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MX2020004063A - Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados. - Google Patents

Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados.

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Publication number
MX2020004063A
MX2020004063A MX2020004063A MX2020004063A MX2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A MX 2020004063 A MX2020004063 A MX 2020004063A
Authority
MX
Mexico
Prior art keywords
systems
methods
selected antibodies
produce
genetically modified
Prior art date
Application number
MX2020004063A
Other languages
English (en)
Inventor
Howell F Moffett
Justin J Taylor
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of MX2020004063A publication Critical patent/MX2020004063A/es

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    • A61K39/12—Viral antigens
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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Abstract

Se describen sistemas y métodos para modificar genéticamente linfocitos B para que expresen anticuerpos seleccionados. Los sistemas y métodos pueden usarse para: evitar la necesidad de vacunas clásicas; proporcionar protección contra agentes infecciosos para los cuales no hay vacunas disponibles en la actualidad; proporcionar protección contra agentes infecciosos cuando los pacientes se encuentran inmunodeprimidos por otras cuestiones; y/o proporcionar un beneficio proporcionado por un anticuerpo terapéutico, tal como en el tratamiento de trastornos autoinmunitarios.
MX2020004063A 2017-10-20 2018-10-19 Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados. MX2020004063A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762575275P 2017-10-20 2017-10-20
US201762580303P 2017-11-01 2017-11-01
US201862623371P 2018-01-29 2018-01-29
PCT/US2018/056789 WO2019079772A1 (en) 2017-10-20 2018-10-19 SYSTEMS AND METHODS FOR GENETICALLY MODIFIED B-LYMPHOCYTES FOR EXPRESSING SELECTED ANTIBODIES

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MX2020004063A true MX2020004063A (es) 2020-10-05

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MX2020004063A MX2020004063A (es) 2017-10-20 2018-10-19 Sistemas y metodos para producir celulas b modificadas geneticamente para expresar anticuerpos seleccionados.

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Country Link
US (2) US11578118B2 (es)
EP (1) EP3697895A4 (es)
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