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TR200002851T2 - MRP1'i inhibe etmek için yöntemler. - Google Patents

MRP1'i inhibe etmek için yöntemler.

Info

Publication number
TR200002851T2
TR200002851T2 TR2000/02851T TR200002851T TR200002851T2 TR 200002851 T2 TR200002851 T2 TR 200002851T2 TR 2000/02851 T TR2000/02851 T TR 2000/02851T TR 200002851 T TR200002851 T TR 200002851T TR 200002851 T2 TR200002851 T2 TR 200002851T2
Authority
TR
Turkey
Prior art keywords
methods
mrp1
inhibit
inhibit mrp1
useful
Prior art date
Application number
TR2000/02851T
Other languages
English (en)
Inventor
Michael Gruber Joseph
Hurst Norman Bryan
Stanley Kroin Julian
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200002851T2 publication Critical patent/TR200002851T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Control Of The Air-Fuel Ratio Of Carburetors (AREA)
  • Magnetically Actuated Valves (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Bu bulus direncin kismen veya tamamen MRP1 tarafindan verildigi, dirençli neoplazmalari inhibe etmek için yararli olan bir formül (I) bilesigine iliskindir.
TR2000/02851T 1998-04-08 1999-04-07 MRP1'i inhibe etmek için yöntemler. TR200002851T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8108098P 1998-04-08 1998-04-08

Publications (1)

Publication Number Publication Date
TR200002851T2 true TR200002851T2 (tr) 2000-12-21

Family

ID=22161981

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02851T TR200002851T2 (tr) 1998-04-08 1999-04-07 MRP1'i inhibe etmek için yöntemler.

Country Status (18)

Country Link
US (1) US6369070B1 (tr)
EP (1) EP1067928A4 (tr)
JP (1) JP2002510625A (tr)
KR (1) KR20010042471A (tr)
CN (1) CN1304306A (tr)
AU (1) AU3476999A (tr)
BR (1) BR9910112A (tr)
CA (1) CA2327617A1 (tr)
EA (1) EA200001034A1 (tr)
HR (1) HRP20000646A2 (tr)
HU (1) HUP0101508A3 (tr)
ID (1) ID27364A (tr)
IL (1) IL138389A0 (tr)
NO (1) NO20005023L (tr)
PL (1) PL343313A1 (tr)
SK (1) SK14982000A3 (tr)
TR (1) TR200002851T2 (tr)
WO (1) WO1999051228A1 (tr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027116A2 (en) * 1999-10-07 2001-04-19 Eli Lilly And Company Condensed dihydroquinolinone derivatives for inhibiting mrp1
DE60016039T2 (de) * 1999-12-22 2005-08-11 Eli Lilly And Co., Indianapolis Verfahren und verbindungen für die hemmung von mrp1
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
CA2411813A1 (en) 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
EP1322652A1 (en) * 2000-09-22 2003-07-02 Eli Lilly And Company Stereoselective process for preparing cyclohexyl amine derivatives
CA2442530A1 (en) * 2001-04-09 2002-10-17 Rosanne Bonjouklian Compounds and methods for inhibiting mrp1
US7101891B2 (en) 2001-04-09 2006-09-05 Eli Lilly And Company Compounds and pharmaceutical compositions for inhibiting MRP1
EP1385852B1 (en) 2001-04-09 2005-07-20 Eli Lilly And Company Compounds and methods for inhibiting mrp1
WO2005048953A2 (en) * 2003-11-13 2005-06-02 Ambit Biosciences Corporation Amide derivatives as kinase modulators
BRPI0511099A (pt) * 2004-05-14 2007-12-26 Irm Llc compostos e composições como moduladores de ppar

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588731A (en) * 1985-06-21 1986-05-13 Roussel Uclaf Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5717092A (en) 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Also Published As

Publication number Publication date
SK14982000A3 (sk) 2001-05-10
CN1304306A (zh) 2001-07-18
NO20005023D0 (no) 2000-10-05
KR20010042471A (ko) 2001-05-25
US6369070B1 (en) 2002-04-09
PL343313A1 (en) 2001-08-13
HUP0101508A2 (hu) 2001-10-28
EP1067928A4 (en) 2001-11-14
NO20005023L (no) 2000-12-05
EA200001034A1 (ru) 2001-04-23
EP1067928A1 (en) 2001-01-17
HUP0101508A3 (en) 2002-04-29
CA2327617A1 (en) 1999-10-14
HRP20000646A2 (en) 2001-06-30
BR9910112A (pt) 2000-12-26
ID27364A (id) 2001-04-05
IL138389A0 (en) 2001-10-31
WO1999051228A1 (en) 1999-10-14
AU3476999A (en) 1999-10-25
JP2002510625A (ja) 2002-04-09

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