[go: up one dir, main page]

PT3000813T - Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infeciosas - Google Patents

Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infeciosas

Info

Publication number
PT3000813T
PT3000813T PT151701430T PT15170143T PT3000813T PT 3000813 T PT3000813 T PT 3000813T PT 151701430 T PT151701430 T PT 151701430T PT 15170143 T PT15170143 T PT 15170143T PT 3000813 T PT3000813 T PT 3000813T
Authority
PT
Portugal
Prior art keywords
allergic
inflammatory
treatment
infectious diseases
purine derivatives
Prior art date
Application number
PT151701430T
Other languages
English (en)
Inventor
Biggadike Keith
Qing Lewell Xiao
Mary Coe Diane
Jane Mitchell Charlotte
Allan Smith Stephen
Trivedi Naimisha
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41187189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3000813(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of PT3000813T publication Critical patent/PT3000813T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT151701430T 2008-08-11 2009-08-07 Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infeciosas PT3000813T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8777708P 2008-08-11 2008-08-11

Publications (1)

Publication Number Publication Date
PT3000813T true PT3000813T (pt) 2018-03-05

Family

ID=41187189

Family Applications (2)

Application Number Title Priority Date Filing Date
PT151701430T PT3000813T (pt) 2008-08-11 2009-08-07 Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infeciosas
PT97816060T PT2324026E (pt) 2008-08-11 2009-08-07 Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infecciosas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT97816060T PT2324026E (pt) 2008-08-11 2009-08-07 Derivados de purina para utilização no tratamento de doenças alérgicas, inflamatórias e infecciosas

Country Status (38)

