląska | Method of producing micellar ionic conjugates based on linear polymers for co-delivery of antituberculosis drugs and their use |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2498803C1 (en) * | 2012-07-31 | 2013-11-20 | Общество с ограниченной ответственностью "ЭДВАНСД ТРЕЙДИНГ" | Antituberculous agent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2155032C1 (en) * | 1999-03-01 | 2000-08-27 | Пятигорская государственная фармацевтическая академия | Method of preparing medicinal form with anti-inflammatory symptomatic effect |
| RU2248797C1 (en) * | 2004-02-09 | 2005-03-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Antitubercular pharmaceutical composition |
-
2008
- 2008-12-03 RU RU2008147739/15A patent/RU2417087C2/en active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102344412A (en) * | 2010-07-30 | 2012-02-08 | 重庆华邦胜凯制药有限公司 | Preparation method of isoniazid para-aminosalicylate |
| CN102344412B (en) * | 2010-07-30 | 2015-11-25 | 重庆华邦胜凯制药有限公司 | A kind of preparation method of isoniazid para-aminosalicylate |
| PL446974A1 (en) * | 2023-12-04 | 2025-06-09 | Politechnika Śląska | Method of producing micellar ionic conjugates based on graft polymers for co-delivery of anti-tuberculosis drugs and their use |
| PL446972A1 (en) * | 2023-12-04 | 2025-06-09 | Politechnika Śląska | Method of producing micellar ionic conjugates based on linear polymers for co-delivery of antituberculosis drugs and their use |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2417087C2 (en) | 2011-04-27 |
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