MX2022006424A - Analogos de equinocandina y metodo de preparacion de los mismos. - Google Patents
Analogos de equinocandina y metodo de preparacion de los mismos.Info
- Publication number
- MX2022006424A MX2022006424A MX2022006424A MX2022006424A MX2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- echinocandine
- analogs
- preventing
- compound
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003405 preventing effect Effects 0.000 abstract 2
- 108010049047 Echinocandins Proteins 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a un análogo de equinocandina y a un método de preparación del mismo. El compuesto se puede usar para prevenir o tratar infecciones fúngicas, o para prevenir, estabilizar o inhibir el crecimiento fúngico o matar hongos. Un compuesto ejemplar está representado por la Formula I, en donde las definiciones de los grupos R1, R2, R3 y G son como se revelan en la descripción. (ver Fórmula).
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911241526 | 2019-12-06 | ||
| CN201911249226 | 2019-12-09 | ||
| CN202010165349 | 2020-03-11 | ||
| CN202010799506 | 2020-08-11 | ||
| CN202011164541 | 2020-10-27 | ||
| CN202011371550 | 2020-11-30 | ||
| PCT/CN2020/133815 WO2021110125A1 (zh) | 2019-12-06 | 2020-12-04 | 棘白菌素类似物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022006424A true MX2022006424A (es) | 2022-06-22 |
Family
ID=76222453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022006424A MX2022006424A (es) | 2019-12-06 | 2020-12-04 | Analogos de equinocandina y metodo de preparacion de los mismos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12466856B2 (es) |
| EP (1) | EP4063381A4 (es) |
| JP (2) | JP7794736B2 (es) |
| KR (1) | KR20220110513A (es) |
| CN (3) | CN120484067A (es) |
| AU (1) | AU2020397311A1 (es) |
| BR (1) | BR112022010441A2 (es) |
| CA (1) | CA3161287A1 (es) |
| MX (1) | MX2022006424A (es) |
| TW (1) | TWI891685B (es) |
| WO (1) | WO2021110125A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240262866A1 (en) * | 2021-06-03 | 2024-08-08 | Shanghai Senhui Medicine Co., Ltd. | Method for preparing anidulafungin derivative |
| AU2023370368A1 (en) * | 2022-10-25 | 2025-06-05 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising echinocandin analog and preparation method for pharmaceutical composition |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
| WO2025152953A1 (zh) * | 2024-01-15 | 2025-07-24 | 深圳市祥根生物有限公司 | 棘白菌素类化合物的抗肿瘤用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2704030A1 (de) * | 1976-02-12 | 1977-08-18 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US5914313A (en) * | 1991-10-17 | 1999-06-22 | Merck & Co., Inc. | 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof |
| US5652213A (en) * | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JP2013503179A (ja) | 2009-08-27 | 2013-01-31 | シーチェイド ファーマシューティカルズ，インコーポレーテッド | エキノキャンディン誘導体 |
| PT2680873T (pt) | 2011-03-03 | 2017-11-01 | Cidara Therapeutics Inc | Agentes antifúngicos e suas utilizações |
| WO2016201283A1 (en) * | 2015-06-12 | 2016-12-15 | Cidara Therapeutics, Inc. | Antifungal agents |
| US20180256673A1 (en) | 2015-09-16 | 2018-09-13 | Cidara Therapeutics, Inc. | Methods for treating fungal infections |
| EP3399995A4 (en) | 2016-01-08 | 2019-08-21 | Cidara Therapeutics, Inc. | METHOD FOR PREVENTING AND TREATING PNEUMOCYSTIS INFECTIONS |
| WO2018102407A1 (en) | 2016-11-29 | 2018-06-07 | Cidara Therapeutics, Inc | Methods for preventing fungal infections |
-
2020
- 2020-12-04 CN CN202510466024.4A patent/CN120484067A/zh active Pending
- 2020-12-04 US US17/756,721 patent/US12466856B2/en active Active
- 2020-12-04 AU AU2020397311A patent/AU2020397311A1/en active Pending
- 2020-12-04 KR KR1020227021867A patent/KR20220110513A/ko active Pending
- 2020-12-04 CA CA3161287A patent/CA3161287A1/en active Pending
- 2020-12-04 WO PCT/CN2020/133815 patent/WO2021110125A1/zh not_active Ceased
- 2020-12-04 MX MX2022006424A patent/MX2022006424A/es unknown
- 2020-12-04 TW TW109142863A patent/TWI891685B/zh active
- 2020-12-04 JP JP2022530717A patent/JP7794736B2/ja active Active
- 2020-12-04 CN CN202080075108.0A patent/CN114616238B/zh active Active
- 2020-12-04 EP EP20897067.3A patent/EP4063381A4/en active Pending
- 2020-12-04 CN CN202510465954.8A patent/CN120484066A/zh active Pending
- 2020-12-04 BR BR112022010441A patent/BR112022010441A2/pt unknown
-
2025
- 2025-07-29 US US19/283,497 patent/US20250353879A1/en active Pending
- 2025-09-19 JP JP2025155845A patent/JP2026001045A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7794736B2 (ja) | 2026-01-06 |
| KR20220110513A (ko) | 2022-08-08 |
| TWI891685B (zh) | 2025-08-01 |
| CN114616238B (zh) | 2025-04-11 |
| CN120484067A (zh) | 2025-08-15 |
| CN114616238A (zh) | 2022-06-10 |
| JP2023504389A (ja) | 2023-02-03 |
| AU2020397311A1 (en) | 2022-07-14 |
| US20230159591A1 (en) | 2023-05-25 |
| CA3161287A1 (en) | 2021-06-10 |
| CN120484066A (zh) | 2025-08-15 |
| JP2026001045A (ja) | 2026-01-06 |
| TW202134257A (zh) | 2021-09-16 |
| BR112022010441A2 (pt) | 2022-09-06 |
| US20250353879A1 (en) | 2025-11-20 |
| WO2021110125A1 (zh) | 2021-06-10 |
| EP4063381A4 (en) | 2023-04-26 |
| US12466856B2 (en) | 2025-11-11 |
| EP4063381A1 (en) | 2022-09-28 |
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