PE38497A1 - Agentes antifungicos de peptidos ciclicos - Google Patents
Agentes antifungicos de peptidos ciclicosInfo
- Publication number
- PE38497A1 PE38497A1 PE1996000374A PE00037496A PE38497A1 PE 38497 A1 PE38497 A1 PE 38497A1 PE 1996000374 A PE1996000374 A PE 1996000374A PE 00037496 A PE00037496 A PE 00037496A PE 38497 A1 PE38497 A1 PE 38497A1
- Authority
- PE
- Peru
- Prior art keywords
- bnrz1rz2
- bencilo
- alcoxy
- ch2c
- antifungal agents
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 208000001388 Opportunistic Infections Diseases 0.000 abstract 1
- 241000233872 Pneumocystis carinii Species 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A PEPTIDOS CICLICOS SEMISINTETICOS DE FORMULA (I), EN DONDE: R`, R" Y R"' SON -H O -CH3 u R' ES -CH2C(O)NH2; Ry1, Ry2, Ry3, Ry4 Y Rx2 SON H O PREFERENTEMENTE -OH; Rx1 ES PREFERENTEMENTE -CH3, BENCILO, -CH2CHOHCH2OH, -CH2COOH , -(CH2)bNRz1Rz2 O -(CH2)2PORz3Rz4, ENTRE OTROS, DONDE: Rz1 Y Rz2 SON H O ALQUILO (C1-C6), ENTRE OTROS; Rz3 Y Rz4 SON PREFERENTEMENTE H O -OCH3; Ro ES -OP(O)(OH)2, -OP(O)(OH)(R1), -OP(O)(OH)(OR1) O PREFERENTEMENTE ES -OH; R1 ES PREFERENTEMENTE -CH3; R2 ES PREFERENTEMENTE (a) -C(O)-C6H4-C6H4-C6H4-O-(CH2)4-CH3, O (b) -C(O)-C6H4-Z-C6H4-R4, ENTRE OTROS, EN DONDE: SI i) R' ES -CH2C(O)NH2 Y Rx1 ES -CH3 O BENCILO O SI ii) Rx1 ES -(CH2)bNRz1Rz2, ENTONCES R2 NO ES (b), EN DONDE: Z ES UN ENLACE; R4 ES ALCOXI(C1-C12) OPCIONALMENTE SUSTITUIDO CON ALQUILAMINO(C1-C4), FENILO SUSTITUIDO CON ALCOXI(C1-C12) O ES -O-(CH2)r-W-R5, ENTRE OTROS, DONDE W ES PIPERIDINO, PIPERAZINO O PIRROLIDINO Y r ES 2, 3 o 4. TAMBIEN SE REFIERE A LA PREPARACION DE LOS COMPUESTO DE FORMULA (I), QUE COMPRENDE LA ETERIFICACION DEL GRUPO OH, OBTENIENDOSE ORx1, DONDE LOS SUSTITUYENTES DE Rx1 FUERON YA SENALADOS. SIENDO USADOS EN EL TRATAMIENTO DE INFECCIONES FUNGICAS DEL GENERO CANDIDA O ASPERGILLUS, ENTRE OTROS, TANTO COMO DE INFECCIONES OPORTUNISTAS EN INDIVIDUOS INMUNOSUPRIMIDOS, CAUSADA POR PNEUMOCYSTIS CARINII, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45305295A | 1995-05-26 | 1995-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE38497A1 true PE38497A1 (es) | 1997-10-09 |
Family
ID=23799020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1996000374A PE38497A1 (es) | 1995-05-26 | 1996-05-22 | Agentes antifungicos de peptidos ciclicos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5652213A (es) |
| EP (1) | EP0744405B1 (es) |
| JP (1) | JPH11505845A (es) |
| AR (1) | AR002103A1 (es) |
| AT (1) | ATE245162T1 (es) |
| AU (1) | AU5799196A (es) |
| CA (1) | CA2220728A1 (es) |
| DE (1) | DE69629075T2 (es) |
| ES (1) | ES2201154T3 (es) |
| IL (1) | IL118334A0 (es) |
| PE (1) | PE38497A1 (es) |
| WO (1) | WO1996037510A1 (es) |
| ZA (1) | ZA964014B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743777B1 (en) * | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| US6384013B1 (en) | 1992-03-19 | 2002-05-07 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| US5965525A (en) * | 1992-03-19 | 1999-10-12 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JP2001503015A (ja) * | 1996-02-01 | 2001-03-06 | イーライ・リリー・アンド・カンパニー | 環状ペプチド抗真菌剤 |
