PE20240825A1 - Anticuerpos anti-c5 y metodos de uso - Google Patents
Anticuerpos anti-c5 y metodos de usoInfo
- Publication number
- PE20240825A1 PE20240825A1 PE2023002969A PE2023002969A PE20240825A1 PE 20240825 A1 PE20240825 A1 PE 20240825A1 PE 2023002969 A PE2023002969 A PE 2023002969A PE 2023002969 A PE2023002969 A PE 2023002969A PE 20240825 A1 PE20240825 A1 PE 20240825A1
- Authority
- PE
- Peru
- Prior art keywords
- antibodies
- seq
- beta chain
- epitope
- domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016120325 | 2016-06-17 | ||
| PCT/JP2017/022253 WO2017217524A1 (en) | 2016-06-17 | 2017-06-16 | Anti-c5 antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240825A1 true PE20240825A1 (es) | 2024-04-18 |
Family
ID=59969459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002969A PE20240825A1 (es) | 2016-06-17 | 2017-06-16 | Anticuerpos anti-c5 y metodos de uso |
| PE2018003148A PE20190394A1 (es) | 2016-06-17 | 2017-06-16 | Anticuerpos anti-c5 y metodos de uso |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018003148A PE20190394A1 (es) | 2016-06-17 | 2017-06-16 | Anticuerpos anti-c5 y metodos de uso |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP3472316A4 (zh) |
| JP (4) | JP6202774B1 (zh) |
| KR (2) | KR101852739B1 (zh) |
| CN (3) | CN115960223A (zh) |
| AU (1) | AU2017285763B2 (zh) |
| BR (1) | BR112018075688A2 (zh) |
| CA (1) | CA3021956A1 (zh) |
| CL (1) | CL2018003573A1 (zh) |
| CR (1) | CR20190013A (zh) |
| EA (1) | EA201990018A1 (zh) |
| IL (2) | IL300611A (zh) |
| MX (2) | MX2018015030A (zh) |
| MY (1) | MY187848A (zh) |
| PE (2) | PE20240825A1 (zh) |
| PH (1) | PH12018502354B1 (zh) |
| SG (2) | SG11201705584VA (zh) |
| TW (5) | TWI610941B (zh) |
| UA (1) | UA126561C2 (zh) |
| WO (1) | WO2017217524A1 (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007114319A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 抗体の血中動態を制御する方法 |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| EP2708559B1 (en) | 2008-04-11 | 2018-03-28 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | 中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| ES2899894T3 (es) | 2014-12-19 | 2022-03-15 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-C5 y métodos de uso |
| CA2963760A1 (en) | 2014-12-19 | 2016-06-23 | Yoshinao Ruike | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| KR102667023B1 (ko) | 2016-06-14 | 2024-05-21 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 및 이의 용도 |
| TWI610941B (zh) * | 2016-06-17 | 2018-01-11 | Chugai Seiyaku Kabushiki Kaisha | 抗c5抗體及使用方法 |
| TWI831965B (zh) | 2016-08-05 | 2024-02-11 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| CA3078362A1 (en) * | 2017-10-04 | 2019-04-11 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of patients with membranoproliferative glomerulonephritis |
| SG11202004662RA (en) | 2017-12-13 | 2020-06-29 | Regeneron Pharma | Anti-c5 antibody combinations and uses thereof |
| BR112021004141A2 (pt) * | 2018-09-06 | 2021-05-25 | The Trustees Of The University Of Pennsylvania | anticorpo dependente de ph que se liga especificamente a c5 humano, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indivíduo e para reduzir a atividade de um sistema complemento de um indivíduo, célula, e, animal não humano geneticamente modificado. |
| WO2020219922A1 (en) * | 2019-04-24 | 2020-10-29 | The Trustees Of The University Of Pennsylvania | Bi-functional humanized anti-c5 antibodies and factor h fusion proteins and uses thereof |
| CN113563467A (zh) * | 2020-04-28 | 2021-10-29 | 上海普铭生物科技有限公司 | 针对人补体蛋白c5的抗体及其应用 |
| WO2022012606A1 (en) * | 2020-07-15 | 2022-01-20 | Biosion Inc. | Antibodies binding c5 and uses thereof |
| EP4267612A4 (en) * | 2020-12-25 | 2024-09-04 | The Trustees of the University of Pennsylvania | HUMANIZED ANTI-C5 ANTIBODIES AND FACTOR H FUSION PROTEINS AND THEIR USES |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0230985Y2 (zh) | 1985-07-08 | 1990-08-21 | ||
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| JP4643139B2 (ja) | 2001-06-12 | 2011-03-02 | テレフオンアクチーボラゲット エル エム エリクソン(パブル) | Umts地上無線アクセスネットワーク(utran)での同期 |
| CN101387646B (zh) | 2001-08-17 | 2016-08-10 | 建南德克公司 | 结合至c5和c5a但不阻止c5b形成的补体途径抑制剂 |
| JP4333939B2 (ja) | 2001-08-27 | 2009-09-16 | ロード・コーポレーション | トロリ線の吊架装置 |
