MX9604305A - Novedosos carbamatos y ureas como modificadores a la resistencia a multiples drogas. - Google Patents
Novedosos carbamatos y ureas como modificadores a la resistencia a multiples drogas.Info
- Publication number
- MX9604305A MX9604305A MX9604305A MX9604305A MX9604305A MX 9604305 A MX9604305 A MX 9604305A MX 9604305 A MX9604305 A MX 9604305A MX 9604305 A MX9604305 A MX 9604305A MX 9604305 A MX9604305 A MX 9604305A
- Authority
- MX
- Mexico
- Prior art keywords
- drug resistance
- ureas
- modifiers
- compounds
- novel carbamates
- Prior art date
Links
- 230000036457 multidrug resistance Effects 0.000 title abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- 239000003607 modifier Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se relaciona con compuestos que pueden mantener, aumentar o restituir la sensibilidad de las células a los agentes terapéuticos o profilácticos. La presente invencion también se relaciona con composiciones farmacéuticas que constan de estos compuestos. Los compuestos y las composiciones farmacéuticas de la presente invencion son particularmente bien adecuados para el tratamiento e células resistentes a drogas multiples, para la prevencion del desarrollo de la resistencia a las drogas multiples, y para su utilizacion en terapias contra el cáncer resistente a drogas multiples.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21812094A | 1994-03-25 | 1994-03-25 | |
| US218,120 | 1994-03-25 | ||
| US218120 | 1994-03-25 | ||
| US08377283 | 1995-01-23 | ||
| US08/377,283 US5744485A (en) | 1994-03-25 | 1995-01-23 | Carbamates and ureas as modifiers of multi-drug resistance |
| PCT/US1995/003716 WO1995026337A1 (en) | 1994-03-25 | 1995-03-23 | Novel carbamates and ureas as modifiers of multi-drug resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9604305A true MX9604305A (es) | 1997-12-31 |
| MXPA96004305A MXPA96004305A (es) | 1998-09-18 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995026337A1 (en) | 1995-10-05 |
| CA2186380C (en) | 2008-12-02 |
| DE69535805D1 (de) | 2008-09-18 |
| AU2194395A (en) | 1995-10-17 |
| ATE210119T1 (de) | 2001-12-15 |
| EP0754176B1 (en) | 2001-12-05 |
| DK0754176T3 (da) | 2002-04-02 |
| ES2311491T3 (es) | 2009-02-16 |
| ES2169127T3 (es) | 2002-07-01 |
| HK1013993A1 (en) | 1999-09-17 |
| AU704475B2 (en) | 1999-04-22 |
| EP1138673A2 (en) | 2001-10-04 |
| JP4421680B2 (ja) | 2010-02-24 |
| EP0754176A1 (en) | 1997-01-22 |
| DE69524400T2 (de) | 2002-08-22 |
| PT754176E (pt) | 2002-05-31 |
| DE69524400D1 (de) | 2002-01-17 |
| CA2186380A1 (en) | 1995-10-05 |
| US5744485A (en) | 1998-04-28 |
| EP1138673B1 (en) | 2008-08-06 |
| NZ283599A (en) | 1998-06-26 |
| EP1138673A3 (en) | 2001-10-17 |
| JPH09510974A (ja) | 1997-11-04 |
| ATE403430T1 (de) | 2008-08-15 |
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