| US6323176B1 (en) | 1998-02-25 | 2001-11-27 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| EP1107981B1 (en) | 1998-08-20 | 2005-01-26 | Eli Lilly & Company | Synthesis of ring-modified cyclic peptide analogs |
| AU6408499A (en) * | 1998-10-05 | 2000-04-26 | Abbott Laboratories | Cyclic peptides as antifungal agents |
| IL143563A0 (en) | 1998-12-09 | 2002-04-21 | Lilly Co Eli | Purification of echinocandin cyclopeptide compounds |
| AU767357B2 (en) * | 1998-12-16 | 2003-11-06 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| KR20020002476A (ko) * | 1999-03-03 | 2002-01-09 | 피터 지. 스트링거 | 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환 |
| BR0008713A (pt) | 1999-03-03 | 2001-12-26 | Lilly Co Eli | Processos para preparar formulações ecomposições farmacêuticas orais com ecb |
| WO2000051564A1 (en) * | 1999-03-03 | 2000-09-08 | Eli Lilly And Company | Echinocandin pharmaceutical formulations containing micelle-forming surfactants |
| WO2000052037A1 (en) | 1999-03-03 | 2000-09-08 | Eli Lilly And Company | Echinocandin/carbohydrate complexes |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| US6991800B2 (en) * | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| EP2470190A4 (en) * | 2009-08-27 | 2013-07-17 | Seachaid Pharmaceuticals Inc | ECHINOCANDINDERIVATE |
| HUE036778T2 (hu) | 2011-03-03 | 2018-07-30 | Cidara Therapeutics Inc | Gombaellenes szerek és alkalmazásuk |
| PT3677252T (pt) | 2012-03-19 | 2023-10-02 | Cidara Therapeutics Inc | Regimes de dosagem para compostos da classe equinocandina |
| EP2883915A1 (en) * | 2013-12-13 | 2015-06-17 | Ecole Polytechnique Federale de Lausanne (EPFL) | Porphyrin based sensitizer for dye-sensitized solar cell |
| WO2017120471A1 (en) | 2016-01-08 | 2017-07-13 | Cidara Therapeutics, Inc. | Methods for preventing and treating pneumocystis infections |
| US11712459B2 (en) | 2016-03-16 | 2023-08-01 | Cidara Therapeutics, Inc. | Dosing regimens for treatment of fungal infections |
| CA3069423C (en) | 2017-07-12 | 2025-04-15 | Napp Pharmaceutical Group Limited | Formulations for the treatment of fungal infections |
| MX2022006424A (es) | 2019-12-06 | 2022-06-22 | Shanghai Senhui Medicine Co Ltd | Analogos de equinocandina y metodo de preparacion de los mismos. |
| CA3219309A1 (en) * | 2021-06-03 | 2022-12-08 | Wei Jiang | Method for preparing anidulafungin derivative |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4293488A (en) * | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912B nucleus |
| US4293489A (en) * | 1979-12-13 | 1981-10-06 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| US4320052A (en) * | 1979-12-13 | 1982-03-16 | Eli Lilly And Company | Derivatives of A-30912A nucleus |
| DK173802B1 (da) * | 1988-09-12 | 2001-11-05 | Merck & Co Inc | Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner |
| US5166135A (en) * | 1988-09-12 | 1992-11-24 | Merck & Company, Inc. | Method for the control of pneumocystis carinii |
| CA2037957A1 (en) * | 1990-03-12 | 1991-09-13 | Merck & Co., Inc. | N-acylated cyclohexapeptide compounds |
| GB2241956A (en) * | 1990-03-16 | 1991-09-18 | Merck & Co Inc | N-acylated cyclohexapeptide compounds |
| US5310726A (en) * | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| US5386009A (en) * | 1990-03-19 | 1995-01-31 | Merck & Co. Inc. | Lipopeptide derivatives |
