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PT1268519E - Inibidores de serina protease, particularmente protease ns3 do virus da hepatite c - Google Patents

Inibidores de serina protease, particularmente protease ns3 do virus da hepatite c

Info

Publication number
PT1268519E
PT1268519E PT01924516T PT01924516T PT1268519E PT 1268519 E PT1268519 E PT 1268519E PT 01924516 T PT01924516 T PT 01924516T PT 01924516 T PT01924516 T PT 01924516T PT 1268519 E PT1268519 E PT 1268519E
Authority
PT
Portugal
Prior art keywords
protease
hepatitis
virus
compounds
serine
Prior art date
Application number
PT01924516T
Other languages
English (en)
Inventor
Perni Robert
Court John
O Malley Ethan
Bhisetti Govinda Rao
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT1268519E publication Critical patent/PT1268519E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT01924516T 2000-04-03 2001-03-29 Inibidores de serina protease, particularmente protease ns3 do virus da hepatite c PT1268519E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19456300P 2000-04-03 2000-04-03
US19833000P 2000-04-18 2000-04-18

Publications (1)

Publication Number Publication Date
PT1268519E true PT1268519E (pt) 2005-08-31

Family

ID=26890159

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01924516T PT1268519E (pt) 2000-04-03 2001-03-29 Inibidores de serina protease, particularmente protease ns3 do virus da hepatite c

Country Status (11)

Country Link
US (1) US7494988B2 (pt)
EP (1) EP1268519B1 (pt)
JP (1) JP4806154B2 (pt)
AT (1) ATE297946T1 (pt)
AU (1) AU2001251165A1 (pt)
CA (1) CA2405043A1 (pt)
DE (1) DE60111509T2 (pt)
ES (1) ES2240446T3 (pt)
IL (2) IL152022A0 (pt)
PT (1) PT1268519E (pt)
WO (1) WO2001074768A2 (pt)

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JP4685775B2 (ja) 2003-09-18 2011-05-18 バーテックス ファーマシューティカルズ インコーポレイテッド セリンプロテアーゼ、とりわけｈｃｖｎｓ３−ｎｓ４ａプロテアーゼの阻害剤
TW200528472A (en) 2003-10-10 2005-09-01 Vertex Pharma Inhibitors of serine proteases, particularly HCV ns3-ns4a protease
EP2311851A3 (en) 2004-02-04 2011-05-25 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c

Also Published As

Publication number Publication date
JP4806154B2 (ja) 2011-11-02
EP1268519B1 (en) 2005-06-15
WO2001074768A3 (en) 2002-06-06
IL152022A (en) 2008-07-08
CA2405043A1 (en) 2001-10-11
EP1268519A2 (en) 2003-01-02
JP2003529583A (ja) 2003-10-07
AU2001251165A1 (en) 2001-10-15
ES2240446T3 (es) 2005-10-16
DE60111509D1 (de) 2005-07-21
US20030236242A1 (en) 2003-12-25
US7494988B2 (en) 2009-02-24
WO2001074768A2 (en) 2001-10-11
DE60111509T2 (de) 2006-05-11
IL152022A0 (en) 2003-04-10
ATE297946T1 (de) 2005-07-15

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