PT1049767E - Coelho transgenico que expressa uma lipoproteina (a) humana funcional - Google Patents

Coelho transgenico que expressa uma lipoproteina (a) humana funcional

Info

Publication number: PT1049767E
Authority: PT; Portugal
Prior art keywords: transgenic rabbit; human functional; rabbit; lipoprotein; expressing
Prior art date: 1998-01-08

Application number

PT99904051T

Other languages

English (en)

Inventor

Louis-Marie Houdebine

Edward Rubin

Patrice Denefle

Didier Rouy

Nicolas Duverger

Florence Emmanuel

Celine Viglietta

Steven D Hughes

Original Assignee

Agronomique Inst Nat Rech

Univ California

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-08

Filing date

1999-01-08

Publication date

2005-10-31

1999-01-08 Application filed by Agronomique Inst Nat Rech, Univ California, Aventis Pharma Inc filed Critical Agronomique Inst Nat Rech

2005-10-31 Publication of PT1049767E publication Critical patent/PT1049767E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Biophysics (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Urology & Nephrology (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Pathology (AREA)
Rheumatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)

PT99904051T 1998-01-08 1999-01-08 Coelho transgenico que expressa uma lipoproteina (a) humana funcional PT1049767E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US7072798P	1998-01-08	1998-01-08

Publications (1)

Publication Number	Publication Date
PT1049767E true PT1049767E (pt)	2005-10-31

Family

ID=22097023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99904051T PT1049767E (pt)	1998-01-08	1999-01-08	Coelho transgenico que expressa uma lipoproteina (a) humana funcional

Country Status (12)

