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PE49495A1 - Derivado tetraciclico y proceso para su preparacion - Google Patents

Derivado tetraciclico y proceso para su preparacion

Info

Publication number
PE49495A1
PE49495A1 PE1995259855A PE25985595A PE49495A1 PE 49495 A1 PE49495 A1 PE 49495A1 PE 1995259855 A PE1995259855 A PE 1995259855A PE 25985595 A PE25985595 A PE 25985595A PE 49495 A1 PE49495 A1 PE 49495A1
Authority
PE
Peru
Prior art keywords
alkyl
hydrogen
benzene
compound
preparation
Prior art date
Application number
PE1995259855A
Other languages
English (en)
Inventor
Claude-Marie Daugan Alain
Original Assignee
Glaxo Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE49495(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Lab Sa filed Critical Glaxo Lab Sa
Publication of PE49495A1 publication Critical patent/PE49495A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) R0 ES HIDROGENO, HALOGENO, o ALQUILO C1-C6; 2) R1 ES HIDROGENO, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, HALOALQUILO C1-C6, CICLOALQUILO C3-C8, CICLOALQUILO C3-C8 UNIDO A ALQUILO C1-C3 , ARILO-ALQUILO C1-C3 o HETEROARIL-ALQUILO C1-C3; 3) R2 ES UN ANILLO AROMATICO MONOCICLICO SUSTITUIDO OPCIONALMENTE, SELECCIONADO DE BENCENO, TIOFENO, FURANO Y PIRIDINA o UN ANILLO BICICLICO DERIVADO DE BENCENO; 4) R3 ES HIDROGENO o ALQUILO C1-C3, o R1 Y R3 CONJUNTAMENTE REPRESENTAN UNA CADENA DE ALQUILO o DE ALQUENILO CON 3 A 4 ELEMENTOS; DICHO COMPUESTO ES UN INHIBIDOR DE FOSFODIESTERASA ESPECIFICO PARA LA ENZIMA 3`,5'-MONOFOSFATO DE GUANOSINA CICLICA; LO QUE PERMITE ELEVAR LA CONCENTRACION DE GMP CICLICO QUE CONDUCE A ACTIVIDADES ANTIPLAQUETAS, ANTINEUTROFILAS, ANTIVASOESPASTICAS, VASODILATADORAS, NATRIURETICAS Y DIURETICAS; PUDIENDO SER UTIL EN EL TRATAMIENTO DE DESORDENES CARDIOVASCULARES
PE1995259855A 1994-01-21 1995-01-19 Derivado tetraciclico y proceso para su preparacion PE49495A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9401090A GB9401090D0 (en) 1994-01-21 1994-01-21 Chemical compounds

Publications (1)

Publication Number Publication Date
PE49495A1 true PE49495A1 (es) 1996-01-10

Family

ID=10749089

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995259855A PE49495A1 (es) 1994-01-21 1995-01-19 Derivado tetraciclico y proceso para su preparacion

Country Status (48)

Country Link
US (5) US5859006A (es)
EP (1) EP0740668B1 (es)
JP (3) JP3808095B2 (es)
KR (1) KR100357411B1 (es)
CN (2) CN1045777C (es)
AP (1) AP556A (es)
AT (1) ATE169018T1 (es)
AU (2) AU689205B2 (es)
BG (1) BG62733B1 (es)
BR (1) BR9506559C8 (es)
CA (1) CA2181377C (es)
CO (1) CO4340684A1 (es)
CZ (1) CZ286566B6 (es)
DE (2) DE69503753T2 (es)
DK (1) DK0740668T3 (es)
EE (1) EE03231B1 (es)
EG (1) EG25852A (es)
ES (1) ES2122543T3 (es)
FI (1) FI113176B (es)
GB (1) GB9401090D0 (es)
HR (1) HRP950023B1 (es)
HU (1) HU222494B1 (es)
IL (1) IL112384A (es)
IN (1) IN183942B (es)
IS (1) IS1888B (es)
LU (1) LU91017I2 (es)
LV (1) LV11690B (es)
MA (1) MA23433A1 (es)
MX (1) MX9602904A (es)
MY (1) MY114663A (es)
NL (1) NL300124I2 (es)
NO (2) NO306465B1 (es)
NZ (1) NZ279199A (es)
OA (1) OA10584A (es)
PE (1) PE49495A1 (es)
PL (1) PL179744B1 (es)
RO (1) RO117794B1 (es)
RU (1) RU2142463C1 (es)
SA (1) SA95150475B1 (es)
SG (1) SG49184A1 (es)
SI (1) SI0740668T1 (es)
SK (1) SK280879B6 (es)
SV (1) SV1995000002A (es)
TN (1) TNSN95004A1 (es)
TW (1) TW378210B (es)
UY (1) UY23893A1 (es)
WO (1) WO1995019978A1 (es)
ZA (1) ZA95424B (es)

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MA23433A1 (fr) 1995-10-01
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NO963015L (no) 1996-09-09
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PL179744B1 (pl) 2000-10-31
US20020119976A1 (en) 2002-08-29
HRP950023A2 (en) 1998-04-30
SG49184A1 (en) 1998-05-18
EE03231B1 (et) 1999-10-15
LV11690A (lv) 1997-02-20
JP3808095B2 (ja) 2006-08-09
JP2004217674A (ja) 2004-08-05
JP4347125B2 (ja) 2009-10-21
NO963015D0 (no) 1996-07-19
FI962927A7 (fi) 1996-07-19
TW378210B (en) 2000-01-01
AU689205B2 (en) 1998-03-26
US6369059B1 (en) 2002-04-09
NO306465B1 (no) 1999-11-08
IS1888B (is) 2003-09-01
OA10584A (en) 2002-08-26
LU91017I2 (fr) 2003-05-26
PL315559A1 (en) 1996-11-12
US6784179B2 (en) 2004-08-31
ATE169018T1 (de) 1998-08-15
SI0740668T1 (en) 1999-02-28
CZ286566B6 (cs) 2000-05-17
BR9506559A (pt) 1997-10-28
IN183942B (es) 2000-05-20
HRP950023B1 (en) 2000-10-31
DE10399006I2 (de) 2004-05-06
IL112384A (en) 1998-08-16
CA2181377C (en) 2002-05-28
NO2003002I2 (no) 2005-03-21
SA95150475B1 (ar) 2005-07-31
JPH09508113A (ja) 1997-08-19
SK280879B6 (sk) 2000-08-14
US6025494A (en) 2000-02-15
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MX9602904A (es) 1997-12-31
KR100357411B1 (ko) 2003-02-05
US5859006A (en) 1999-01-12
EP0740668B1 (en) 1998-07-29
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FI962927A0 (fi) 1996-07-19
CZ211696A3 (en) 1997-06-11
CA2181377A1 (en) 1995-07-27
UY23893A1 (es) 1995-07-11
AU707055B2 (en) 1999-07-01
LV11690B (en) 1997-06-20
DE69503753D1 (de) 1998-09-03
CN1143963A (zh) 1997-02-26
GB9401090D0 (en) 1994-03-16
RU2142463C1 (ru) 1999-12-10
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HK1013286A1 (en) 1999-08-20
CN1070492C (zh) 2001-09-05
FI113176B (fi) 2004-03-15
CN1224720A (zh) 1999-08-04
NZ279199A (en) 1998-01-26
BR9506559C8 (pt) 2020-07-07
ZA95424B (en) 1995-09-27
HUT74943A (en) 1997-03-28

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