PL352827A1 - Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants - Google Patents

Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Info

Publication number: PL352827A1
Authority: PL; Poland
Prior art keywords: pyrymidinones; anticoagulants; heteroaryl; useful; polycyclic aryl
Prior art date: 1999-05-19

Application number

PL00352827A

Other languages

English (en)

Polish (pl)

Inventor

Michael S. South

Ashton T.II Hamme

William Neumann

Darin E. Jones

Melvin L. Rueppel

Original Assignee

Pharmacia Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-19

Filing date

2000-05-17

Publication date

2003-09-08

2000-05-17 Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation

2003-09-08 Publication of PL352827A1 publication Critical patent/PL352827A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL00352827A 1999-05-19 2000-05-17 Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants PL352827A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13479499P	1999-05-19	1999-05-19
PCT/US2000/009806 WO2000069832A1 (en)	1999-05-19	2000-05-17	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Publications (1)

Publication Number	Publication Date
PL352827A1 true PL352827A1 (en)	2003-09-08

Family

ID=22465042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL00352827A PL352827A1 (en)	1999-05-19	2000-05-17	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Country Status (22)

Country	Link
EP (1)	EP1178970A1 (hu)
JP (1)	JP2002544262A (hu)
KR (1)	KR20010114271A (hu)
CN (1)	CN1157380C (hu)
AR (1)	AR030021A1 (hu)
AU (2)	AU771718B2 (hu)
BR (1)	BR0010758A (hu)
CA (1)	CA2373614A1 (hu)
CZ (1)	CZ20014116A3 (hu)
EA (1)	EA004867B1 (hu)
HU (1)	HUP0201242A3 (hu)
IL (1)	IL146243A0 (hu)
MX (1)	MXPA01011804A (hu)
NO (1)	NO20015604L (hu)
NZ (1)	NZ514874A (hu)
PE (1)	PE20010229A1 (hu)
PL (1)	PL352827A1 (hu)
SK (1)	SK15852001A3 (hu)
TW (1)	TWI222445B (hu)
UY (1)	UY26156A1 (hu)
WO (1)	WO2000069832A1 (hu)
ZA (2)	ZA200109339B (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6716838B1 (en)	1999-05-19	2004-04-06	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6664255B1 (en)	1999-05-19	2003-12-16	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
NZ514877A (en) *	1999-05-19	2004-10-29	Pharmacia Corp	Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6458952B1 (en)	1999-05-19	2002-10-01	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en)	1999-05-19	2003-11-25	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6750342B1 (en)	1999-05-19	2004-06-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en)	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en)	1999-05-19	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6660885B2 (en)	2000-03-13	2003-12-09	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
PT1268463E (pt)	2000-04-05	2005-05-31	Pharmacia Corp	4-pironas substituidas com arilo e heteroarilo policiclicos uteis para a inibicao selectiva da cascata de coagulacao
US6693121B2 (en)	2000-04-05	2004-02-17	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
EP1274676A2 (en)	2000-04-17	2003-01-15	Pharmacia Corporation	Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
AU2001222501A1 (en) *	2000-05-18	2001-11-26	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7119094B1 (en)	2000-11-20	2006-10-10	Warner-Lambert Company	Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
CA2430037A1 (en)	2000-11-20	2002-05-30	Michael S. South	Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7015223B1 (en)	2000-11-20	2006-03-21	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
JP2005525413A (ja)	2001-10-03	2005-08-25	ファルマシア・コーポレーション	凝固カスケードの選択的抑制に有用な置換５員多環状化合物
JP2005519866A (ja)	2001-10-03	2005-07-07	ファルマシア・コーポレーション	凝固カスケードの選択阻害に有用な６員複素環式化合物
MXPA04003167A (es) *	2001-10-03	2004-07-08	Pharmacia Corp	Compuestos heterociclicos insaturados de 6 miembros utiles para la inhibicion selectiva de la cascada de coagulacion.
JP2005532268A (ja)	2002-02-22	2005-10-27	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	置換されたピリミジノンおよびピリミジンチオン
TW200307667A (en)	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
US7217794B2 (en)	2003-04-02	2007-05-15	Daiamed, Inc.	Compounds and methods for treatment of thrombosis
US7182738B2 (en)	2003-04-23	2007-02-27	Marctec, Llc	Patient monitoring apparatus and method for orthosis and other devices
CN101212969B (zh) *	2005-06-07	2013-08-07	药典公司	用于抑郁和应激障碍的嗪酮和二嗪酮v3抑制剂
CN104311537B (zh) *	2014-09-19	2016-08-24	广东东阳光药业有限公司	含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途
AU2020396565C1 (en) *	2019-12-04	2025-05-15	Omeros Corporation	MASP-2 inhibitors and methods of use
CN115779953B (zh) *	2022-12-19	2024-06-21	中南大学	铜负载碳基单原子材料及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5948785A (en) *	1995-04-27	1999-09-07	The Green Cross Corporation	Heterocyclic amide compounds and pharmaceutical use of the same

2000
- 2000-05-17 BR BR0010758-1A patent/BR0010758A/pt not_active IP Right Cessation
- 2000-05-17 SK SK1585-2001A patent/SK15852001A3/sk unknown
- 2000-05-17 EA EA200101214A patent/EA004867B1/ru not_active IP Right Cessation
- 2000-05-17 PL PL00352827A patent/PL352827A1/xx not_active Application Discontinuation
- 2000-05-17 MX MXPA01011804A patent/MXPA01011804A/es unknown
- 2000-05-17 EP EP00931928A patent/EP1178970A1/en not_active Withdrawn
- 2000-05-17 IL IL14624300A patent/IL146243A0/xx unknown
- 2000-05-17 HU HU0201242A patent/HUP0201242A3/hu unknown
- 2000-05-17 JP JP2000618249A patent/JP2002544262A/ja active Pending
- 2000-05-17 CA CA002373614A patent/CA2373614A1/en not_active Abandoned
- 2000-05-17 NZ NZ514874A patent/NZ514874A/en unknown
- 2000-05-17 WO PCT/US2000/009806 patent/WO2000069832A1/en not_active Ceased
- 2000-05-17 KR KR1020017014753A patent/KR20010114271A/ko not_active Withdrawn
- 2000-05-17 CZ CZ20014116A patent/CZ20014116A3/cs unknown
- 2000-05-17 CN CNB008077479A patent/CN1157380C/zh not_active Expired - Fee Related
- 2000-05-17 AU AU49734/00A patent/AU771718B2/en not_active Ceased
- 2000-05-19 AR ARP000102446A patent/AR030021A1/es unknown
- 2000-05-19 UY UY26156A patent/UY26156A1/es not_active Application Discontinuation
- 2000-06-09 PE PE2000000575A patent/PE20010229A1/es not_active Application Discontinuation
- 2000-07-25 TW TW089109595A patent/TWI222445B/zh not_active IP Right Cessation
2001
- 2001-11-13 ZA ZA200109339A patent/ZA200109339B/xx unknown
- 2001-11-16 NO NO20015604A patent/NO20015604L/no not_active Application Discontinuation
2004
- 2004-01-21 ZA ZA200400448A patent/ZA200400448B/xx unknown
- 2004-05-31 AU AU2004202375A patent/AU2004202375A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0201242A3 (en)	2003-02-28
PE20010229A1 (es)	2001-03-07
BR0010758A (pt)	2003-06-10
CN1351593A (zh)	2002-05-29
UY26156A1 (es)	2000-12-29
AU2004202375A1 (en)	2004-06-24
ZA200109339B (en)	2004-05-26
NZ514874A (en)	2004-11-26
TWI222445B (en)	2004-10-21
ZA200400448B (en)	2004-09-29
KR20010114271A (ko)	2001-12-31
CN1157380C (zh)	2004-07-14
AR030021A1 (es)	2003-08-13
NO20015604D0 (no)	2001-11-16
AU4973400A (en)	2000-12-05
NO20015604L (no)	2002-01-11
JP2002544262A (ja)	2002-12-24
EA004867B1 (ru)	2004-08-26
MXPA01011804A (es)	2003-09-04
CZ20014116A3 (cs)	2002-06-12
AU771718B2 (en)	2004-04-01
IL146243A0 (en)	2002-07-25
CA2373614A1 (en)	2000-11-23
HUP0201242A2 (hu)	2002-12-28
SK15852001A3 (sk)	2003-06-03
WO2000069832A1 (en)	2000-11-23
EP1178970A1 (en)	2002-02-13
EA200101214A1 (ru)	2002-06-27

Publication	Publication Date	Title
IL146243A0 (en)	2002-07-25	Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants
GB9923894D0 (en)	1999-12-08	Accelerometer
FI19991996L (fi)	2001-03-20	Suodatuslaitteisto
ZA200109338B (en)	2004-05-26	Substituted polycyclic aryl and heteroaryl uracils as anti-coagulative agents.
EP1223932A4 (en)	2003-01-15	COMPOUNDS AND METHODS
EP1146790A4 (en)	2004-03-17	COMPOUNDS AND METHODS
EP1140083A4 (en)	2004-01-02	NEW CONNECTIONS
GB9903584D0 (en)	1999-04-07	Modified calycins
EG24063A (en)	2008-05-08	Novel compounds
GB0000276D0 (en)	2000-03-01	Capacitor
FI19992429L (fi)	2001-05-12	Suodatuslaitteisto
PL357603A1 (en)	2004-07-26	Substituted pyrroles
GB2349217B (en)	2001-04-04	Compound screening methods
GB9922942D0 (en)	1999-12-01	Catch
GC0000265A (en)	2006-11-01	Substituted pyrroles
GB9922530D0 (en)	1999-11-24	Distractor
GB9929107D0 (en)	2000-02-02	Window component etc
GB9921851D0 (en)	1999-11-17	Structural elements
GB9929433D0 (en)	2000-02-09	Cyclic compound
GB2357543B (en)	2003-12-31	Structural members
GB0004744D0 (en)	2000-04-19	Crane
AU139821S (en)	2000-02-18	Height chart
GB9927083D0 (en)	2000-01-12	Rodenticides
GB9929538D0 (en)	2000-02-09	Rodenticides
GB9904510D0 (en)	1999-04-21	Multifunctional set square

Legal Events

Date	Code	Title	Description
2007-11-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)