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RU2006104035A - SOLID MEDICINAL FORM OF DIINDOLYLMETHANE FOR THE TREATMENT OF NEOPLASTIC DISEASES - Google Patents

SOLID MEDICINAL FORM OF DIINDOLYLMETHANE FOR THE TREATMENT OF NEOPLASTIC DISEASES Download PDF

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Publication number
RU2006104035A
RU2006104035A RU2006104035/15A RU2006104035A RU2006104035A RU 2006104035 A RU2006104035 A RU 2006104035A RU 2006104035/15 A RU2006104035/15 A RU 2006104035/15A RU 2006104035 A RU2006104035 A RU 2006104035A RU 2006104035 A RU2006104035 A RU 2006104035A
Authority
RU
Russia
Prior art keywords
diindolylmethane
enteric coating
poloxamer
antioxidant
treatment
Prior art date
Application number
RU2006104035/15A
Other languages
Russian (ru)
Other versions
RU2318509C2 (en
Inventor
Всеволод Иванович Киселев (RU)
Всеволод Иванович Киселев
Original Assignee
Всеволод Иванович Киселев (RU)
Всеволод Иванович Киселев
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Всеволод Иванович Киселев (RU), Всеволод Иванович Киселев filed Critical Всеволод Иванович Киселев (RU)
Priority to RU2006104035/15A priority Critical patent/RU2318509C2/en
Publication of RU2006104035A publication Critical patent/RU2006104035A/en
Application granted granted Critical
Publication of RU2318509C2 publication Critical patent/RU2318509C2/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

1. Средство, ингибирующее неопластические процессы в виде твердой лекарственной формы, представляющее собой таблетку, состоящую из ядра, содержащего дииндолилметан в качестве действующего вещества, связующее, антиоксидант, разрыхлитель, смазывающее, наполнитель, стабилизатор, выбранный из группы: поливинилпирролидон, кроскармелоза, альгинат натрия, глицерофосфат кальция или их смеси, полоксамер, и кишечнорастворимого покрытия, при следующем содержании компонентов, г:1. An agent that inhibits neoplastic processes in the form of a solid dosage form, which is a tablet consisting of a core containing diindolylmethane as an active substance, a binder, an antioxidant, a disintegrant, a lubricant, a filler, a stabilizer selected from the group: polyvinylpyrrolidone, croscarmellose, sodium alginate calcium glycerophosphate or mixtures thereof, poloxamer, and enteric coating, with the following components, g: ДииндолилметанDiindolylmethane 0,05-0,20.05-0.2 СвязующееBinder 0,01-0,020.01-0.02 АнтиоксидантAntioxidant 0,0001-0,0030.0001-0.003 РазрыхлительBaking powder 0,01-0,040.01-0.04 НаполнительFiller 0,05-0,30.05-0.3 СмазывающееLubricating 0,001-0,0030.001-0.003 СтабилизаторStabilizer 0,003-0,020.003-0.02 ПолоксамерPoloxamer 0,006-0,010.006-0.01 Кишечнорастворимое покрытиеEnteric coating 0,03-0,050.03-0.05
2. Лекарственная форма по п.1, отличающаяся тем, что в качестве кишечно-растворимого покрытия она содержит покрытие, содержащее, %:2. The dosage form according to claim 1, characterized in that as an enteric coating, it contains a coating containing,%: Сополимер метакриловой кислоты сMethacrylic Acid Copolymer   этилакрилатом 1:1ethyl acrylate 1: 1 4040 Двуокись титанаTitanium dioxide 15fifteen ТалькTalc 37,2537.25 ТриэтилацетатTriethyl acetate 4,84.8 Кремния оксид коллоидный безводныйSilicon Colloidal Anhydrous Oxide 1,251.25 Натрия гидрокарбонатSodium bicarbonate 1,21,2 Натрия лаурилсульфатSodium Lauryl Sulfate 0,50.5
RU2006104035/15A 2006-02-10 2006-02-10 Diindolylmethane solid medicinal formulation for treatment of neoplastic disease RU2318509C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2006104035/15A RU2318509C2 (en) 2006-02-10 2006-02-10 Diindolylmethane solid medicinal formulation for treatment of neoplastic disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2006104035/15A RU2318509C2 (en) 2006-02-10 2006-02-10 Diindolylmethane solid medicinal formulation for treatment of neoplastic disease

Publications (2)

Publication Number Publication Date
RU2006104035A true RU2006104035A (en) 2007-08-27
RU2318509C2 RU2318509C2 (en) 2008-03-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006104035/15A RU2318509C2 (en) 2006-02-10 2006-02-10 Diindolylmethane solid medicinal formulation for treatment of neoplastic disease

Country Status (1)

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RU (1) RU2318509C2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2409363C9 (en) 2009-09-18 2013-12-10 Всеволод Иванович Киселев Pharmaceutical compositions for peroral delivery of diindolylmethane (dim) and methods for application of these compositions
RU2419426C1 (en) * 2010-04-26 2011-05-27 Всеволод Иванович Киселев Diindolylmethane (dim)-based medication with increased bioaccessebility and its application in treatment of human hyperplastic and inflammatory diseases
RU2537025C1 (en) * 2013-05-28 2014-12-27 Всеволод Иванович Киселев Diindolylmethane drug preparation and using it for treating influenza and respiratory viral infections
RU2601893C1 (en) * 2015-11-30 2016-11-10 Всеволод Иванович Киселев Drug preparation based on indole-3-carbinol with increased epigenetic activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5838494A (en) * 1993-01-14 1994-08-15 Cancer Research Campaign Technology Limited Potentiation of temozolomide in human tumour cells
RU2102079C1 (en) * 1996-11-11 1998-01-20 Юрий Александрович Страхов Method of treatment of uterus myoma
US6001868A (en) * 1997-05-30 1999-12-14 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
US6544564B1 (en) * 2001-11-27 2003-04-08 Michael Donald Farley Cytotoxic pharmaceutical composition

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Publication number Publication date
RU2318509C2 (en) 2008-03-10

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Legal Events

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PC41 Official registration of the transfer of exclusive right

Effective date: 20180907

RH4A Copy of patent granted that was duplicated for the russian federation

Effective date: 20190606