Country Link
US (7) US8765772B2 (pt)
EP (3) EP3000813B1 (pt)
JP (1) JP5529867B2 (pt)
KR (1) KR101669939B1 (pt)
CN (2) CN102177159B (pt)
AU (1) AU2009281197B2 (pt)
BR (1) BRPI0917138A2 (pt)
CA (1) CA2733749C (pt)
CL (1) CL2011000301A1 (pt)
CO (1) CO6351791A2 (pt)
CR (1) CR20110116A (pt)
CY (1) CY1119992T1 (pt)
DK (2) DK3000813T3 (pt)
DO (1) DOP2011000048A (pt)
EA (1) EA020631B1 (pt)
ES (2) ES2549154T3 (pt)
HK (1) HK1253532A1 (pt)
HR (2) HRP20150938T1 (pt)
HU (2) HUE036570T2 (pt)
IL (1) IL210757A (pt)
LT (1) LT3000813T (pt)
MA (1) MA32624B1 (pt)
ME (1) ME02274B (pt)
MX (2) MX336345B (pt)
MY (1) MY162538A (pt)
NO (1) NO3000813T3 (pt)
NZ (2) NZ602812A (pt)
PE (1) PE20110674A1 (pt)
PL (2) PL3000813T3 (pt)
PT (2) PT3000813T (pt)
RS (2) RS56984B1 (pt)
SG (1) SG192547A1 (pt)
SI (2) SI2324026T1 (pt)
SM (2) SMT201800123T1 (pt)
TR (1) TR201802648T4 (pt)
UA (1) UA103195C2 (pt)
WO (1) WO2010018133A1 (pt)
ZA (1) ZA201100845B (pt)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI392678B (zh) * 2004-03-26 2013-04-11 Dainippon Sumitomo Pharma Co 9-取代-8-氧基腺嘌呤化合物
KR20080013886A (ko) * 2005-04-05 2008-02-13 파마코페이아, 인코포레이티드 면역억제용 퓨린 및 이미다조피리딘 유도체
US20090118263A1 (en) * 2005-09-22 2009-05-07 Dainippon Sumitomo Pharma Co., Ltd. Novel Adenine Compound
JP2009542645A (ja) * 2006-07-05 2009-12-03 アストラゼネカ・アクチエボラーグ Tlr7のモジュレーターとして作用する8−オキソアデニン誘導体
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
WO2008101867A1 (en) * 2007-02-19 2008-08-28 Smithkline Beecham Corporation Purine derivatives as immunomodulators
JP5480637B2 (ja) * 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物
ATE530549T1 (de) * 2007-03-19 2011-11-15 Astrazeneca Ab 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
US8044056B2 (en) * 2007-03-20 2011-10-25 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound
PE20081887A1 (es) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Nuevo compuesto de adenina
DK2155743T3 (da) * 2007-05-08 2012-11-05 Astrazeneca Ab Imidazoquinoliner med immunmodulerende egenskaber
MX2009013832A (es) * 2007-06-29 2010-03-10 Gilead Sciences Inc Derivados de purina y su uso como moduladores del receptor 7 similar a un puente.
UY31531A1 (es) 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
WO2009091032A1 (ja) 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co., Ltd. アデニン化合物の製造方法
WO2009091031A1 (ja) * 2008-01-17 2009-07-23 Dainippon Sumitomo Pharma Co., Ltd. アデニン化合物の製造方法
MX2011001663A (es) 2008-08-11 2011-03-24 Glaxosmithkline Llc Derivados novedosos de adenina.
US8802684B2 (en) 2008-08-11 2014-08-12 Glaxosmithkline Llc Adenine derivatives
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
JP5519670B2 (ja) 2008-08-11 2014-06-11 グラクソスミスクライン エルエルシー アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体
NZ612380A (en) 2008-12-09 2015-01-30 Gilead Sciences Inc Modulators of toll-like receptors
CA2762650A1 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
WO2011049825A1 (en) * 2009-10-22 2011-04-28 Gilead Sciences, Inc. Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
EP2507237A1 (en) * 2009-12-03 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
US20110150836A1 (en) * 2009-12-22 2011-06-23 Gilead Sciences, Inc. Methods of treating hbv and hcv infection
PL2534149T3 (pl) * 2010-02-10 2015-03-31 Glaxosmithkline Llc Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu
JP2013519644A (ja) 2010-02-10 2013-05-30 グラクソスミスクライン エルエルシー プリン誘導体およびそれらの薬学的使用