| US5330973A (en) * | 1990-03-19 | 1994-07-19 | Merck & Co., Inc. | Lipopeptide derivatives |
| IE910892A1 (en) * | 1990-03-19 | 1991-09-25 | Merck & Co Inc | Lipopeptide compounds |
| IL97347A0 (en) * | 1990-03-19 | 1992-05-25 | Merck & Co Inc | Lipopeptide derivatives and antimicrobial compositions containing them |
| US5049546A (en) * | 1990-03-19 | 1991-09-17 | Merck & Co., Inc. | Antibiotic agents |
| IE912046A1 (en) * | 1990-06-18 | 1991-12-18 | Fujisawa Pharmaceutical Co | New polypeptide compound and a process for preparation¹thereof |
| US5369093A (en) * | 1991-03-15 | 1994-11-29 | Merck & Co., Inc. | Lipopeptide derivatives |
| US5233023A (en) * | 1991-07-30 | 1993-08-03 | Merck & Co., Inc. | Process for phosphate ester compounds of certain cyclohexapeptides |
| US6030944A (en) * | 1991-10-01 | 2000-02-29 | Merck & Co., Inc. | Cyclohexapeptidyl bisamine compounds |
| US5399552A (en) * | 1991-10-17 | 1995-03-21 | Merck & Co, Inc | Antibiotic peptides bearing aminoalkylthioether moieties |
| IL122315A (en) * | 1992-03-19 | 2002-03-10 | Lilly Co Eli | Cyclic peptides and antifungal pharmaceutical compositions containing them |
| US6268338B1 (en) * | 1993-04-30 | 2001-07-31 | Merck & Co., Inc. | Cyclohexapeptidyl amine compounds |
| WO1994025045A1 (en) * | 1993-05-04 | 1994-11-10 | Merck & Co., Inc. | Cyclohexapeptidyl aminoalkyl ethers |
| US5948753A (en) * | 1993-05-04 | 1999-09-07 | Merck & Co., Inc. | Cyclohexapeptidyl propanolamine compounds |
| AU7874494A (en) * | 1993-09-22 | 1995-04-10 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
-
1996
- 1996-03-11 US US08/613,949 patent/US5652213A/en not_active Expired - Fee Related
- 1996-05-20 AU AU57991/96A patent/AU5799196A/en not_active Abandoned
- 1996-05-20 CA CA002220728A patent/CA2220728A1/en not_active Abandoned
- 1996-05-20 WO PCT/US1996/007244 patent/WO1996037510A1/en not_active Ceased
- 1996-05-20 IL IL11833496A patent/IL118334A0/xx unknown
- 1996-05-20 JP JP8535782A patent/JPH11505845A/ja not_active Withdrawn
- 1996-05-20 ZA ZA9604014A patent/ZA964014B/xx unknown
- 1996-05-21 AT AT96303602T patent/ATE245162T1/de not_active IP Right Cessation
- 1996-05-21 DE DE69629075T patent/DE69629075T2/de not_active Expired - Fee Related
- 1996-05-21 EP EP96303602A patent/EP0744405B1/en not_active Expired - Lifetime
- 1996-05-21 ES ES96303602T patent/ES2201154T3/es not_active Expired - Lifetime
- 1996-05-22 PE PE1996000374A patent/PE38497A1/es not_active Application Discontinuation
- 1996-05-24 AR ARP960102716A patent/AR002103A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996037510A1 (en) | 1996-11-28 |
| ATE245162T1 (de) | 2003-08-15 |
| EP0744405A3 (en) | 1998-05-27 |
| IL118334A0 (en) | 1996-09-12 |
| DE69629075T2 (de) | 2004-04-15 |
| DE69629075D1 (de) | 2003-08-21 |
| AU5799196A (en) | 1996-12-11 |
| US5652213A (en) | 1997-07-29 |
| JPH11505845A (ja) | 1999-05-25 |
| EP0744405B1 (en) | 2003-07-16 |
| ZA964014B (en) | 1997-11-20 |
| AR002103A1 (es) | 1998-01-07 |
| CA2220728A1 (en) | 1996-11-28 |
| EP0744405A2 (en) | 1996-11-27 |
| ES2201154T3 (es) | 2004-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |