BR0318594A - proteìna recombinante que possui um efeito anticancerìgeno, seu gene de codificação e usos desta - Google Patents
proteìna recombinante que possui um efeito anticancerìgeno, seu gene de codificação e usos destaInfo
- Publication number
- BR0318594A BR0318594A BRPI0318594-0A BR0318594A BR0318594A BR 0318594 A BR0318594 A BR 0318594A BR 0318594 A BR0318594 A BR 0318594A BR 0318594 A BR0318594 A BR 0318594A
- Authority
- BR
- Brazil
- Prior art keywords
- seq
- amino acid
- protein
- recombinant protein
- same activity
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 4
- 230000001093 anti-cancer Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 4
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 238000007792 addition Methods 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"PROTEìNA RECOMBINANTE QUE POSSUI UM EFEITO ANTICANCERìGENO, SEU GENE DE CODIFICAçãO E USOS DESTA". A presente invenção refere-se a uma proteína recombinante que possui um efeito anticancerígeno, seu gene de codificação e usos desta. A proteína recombinante que possui um efeito anticancerígeno proporcionada pela presente invenção é uma selecionada a partir do grupo que consiste em: 1) uma proteína que possui a seqüência de aminoácido de SEQ ID No:2 mostrada na listagem de seqüência; 2) uma proteína derivada de SEQ ID No:2, que possui uma homologia de seqüência de mais que 90% com SEQ ID No:2 e que possui a mesma atividade daquela de SEQ ID No:2; 3) uma proteína derivada de SEQ ID No:2, que é obtida ao adicionar ou remover 15 ou menos resíduos de aminoácido na terminação-N da seqüência de aminoácido de SEQ ID No:2, e que possui a mesma atividade daquela de SEQ ID No:2; 4) uma proteína derivada de SEQ ID No:2, que é obtida ao adicionar ou remover 15 ou menos resíduos de aminoácido na terminação-C da seqüência de aminoácido de SEQ ID No:2, e que possui a mesma atividade daquela de SEQ ID No:2; 5) uma proteína derivada de SEQ ID No:2, que é obtida por substituição, anulação, ou adição de um ou diversos resíduos de aminoácido na seqüência de aminoácido de SEQ ID No:2, e que possui a mesma atividade daquela de SEQ ID No:2. O medicamento que contém a proteína recombinante acima como componente ativo possui efeito inibidor seletivo significativo sobre células de tumor, e não provoca a apoptose de células de tecido normais, e possui valor aplicável importante.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2003/000928 WO2005042744A1 (en) | 2003-11-03 | 2003-11-03 | A recombinant protein with cancer suppression action, its encoding gene and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0318594A true BR0318594A (pt) | 2006-10-17 |
| BRPI0318594B1 BRPI0318594B1 (pt) | 2017-12-26 |
| BRPI0318594B8 BRPI0318594B8 (pt) | 2021-05-25 |
Family
ID=34529378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318594A BRPI0318594B8 (pt) | 2003-11-03 | 2003-11-03 | proteína recombinante que possui um efeito anticâncer, seu gene de codificação, seu uso, medicamento para tratar cânceres, vetor de expressão e microrganismo transgênico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7666989B2 (pt) |
| EP (1) | EP1688498B1 (pt) |
| JP (1) | JP4688678B2 (pt) |
| CN (1) | CN100549175C (pt) |
| AT (1) | ATE501256T1 (pt) |
| AU (1) | AU2003280921B2 (pt) |
| BR (1) | BRPI0318594B8 (pt) |
| CA (1) | CA2544473C (pt) |
| DE (1) | DE60336353D1 (pt) |
| NZ (1) | NZ547274A (pt) |