EP2575773A4 (en) 2010-05-26 2014-06-25 Selecta Biosciences Inc SYNTHETIC NANOTRÄGERKOMBINATIONSIMPFSTOFFE
WO2012061717A1 (en) 2010-11-05 2012-05-10 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
CN103370317B (zh) 2010-12-16 2015-10-07 阿斯利康(瑞典)有限公司 可用于治疗的咪唑并[4,5-c]喹啉-1-基衍生物
JP5978226B2 (ja) 2010-12-17 2016-08-24 大日本住友製薬株式会社 プリン誘導体
EA201790045A1 (ru) 2011-04-29 2017-09-29 Селекта Байосайенсиз, Инк. Наноносители, вырабатывающие имунную толерантность, для антиген-специфического удаления т-эффекторных клеток
LT2734186T (lt) * 2011-07-22 2018-12-10 Glaxosmithkline Llc Kompozicija
WO2013019669A2 (en) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
EP2674170B1 (en) 2012-06-15 2014-11-19 Invivogen Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids
WO2014031815A1 (en) 2012-08-24 2014-02-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
EP2732825B1 (en) 2012-11-19 2015-07-01 Invivogen Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist
RS56233B1 (sr) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nova jedinjenja
WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
AU2013348216B2 (en) * 2012-11-20 2016-10-13 Glaxosmithkline Llc Novel compounds
EP2769738B1 (en) 2013-02-22 2016-07-20 Invivogen Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
CN106029668B (zh) * 2014-02-20 2018-02-23 葛兰素史克知识产权第二有限公司 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂
EP3110401A4 (en) 2014-02-25 2017-10-25 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
WO2015200728A1 (en) 2014-06-25 2015-12-30 Selecta Biosciences, Inc. Methods and compositions for treatment with synthetic nanocarriers and immune checkpoint inhibitors
TWI733652B (zh) 2014-07-11 2021-07-21 美商基利科學股份有限公司 用於治療HIV之toll樣受體調節劑
ES2835717T3 (es) 2014-09-16 2021-06-23 Gilead Sciences Inc Formas sólidas de un modulador de receptor de tipo Toll
BR112017009648A2 (pt) * 2014-11-13 2017-12-19 Glaxosmithkline Biologicals Sa composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto.
WO2017205383A1 (en) * 2016-05-23 2017-11-30 University Of Iowa Research Foundation Method of treating cystic fibrosis airway disease
US10010555B2 (en) * 2016-06-02 2018-07-03 Celgene Corporation Animal and human anti-trypanosomonal and anti-leishmania agents
WO2018181420A1 (ja) 2017-03-29 2018-10-04 大日本住友製薬株式会社 ワクチンアジュバント製剤
CN108948016B (zh) * 2017-05-19 2021-02-26 江苏恒瑞医药股份有限公司 嘌呤酮类衍生物、其制备方法及其在医药上的应用
KR102740831B1 (ko) 2017-11-14 2024-12-11 칠드런'즈 메디컬 센터 코포레이션 신규 이미다조피리미딘 화합물 및 그의 용도
KR102775718B1 (ko) 2017-11-14 2025-03-06 칠드런'즈 메디컬 센터 코포레이션 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도
EP3713322A4 (en) 2017-11-17 2021-06-23 Ntt Docomo, Inc. USER TERMINAL DEVICE AND WIRELESS COMMUNICATION PROCEDURE
EP3730152A4 (en) 2017-12-21 2022-01-12 Sumitomo Dainippon Pharma Co., Ltd. COMBINATION DRUGS WITH TLR7 AGONIST
CN112292391A (zh) 2018-03-05 2021-01-29 芝加哥大学 用与细胞因子连接的ecm亲和肽治疗癌症的方法和组合物
SG11202100706UA (en) 2018-07-23 2021-03-30 Japan As Represented By Director General Of Nat Institute Of Infectious Diseases Composition containing influenza vaccine
US11486970B1 (en) 2019-02-11 2022-11-01 Innovusion, Inc. Multiple beam generation from a single source beam for use with a LiDAR system
KR20220018503A (ko) 2019-05-23 2022-02-15 더 유니버시티 오브 몬타나 Tlr 수용체 리간드에 기반한 백신 애주번트
US12391694B2 (en) * 2019-06-24 2025-08-19 Merck Sharp & Dohme Llc Process for the preparation of 2-fluoroadenine
CN110772523B (zh) * 2019-11-07 2020-06-26 黑龙江中医药大学 一种用于防治肾病的药物组合物
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2025248505A1 (en) 2024-05-31 2025-12-04 Wayne State University Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB427857A (en) 1934-08-02 1935-05-01 Newsum Sons & Company Ltd H A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
AU3176297A (en) 1996-06-25 1998-01-14 Novartis Ag Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
TW572758B (en) 1997-12-22 2004-01-21 Sumitomo Pharma Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
CA2310896A1 (en) 1999-07-02 2001-01-02 Japan Tobacco Inc. Hcv polymerase suitable for crystal structure analysis and method for using the enzyme
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
DE60118521T2 (de) 2000-01-07 2006-10-12 Universitaire Instelling Antwerpen Purin derivate, ihre herstellung und verwendung
CN1814596A (zh) 2000-04-28 2006-08-09 阿卡蒂亚药品公司 毒蕈碱性激动剂
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US6310224B1 (en) 2001-01-19 2001-10-30 Arco Chemical Technology, L.P. Epoxidation catalyst and process
EP1539188B1 (en) 2001-01-22 2015-01-07 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US7285552B2 (en) 2001-03-19 2007-10-23 Ono Pharmaceuticals Co., Ltd. Drugs containing triazaspiro[5.5]undecane derivatives as the active ingredient
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
ATE541246T1 (de) 2001-06-29 2012-01-15 Maruman Products Co Ltd Funkarmbanduhr
CA2448737C (en) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
TW200301251A (en) 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
EP1348707B1 (en) 2002-03-28 2010-08-25 Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
WO2003085375A2 (en) 2002-04-04 2003-10-16 Achillion Pharmaceuticals, Inc. Hcv antiviral and cytotoxicity drug screening assay
NZ536123A (en) 2002-05-06 2006-09-29 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
DOP2003000641A (es) 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US6713241B2 (en) 2002-08-09 2004-03-30 Eastman Kodak Company Thermally developable emulsions and imaging materials containing binder mixture
PT1539783E (pt) 2002-08-21 2011-06-01 Einstein Coll Med Inibidores de nucleósido fosforilases e de nucleosidases
WO2004029054A1 (ja) 2002-09-27 2004-04-08 Sumitomo Pharmaceuticals Company, Limited 新規アデニン化合物及びその用途
TW200418848A (en) 2002-10-24 2004-10-01 Glaxo Group Ltd Compounds
WO2004054581A2 (en) 2002-12-13 2004-07-01 Smithkline Beecham Corporation Cyclohexyl compounds as ccr5 antagonists
CA2509711A1 (en) 2002-12-13 2004-07-01 Smithkline Beecham Corporation Piperidine derivatives as ccr5 antagonists
EP1569931B1 (en) 2002-12-13 2008-10-08 Smithkline Beecham Corporation Heterocyclic compounds as ccr5 antagonists
US7271172B2 (en) 2002-12-13 2007-09-18 Smithkline Beecham Corporation Pyrrolidine and azetidine compounds as CCR5 antagonists
DE60318891T2 (de) 2002-12-13 2009-01-22 Smithkline Beecham Corp. Cyclopropylverbindungen als ccr5 antagonisten
US7531661B2 (en) 2002-12-13 2009-05-12 Smithkline Beecham Corporation Indane compounds as CCR5 antagonists
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7148226B2 (en) 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
CA2530081A1 (en) 2003-07-01 2005-01-13 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
WO2005014543A1 (ja) 2003-08-06 2005-02-17 Japan Tobacco Inc. 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用
WO2005020892A2 (en) 2003-08-08 2005-03-10 Mitochroma Research, Inc. Pharmaceutical compositions and methods for metabolic modulation
JP2007504232A (ja) 2003-09-05 2007-03-01 アナディス ファーマシューティカルズ インク C型肝炎ウイルス感染治療用のtlr7リガンド及びそのプロドラッグの投与
KR101494056B1 (ko) 2003-10-03 2015-02-16 쓰리엠 이노베이티브 프로퍼티즈 컴파니 피라졸로피리딘 및 그의 유사체
CA2544378A1 (en) 2003-11-03 2005-05-19 Glaxo Group Limited A fluid dispensing device
ES2326082T3 (es) 2003-12-01 2009-09-30 L'oreal Derivados de 4-5-diamino-n,n-dihidro-pirazol-3-ona condensados, utilizados para la tincion de fibras queratinicas.
EA200901463A1 (ru) 2004-02-20 2010-08-30 Бёрингер Ингельхайм Интернациональ Гмбх Ингибиторы вирусной полимеразы
EP1728792A4 (en) * 2004-03-26 2010-12-15 Dainippon Sumitomo Pharma Co 8-OXOADENINE COMPOUND
TWI392678B (zh) * 2004-03-26 2013-04-11 Dainippon Sumitomo Pharma Co 9-取代-8-氧基腺嘌呤化合物
JP4691020B2 (ja) 2004-03-31 2011-06-01 株式会社湯山製作所 錠剤フィーダ
CN1960993A (zh) 2004-04-02 2007-05-09 Osi制药公司 6,6-双环取代的杂双环蛋白激酶抑制剂
CA2564175A1 (en) 2004-04-28 2005-11-10 Arrow Therapeutics Limited Chemical compounds
WO2005110410A2 (en) 2004-05-14 2005-11-24 Abbott Laboratories Kinase inhibitors as therapeutic agents
US20060029642A1 (en) 2004-08-03 2006-02-09 Dusan Miljkovic Methods and compositions for improved chromium complexes
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
AU2005273619B2 (en) 2004-08-18 2009-05-28 Pfizer Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
WO2006026394A2 (en) 2004-08-27 2006-03-09 3M Innovative Properties Company Method of eliciting an immune response against hiv
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0423673D0 (en) 2004-10-25 2004-11-24 Glaxo Group Ltd Compounds
EA200702235A1 (ru) * 2005-05-04 2008-04-28 Пфайзер Лимитед Производные 2-амидо-6-амино-8-оксопурина в качестве модуляторов toll-подобных рецепторов для лечения рака и вирусных инфекций, таких как гепатит с
BRPI0608910A2 (pt) 2005-05-09 2010-02-17 Achillion Pharmaceuticals Inc uso de um composto da fórmula ou um sal ou hidrato farmaceuticamente aceitável desse, composto ou sal ou hidrato do mesmo, composição farmacêutica e composição farmacêutica embalada
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
EP1915377A1 (en) 2005-07-22 2008-04-30 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
JP2009504803A (ja) * 2005-08-22 2009-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Tlrアゴニスト
AU2006283104A1 (en) 2005-08-25 2007-03-01 Pharmacopeia, Inc. Imidazole derivatives as functionally selective alpha2C adrenoreceptor agonists
US8003624B2 (en) 2005-08-25 2011-08-23 Schering Corporation Functionally selective ALPHA2C adrenoreceptor agonists
US20100152230A1 (en) 2005-09-02 2010-06-17 Pfizer Inc. Hydroxy substituted 1h-imidazopyridines and methods
TW200801003A (en) * 2005-09-16 2008-01-01 Astrazeneca Ab Novel compounds
US20090118263A1 (en) * 2005-09-22 2009-05-07 Dainippon Sumitomo Pharma Co., Ltd. Novel Adenine Compound
WO2007034916A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
US20080269240A1 (en) * 2005-09-22 2008-10-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel Adenine Compound
US20090192153A1 (en) * 2005-09-22 2009-07-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel adenine compound
JPWO2007034917A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規なアデニン化合物
TW200745114A (en) * 2005-09-22 2007-12-16 Astrazeneca Ab Novel compounds
CN1947717B (zh) 2005-10-14 2012-09-26 卓敏 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
EP1987030B1 (en) 2006-02-17 2011-11-09 Pfizer Limited 3 -deazapurine derivatives as tlr7 modulators
EP2010505B1 (en) 2006-03-28 2012-12-05 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
GB0610666D0 (en) 2006-05-30 2006-07-05 Glaxo Group Ltd Fluid dispenser
EP2029597A4 (en) * 2006-05-31 2011-11-23 Univ California purine analogs
US20070282962A1 (en) 2006-06-01 2007-12-06 Microsoft Corporation Auto-Subscribing to Syndication Feeds Using Contact Lists
JP2009542645A (ja) 2006-07-05 2009-12-03 アストラゼネカ・アクチエボラーグ Tlr7のモジュレーターとして作用する8−オキソアデニン誘導体
EP2038290B1 (en) * 2006-07-07 2013-09-04 Gilead Sciences, Inc. Modulators of toll-like receptor 7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
WO2008101867A1 (en) * 2007-02-19 2008-08-28 Smithkline Beecham Corporation Purine derivatives as immunomodulators
ATE530549T1 (de) * 2007-03-19 2011-11-15 Astrazeneca Ab 9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
JP5480637B2 (ja) 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ Toll様受容体(tlr7)モジュレーターとしての9−置換−8−オキソ−アデニン化合物
PE20081887A1 (es) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Nuevo compuesto de adenina
US8044056B2 (en) * 2007-03-20 2011-10-25 Dainippon Sumitomo Pharma Co., Ltd. Adenine compound
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
MX2009013832A (es) * 2007-06-29 2010-03-10 Gilead Sciences Inc Derivados de purina y su uso como moduladores del receptor 7 similar a un puente.
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
BRPI0814939A2 (pt) 2007-08-10 2015-01-27 Glaxosmithkline Llc Entidade química, composição farmacêutica, e, método para tratar uma infecção viral em um mamífero.
UY31531A1 (es) 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
EP2324025A1 (en) 2008-08-11 2011-05-25 Smithkline Beecham Corporation Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
US8802684B2 (en) 2008-08-11 2014-08-12 Glaxosmithkline Llc Adenine derivatives
MX2011001663A (es) 2008-08-11 2011-03-24 Glaxosmithkline Llc Derivados novedosos de adenina.
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010018132A1 (en) 2008-08-11 2010-02-18 Smithkline Beecham Corporation Compounds
JP5519670B2 (ja) 2008-08-11 2014-06-11 グラクソスミスクライン エルエルシー アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体
CN102548999A (zh) 2009-01-20 2012-07-04 山东轩竹医药科技有限公司 含有取代的含氮稠杂环的头孢菌素衍生物
EP2461690A4 (en) 2009-08-07 2013-03-27 Glaxosmithkline Biolog Sa LIPIDED OXOADENINE DERIVATIVES
JP2013519644A (ja) 2010-02-10 2013-05-30 グラクソスミスクライン エルエルシー プリン誘導体およびそれらの薬学的使用
PL2534149T3 (pl) 2010-02-10 2015-03-31 Glaxosmithkline Llc Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu
WO2012009258A2 (en) 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
US20120171229A1 (en) 2010-12-30 2012-07-05 Selecta Biosciences, Inc. Synthetic nanocarriers with reactive groups that release biologically active agents
EP2670733B1 (en) 2011-02-01 2019-04-10 The Board of Trustees of the University of Illionis N-hydroxybenzamide derivatives as hdac inhibitors and therapeutic methods using the same
JP5813785B2 (ja) 2011-02-04 2015-11-17 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法
LT2734186T (lt) 2011-07-22 2018-12-10 Glaxosmithkline Llc Kompozicija
WO2014031815A1 (en) 2012-08-24 2014-02-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
RS56233B1 (sr) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nova jedinjenja
AU2013348216B2 (en) 2012-11-20 2016-10-13 Glaxosmithkline Llc Novel compounds
CN106029668B (zh) 2014-02-20 2018-02-23 葛兰素史克知识产权第二有限公司 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂

Also Published As

Publication number Publication date
DK2324026T3 (en) 2015-09-21
MX336345B (es) 2016-01-15
AU2009281197B2 (en) 2014-09-11
TR201802648T4 (tr) 2018-03-21
US20100075995A1 (en) 2010-03-25
EA201100113A1 (ru) 2011-10-31
HK1222857A1 (en) 2017-07-14
PE20110674A1 (es) 2011-10-07
HRP20180202T1 (hr) 2018-03-09
US10117873B2 (en) 2018-11-06
IL210757A (en) 2014-09-30
US8765772B2 (en) 2014-07-01
CA2733749C (en) 2016-10-11
MA32624B1 (fr) 2011-09-01
PL2324026T3 (pl) 2015-11-30
IL210757A0 (en) 2011-03-31
NO3000813T3 (pt) 2018-05-12
SMT201500224B (it) 2015-10-30
US9346806B2 (en) 2016-05-24
SG192547A1 (en) 2013-08-30
US20140336175A1 (en) 2014-11-13
US20120035193A1 (en) 2012-02-09
SI2324026T1 (sl) 2015-10-30
US20110229500A1 (en) 2011-09-22
ES2549154T3 (es) 2015-10-23
US9233962B2 (en) 2016-01-12
HUE027637T2 (en) 2016-11-28
US20180117048A1 (en) 2018-05-03
SMT201800123T1 (it) 2018-05-02
SI3000813T1 (en) 2018-03-30
MY162538A (en) 2017-06-15
CN104098568A (zh) 2014-10-15
ME02274B (me) 2016-02-20
US8067426B2 (en) 2011-11-29
PT2324026E (pt) 2015-10-22
RS54266B1 (sr) 2016-02-29
CN102177159B (zh) 2014-07-23
UA103195C2 (uk) 2013-09-25
CL2011000301A1 (es) 2011-07-15
RS56984B1 (sr) 2018-05-31
PL3000813T3 (pl) 2018-05-30
DK3000813T3 (da) 2018-01-29
US9877968B2 (en) 2018-01-30
KR20110042230A (ko) 2011-04-25
JP2011530563A (ja) 2011-12-22
EP2324026B1 (en) 2015-07-08
AU2009281197A1 (en) 2010-02-18
US20160228445A1 (en) 2016-08-11
WO2010018133A1 (en) 2010-02-18
EP3000813A1 (en) 2016-03-30
NZ602812A (en) 2014-04-30
MX2011001666A (es) 2011-03-24
HRP20150938T1 (hr) 2015-10-09
CN104098568B (zh) 2016-08-17
KR101669939B1 (ko) 2016-10-27
EP2324026A1 (en) 2011-05-25
CY1119992T1 (el) 2018-12-12
CO6351791A2 (es) 2011-12-20
EP3336089A1 (en) 2018-06-20
ES2661671T3 (es) 2018-04-03
CR20110116A (es) 2011-07-28
CN102177159A (zh) 2011-09-07
EP3000813B1 (en) 2017-12-13
HUE036570T2 (hu) 2018-07-30
EA020631B1 (ru) 2014-12-30
DOP2011000048A (es) 2011-03-31
US20190038631A1 (en) 2019-02-07
LT3000813T (lt) 2018-03-12
ZA201100845B (en) 2012-07-25
JP5529867B2 (ja) 2014-06-25
HK1253532A1 (en) 2019-06-21
BRPI0917138A2 (pt) 2015-11-17
HK1157770A1 (en) 2012-07-06
NZ590782A (en) 2012-10-26
CA2733749A1 (en) 2010-02-18

Similar Documents

Publication Publication Date Title
ZA201100845B (en) Purine derivatives for use in the treatment of allergic,inflammatory and infectious diseases
IL210803A0 (en) Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
IL210802A0 (en) Purin derivatives for use in the treatment of fab-related diseases
ZA201000075B (en) Purin derivatives for use in the treatment of fab-related diseases
PL2771342T3 (pl) Nowe pochodne puryny i ich zastosowanie w leczeniu chorób
PL2254870T3 (pl) Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1
EP2262778B8 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
IL216967B (en) The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases
EP2262777B8 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1
PL2148667T3 (pl) Stosowanie pochodnych cycloheksanoheksolu w leczeniu chorób oczu
ZA201108106B (en) Use of phthalimide derivatives in the treatment of diseases
HRP20151393T8 (hr) UPORABA BENZIDAMINA U LIJEČENJU BOLESTI KOJE SU p40-OVISNE
TH0901005786A (th) อนุพันธ์พิวรีนเพื่อใช้ในการรักษาโรคภูมิแพ้, อาการอักเสบ และโรคติดเชื้อ
PL2224934T3 (pl) Zastosowanie osteoblastów w leczeniu zapalnych chorób reumatycznych
HK1196617A (en) Novel purine derivatives and their use in the treatment of disease
HK1145323A (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1
IL202502A0 (en) Agents for the treatment of inflammatory diseases and methods of using same