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PT754176E - Novos carbamatos e ureias como modificadores da resistencia a multiplas drogas - Google Patents

Novos carbamatos e ureias como modificadores da resistencia a multiplas drogas

Info

Publication number
PT754176E
PT754176E PT95914866T PT95914866T PT754176E PT 754176 E PT754176 E PT 754176E PT 95914866 T PT95914866 T PT 95914866T PT 95914866 T PT95914866 T PT 95914866T PT 754176 E PT754176 E PT 754176E
Authority
PT
Portugal
Prior art keywords
resistance
ureias
modifiers
compounds
multiple drugs
Prior art date
Application number
PT95914866T
Other languages
English (en)
Inventor
Robert Edward Zelle
Matthew W Harding
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT754176E publication Critical patent/PT754176E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT95914866T 1994-03-25 1995-03-23 Novos carbamatos e ureias como modificadores da resistencia a multiplas drogas PT754176E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21812094A 1994-03-25 1994-03-25
US08/377,283 US5744485A (en) 1994-03-25 1995-01-23 Carbamates and ureas as modifiers of multi-drug resistance

Publications (1)

Publication Number Publication Date
PT754176E true PT754176E (pt) 2002-05-31

Family

ID=26912595

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95914866T PT754176E (pt) 1994-03-25 1995-03-23 Novos carbamatos e ureias como modificadores da resistencia a multiplas drogas

Country Status (12)

Country Link
US (1) US5744485A (pt)
EP (2) EP0754176B1 (pt)
JP (1) JP4421680B2 (pt)
AT (2) ATE210119T1 (pt)
AU (1) AU704475B2 (pt)
CA (1) CA2186380C (pt)
DE (2) DE69524400T2 (pt)
DK (1) DK0754176T3 (pt)
ES (2) ES2169127T3 (pt)
NZ (1) NZ283599A (pt)
PT (1) PT754176E (pt)
WO (1) WO1995026337A1 (pt)

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US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
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US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
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US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
EP1084106A1 (en) 1998-06-03 2001-03-21 GPI NIL Holdings, Inc. N-linked sulfonamides of heterocyclic carboxylic acids or carboxylic acid isosteres
EP1082301A1 (en) * 1998-06-03 2001-03-14 GPI NIL Holdings, Inc. Ureas and carbamates of n-heterocyclic carboxylic acids and carboxylic acid isosteres
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
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US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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Also Published As

Publication number Publication date
WO1995026337A1 (en) 1995-10-05
MX9604305A (es) 1997-12-31
CA2186380C (en) 2008-12-02
DE69535805D1 (de) 2008-09-18
AU2194395A (en) 1995-10-17
ATE210119T1 (de) 2001-12-15
EP0754176B1 (en) 2001-12-05
DK0754176T3 (da) 2002-04-02
ES2311491T3 (es) 2009-02-16
ES2169127T3 (es) 2002-07-01
HK1013993A1 (en) 1999-09-17
AU704475B2 (en) 1999-04-22
EP1138673A2 (en) 2001-10-04
JP4421680B2 (ja) 2010-02-24
EP0754176A1 (en) 1997-01-22
DE69524400T2 (de) 2002-08-22
DE69524400D1 (de) 2002-01-17
CA2186380A1 (en) 1995-10-05
US5744485A (en) 1998-04-28
EP1138673B1 (en) 2008-08-06
NZ283599A (en) 1998-06-26
EP1138673A3 (en) 2001-10-17
JPH09510974A (ja) 1997-11-04
ATE403430T1 (de) 2008-08-15

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