| WO (1) | WO2005042744A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1577323B1 (en) | 2002-12-26 | 2013-07-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| NZ552029A (en) | 2004-06-25 | 2009-01-31 | Takeda Pharmaceutical | Metastin derivatives and use thereof |
| US8404643B2 (en) | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| JO3048B1 (ar) | 2006-10-25 | 2016-09-05 | Takeda Pharmaceuticals Co | مشتقات متاستين واستخدامها |
| JPWO2009131191A1 (ja) * | 2008-04-24 | 2011-08-25 | 武田薬品工業株式会社 | メタスチン誘導体およびその用途 |
| KR101952460B1 (ko) | 2010-12-03 | 2019-02-27 | 아다메드 파르마 에스.에이. | 항암 융합 단백질 |
| PL219845B1 (pl) | 2011-01-05 | 2015-07-31 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
| PL394618A1 (pl) | 2011-04-19 | 2012-10-22 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
| JP5956580B2 (ja) * | 2011-09-16 | 2016-07-27 | 北京沙▲東▼生物技▲術▼有限公司Ｂｅｉｊｉｎｇ Ｓｕｎｂｉｏ Ｂｉｏｔｅｃｈ Ｃｏ．， Ｌｔｄ． | Ｔｒａｉｌ／ａｐｏ２ｌの円順列変異形を含む融合タンパク質、コーディング遺伝子およびそれらの使用 |
| PL397167A1 (pl) | 2011-11-28 | 2013-06-10 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe bialko fuzyjne |
| PL223487B1 (pl) | 2011-12-28 | 2016-10-31 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Przeciwnowotworowe białko fuzyjne |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997001633A1 (en) * | 1995-06-29 | 1997-01-16 | Immunex Corporation | Cytokine that induces apoptosis |
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| KR20010019100A (ko) * | 1999-08-25 | 2001-03-15 | 황규언 | 인간 유래 세포소멸인자 ｔｒａｉｌ의 결정화에 의한 3차원 구조 |
| US6900185B1 (en) * | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
| KR100436089B1 (ko) * | 2000-07-06 | 2004-06-14 | 설대우 | 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료 |
| CN1205335C (zh) * | 2001-11-30 | 2005-06-08 | 中国人民解放军第二军医大学 | 肿瘤凋亡诱导配体基因、基因表达蛋白及其制备方法 |
-
2003
- 2003-11-03 JP JP2005510086A patent/JP4688678B2/ja not_active Expired - Lifetime
- 2003-11-03 NZ NZ547274A patent/NZ547274A/en not_active IP Right Cessation
- 2003-11-03 AU AU2003280921A patent/AU2003280921B2/en not_active Expired
- 2003-11-03 US US10/577,535 patent/US7666989B2/en not_active Expired - Lifetime
- 2003-11-03 WO PCT/CN2003/000928 patent/WO2005042744A1/zh not_active Ceased
- 2003-11-03 EP EP03770858A patent/EP1688498B1/en not_active Expired - Lifetime
- 2003-11-03 BR BRPI0318594A patent/BRPI0318594B8/pt not_active IP Right Cessation
- 2003-11-03 AT AT03770858T patent/ATE501256T1/de not_active IP Right Cessation
- 2003-11-03 CN CNB2003801106041A patent/CN100549175C/zh not_active Expired - Lifetime
- 2003-11-03 DE DE60336353T patent/DE60336353D1/de not_active Expired - Lifetime
- 2003-11-03 CA CA2544473A patent/CA2544473C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE501256T1 (de) | 2011-03-15 |
| NZ547274A (en) | 2009-02-28 |
| EP1688498A4 (en) | 2007-06-20 |
| CN1860229A (zh) | 2006-11-08 |
| US20080280821A1 (en) | 2008-11-13 |
| CA2544473C (en) | 2013-08-13 |
| CA2544473A1 (en) | 2005-05-12 |
| JP2007536891A (ja) | 2007-12-20 |
| JP4688678B2 (ja) | 2011-05-25 |
| BRPI0318594B8 (pt) | 2021-05-25 |
| AU2003280921A1 (en) | 2005-05-19 |
| EP1688498A1 (en) | 2006-08-09 |
| HK1089788A1 (zh) | 2006-12-08 |
| DE60336353D1 (de) | 2011-04-21 |
| US7666989B2 (en) | 2010-02-23 |
| CN100549175C (zh) | 2009-10-14 |
| WO2005042744A1 (en) | 2005-05-12 |
| EP1688498B1 (en) | 2011-03-09 |
| BRPI0318594B1 (pt) | 2017-12-26 |
| AU2003280921B2 (en) | 2007-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2017, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/11/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2799 DE 27-08-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |