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PT871656E - Derivados de dolastatina sua preparacao e utilizacao - Google Patents

Derivados de dolastatina sua preparacao e utilizacao

Info

Publication number
PT871656E
PT871656E PT96918661T PT96918661T PT871656E PT 871656 E PT871656 E PT 871656E PT 96918661 T PT96918661 T PT 96918661T PT 96918661 T PT96918661 T PT 96918661T PT 871656 E PT871656 E PT 871656E
Authority
PT
Portugal
Prior art keywords
utilization
preparation
dolastatin derivatives
dolastatin
derivatives
Prior art date
Application number
PT96918661T
Other languages
English (en)
Inventor
Franz Emling
Andreas Haupt
Cynthia A Romerdahl
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of PT871656E publication Critical patent/PT871656E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT96918661T 1995-06-07 1996-06-03 Derivados de dolastatina sua preparacao e utilizacao PT871656E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/472,453 US5831002A (en) 1992-05-20 1995-06-07 Antitumor peptides

Publications (1)

Publication Number Publication Date
PT871656E true PT871656E (pt) 2002-12-31

Family

ID=23875567

Family Applications (2)

Application Number Title Priority Date Filing Date
PT96918660T PT832104E (pt) 1995-06-07 1996-06-03 Derivados de dolastatina sua preparacao e utilizacao
PT96918661T PT871656E (pt) 1995-06-07 1996-06-03 Derivados de dolastatina sua preparacao e utilizacao

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT96918660T PT832104E (pt) 1995-06-07 1996-06-03 Derivados de dolastatina sua preparacao e utilizacao

Country Status (33)

Country Link
US (1) US5831002A (pt)
EP (2) EP0832104B1 (pt)
JP (2) JP4221062B2 (pt)
KR (2) KR100437985B1 (pt)
CN (2) CN1182153C (pt)
AR (2) AR003136A1 (pt)
AT (2) ATE223431T1 (pt)
AU (2) AU725164B2 (pt)
BG (2) BG102125A (pt)
BR (2) BR9609423A (pt)
CA (2) CA2219819C (pt)
CO (2) CO4700526A1 (pt)
CZ (2) CZ293683B6 (pt)
DE (2) DE69623472T2 (pt)
DK (2) DK0832104T3 (pt)
ES (2) ES2186783T3 (pt)
HR (2) HRP960277A2 (pt)
HU (2) HU228071B1 (pt)
IL (2) IL122215A (pt)
MX (2) MX9709147A (pt)
MY (2) MY119042A (pt)
NO (2) NO318384B1 (pt)
NZ (2) NZ310444A (pt)
PL (2) PL185763B1 (pt)
PT (2) PT832104E (pt)
RO (2) RO118953B1 (pt)
SI (2) SI0832104T1 (pt)
SK (1) SK282466B6 (pt)
TR (2) TR199701545T1 (pt)
TW (2) TW508357B (pt)
UA (2) UA46775C2 (pt)
WO (2) WO1996040751A1 (pt)
ZA (2) ZA964711B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN100350036C (zh) 2001-04-27 2007-11-21 宝洁公司 用于控制生物膜的装置和方法
WO2003051835A2 (en) * 2001-12-18 2003-06-26 Proteologics, Inc. Methods and compositions for the inhibition of viral release
AU2003224644A1 (en) * 2002-02-27 2003-09-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
AU2006283677A1 (en) * 2005-08-19 2007-03-01 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Topical formulations of histone deacetylase inhibitors and methods of using the same
WO2007043048A2 (en) * 2005-10-11 2007-04-19 Ramot At Tel Aviv University Ltd. Self-assembled fmoc-ff hydrogels
SG171682A1 (en) 2006-05-16 2011-06-29 Aegera Therapeutics Inc Iap bir domain binding compounds
US8143426B2 (en) * 2006-07-24 2012-03-27 Tetralogic Pharmaceuticals Corporation IAP inhibitors
CN101674835B (zh) 2007-04-12 2013-12-11 台湾神隆股份有限公司 制备加兰他敏的方法
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
US8937041B2 (en) 2010-12-30 2015-01-20 Abbvie, Inc. Macrocyclic hepatitis C serine protease inhibitors
SG191759A1 (en) 2010-12-30 2013-08-30 Enanta Pharm Inc Phenanthridine macrocyclic hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
KR102356286B1 (ko) * 2011-05-27 2022-02-08 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
KR20240051956A (ko) 2021-09-03 2024-04-22 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
CA2115355C (en) * 1991-08-09 2007-09-11 Kyoichi Sakakibara Novel tetrapeptide derivative
KR100286242B1 (ko) * 1992-05-20 2001-04-16 스타르크, 카르크 돌라스타틴 유도체
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters

Also Published As

Publication number Publication date
CA2219819A1 (en) 1996-12-19
PL185763B1 (pl) 2003-07-31
CZ293682B6 (cs) 2004-07-14
CA2219819C (en) 2008-05-20
KR19990022582A (ko) 1999-03-25
CA2219818A1 (en) 1996-12-19
CZ376597A3 (cs) 1998-06-17
HUP9801910A3 (en) 1999-06-28
EP0832104A1 (en) 1998-04-01
ES2186783T3 (es) 2003-05-16
TW424096B (en) 2001-03-01
CN1182154C (zh) 2004-12-29
BR9609424A (pt) 2000-03-28
DE69623992D1 (de) 2002-10-31
NO975711L (no) 1998-01-30
IL122215A0 (en) 1998-04-05
US5831002A (en) 1998-11-03
MX9709147A (es) 1998-03-31
IL122216A0 (en) 1998-04-05
NO975710D0 (no) 1997-12-05
CZ376397A3 (cs) 1998-06-17
JP4221062B2 (ja) 2009-02-12
EP0832104B1 (en) 2002-09-04
RO119783B1 (ro) 2005-03-30
EP0871656A1 (en) 1998-10-21
DE69623992T2 (de) 2003-05-22
WO1996040751A1 (en) 1996-12-19
AU725170B2 (en) 2000-10-05
JP3957751B2 (ja) 2007-08-15
NO317670B1 (no) 2004-11-29
AR003136A1 (es) 1998-07-08
DK0871656T3 (da) 2003-01-27
RO118953B1 (ro) 2004-01-30
JPH11504652A (ja) 1999-04-27
PL185762B1 (pl) 2003-07-31
BR9609423A (pt) 1999-06-29
SI0832104T1 (en) 2003-08-31
MY124487A (en) 2006-06-30
TW508357B (en) 2002-11-01
WO1996040752A1 (en) 1996-12-19
CN1182153C (zh) 2004-12-29
CN1187198A (zh) 1998-07-08
DK0832104T3 (da) 2003-01-06
SK282466B6 (sk) 2002-02-05
CN1187199A (zh) 1998-07-08
ATE223431T1 (de) 2002-09-15
BG102152A (en) 1998-09-30
KR100437985B1 (ko) 2004-09-18
JPH11504653A (ja) 1999-04-27
CO4700526A1 (es) 1998-12-29
IL122215A (en) 2001-08-26
PL323726A1 (en) 1998-04-14
MX9709146A (es) 1998-03-31
HUP9801817A3 (en) 1999-06-28
HRP960277A2 (en) 1997-10-31
TR199701544T1 (xx) 1998-03-21
NZ310443A (en) 1999-10-28
ZA964711B (en) 1997-12-08
ES2188759T3 (es) 2003-07-01
EP0871656B1 (en) 2002-09-25
AU6124196A (en) 1996-12-30
AR003427A1 (es) 1998-08-05
CZ293683B6 (cs) 2004-07-14
BG102125A (en) 1998-09-30
NO975711D0 (no) 1997-12-05
UA46775C2 (uk) 2002-06-17
HU228071B1 (hu) 2012-09-28
CA2219818C (en) 2008-05-20
IL122216A (en) 2002-02-10
HRP960257A2 (en) 1998-02-28
KR19990022583A (ko) 1999-03-25
HU228073B1 (hu) 2012-09-28
DE69623472D1 (de) 2002-10-10
NO318384B1 (no) 2005-03-14
SK165397A3 (en) 1998-10-07
ZA964710B (en) 1997-12-08
KR100437986B1 (ko) 2004-09-18
NO975710L (no) 1998-02-02
AU6124296A (en) 1996-12-30
NZ310444A (en) 1999-11-29
UA46776C2 (uk) 2002-06-17
AU725164B2 (en) 2000-10-05
ATE224910T1 (de) 2002-10-15
DE69623472T2 (de) 2003-08-21
MY119042A (en) 2005-03-31
HUP9801817A2 (hu) 1998-11-30
TR199701545T1 (xx) 1998-04-21
PL323723A1 (en) 1998-04-14
SI0871656T1 (en) 2003-08-31
CO4700527A1 (es) 1998-12-29
HUP9801910A2 (hu) 1999-01-28
PT832104E (pt) 2002-12-31

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