Country	Link
US (1)	US6512161B1 (pt)
EP (1)	EP1049767B1 (pt)
JP (2)	JP2002500039A (pt)
AT (1)	ATE302267T1 (pt)
AU (1)	AU759707B2 (pt)
CA (1)	CA2316808C (pt)
DE (1)	DE69926729T2 (pt)
DK (1)	DK1049767T3 (pt)
ES (1)	ES2247780T3 (pt)
PT (1)	PT1049767E (pt)
WO (1)	WO1999035241A1 (pt)
ZA (1)	ZA99133B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1122314A1 (en) *	2000-02-04	2001-08-08	Leja Research B.V.	Method for the production of a protein
US7888324B2 (en) *	2001-08-01	2011-02-15	Genzyme Corporation	Antisense modulation of apolipoprotein B expression
US7407943B2 (en) *	2001-08-01	2008-08-05	Isis Pharmaceuticals, Inc.	Antisense modulation of apolipoprotein B expression
US7259150B2 (en)	2001-08-07	2007-08-21	Isis Pharmaceuticals, Inc.	Modulation of apolipoprotein (a) expression
AU2012258396B2 (en) *	2001-08-07	2015-05-07	Isis Pharmaceuticals, Inc.	Antisense modulation of apolipoprotein (a) expression
US7227014B2 (en) *	2001-08-07	2007-06-05	Isis Pharmaceuticals, Inc.	Antisense modulation of apolipoprotein (a) expression
US7585511B2 (en)	2002-08-02	2009-09-08	Universite Libre De Bruxelles	Apolipoprotein L-I and/or derivated polypeptide for the treatment of and/or the prevention of diseases induced by trypanosoma
US20040033480A1 (en) *	2002-08-15	2004-02-19	Wong Norman C.W.	Use of resveratrol to regulate expression of apolipoprotein A1
US7511131B2 (en)	2002-11-13	2009-03-31	Genzyme Corporation	Antisense modulation of apolipoprotein B expression
US20060009410A1 (en) *	2002-11-13	2006-01-12	Crooke Rosanne M	Effects of apolipoprotein B inhibition on gene expression profiles in animals
AU2005215786A1 (en) *	2004-02-17	2005-09-01	Nielsen Media Research, Inc. Et Al.	Methods and apparatus for monitoring video games
US20050287558A1 (en)	2004-05-05	2005-12-29	Crooke Rosanne M	SNPs of apolipoprotein B and modulation of their expression
PT1786472E (pt) *	2004-08-10	2013-03-06	Genzyme Corp	Modulação anti-sentido de expressão de apolipoproteína
EP2332527A3 (en) *	2004-10-20	2011-11-16	Resverlogix Corp.	Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
AU2006275514B2 (en) *	2005-07-29	2012-04-05	Resverlogix Corp.	Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US8143230B2 (en)	2006-05-05	2012-03-27	Isis Pharmaceuticals, Inc.	Compounds and methods for modulating expression of PCSK9
KR101444489B1 (ko) *	2007-02-01	2014-09-24	리스버로직스 코퍼레이션	심혈관 질환을 예방 및 치료하기 위한 화합물
AU2008230886B9 (en)	2007-03-24	2014-09-04	Kastle Therapeutics, Llc	Administering antisense oligonucleotides complementary to human apolipoprotein B
US8114995B2 (en)	2008-06-26	2012-02-14	Resverlogix Corp.	Methods of preparing quinazolinone derivatives
US20110023140A1 (en) *	2008-12-04	2011-01-27	Sigma-Aldrich Co.	Rabbit genome editing with zinc finger nucleases
ES2542835T3 (es)	2009-01-08	2015-08-12	Resverlogix Corporation	Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
EP2408796B1 (en)	2009-03-16	2020-04-22	Ionis Pharmaceuticals, Inc.	Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III
KR101841003B1 (ko)	2009-03-18	2018-03-22	리스버로직스 코퍼레이션	신규한 소염제
US9757368B2 (en)	2009-04-22	2017-09-12	Resverlogix Corp.	Anti-inflammatory agents
EP2464220A4 (en)	2009-08-13	2014-05-07	Crystal Bioscience Inc	Transgenic animal for the production of antibodies with minimal complementarity-determining regions
KR20140048119A (ko)	2011-04-15	2014-04-23	고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸	Ｄｎａ 백신
US9610251B2 (en)	2011-11-01	2017-04-04	Resverlogix Corp.	Pharmaceutical compositions for substituted quinazolinones
US9574193B2 (en)	2012-05-17	2017-02-21	Ionis Pharmaceuticals, Inc.	Methods and compositions for modulating apolipoprotein (a) expression
WO2013173789A2 (en)	2012-05-17	2013-11-21	Isis Pharmaceuticals, Inc.	Antisense oligonucleotide compositions
ES2820548T3 (es) *	2012-05-24	2021-04-21	Ionis Pharmaceuticals Inc	Métodos y composiciones para modular la expresión de la apolipoproteína (a)
JP6001974B2 (ja) *	2012-09-21	2016-10-05	アンジェスＭｇ株式会社	アポリポプロテイン（ａ）の特異的エピトープを含むＤＮＡワクチン
WO2014080290A2 (en)	2012-11-21	2014-05-30	Rvx Therapeutics Inc.	Cyclic amines as bromodomain inhibitors
US9765039B2 (en)	2012-11-21	2017-09-19	Zenith Epigenetics Ltd.	Biaryl derivatives as bromodomain inhibitors
WO2014096965A2 (en)	2012-12-21	2014-06-26	Rvx Therapeutics Inc.	Novel heterocyclic compounds as bromodomain inhibitors
US9018437B2 (en)	2013-09-12	2015-04-28	Matthias W. Rath	Transgenic mouse expressing human apo(a) and human apo(B-100) with disabled vitamin C gene produces human Lp(a)
WO2016057050A1 (en)	2014-10-05	2016-04-14	Matthias W. Rath	Transgenic mouse expressing human lipoprotein (a) with disabled vitamin c gene and its use as a disease treatment model
CN107530356A (zh)	2015-03-13	2018-01-02	雷斯韦洛吉克斯公司	用于治疗补体相关疾病之组合物及治疗方法
JP2024500035A (ja)	2020-12-23	2024-01-04	アルゴノートアールエヌエーリミテッド	心血管疾患の治療

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341091C (en)	1983-10-20	2000-09-05	Masayori Inouye	Regulation of gene expression by employing translational inhibition utilizaing mrna interfering complementary rna
GB8424757D0 (en)	1984-10-01	1984-11-07	Pasteur Institut	Retroviral vector
US5168062A (en)	1985-01-30	1992-12-01	University Of Iowa Research Foundation	Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4797368A (en)	1985-03-15	1989-01-10	The United States Of America As Represented By The Department Of Health And Human Services	Adeno-associated virus as eukaryotic expression vector
US5139941A (en)	1985-10-31	1992-08-18	University Of Florida Research Foundation, Inc.	AAV transduction vectors
US4861719A (en)	1986-04-25	1989-08-29	Fred Hutchinson Cancer Research Center	DNA constructs for retrovirus packaging cell lines
CA1315719C (en)	1988-02-05	1993-04-06	Arthur Bank	Retroviral packaging cell lines and processes of using same
CA1339354C (en)	1988-09-01	1997-08-26	The Whitehead Institute For Biomedical Research	Recombinant retroviruses with amphotropic and ecotropic host ranges
US5703055A (en)	1989-03-21	1997-12-30	Wisconsin Alumni Research Foundation	Generation of antibodies through lipid mediated DNA delivery
US5585362A (en)	1989-08-22	1996-12-17	The Regents Of The University Of Michigan	Adenovirus vectors for gene therapy
CA2039921A1 (en)	1990-04-16	1991-10-17	Xandra O. Breakefield	Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
WO1991018088A1 (en)	1990-05-23	1991-11-28	The United States Of America, Represented By The Secretary, United States Department Of Commerce	Adeno-associated virus (aav)-based eucaryotic vectors
US5173414A (en)	1990-10-30	1992-12-22	Applied Immune Sciences, Inc.	Production of recombinant adeno-associated virus vectors
US5252479A (en)	1991-11-08	1993-10-12	Research Corporation Technologies, Inc.	Safe vector for gene therapy
ATE348175T1 (de)	1992-07-17	2007-01-15	Dana Farber Cancer Inst Inc	Method eder intrazellularen bindung von zielgerichteten molekülen
WO1994012649A2 (en)	1992-12-03	1994-06-09	Genzyme Corporation	Gene therapy for cystic fibrosis
US5434058A (en)	1993-02-09	1995-07-18	Arch Development Corporation	Apolipoprotein B MRNA editing protein compositions and methods
FR2705361B1 (fr)	1993-05-18	1995-08-04	Centre Nat Rech Scient	Vecteurs viraux et utilisation en thérapie génique.
FR2705686B1 (fr)	1993-05-28	1995-08-18	Transgene Sa	Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
US5866755A (en)	1993-06-14	1999-02-02	Basf Aktiengellschaft	Animals transgenic for a tetracycline-regulated transcriptional inhibitor
AU7264694A (en)	1993-07-13	1995-02-13	Rhone-Poulenc Rorer S.A.	Defective adenovirus vectors and use thereof in gene therapy
US5877399A (en) *	1994-01-27	1999-03-02	Johns Hopkins University	Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
FR2718329B1 (fr) *	1994-03-21	2002-09-20	Rhone Poulenc Rorer Sa	Lapin transgénique sensibilisé aux dyslipoprotéinémies.
IL116816A (en)	1995-01-20	2003-05-29	Rhone Poulenc Rorer Sa	Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof

1999
- 1999-01-08 AT AT99904051T patent/ATE302267T1/de active
- 1999-01-08 PT PT99904051T patent/PT1049767E/pt unknown
- 1999-01-08 DE DE69926729T patent/DE69926729T2/de not_active Expired - Lifetime
- 1999-01-08 WO PCT/US1999/000401 patent/WO1999035241A1/en not_active Ceased
- 1999-01-08 DK DK99904051T patent/DK1049767T3/da active
- 1999-01-08 CA CA002316808A patent/CA2316808C/en not_active Expired - Fee Related
- 1999-01-08 ES ES99904051T patent/ES2247780T3/es not_active Expired - Lifetime
- 1999-01-08 US US09/227,701 patent/US6512161B1/en not_active Expired - Lifetime
- 1999-01-08 AU AU24536/99A patent/AU759707B2/en not_active Ceased
- 1999-01-08 ZA ZA9900133A patent/ZA99133B/xx unknown
- 1999-01-08 JP JP2000527627A patent/JP2002500039A/ja active Pending
- 1999-01-08 EP EP99904051A patent/EP1049767B1/en not_active Expired - Lifetime
2009
- 2009-09-28 JP JP2009223202A patent/JP2010000090A/ja active Pending

Also Published As

Publication number	Publication date
WO1999035241A1 (en)	1999-07-15
US6512161B1 (en)	2003-01-28
JP2002500039A (ja)	2002-01-08
EP1049767A4 (en)	2002-05-08
ZA99133B (en)	1999-09-16
DE69926729D1 (de)	2005-09-22
DE69926729T2 (de)	2006-06-08
ATE302267T1 (de)	2005-09-15
WO1999035241A9 (en)	2000-04-13
ES2247780T3 (es)	2006-03-01
DK1049767T3 (da)	2005-09-19
JP2010000090A (ja)	2010-01-07
AU759707B2 (en)	2003-04-17
EP1049767B1 (en)	2005-08-17
CA2316808C (en)	2007-04-10
AU2453699A (en)	1999-07-26
CA2316808A1 (en)	1999-07-15
EP1049767A1 (en)	2000-11-08

Publication	Publication Date	Title
PT1049767E (pt)	2005-10-31	Coelho transgenico que expressa uma lipoproteina (a) humana funcional
CY1116385T1 (el)	2017-02-08	Αντινοηματικη διαμορφωση της εκφρασης της απολιποπρωτεινης β
AR020884A1 (es)	2002-06-05	Genes de enzimas modificadoras de acidos grasos vegetales asociadas con la formacion de dobles enlaces
DE60023936D1 (de)	2005-12-15	Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
ATE322902T1 (de)	2006-04-15	Verwendung von azetogenischen hydrogenotrophischen stämmen zur vorbeugung und behandlung von verdauungskrankheiten
TR199902545T2 (xx)	2000-01-21	Kalp damar hastal�klar�n�n �nlenmesinde siklooksijenaz-2 inhibit�rlerini kullanma y�ntemi
DE69323983D1 (de)	1999-04-22	Methode zur Modifizierung des Fettdruckes von Buchstaben
HUP9902571A2 (hu)	1999-11-29	Timidin kináz variánsai, ezeket kódoló nukleinsav-szekvenciák és alkalmazásuk génterápiában
DE60139122D1 (de)	2009-08-13	Verfahren zur produktion von natürlichen medizin präparaten
DE60021381D1 (de)	2005-08-25	Chinonverbindungen zur behandlung von krankheiten
GB9924957D0 (en)	1999-12-22	Novel treatment
DE58906239D1 (de)	1994-01-05	Einrichtung zur Behandlung von Erkrankungen, insbesondere der Sehbahn.
DE69433243D1 (de)	2003-11-20	Verwendunf von ApoE zum Binden von TAU und MAP2c Proteinen und zur Behandlung von Alzheimer's Krankheit
BR0309122A (pt)	2005-02-01	Plantas com morfogênese melhorada e método para sua construção
ATE230414T1 (de)	2003-01-15	Mimetika von beta-faltblatt und verfahren zur verwendung davon
DE60135763D1 (de)	2008-10-23	System zur herstellung von bauholz mit abgerundeten enden
PT914419E (pt)	2004-10-29	Ratinhos transgenicos capazes de expressar o factor de inibicao de leucemia
DE60016405D1 (de)	2005-01-05	Neurodegenerative-erkrankung verwandtes gen
DE68911132D1 (de)	1994-01-13	Hematopoietische kolonien stimulierende faktoren zur verbesserung des lipoprotein/cholesterin-profils.
DE69532725D1 (de)	2004-04-22	Methode zur direkter klonierung von nukleasegenen in e.coli
DE602004001047D1 (de)	2006-07-06	Phospholipidester von Clofarabin
DE69812438D1 (de)	2003-04-24	Zusammensetzung zur herstellung von brennstoff-briketts
DE68915214D1 (de)	1994-06-16	Methode zur Bestimmung des Pyrogengehaltes.
ATE382054T1 (de)	2008-01-15	Verwendung von oxytocinfragmenten zur herstellung einer pharmazeutischen zusammensetzung zum bewirken von eustasis
BR9709264A (pt)	1999-08-10	Processo para produzir e composto