| DE10253331A1 (de) | 2002-11-14 | 2004-06-03 | Symrise Gmbh & Co. Kg | Verwendung von trans-Pellitori als Aromastoff |
| US7267849B2 (en) | 2004-03-02 | 2007-09-11 | Nitto Denko Corporation | Compensator for liquid crystal display |
| KR20080069889A (ko) | 2007-03-20 | 2008-07-29 | (주)화도 | 폴리에틸렌 관 |
| BRPI0809105A2 (pt) * | 2007-03-22 | 2019-09-10 | Novartis Ag | antígenos c5 e uso destes |
| US8420298B2 (en) | 2007-04-11 | 2013-04-16 | Sekisui Chemical Co., Ltd. | Method for production of crosslinked polyvinyl acetal resin, and crosslinked polyvinyl acetal resin |
| EP2708559B1 (en) * | 2008-04-11 | 2018-03-28 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| SG10201405377XA (en) * | 2008-08-05 | 2014-12-30 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| KR20100054403A (ko) | 2008-11-14 | 2010-05-25 | 삼성전자주식회사 | 온라인 공동 작문 장치 및 방법 |
| EP2545079A2 (en) * | 2010-03-11 | 2013-01-16 | Rinat Neuroscience Corporation | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| TW201206466A (en) * | 2010-03-11 | 2012-02-16 | Rinat Neuroscience Corp | Antibodies with pH dependent antigen binding |
| KR20110111007A (ko) | 2010-04-02 | 2011-10-10 | 이화여자대학교 산학협력단 | L/d 광학변환 및 광학분할을 위한 옥타하이드로-바이나프톨 유도체 |
| KR20110122011A (ko) | 2010-05-03 | 2011-11-09 | 황보철종 | 매장 포인트 통합 관리 시스템 및 그 방법 |
| JP6309521B2 (ja) * | 2012-08-13 | 2018-04-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | pH依存性結合特性を有する抗PCSK9抗体 |
| CN105143261B (zh) * | 2013-01-31 | 2021-04-09 | 首尔大学校产学协力团 | C5抗体以及用于预防和治疗补体-相关的疾病的方法 |
| JP6505079B2 (ja) * | 2013-03-29 | 2019-04-24 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体c5を標的とする治療薬の血清半減期を増加させるための組成物及び方法 |
| NZ631007A (en) * | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| ES2899894T3 (es) * | 2014-12-19 | 2022-03-15 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-C5 y métodos de uso |
| EP3390442B1 (en) * | 2015-12-18 | 2023-11-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-c5 antibodies and methods of use |
| TWI610941B (zh) * | 2016-06-17 | 2018-01-11 | Chugai Seiyaku Kabushiki Kaisha | 抗c5抗體及使用方法 |
-
2017
- 2017-06-16 TW TW106120143A patent/TWI610941B/zh active
- 2017-06-16 EP EP17813418.5A patent/EP3472316A4/en active Pending
- 2017-06-16 TW TW112120479A patent/TW202337903A/zh unknown
- 2017-06-16 EA EA201990018A patent/EA201990018A1/ru unknown
- 2017-06-16 PH PH1/2018/502354A patent/PH12018502354B1/en unknown
- 2017-06-16 WO PCT/JP2017/022253 patent/WO2017217524A1/en not_active Ceased
- 2017-06-16 CR CR20190013A patent/CR20190013A/es unknown
- 2017-06-16 PE PE2023002969A patent/PE20240825A1/es unknown
- 2017-06-16 SG SG11201705584VA patent/SG11201705584VA/en unknown
- 2017-06-16 MX MX2018015030A patent/MX2018015030A/es unknown
- 2017-06-16 AU AU2017285763A patent/AU2017285763B2/en active Active
- 2017-06-16 PE PE2018003148A patent/PE20190394A1/es unknown
- 2017-06-16 BR BR112018075688-1A patent/BR112018075688A2/pt unknown
- 2017-06-16 UA UAA201810992A patent/UA126561C2/uk unknown
- 2017-06-16 TW TW111107923A patent/TWI807666B/zh active
- 2017-06-16 KR KR1020177020545A patent/KR101852739B1/ko active Active
- 2017-06-16 CA CA3021956A patent/CA3021956A1/en active Pending
- 2017-06-16 SG SG10201800265UA patent/SG10201800265UA/en unknown
- 2017-06-16 TW TW114113992A patent/TW202532438A/zh unknown
- 2017-06-16 CN CN202211018018.5A patent/CN115960223A/zh active Pending
- 2017-06-16 MY MYPI2018002581A patent/MY187848A/en unknown
- 2017-06-16 CN CN201780036916.4A patent/CN109312326B/zh active Active
- 2017-06-16 TW TW106141573A patent/TWI789369B/zh active
- 2017-06-16 IL IL300611A patent/IL300611A/en unknown
- 2017-06-16 KR KR1020187010179A patent/KR102226975B1/ko active Active
- 2017-06-16 CN CN202211023851.9A patent/CN115925922A/zh active Pending
- 2017-06-16 JP JP2017118226A patent/JP6202774B1/ja active Active
- 2017-08-28 JP JP2017162934A patent/JP7032077B2/ja active Active
-
2018
- 2018-12-04 MX MX2023001360A patent/MX2023001360A/es unknown
- 2018-12-12 CL CL2018003573A patent/CL2018003573A1/es unknown
- 2018-12-12 IL IL263657A patent/IL263657B2/en unknown
-
2022
- 2022-02-24 JP JP2022026406A patent/JP2022091748A/ja active Pending
-
2024
- 2024-04-30 JP JP2024073302A patent/JP2024102181A/ja active Pending
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