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BG102152A - New dolastine derivatives, their preparation and application - Google Patents

New dolastine derivatives, their preparation and application

Info

Publication number
BG102152A
BG102152A BG102152A BG10215297A BG102152A BG 102152 A BG102152 A BG 102152A BG 102152 A BG102152 A BG 102152A BG 10215297 A BG10215297 A BG 10215297A BG 102152 A BG102152 A BG 102152A
Authority
BG
Bulgaria
Prior art keywords
dolastine
derivatives
preparation
new
application
Prior art date
Application number
BG102152A
Other languages
Bulgarian (bg)
English (en)
Inventor
Andreas Haupt
Franz Emling
Cynthia Romerdahl
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG102152A publication Critical patent/BG102152A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG102152A 1995-06-07 1997-12-29 New dolastine derivatives, their preparation and application BG102152A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,453 US5831002A (en) 1992-05-20 1995-06-07 Antitumor peptides
PCT/EP1996/002393 WO1996040752A1 (en) 1995-06-07 1996-06-03 Novel dolastatin derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
BG102152A true BG102152A (en) 1998-09-30

Family

ID=23875567

Family Applications (2)

Application Number Title Priority Date Filing Date
BG102125A BG102125A (en) 1995-06-07 1997-12-18 New dolastine derivatives, their preparation and application
BG102152A BG102152A (en) 1995-06-07 1997-12-29 New dolastine derivatives, their preparation and application

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG102125A BG102125A (en) 1995-06-07 1997-12-18 New dolastine derivatives, their preparation and application

Country Status (33)

Country Link
US (1) US5831002A (xx)
EP (2) EP0871656B1 (xx)
JP (2) JP4221062B2 (xx)
KR (2) KR100437985B1 (xx)
CN (2) CN1182153C (xx)
AR (2) AR003136A1 (xx)
AT (2) ATE224910T1 (xx)
AU (2) AU725170B2 (xx)
BG (2) BG102125A (xx)
BR (2) BR9609423A (xx)
CA (2) CA2219819C (xx)
CO (2) CO4700526A1 (xx)
CZ (2) CZ293682B6 (xx)
DE (2) DE69623992T2 (xx)
DK (2) DK0832104T3 (xx)
ES (2) ES2188759T3 (xx)
HR (2) HRP960277A2 (xx)
HU (2) HU228073B1 (xx)
IL (2) IL122215A (xx)
MX (2) MX9709146A (xx)
MY (2) MY119042A (xx)
NO (2) NO318384B1 (xx)
NZ (2) NZ310444A (xx)
PL (2) PL185763B1 (xx)
PT (2) PT871656E (xx)
RO (2) RO119783B1 (xx)
SI (2) SI0871656T1 (xx)
SK (1) SK282466B6 (xx)
TR (2) TR199701544T1 (xx)
TW (2) TW508357B (xx)
UA (2) UA46775C2 (xx)
WO (2) WO1996040752A1 (xx)
ZA (2) ZA964710B (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JP2004528356A (ja) 2001-04-27 2004-09-16 ザ プロクター アンド ギャンブル カンパニー バイオフィルムを制御する化合物、組成物、及び方法
AU2002359792A1 (en) * 2001-12-18 2003-06-30 Proteologics, Inc. Methods and compositions for the inhibition of viral release
WO2003072754A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
EP1781310B1 (en) 2004-08-02 2015-10-14 Ramot at Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
WO2007024574A2 (en) * 2005-08-19 2007-03-01 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Topical formulations of histone deacetylase inhibitors and methods of using the same
EP1973928A2 (en) * 2005-10-11 2008-10-01 Ramot at Tel-Aviv University Ltd. Self-assembled fmoc-ff hydrogels
SG10201407457UA (en) 2006-05-16 2014-12-30 Pharmascience Inc Iap bir domain binding compounds
AR064235A1 (es) * 2006-07-24 2009-03-25 Tetralogic Pharmaceuticals Cor Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer
NZ580271A (en) * 2007-04-12 2011-03-31 Scinopharm Taiwan Ltd Process for making galantamine
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
WO2012092409A2 (en) 2010-12-30 2012-07-05 Enanta Phararmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
CA2821340A1 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc. Phenanthridine macrocyclic hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
EP2714684B1 (en) * 2011-05-27 2018-09-05 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
US20250281630A1 (en) 2021-09-03 2025-09-11 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
EP0934950B1 (en) * 1991-08-09 2002-04-10 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptide derivative
JP3523253B2 (ja) * 1992-05-20 2004-04-26 アボット ゲーエムベーハー ウント カンパニー カーゲー ドラスタチン誘導体
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters

Also Published As

Publication number Publication date
KR19990022582A (ko) 1999-03-25
CN1187198A (zh) 1998-07-08
DK0832104T3 (da) 2003-01-06
MX9709147A (es) 1998-03-31
ATE223431T1 (de) 2002-09-15
ES2188759T3 (es) 2003-07-01
ES2186783T3 (es) 2003-05-16
CZ376397A3 (cs) 1998-06-17
SI0871656T1 (en) 2003-08-31
CO4700526A1 (es) 1998-12-29
HUP9801910A2 (hu) 1999-01-28
NO975711L (no) 1998-01-30
DE69623472D1 (de) 2002-10-10
EP0871656B1 (en) 2002-09-25
HUP9801817A2 (hu) 1998-11-30
PT871656E (pt) 2002-12-31
CA2219819A1 (en) 1996-12-19
DE69623992D1 (de) 2002-10-31
BG102125A (en) 1998-09-30
NO975710L (no) 1998-02-02
TR199701544T1 (xx) 1998-03-21
PL323726A1 (en) 1998-04-14
PL185763B1 (pl) 2003-07-31
CA2219818A1 (en) 1996-12-19
JPH11504653A (ja) 1999-04-27
KR100437986B1 (ko) 2004-09-18
DE69623992T2 (de) 2003-05-22
IL122216A0 (en) 1998-04-05
AR003427A1 (es) 1998-08-05
CZ293682B6 (cs) 2004-07-14
WO1996040751A1 (en) 1996-12-19
BR9609424A (pt) 2000-03-28
CN1182154C (zh) 2004-12-29
JP3957751B2 (ja) 2007-08-15
CZ376597A3 (cs) 1998-06-17
PL323723A1 (en) 1998-04-14
AU725164B2 (en) 2000-10-05
DK0871656T3 (da) 2003-01-27
HUP9801910A3 (en) 1999-06-28
CO4700527A1 (es) 1998-12-29
UA46776C2 (uk) 2002-06-17
TW424096B (en) 2001-03-01
PT832104E (pt) 2002-12-31
NO975710D0 (no) 1997-12-05
AU6124196A (en) 1996-12-30
JPH11504652A (ja) 1999-04-27
AR003136A1 (es) 1998-07-08
CA2219819C (en) 2008-05-20
TW508357B (en) 2002-11-01
ATE224910T1 (de) 2002-10-15
MX9709146A (es) 1998-03-31
SI0832104T1 (en) 2003-08-31
HRP960257A2 (en) 1998-02-28
ZA964710B (en) 1997-12-08
EP0832104A1 (en) 1998-04-01
IL122215A (en) 2001-08-26
NO318384B1 (no) 2005-03-14
RO119783B1 (ro) 2005-03-30
KR19990022583A (ko) 1999-03-25
RO118953B1 (ro) 2004-01-30
EP0871656A1 (en) 1998-10-21
KR100437985B1 (ko) 2004-09-18
UA46775C2 (uk) 2002-06-17
JP4221062B2 (ja) 2009-02-12
CN1182153C (zh) 2004-12-29
NO975711D0 (no) 1997-12-05
IL122215A0 (en) 1998-04-05
NO317670B1 (no) 2004-11-29
IL122216A (en) 2002-02-10
MY124487A (en) 2006-06-30
WO1996040752A1 (en) 1996-12-19
HU228071B1 (hu) 2012-09-28
AU6124296A (en) 1996-12-30
US5831002A (en) 1998-11-03
AU725170B2 (en) 2000-10-05
PL185762B1 (pl) 2003-07-31
SK165397A3 (en) 1998-10-07
EP0832104B1 (en) 2002-09-04
HRP960277A2 (en) 1997-10-31
NZ310443A (en) 1999-10-28
CZ293683B6 (cs) 2004-07-14
CA2219818C (en) 2008-05-20
ZA964711B (en) 1997-12-08
TR199701545T1 (xx) 1998-04-21
BR9609423A (pt) 1999-06-29
MY119042A (en) 2005-03-31
HU228073B1 (hu) 2012-09-28
HUP9801817A3 (en) 1999-06-28
CN1187199A (zh) 1998-07-08
DE69623472T2 (de) 2003-08-21
SK282466B6 (sk) 2002-02-05
NZ310444A (en) 1999-11-29

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