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DE60111509D1 - Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease - Google Patents

Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease

Info

Publication number
DE60111509D1
DE60111509D1 DE60111509T DE60111509T DE60111509D1 DE 60111509 D1 DE60111509 D1 DE 60111509D1 DE 60111509 T DE60111509 T DE 60111509T DE 60111509 T DE60111509 T DE 60111509T DE 60111509 D1 DE60111509 D1 DE 60111509D1
Authority
DE
Germany
Prior art keywords
hepatitis
protease
virus
compounds
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60111509T
Other languages
English (en)
Other versions
DE60111509T2 (de
Inventor
Robert Perni
John Court
Ethan O'malley
Govinda Rao Bhisetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE60111509D1 publication Critical patent/DE60111509D1/de
Application granted granted Critical
Publication of DE60111509T2 publication Critical patent/DE60111509T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60111509T 2000-04-03 2001-03-29 Inhibitoren von Serin-Proteasen, insbesondere der Hepatitis-C-Virus NS23-Protease Expired - Lifetime DE60111509T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19456300P 2000-04-03 2000-04-03
US194563P 2000-04-03
US19833000P 2000-04-18 2000-04-18
US198330P 2000-04-18
PCT/US2001/010367 WO2001074768A2 (en) 2000-04-03 2001-03-29 Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Publications (2)

Publication Number Publication Date
DE60111509D1 true DE60111509D1 (de) 2005-07-21
DE60111509T2 DE60111509T2 (de) 2006-05-11

Family

ID=26890159

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60111509T Expired - Lifetime DE60111509T2 (de) 2000-04-03 2001-03-29 Inhibitoren von Serin-Proteasen, insbesondere der Hepatitis-C-Virus NS23-Protease

Country Status (11)

Country Link
US (1) US7494988B2 (de)
EP (1) EP1268519B1 (de)
JP (1) JP4806154B2 (de)
AT (1) ATE297946T1 (de)
AU (1) AU2001251165A1 (de)
CA (1) CA2405043A1 (de)
DE (1) DE60111509T2 (de)
ES (1) ES2240446T3 (de)
IL (2) IL152022A0 (de)
PT (1) PT1268519E (de)
WO (1) WO2001074768A2 (de)

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PT1268519E (pt) 2005-08-31
ATE297946T1 (de) 2005-07-15
EP1268519B1 (de) 2005-06-15
US20030236242A1 (en) 2003-12-25
JP2003529583A (ja) 2003-10-07
AU2001251165A1 (en) 2001-10-15
DE60111509T2 (de) 2006-05-11
WO2001074768A3 (en) 2002-06-06
IL152022A (en) 2008-07-08
CA2405043A1 (en) 2001-10-11
WO2001074768A2 (en) 2001-10-11
IL152022A0 (en) 2003-04-10
ES2240446T3 (es) 2005-10-16
JP4806154B2 (ja) 2011-11-02
US7494988B2 (en) 2009-02-24
EP1268519A2 (de) 2003-01-02

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