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PT796848E - Antagonistas de bradiquinina heterociclicos substituidos com fluoroalquilo ou fluoroalcoxilo - Google Patents

Antagonistas de bradiquinina heterociclicos substituidos com fluoroalquilo ou fluoroalcoxilo

Info

Publication number
PT796848E
PT796848E PT97103611T PT97103611T PT796848E PT 796848 E PT796848 E PT 796848E PT 97103611 T PT97103611 T PT 97103611T PT 97103611 T PT97103611 T PT 97103611T PT 796848 E PT796848 E PT 796848E
Authority
PT
Portugal
Prior art keywords
fluoroalcoxyl
bradiquinine
fluoroalkyl
antagonists
heterocyclics
Prior art date
Application number
PT97103611T
Other languages
English (en)
Inventor
Adalbert Wagner
Holger Heitsch
Klaus Wirth
Gerhard Nolkne
Prof Dr Bernard
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT796848E publication Critical patent/PT796848E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D257/12Six-membered rings having four nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT97103611T 1996-03-19 1997-03-05 Antagonistas de bradiquinina heterociclicos substituidos com fluoroalquilo ou fluoroalcoxilo PT796848E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19610784A DE19610784A1 (de) 1996-03-19 1996-03-19 Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
PT796848E true PT796848E (pt) 2003-08-29

Family

ID=7788755

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97103611T PT796848E (pt) 1996-03-19 1997-03-05 Antagonistas de bradiquinina heterociclicos substituidos com fluoroalquilo ou fluoroalcoxilo

Country Status (24)

Country Link
US (1) US5859025A (pt)
EP (1) EP0796848B1 (pt)
JP (1) JP4199315B2 (pt)
KR (1) KR970065522A (pt)
AR (1) AR006261A1 (pt)
AT (1) ATE242215T1 (pt)
AU (1) AU1628397A (pt)
BR (1) BR9701332A (pt)
CA (1) CA2199925A1 (pt)
CZ (1) CZ81097A3 (pt)
DE (2) DE19610784A1 (pt)
DK (1) DK0796848T3 (pt)
ES (1) ES2196207T3 (pt)
HR (1) HRP970155A2 (pt)
HU (1) HUP9700595A1 (pt)
ID (1) ID16274A (pt)
IL (1) IL120477A0 (pt)
NO (1) NO971238L (pt)
PL (1) PL318924A1 (pt)
PT (1) PT796848E (pt)
SI (1) SI0796848T1 (pt)
SK (1) SK34897A3 (pt)
TR (1) TR199700206A2 (pt)
ZA (1) ZA972328B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712960A1 (de) * 1997-03-27 1998-10-01 Hoechst Ag Benzyloxy-substituierte, anellierte N-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Bradykininrezeptorantagonisten
PT1106614E (pt) * 1999-12-10 2004-04-30 Pfizer Compostos de 1,4-dihidropiridina substituidos com heteroarilos de 5 membros como antagonistas de bradiquinina
JP2005525398A (ja) * 2002-04-10 2005-08-25 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ブラジキニン受容体モジュレーターとして有用な新規なヘテロアリールアルキルアミド誘導体
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
US7256207B2 (en) 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
BRPI0607404A2 (pt) 2005-03-01 2009-09-01 Wyeth Corp compostos de cinolina e seu uso como moduladores de receptor de x hepático
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽b2受體調節劑
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden
SMT202200154T1 (it) 2017-11-24 2022-05-12 Pharvaris Netherlands B V Nuovi antagonisti del recettore della bradichinina b2
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
UY38707A (es) 2019-05-23 2020-12-31 Pharvaris Gmbh Nuevos antagonistas cíclicos del receptor b2 de bradiquinina
JP2024528195A (ja) 2021-08-05 2024-07-26 ファルバリス ゲーエムベーハー ブラジキニンb2受容体拮抗薬を経口投与するための脂質ベースの組成物
EP4499038B1 (en) 2022-03-25 2025-12-03 Pharvaris GmbH Solid composition comprising solubilised bradykinin b2-receptor antagonists
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽b2受體拮抗劑之固態延長釋放組成物
US20250268887A1 (en) 2022-03-25 2025-08-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212182A (en) * 1990-10-03 1993-05-18 American Home Products Corpooration Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5438064A (en) * 1991-12-23 1995-08-01 American Home Products Corporation Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
WO1996005202A1 (en) * 1994-08-17 1996-02-22 Nippon Hypox Laboratories Inc. Imidazoquinoline derivative
WO1996013485A1 (en) * 1994-10-27 1996-05-09 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused n-heretocycles as bradykinin antagonists

Also Published As

Publication number Publication date
HUP9700595A1 (hu) 2000-08-28
HRP970155A2 (en) 1998-04-30
EP0796848A1 (de) 1997-09-24
KR970065522A (ko) 1997-10-13
CA2199925A1 (en) 1997-09-19
JPH107656A (ja) 1998-01-13
HU9700595D0 (en) 1997-05-28
US5859025A (en) 1999-01-12
TR199700206A2 (xx) 1997-10-21
CZ81097A3 (en) 1997-10-15
ATE242215T1 (de) 2003-06-15
MX9702028A (es) 1997-09-30
DE59710191D1 (de) 2003-07-10
BR9701332A (pt) 1998-08-18
DE19610784A1 (de) 1997-09-25
SI0796848T1 (en) 2003-12-31
ES2196207T3 (es) 2003-12-16
AU1628397A (en) 1997-09-25
JP4199315B2 (ja) 2008-12-17
NO971238L (no) 1997-09-22
PL318924A1 (en) 1997-09-29
DK0796848T3 (da) 2003-09-22
ZA972328B (en) 1997-09-19
NO971238D0 (no) 1997-03-18
IL120477A0 (en) 1997-07-13
EP0796848B1 (de) 2003-06-04
SK34897A3 (en) 1998-01-14
AR006261A1 (es) 1999-08-11
ID16274A (id) 1997-09-18

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