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AR002103A1 - Agentes antifungicos de peptidos ciclicos. - Google Patents

Agentes antifungicos de peptidos ciclicos.

Info

Publication number
AR002103A1
AR002103A1 ARP960102716A AR10271696A AR002103A1 AR 002103 A1 AR002103 A1 AR 002103A1 AR P960102716 A ARP960102716 A AR P960102716A AR 10271696 A AR10271696 A AR 10271696A AR 002103 A1 AR002103 A1 AR 002103A1
Authority
AR
Argentina
Prior art keywords
benzyl
alkyl
independently
hydrogen
antifungal agents
Prior art date
Application number
ARP960102716A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR002103A1 publication Critical patent/AR002103A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan formulaciones farmacéuticas y métodos para la inhibición de la actividad fúngica y parasitaria, utilizando un compuesto de fórmula (I),en la que R es hidrógeno, metilo o -CH2C(O)NH2; R y R son independientemente hidrógeno o metilo; Rx1 es alquilo C1-C6, bencilo,-(CH2)2Si(CH3)3, CH2CH=CH2, CH2CHOHCH2OH, -(CH2)aCOOH, -(CH2)bNRz1Rz2, -(CH2)cPORz3Rz4 o -[(CH2)2O]d-alquilo (C1-C6)]; a, b y c son,independientemente, 1,2,3,4,5 ó 6; Rz1 y Rz2 son, independientemente,hidrógeno, alquilo C1-C6 o Rz1 y Rz2 se combinan para formar -CH2(CH2)eCH2-;Rz3 y Rz4 son,independientemente,hidroxi o alcoxi C1-C6;d es 1 ó 2;e es 1,2 ó 3;Rx2,Ry1, Ry2 ry3,Ry4 son,independientemente, hidroxi o hidrógeno;R0 es hidroxi, -OP(O)(OH)2o un grupo de fórmulas (II),R1 es alquilo C1-C6,fenilo,p-halo-fenilo,p- nitrofenilo, bencilo, p-halo-bencilo o p-nitro-bencilo; y R2 es una cadenalateral como se ha definido en la presente.
ARP960102716A 1995-05-26 1996-05-24 Agentes antifungicos de peptidos ciclicos. AR002103A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45305295A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
AR002103A1 true AR002103A1 (es) 1998-01-07

Family

ID=23799020

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102716A AR002103A1 (es) 1995-05-26 1996-05-24 Agentes antifungicos de peptidos ciclicos.

Country Status (13)

Country Link
US (1) US5652213A (es)
EP (1) EP0744405B1 (es)
JP (1) JPH11505845A (es)
AR (1) AR002103A1 (es)
AT (1) ATE245162T1 (es)
AU (1) AU5799196A (es)
CA (1) CA2220728A1 (es)
DE (1) DE69629075T2 (es)
ES (1) ES2201154T3 (es)
IL (1) IL118334A0 (es)
PE (1) PE38497A1 (es)
WO (1) WO1996037510A1 (es)
ZA (1) ZA964014B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
JP2001503015A (ja) * 1996-02-01 2001-03-06 イーライ・リリー・アンド・カンパニー 環状ペプチド抗真菌剤
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
EP1107981B1 (en) 1998-08-20 2005-01-26 Eli Lilly & Company Synthesis of ring-modified cyclic peptide analogs
AU6408499A (en) * 1998-10-05 2000-04-26 Abbott Laboratories Cyclic peptides as antifungal agents
IL143563A0 (en) 1998-12-09 2002-04-21 Lilly Co Eli Purification of echinocandin cyclopeptide compounds
AU767357B2 (en) * 1998-12-16 2003-11-06 Eli Lilly And Company Cyclic peptide antifungal agents
KR20020002476A (ko) * 1999-03-03 2002-01-09 피터 지. 스트링거 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
BR0008713A (pt) 1999-03-03 2001-12-26 Lilly Co Eli Processos para preparar formulações ecomposições farmacêuticas orais com ecb
WO2000051564A1 (en) * 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
WO2000052037A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Echinocandin/carbohydrate complexes
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP2470190A4 (en) * 2009-08-27 2013-07-17 Seachaid Pharmaceuticals Inc ECHINOCANDINDERIVATE
HUE036778T2 (hu) 2011-03-03 2018-07-30 Cidara Therapeutics Inc Gombaellenes szerek és alkalmazásuk
PT3677252T (pt) 2012-03-19 2023-10-02 Cidara Therapeutics Inc Regimes de dosagem para compostos da classe equinocandina
EP2883915A1 (en) * 2013-12-13 2015-06-17 Ecole Polytechnique Federale de Lausanne (EPFL) Porphyrin based sensitizer for dye-sensitized solar cell
WO2017120471A1 (en) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
US11712459B2 (en) 2016-03-16 2023-08-01 Cidara Therapeutics, Inc. Dosing regimens for treatment of fungal infections
CA3069423C (en) 2017-07-12 2025-04-15 Napp Pharmaceutical Group Limited Formulations for the treatment of fungal infections
MX2022006424A (es) 2019-12-06 2022-06-22 Shanghai Senhui Medicine Co Ltd Analogos de equinocandina y metodo de preparacion de los mismos.
CA3219309A1 (en) * 2021-06-03 2022-12-08 Wei Jiang Method for preparing anidulafungin derivative
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE912046A1 (en) * 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5399552A (en) * 1991-10-17 1995-03-21 Merck & Co, Inc Antibiotic peptides bearing aminoalkylthioether moieties
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
WO1994025045A1 (en) * 1993-05-04 1994-11-10 Merck & Co., Inc. Cyclohexapeptidyl aminoalkyl ethers
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use

Also Published As

Publication number Publication date
WO1996037510A1 (en) 1996-11-28
ATE245162T1 (de) 2003-08-15
EP0744405A3 (en) 1998-05-27
IL118334A0 (en) 1996-09-12
DE69629075T2 (de) 2004-04-15
DE69629075D1 (de) 2003-08-21
AU5799196A (en) 1996-12-11
US5652213A (en) 1997-07-29
JPH11505845A (ja) 1999-05-25
EP0744405B1 (en) 2003-07-16
ZA964014B (en) 1997-11-20
PE38497A1 (es) 1997-10-09
CA2220728A1 (en) 1996-11-28
EP0744405A2 (en) 1996-11-27
ES2201154T3 (es) 2004-03-16

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