PT1291429E - Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão - Google Patents
Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão Download PDFInfo
- Publication number
- PT1291429E PT1291429E PT01938602T PT01938602T PT1291429E PT 1291429 E PT1291429 E PT 1291429E PT 01938602 T PT01938602 T PT 01938602T PT 01938602 T PT01938602 T PT 01938602T PT 1291429 E PT1291429 E PT 1291429E
- Authority
- PT
- Portugal
- Prior art keywords
- gene
- expression product
- amino acid
- protein
- splice variant
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 4
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 title 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 title 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 8
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 238000003259 recombinant expression Methods 0.000 abstract 2
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000176631 | 2000-06-13 | ||
| JP2000290679A JP4601143B2 (ja) | 2000-06-13 | 2000-09-25 | 新規酵素遺伝子およびその発現産物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1291429E true PT1291429E (pt) | 2008-12-15 |
Family
ID=26593812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01938602T PT1291429E (pt) | 2000-06-13 | 2001-06-12 | Variante de splicing da glutamina-frutose-6-fosfatoamidotransferase e seu produto de expressão |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7091018B2 (pt) |
| EP (1) | EP1291429B1 (pt) |
| JP (1) | JP4601143B2 (pt) |
| KR (1) | KR100882407B1 (pt) |
| CN (1) | CN100390286C (pt) |
| AR (1) | AR029130A1 (pt) |
| AT (1) | ATE407212T1 (pt) |
| AU (2) | AU6424501A (pt) |
| CA (1) | CA2412880C (pt) |
| DE (1) | DE60135650D1 (pt) |
| DK (1) | DK1291429T3 (pt) |
| ES (1) | ES2312442T3 (pt) |
| PT (1) | PT1291429E (pt) |
| TW (1) | TWI232883B (pt) |
| WO (1) | WO2001096574A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006262364A1 (en) * | 2005-06-20 | 2007-01-04 | Exelixis, Inc. | GFATs as modifiers of the Axin pathway and methods of use |
| CA2624973C (en) * | 2005-10-05 | 2016-01-19 | Bayer Cropscience Ag | Production of hyaluronan from plants transgenic for hyaluronan synthase, gfat and udp-glucose dehydrogenase |
| CA2656228C (en) * | 2006-06-30 | 2016-02-09 | Hokkaido System Science Co., Ltd. | Composition for nucleic-acid transfection |
| CN103301447B (zh) * | 2013-06-25 | 2014-12-31 | 哈尔滨医科大学 | DNA-PKcs在制备改变肿瘤细胞对MTX耐药性的药物中的应用 |
| CN112980914A (zh) * | 2019-12-12 | 2021-06-18 | 中国科学院大连化学物理研究所 | Gfpt1基因作为靶点在筛选抗肿瘤药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993021330A1 (en) * | 1992-04-22 | 1993-10-28 | Zymogenetics, Inc. | Human glutamine:fructose-6-phosphate amino-transferase |
| JPH1018683A (ja) * | 1996-06-29 | 1998-01-20 | Tesco Joho Center:Kk | 吊下扉のレール装置 |
| JP4175680B2 (ja) * | 1996-08-13 | 2008-11-05 | 武田薬品工業株式会社 | 新規タンパク質およびそのｄｎａ |
| US5876713A (en) * | 1996-08-13 | 1999-03-02 | Takeda Chemical Industries Ltd | Glutamine: fructose-6-phosphate amidotransferase, its production and use |
| AU2216300A (en) * | 1998-12-22 | 2000-07-12 | G.D. Searle & Co. | Glutamine: fructose-6-phosphate aminotransferase ii enzyme and their encoding nucleic acids |
-
2000
- 2000-09-25 JP JP2000290679A patent/JP4601143B2/ja not_active Expired - Fee Related
-
2001
- 2001-06-12 AU AU6424501A patent/AU6424501A/xx active Pending
- 2001-06-12 DE DE60135650T patent/DE60135650D1/de not_active Expired - Lifetime
- 2001-06-12 KR KR1020027016418A patent/KR100882407B1/ko not_active Expired - Fee Related
- 2001-06-12 EP EP01938602A patent/EP1291429B1/en not_active Expired - Lifetime
- 2001-06-12 DK DK01938602T patent/DK1291429T3/da active
- 2001-06-12 ES ES01938602T patent/ES2312442T3/es not_active Expired - Lifetime
- 2001-06-12 AU AU2001264245A patent/AU2001264245B2/en not_active Ceased
- 2001-06-12 AT AT01938602T patent/ATE407212T1/de active
- 2001-06-12 WO PCT/JP2001/004941 patent/WO2001096574A1/ja not_active Ceased
- 2001-06-12 CA CA2412880A patent/CA2412880C/en not_active Expired - Fee Related
- 2001-06-12 US US10/297,599 patent/US7091018B2/en not_active Expired - Fee Related
- 2001-06-12 CN CNB018111114A patent/CN100390286C/zh not_active Expired - Fee Related
- 2001-06-12 AR ARP010102776A patent/AR029130A1/es not_active Application Discontinuation
- 2001-06-12 PT PT01938602T patent/PT1291429E/pt unknown
- 2001-10-16 TW TW090125551A patent/TWI232883B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100390286C (zh) | 2008-05-28 |
| CA2412880A1 (en) | 2002-12-13 |
| EP1291429A1 (en) | 2003-03-12 |
| CN1436239A (zh) | 2003-08-13 |
| US7091018B2 (en) | 2006-08-15 |
| EP1291429A4 (en) | 2004-05-26 |
| JP2002065284A (ja) | 2002-03-05 |
| JP4601143B2 (ja) | 2010-12-22 |
| CA2412880C (en) | 2010-05-04 |
| WO2001096574A1 (en) | 2001-12-20 |
| EP1291429B1 (en) | 2008-09-03 |
| KR100882407B1 (ko) | 2009-02-05 |
| KR20030011868A (ko) | 2003-02-11 |
| DE60135650D1 (de) | 2008-10-16 |
| DK1291429T3 (da) | 2009-01-19 |
| AU2001264245B2 (en) | 2006-04-27 |
| AR029130A1 (es) | 2003-06-04 |
| ES2312442T3 (es) | 2009-03-01 |
| TWI232883B (en) | 2005-05-21 |
| US20040132020A1 (en) | 2004-07-08 |
| ATE407212T1 (de) | 2008-09-15 |
| AU6424501A (en) | 2001-12-24 |
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