PT1991680E - Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas - Google Patents
Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas Download PDFInfo
- Publication number
- PT1991680E PT1991680E PT77526010T PT07752601T PT1991680E PT 1991680 E PT1991680 E PT 1991680E PT 77526010 T PT77526010 T PT 77526010T PT 07752601 T PT07752601 T PT 07752601T PT 1991680 E PT1991680 E PT 1991680E
- Authority
- PT
- Portugal
- Prior art keywords
- expression
- host cells
- translation components
- orthogonal translation
- eubacterial host
- Prior art date
Links
- 241001112695 Clostridiales Species 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78097306P | 2006-03-09 | 2006-03-09 | |
| US78349706P | 2006-03-17 | 2006-03-17 | |
| US85533606P | 2006-10-29 | 2006-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1991680E true PT1991680E (pt) | 2013-10-30 |
Family
ID=38475556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT77526010T PT1991680E (pt) | 2006-03-09 | 2007-03-07 | Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7960141B2 (pt) |
| EP (1) | EP1991680B1 (pt) |
| JP (1) | JP5589186B2 (pt) |
| KR (1) | KR20080106430A (pt) |
| CN (1) | CN101400796B (pt) |
| AU (1) | AU2007223830A1 (pt) |
| BR (1) | BRPI0709935A2 (pt) |
| CA (1) | CA2638763A1 (pt) |
| ES (1) | ES2432391T3 (pt) |
| IL (1) | IL193394A0 (pt) |
| MX (1) | MX2008011470A (pt) |
| PL (1) | PL1991680T3 (pt) |
| PT (1) | PT1991680E (pt) |
| WO (1) | WO2007103490A2 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03009566A (es) * | 2001-04-19 | 2004-12-06 | Scripps Research Inst | Metodos y composicion para la produccion de pares trna-aminoaciltrna sintetasa ortogonales. |
| DE60329700D1 (en) * | 2002-10-16 | 2009-11-26 | Scripps Research Inst | Glycoproteinsynthese |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| SI1666604T1 (sl) * | 2003-07-07 | 2008-08-31 | Scripps Research Inst | Sestavki ortogonalnih parov lizil-tRNA in aminoacil-tRNA in aminoacil-tRNA-sintetaze in njihove uporabe |
| US20080171317A1 (en) * | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| EP2383340B1 (en) | 2004-10-27 | 2014-07-16 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| EP1991680B1 (en) * | 2006-03-09 | 2013-08-21 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| MX2008011669A (es) | 2006-03-16 | 2008-09-22 | Scripps Research Inst | Expresion programada geneticamente de proteinas que contienen el aminoacido no natural fenilselenocisteina. |
| WO2007139870A1 (en) | 2006-05-23 | 2007-12-06 | The Scripps Research Institute | Genetically encoded fluorescent coumarin amino acids |
| US8114652B2 (en) | 2006-09-21 | 2012-02-14 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| RU2009112104A (ru) | 2006-10-18 | 2010-11-27 | Зе Скрипс Ресеч Инститьют (Us) | Генетическое встраивание не встречающихся в природе аминокислот в белки клеток млекопитающих |
| WO2009059056A2 (en) * | 2007-11-02 | 2009-05-07 | The Scripps Research Institute | A genetically encoded boronate amino acid |
| JP2011527886A (ja) * | 2007-12-11 | 2011-11-10 | ザ スクリプス リサーチ インスティチュート | メタノール資化性酵母ピキア・パストリスにおけるインビボ非天然アミノ酸発現 |
| BRPI0906388A2 (pt) * | 2008-02-08 | 2015-07-07 | Scripps Research Inst | Quebra de tolerância imunológica com um aminoácido não natural geneticamente codificado |
| PT2337846T (pt) | 2008-09-26 | 2018-04-05 | Ambrx Inc | Vacinas e microrganismos dependentes da replicação de aminoácidos não naturais |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| CN102307905B (zh) * | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
| AU2011291943B2 (en) * | 2010-08-17 | 2015-01-22 | Ambrx, Inc. | Modified relaxin polypeptides and their uses |
| KR20160027217A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| JO3564B1 (ar) | 2013-03-08 | 2020-07-05 | Novartis Ag | ببتيدات وتركيبات لعلاج ضرر المفاصل |
| EP3021942A4 (en) | 2013-07-19 | 2017-04-19 | The Regents of The University of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
| WO2018087720A1 (en) | 2016-11-14 | 2018-05-17 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CN109963579A (zh) | 2016-11-14 | 2019-07-02 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| KR102670432B1 (ko) | 2017-02-08 | 2024-05-28 | 브리스톨-마이어스 스큅 컴퍼니 | 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 |
| AU2020378327A1 (en) * | 2019-11-05 | 2022-05-26 | Nitro Biosciences, Inc. | Biosynthesis of para-nitro-L-phenylalanine |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| CN113322267B (zh) * | 2021-03-15 | 2024-01-05 | 天津大学 | 系统在提高非天然氨基酸的插入效率中的应用 |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5024939A (en) | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
| EP1124939B1 (en) | 1998-10-08 | 2003-04-23 | AstraZeneca AB | Microfabricated cell injector |
| ATE556149T1 (de) | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| MXPA03009566A (es) | 2001-04-19 | 2004-12-06 | Scripps Research Inst | Metodos y composicion para la produccion de pares trna-aminoaciltrna sintetasa ortogonales. |
| US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
| DE60329700D1 (en) | 2002-10-16 | 2009-11-26 | Scripps Research Inst | Glycoproteinsynthese |
| DE60327369D1 (de) * | 2002-10-16 | 2009-06-04 | Scripps Research Inst | Stellenspezifischer einbau von ketoaminosäuren in proteine |
| MXPA05006836A (es) | 2002-12-22 | 2005-08-16 | Scripps Research Inst | Colecciones ordenadas de proteinas. |
| CN103289960B (zh) * | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| EP2392923B1 (en) * | 2003-06-18 | 2014-05-21 | The Scripps Research Institute | Method of producing proteins comprising unnatural amino acid |
| SI1666604T1 (sl) * | 2003-07-07 | 2008-08-31 | Scripps Research Inst | Sestavki ortogonalnih parov lizil-tRNA in aminoacil-tRNA in aminoacil-tRNA-sintetaze in njihove uporabe |
| US7527943B2 (en) | 2003-07-07 | 2009-05-05 | The Scripps Research Institute | Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof |
| US20060160175A1 (en) * | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| US8008041B2 (en) | 2003-10-14 | 2011-08-30 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| CA2549830A1 (en) * | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| US7718410B2 (en) | 2004-09-21 | 2010-05-18 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| JP2008513040A (ja) | 2004-09-21 | 2008-05-01 | ザ スクリップス リサーチ インスティテュート | 光調節型アミノ酸の遺伝コード付加 |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| US20080064059A1 (en) | 2004-10-20 | 2008-03-13 | Scripps Research Institute | In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria |
| EP2383340B1 (en) * | 2004-10-27 | 2014-07-16 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| KR20080069993A (ko) * | 2005-10-12 | 2008-07-29 | 더 스크립스 리서치 인스티튜트 | 파지-디스플레이된 폴리펩티드의 선별적인 번역후 변형 |
| EP1991680B1 (en) * | 2006-03-09 | 2013-08-21 | The Scripps Research Institute | System for the expression of orthogonal translation components in eubacterial host cells |
| MX2008011669A (es) | 2006-03-16 | 2008-09-22 | Scripps Research Inst | Expresion programada geneticamente de proteinas que contienen el aminoacido no natural fenilselenocisteina. |
-
2007
- 2007-03-07 EP EP07752601.0A patent/EP1991680B1/en not_active Not-in-force
- 2007-03-07 US US11/715,672 patent/US7960141B2/en active Active
- 2007-03-07 ES ES07752601T patent/ES2432391T3/es active Active
- 2007-03-07 US US12/224,773 patent/US8198044B2/en active Active
- 2007-03-07 JP JP2008558393A patent/JP5589186B2/ja not_active Expired - Fee Related
- 2007-03-07 BR BRPI0709935-5A patent/BRPI0709935A2/pt not_active Application Discontinuation
- 2007-03-07 MX MX2008011470A patent/MX2008011470A/es active IP Right Grant
- 2007-03-07 CN CN2007800084039A patent/CN101400796B/zh not_active Expired - Fee Related
- 2007-03-07 PT PT77526010T patent/PT1991680E/pt unknown
- 2007-03-07 KR KR1020087022447A patent/KR20080106430A/ko not_active Ceased
- 2007-03-07 AU AU2007223830A patent/AU2007223830A1/en not_active Abandoned
- 2007-03-07 PL PL07752601T patent/PL1991680T3/pl unknown
- 2007-03-07 WO PCT/US2007/005914 patent/WO2007103490A2/en not_active Ceased
- 2007-03-07 CA CA002638763A patent/CA2638763A1/en not_active Abandoned
-
2008
- 2008-08-12 IL IL193394A patent/IL193394A0/en unknown
-
2012
- 2012-05-10 US US13/468,736 patent/US8357512B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8357512B2 (en) | 2013-01-22 |
| CA2638763A1 (en) | 2007-09-13 |
| WO2007103490A3 (en) | 2008-06-12 |
| US20070281335A1 (en) | 2007-12-06 |
| EP1991680A2 (en) | 2008-11-19 |
| IL193394A0 (en) | 2009-09-22 |
| AU2007223830A1 (en) | 2007-09-13 |
| MX2008011470A (es) | 2008-09-24 |
| JP5589186B2 (ja) | 2014-09-17 |
| CN101400796B (zh) | 2013-03-27 |
| ES2432391T3 (es) | 2013-12-03 |
| US20090181429A1 (en) | 2009-07-16 |
| CN101400796A (zh) | 2009-04-01 |
| KR20080106430A (ko) | 2008-12-05 |
| US8198044B2 (en) | 2012-06-12 |
| BRPI0709935A2 (pt) | 2011-08-02 |
| US7960141B2 (en) | 2011-06-14 |
| US20120252067A1 (en) | 2012-10-04 |
| WO2007103490A2 (en) | 2007-09-13 |
| JP2009529328A (ja) | 2009-08-20 |
| PL1991680T3 (pl) | 2014-01-31 |
| EP1991680A4 (en) | 2009-10-21 |
| EP1991680B1 (en) | 2013-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1991680E (pt) | Sistema para a expressão de componentes ortogonais de tradução em células hospedeiras eubacterianas | |
| MX2009010492A (es) | Elementos de vector de expresion recombinante (reves) para mejorar la expresion de proteinas recombinantes en celulas huesped. | |
| IL250946B (en) | Nanobodies against tumor necrosis factor-alpha (tnf-alpha) | |
| EA200801531A1 (ru) | Способы регулирования содержания маннозы в рекомбинантных белках | |
| WO2010034032A3 (en) | Methods for preparing purified polypeptide compositions | |
| MX2010005919A (es) | Formulaciones de proteinas y metodos para elaborarlas. | |
| AU2007325952A8 (en) | Cell-free synthesis of proteins containing unnatural amino acids | |
| UA103774C2 (uk) | Модифіковані поліпептиди бичачого гранулоцитарного колонієстимулювального фактора (g-csf) та їх застосування | |
| MX2010005783A (es) | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. | |
| CA2705357C (en) | Formulations for taci-immunoglobulin fusion proteins | |
| CA2818969A1 (en) | Improved n-terminal capping modules for designed ankyrin repeat proteins | |
| IL226857A (en) | Recombinant proteins that underwent glycosylation at site n correspond to prokaryotes | |
| PH12012502272A1 (en) | Biological materials related to her3 | |
| PH12012500816A1 (en) | Modified oil encapsulating proteins and uses thereof | |
| PL1940381T3 (pl) | Farmaceutyczne kompozycje do oczu oparte na aminokwasach i hialuronianie sodu | |
| MX2009002787A (es) | Composiciones y métodos para prevenir el cáncer con cupredoxinas. | |
| IL197594A0 (en) | Compositions comprising high pressure-treated proteins and methods of preparing the same | |
| WO2009095646A3 (en) | Peptides from factor viii | |
| WO2010030641A3 (en) | Pancreatic cancer markers | |
| AU2015201137B2 (en) | Compositions and method for tissue preservation | |
| WO2011050152A3 (en) | Site-specific modification of proteins | |
| HK1138010A (en) | Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells | |
| HK1121056A (en) | Pharmaceutical compositions comprising sods and prolamine based peptide fragments | |
| HK1147109A (en) | Directed evolution using proteins comprising unnatural amino acids | |
| HK1123195A (en) | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |